Amino acid dipepetide frequency for Terrimicrobium sacchariphilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.515AlaAla: 12.515 ± 0.139	0.962AlaCys: 0.962 ± 0.033	5.235AlaAsp: 5.235 ± 0.06	6.302AlaGlu: 6.302 ± 0.091	4.0AlaPhe: 4.0 ± 0.053	8.955AlaGly: 8.955 ± 0.096	1.756AlaHis: 1.756 ± 0.035	5.695AlaIle: 5.695 ± 0.066	3.958AlaLys: 3.958 ± 0.06	10.542AlaLeu: 10.542 ± 0.102	2.538AlaMet: 2.538 ± 0.045	3.138AlaAsn: 3.138 ± 0.055	4.818AlaPro: 4.818 ± 0.069	3.498AlaGln: 3.498 ± 0.063	6.634AlaArg: 6.634 ± 0.086	6.834AlaSer: 6.834 ± 0.087	5.623AlaThr: 5.623 ± 0.072	7.351AlaVal: 7.351 ± 0.081	1.608AlaTrp: 1.608 ± 0.037	2.543AlaTyr: 2.543 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.963CysAla: 0.963 ± 0.03	0.141CysCys: 0.141 ± 0.012	0.554CysAsp: 0.554 ± 0.022	0.573CysGlu: 0.573 ± 0.022	0.43CysPhe: 0.43 ± 0.018	0.971CysGly: 0.971 ± 0.027	0.234CysHis: 0.234 ± 0.014	0.481CysIle: 0.481 ± 0.016	0.258CysLys: 0.258 ± 0.015	1.029CysLeu: 1.029 ± 0.026	0.178CysMet: 0.178 ± 0.01	0.252CysAsn: 0.252 ± 0.014	0.555CysPro: 0.555 ± 0.019	0.267CysGln: 0.267 ± 0.014	0.741CysArg: 0.741 ± 0.026	0.582CysSer: 0.582 ± 0.019	0.425CysThr: 0.425 ± 0.018	0.682CysVal: 0.682 ± 0.022	0.152CysTrp: 0.152 ± 0.011	0.259CysTyr: 0.259 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.252AspAla: 5.252 ± 0.06	0.503AspCys: 0.503 ± 0.02	2.44AspAsp: 2.44 ± 0.043	3.061AspGlu: 3.061 ± 0.049	2.516AspPhe: 2.516 ± 0.047	4.749AspGly: 4.749 ± 0.06	1.088AspHis: 1.088 ± 0.033	2.737AspIle: 2.737 ± 0.058	1.76AspLys: 1.76 ± 0.036	5.393AspLeu: 5.393 ± 0.063	0.919AspMet: 0.919 ± 0.025	1.431AspAsn: 1.431 ± 0.034	3.133AspPro: 3.133 ± 0.051	1.761AspGln: 1.761 ± 0.037	3.347AspArg: 3.347 ± 0.058	2.886AspSer: 2.886 ± 0.045	2.49AspThr: 2.49 ± 0.042	3.601AspVal: 3.601 ± 0.05	1.068AspTrp: 1.068 ± 0.03	1.727AspTyr: 1.727 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.139GluAla: 6.139 ± 0.089	0.483GluCys: 0.483 ± 0.022	2.608GluAsp: 2.608 ± 0.045	3.726GluGlu: 3.726 ± 0.072	2.303GluPhe: 2.303 ± 0.041	4.127GluGly: 4.127 ± 0.062	1.16GluHis: 1.16 ± 0.029	3.885GluIle: 3.885 ± 0.056	3.129GluLys: 3.129 ± 0.051	5.368GluLeu: 5.368 ± 0.078	1.476GluMet: 1.476 ± 0.038	2.043GluAsn: 2.043 ± 0.04	2.641GluPro: 2.641 ± 0.041	2.002GluGln: 2.002 ± 0.043	3.967GluArg: 3.967 ± 0.065	3.322GluSer: 3.322 ± 0.055	3.343GluThr: 3.343 ± 0.043	4.063GluVal: 4.063 ± 0.056	0.924GluTrp: 0.924 ± 0.032	