Amino acid dipepetide frequency for Geobacter sp. DSM 9736

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.459AlaAla: 11.459 ± 0.164
1.303AlaCys: 1.303 ± 0.038
4.689AlaAsp: 4.689 ± 0.054
6.547AlaGlu: 6.547 ± 0.102
3.483AlaPhe: 3.483 ± 0.063
8.731AlaGly: 8.731 ± 0.101
1.605AlaHis: 1.605 ± 0.036
4.993AlaIle: 4.993 ± 0.077
3.736AlaLys: 3.736 ± 0.06
9.274AlaLeu: 9.274 ± 0.112
2.286AlaMet: 2.286 ± 0.043
2.466AlaAsn: 2.466 ± 0.062
3.794AlaPro: 3.794 ± 0.076
2.497AlaGln: 2.497 ± 0.053
5.58AlaArg: 5.58 ± 0.077
5.345AlaSer: 5.345 ± 0.088
4.856AlaThr: 4.856 ± 0.095
7.574AlaVal: 7.574 ± 0.083
0.915AlaTrp: 0.915 ± 0.03
2.255AlaTyr: 2.255 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.045CysAla: 1.045 ± 0.031
0.221CysCys: 0.221 ± 0.014
0.66CysAsp: 0.66 ± 0.025
0.569CysGlu: 0.569 ± 0.028
0.473CysPhe: 0.473 ± 0.02
1.358CysGly: 1.358 ± 0.039
1.149CysHis: 1.149 ± 0.146
0.653CysIle: 0.653 ± 0.027
0.394CysLys: 0.394 ± 0.018
1.053CysLeu: 1.053 ± 0.035
0.299CysMet: 0.299 ± 0.017
0.426CysAsn: 0.426 ± 0.023
0.655CysPro: 0.655 ± 0.035
0.279CysGln: 0.279 ± 0.015
0.929CysArg: 0.929 ± 0.032
1.044CysSer: 1.044 ± 0.036
0.734CysThr: 0.734 ± 0.029
0.679CysVal: 0.679 ± 0.027
0.132CysTrp: 0.132 ± 0.011
0.405CysTyr: 0.405 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.364AspAla: 4.364 ± 0.064
0.728AspCys: 0.728 ± 0.036
2.431AspAsp: 2.431 ± 0.051
3.381AspGlu: 3.381 ± 0.06
2.251AspPhe: 2.251 ± 0.05
4.134AspGly: 4.134 ± 0.075
0.998AspHis: 0.998 ± 0.034
3.522AspIle: 3.522 ± 0.059
1.974AspLys: 1.974 ± 0.043
5.461AspLeu: 5.461 ± 0.074
1.193AspMet: 1.193 ± 0.031
1.555AspAsn: 1.555 ± 0.041
2.833AspPro: 2.833 ± 0.057
1.448AspGln: 1.448 ± 0.037
3.71AspArg: 3.71 ± 0.063
2.764AspSer: 2.764 ± 0.05
2.563AspThr: 2.563 ± 0.054
3.625AspVal: 3.625 ± 0.068
0.57AspTrp: 0.57 ± 0.021
1.719AspTyr: 1.719 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.138GluAla: 6.138 ± 0.081
0.645GluCys: 0.645 ± 0.024
2.813GluAsp: 2.813 ± 0.055
5.644GluGlu: 5.644 ± 0.112
2.166GluPhe: 2.166 ± 0.048
4.951GluGly: 4.951 ± 0.076
1.292GluHis: 1.292 ± 0.037
4.307GluIle: 4.307 ± 0.073
4.512GluLys: 4.512 ± 0.091
6.62GluLeu: 6.62 ± 0.109
1.987GluMet: 1.987 ± 0.043
2.114GluAsn: 2.114 ± 0.042
2.382GluPro: 2.382 ± 0.046
2.567GluGln: 2.567 ± 0.059
5.021GluArg: 5.021 ± 0.085
3.096GluSer: 3.096 ± 0.054
3.407GluThr: 3.407 ± 0.064
4.818GluVal: 4.818