1.439GluTyr: 1.439 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.114PheAla: 4.114 ± 0.061	0.51PheCys: 0.51 ± 0.021	2.446PheAsp: 2.446 ± 0.044	2.183PheGlu: 2.183 ± 0.041	1.862PhePhe: 1.862 ± 0.045	3.512PheGly: 3.512 ± 0.052	0.971PheHis: 0.971 ± 0.024	1.789PheIle: 1.789 ± 0.035	1.038PheLys: 1.038 ± 0.028	4.395PheLeu: 4.395 ± 0.062	0.618PheMet: 0.618 ± 0.022	1.273PheAsn: 1.273 ± 0.032	2.163PhePro: 2.163 ± 0.042	1.507PheGln: 1.507 ± 0.032	2.74PheArg: 2.74 ± 0.039	3.117PheSer: 3.117 ± 0.046	2.508PheThr: 2.508 ± 0.041	2.849PheVal: 2.849 ± 0.041	0.686PheTrp: 0.686 ± 0.028	1.179PheTyr: 1.179 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.642GlyAla: 7.642 ± 0.09	0.876GlyCys: 0.876 ± 0.027	4.229GlyAsp: 4.229 ± 0.059	4.647GlyGlu: 4.647 ± 0.066	3.647GlyPhe: 3.647 ± 0.051	7.248GlyGly: 7.248 ± 0.154	1.55GlyHis: 1.55 ± 0.038	4.65GlyIle: 4.65 ± 0.068	3.99GlyLys: 3.99 ± 0.057	7.672GlyLeu: 7.672 ± 0.088	1.876GlyMet: 1.876 ± 0.042	2.819GlyAsn: 2.819 ± 0.06	2.896GlyPro: 2.896 ± 0.04	2.669GlyGln: 2.669 ± 0.044	4.982GlyArg: 4.982 ± 0.055	5.598GlySer: 5.598 ± 0.107	5.045GlyThr: 5.045 ± 0.108	5.996GlyVal: 5.996 ± 0.071	1.638GlyTrp: 1.638 ± 0.034	2.539GlyTyr: 2.539 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.98HisAla: 1.98 ± 0.034	0.259HisCys: 0.259 ± 0.013	1.019HisAsp: 1.019 ± 0.029	1.072HisGlu: 1.072 ± 0.028	0.951HisPhe: 0.951 ± 0.028	1.796HisGly: 1.796 ± 0.044	0.596HisHis: 0.596 ± 0.021	0.959HisIle: 0.959 ± 0.028	0.503HisLys: 0.503 ± 0.017	2.059HisLeu: 2.059 ± 0.042	0.363HisMet: 0.363 ± 0.016	0.49HisAsn: 0.49 ± 0.018	1.445HisPro: 1.445 ± 0.035	0.579HisGln: 0.579 ± 0.02	1.401HisArg: 1.401 ± 0.035	1.12HisSer: 1.12 ± 0.03	0.906HisThr: 0.906 ± 0.027	1.312HisVal: 1.312 ± 0.035	0.359HisTrp: 0.359 ± 0.018	0.586HisTyr: 0.586 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.876IleAla: 5.876 ± 0.075	0.618IleCys: 0.618 ± 0.018	3.075IleAsp: 3.075 ± 0.047	3.359IleGlu: 3.359 ± 0.049	2.202IlePhe: 2.202 ± 0.043	4.391IleGly: 4.391 ± 0.06	1.072IleHis: 1.072 ± 0.027	2.586IleIle: 2.586 ± 0.048	1.723IleLys: 1.723 ± 0.038	5.168IleLeu: 5.168 ± 0.072	0.788IleMet: 0.788 ± 0.028	1.671IleAsn: 1.671 ± 0.037	3.103IlePro: 3.103 ± 0.046	1.664IleGln: 1.664 ± 0.039	3.397IleArg: 3.397 ± 0.053	3.721IleSer: 3.721 ± 0.054	3.258IleThr: 3.258 ± 0.046	3.945IleVal: 3.945 ± 0.057	0.719IleTrp: 0.719 ± 0.025	1.445IleTyr: 1.445 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.078LysAla: 4.078 ± 0.066	0.265LysCys: 0.265 ± 0.013	2.152LysAsp: 2.152 ± 0.046	2.32LysGlu: 2.32 ± 0.044	1.388LysPhe: 1.388 ± 0.027	2.815LysGly: 2.815 ± 0.051	0.66LysHis: 0.66 ± 0.023	2.208LysIle: 2.208 ± 0.045	1.946LysLys: 1.946 ± 0.045	3.706LysLeu: 3.706 ± 0.05	0.911LysMet: 0.911 ± 0.025	1.324LysAsn: 1.324 ± 0.031	2.373LysPro: 2.373 ± 0.043	1.216LysGln: 1.216 ± 0.035	2.208LysArg: 2.208 ± 0.041	2.39LysSer: 2.39 ± 0.041	2.324LysThr: 2.324 ± 0.037	2.927LysVal: 2.927 ± 0.054	0.556LysTrp: 0.556 ± 0.019	1.004LysTyr: 1.004 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.321LeuAla: 11.321 ± 0.115	1.132LeuCys: 1.132 ± 0.026	5.39LeuAsp: 5.39 ± 0.07	5.345LeuGlu: 5.345 ± 0.075	3.799LeuPhe: 3.799 ± 0.062	7.988LeuGly: 7.988 ± 0.084	2.005LeuHis: 2.005 ± 0.041	5.011LeuIle: 5.011 ± 0.074	3.898LeuLys: 3.898 ± 0.055	10.016LeuLeu: 10.016 ± 0.107	1.853LeuMet: 1.853 ± 0.041	3.123LeuAsn: 3.123 ± 0.055	5.842LeuPro: 5.842 ± 0.069	3.258LeuGln: 3.258 ± 0.044	6.81LeuArg: 6.81 ± 0.078	6.862LeuSer: 6.862 ± 0.07	5.604LeuThr: 5.604 ± 0.077	6.967LeuVal: 6.967 ± 0.079	1.327LeuTrp: 1.327 ± 0.039	2.254LeuTyr: 2.254 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.229MetAla: 2.229 ± 0.045	0.165MetCys: 0.165 ± 0.011	0.95MetAsp: 0.95 ± 0.029	1.158MetGlu: 1.158 ± 0.028	0.653MetPhe: 0.653 ± 0.022	1.423MetGly: 1.423 ± 0.033	0.375MetHis: 0.375 ± 0.015	1.207MetIle: 1.207 ± 0.034	1.271MetLys: 1.271 ± 0.029	2.003MetLeu: 2.003 ± 0.039	0.443MetMet: 0.443 ± 0.02	0.824MetAsn: 0.824 ± 0.024	1.196MetPro: 1.196 ± 0.033	0.72MetGln: 0.72 ± 0.026	1.356MetArg: 1.356 ± 0.029	1.467MetSer: 1.467 ± 0.031	1.307MetThr: 1.307 ± 0.032	1.413MetVal: 1.413 ± 0.035	0.205MetTrp: 0.205 ± 0.013	0.344MetTyr: 0.344 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.233AsnAla: 3.233 ± 0.053	0.271AsnCys: 0.271 ± 0.015	1.571AsnAsp: 1.571 ± 0.032	1.487AsnGlu: 1.487 ± 0.037	1.351AsnPhe: 1.351 ± 0.034	2.942AsnGly: 2.942 ± 0.067	0.632AsnHis: 0.632 ± 0.024	1.703AsnIle: 1.703 ± 0.035	0.924AsnLys: 0.924 ± 0.029	3.188AsnLeu: 3.188 ± 0.045	0.581AsnMet: 0.581 ± 0.019	1.14AsnAsn: 1.14 ± 0.039	2.346AsnPro: 2.346 ± 0.045	1.038AsnGln: 1.038 ± 0.03	1.886AsnArg: 1.886 ± 0.04	2.08AsnSer: 2.08 ± 0.049	1.898AsnThr: 1.898 ± 0.044	2.18AsnVal: 2.18 ± 0.036	0.595AsnTrp: 0.595 ± 0.021	0.976AsnTyr: 0.976 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.252ProAla: 6.252 ± 0.079	0.374ProCys: 0.374 ± 0.018	3.302ProAsp: 3.302 ± 0.049	4.07ProGlu: 4.07 ± 0.056	2.064ProPhe: 2.064 ± 0.04	4.773ProGly: 4.773 ± 0.059	1.042ProHis: 1.042 ± 0.024	2.384ProIle: 2.384 ± 0.04	1.94ProLys: 1.94 ± 0.044	4.696ProLeu: 4.696 ± 0.057	1.12ProMet: 1.12 ± 0.028	1.526ProAsn: 1.526 ± 0.034	2.654ProPro: 2.654 ± 0.057	1.802ProGln: 1.802 ± 0.032	2.813ProArg: 2.813 ± 0.048	3.356ProSer: 3.356 ± 0.054	2.919ProThr: 2.919 ± 0.069	4.29ProVal: 4.29 ± 0.063	0.842ProTrp: 0.842 ± 0.024	1.337ProTyr: 1.337 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.674GlnAla: 3.674 ± 0.057	0.258GlnCys: 0.258 ± 0.013	1.462GlnAsp: 1.462 ± 0.032	1.74GlnGlu: 1.74 ± 0.035	1.253GlnPhe: 1.253 ± 0.032	2.432GlnGly: 2.432 ± 0.046	0.619GlnHis: 0.619 ± 0.021	2.093GlnIle: 2.093 ± 0.042	1.567GlnLys: 1.567 ± 0.036	3.057GlnLeu: 3.057 ± 0.054	0.848GlnMet: 0.848 ± 0.025	1.169GlnAsn: 1.169 ± 0.03	1.996GlnPro: 1.996 ± 0.046	1.402GlnGln: 1.402 ± 0.046	2.333GlnArg: 2.333 ± 0.043	2.099GlnSer: 2.099 ± 0.038	1.968GlnThr: 1.968 ± 0.036	2.275GlnVal: 2.275 ± 0.039	0.553GlnTrp: 0.553 ± 0.019	0.889GlnTyr: 0.889 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.632ArgAla: 5.632 ± 0.07	0.582ArgCys: 0.582 ± 0.021	3.466ArgAsp: 3.466 ± 0.057	4.539ArgGlu: 4.539 ± 0.068	2.785ArgPhe: 2.785 ± 0.047	4.079ArgGly: 4.079 ± 0.071	1.426ArgHis: 1.426 ± 0.034	3.845ArgIle: 3.845 ± 0.06	2.77ArgLys: 2.77 ± 0.054	6.68ArgLeu: 6.68 ± 0.083	1.572ArgMet: 1.572 ± 0.034	2.102ArgAsn: 2.102 ± 0.042	2.997ArgPro: 2.997 ± 0.046	2.544ArgGln: 2.544 ± 0.046	4.579ArgArg: 4.579 ± 0.071	3.819ArgSer: 3.819 ± 0.054	3.258ArgThr: 3.258 ± 0.046	4.392ArgVal: 4.392 ± 0.055	1.131ArgTrp: 1.131 ± 0.028	1.869ArgTyr: 1.869 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.585SerAla: 6.585 ± 0.085	0.557SerCys: 0.557 ± 0.018	3.209SerAsp: 3.209 ± 0.05	3.307SerGlu: 3.307 ± 0.05	2.617SerPhe: 2.617 ± 0.039	6.356SerGly: 6.356 ± 0.111	1.319SerHis: 1.319 ± 0.032	3.264SerIle: 3.264 ± 0.053	2.027SerLys: 2.027 ± 0.039	6.959SerLeu: 6.959 ± 0.078	1.304SerMet: 1.304 ± 0.028	1.906SerAsn: 1.906 ± 0.046	3.701SerPro: 3.701 ± 0.052	2.187SerGln: 2.187 ± 0.047	4.056SerArg: 4.056 ± 0.053	4.607SerSer: 4.607 ± 0.087	3.653SerThr: 3.653 ± 0.064	4.473SerVal: 4.473 ± 0.055	1.033SerTrp: 1.033 ± 0.026	1.748SerTyr: 1.748 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.748ThrAla: 5.748 ± 0.074	0.46ThrCys: 0.46 ± 0.019	2.656ThrAsp: 2.656 ± 0.044	2.786ThrGlu: 2.786 ± 0.045	2.479ThrPhe: 2.479 ± 0.048	5.249ThrGly: 5.249 ± 0.084	1.035ThrHis: 1.035 ± 0.03	3.225ThrIle: 3.225 ± 0.057	1.806ThrLys: 1.806 ± 0.035	6.094ThrLeu: 6.094 ± 0.088	1.056ThrMet: 1.056 ± 0.028	1.818ThrAsn: 1.818 ± 0.051	3.914ThrPro: 3.914 ± 0.071	1.644ThrGln: 1.644 ± 0.035	3.126ThrArg: 3.126 ± 0.047	3.546ThrSer: 3.546 ± 0.073	3.337ThrThr: 3.337 ± 0.076	4.343ThrVal: 4.343 ± 0.064	0.95ThrTrp: 0.95 ± 0.026	1.536ThrTyr: 1.536 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.601ValAla: 7.601 ± 0.079	0.822ValCys: 0.822 ± 0.025	3.72ValAsp: 3.72 ± 0.058	4.152ValGlu: 4.152 ± 0.052	3.083ValPhe: 3.083 ± 0.047	5.141ValGly: 5.141 ± 0.071	1.274ValHis: 1.274 ± 0.034	4.048ValIle: 4.048 ± 0.063	2.629ValLys: 2.629 ± 0.047	7.178ValLeu: 7.178 ± 0.083	1.426ValMet: 1.426 ± 0.03	2.358ValAsn: 2.358 ± 0.043	3.701ValPro: 3.701 ± 0.046	2.218ValGln: 2.218 ± 0.04	4.47ValArg: 4.47 ± 0.069	4.762ValSer: 4.762 ± 0.057	4.508ValThr: 4.508 ± 0.064	5.375ValVal: 5.375 ± 0.079	1.022ValTrp: 1.022 ± 0.024	1.801ValTyr: 1.801 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.266TrpAla: 1.266 ± 0.032	0.173TrpCys: 0.173 ± 0.01	0.837TrpAsp: 0.837 ± 0.028	0.862TrpGlu: 0.862 ± 0.025	0.682TrpPhe: 0.682 ± 0.02	1.059TrpGly: 1.059 ± 0.033	0.358TrpHis: 0.358 ± 0.017	0.897TrpIle: 0.897 ± 0.026	0.828TrpLys: 0.828 ± 0.023	1.831TrpLeu: 1.831 ± 0.046	0.427TrpMet: 0.427 ± 0.019	0.74TrpAsn: 0.74 ± 0.024	0.688TrpPro: 0.688 ± 0.025	0.697TrpGln: 0.697 ± 0.023	1.137TrpArg: 1.137 ± 0.029	0.984TrpSer: 0.984 ± 0.023	0.989TrpThr: 0.989 ± 0.028	1.059TrpVal: 1.059 ± 0.033	0.314TrpTrp: 0.314 ± 0.014	0.383TrpTyr: 0.383 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.403TyrAla: 2.403 ± 0.04	0.315TyrCys: 0.315 ± 0.015	1.541TyrAsp: 1.541 ± 0.036	1.458TyrGlu: 1.458 ± 0.031	1.392TyrPhe: 1.392 ± 0.027	2.202TyrGly: 2.202 ± 0.04	0.583TyrHis: 0.583 ± 0.021	1.114TyrIle: 1.114 ± 0.031	0.806TyrLys: 0.806 ± 0.025	2.774TyrLeu: 2.774 ± 0.046	0.411TyrMet: 0.411 ± 0.018	0.877TyrAsn: 0.877 ± 0.027	1.394TyrPro: 1.394 ± 0.036	1.013TyrGln: 1.013 ± 0.03	2.088TyrArg: 2.088 ± 0.044	1.716TyrSer: 1.716 ± 0.035	1.445TyrThr: 1.445 ± 0.039	1.795TyrVal: 1.795 ± 0.037	0.529TyrTrp: 0.529 ± 0.02	0.903TyrTyr: 0.903 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4168 proteins (1458384 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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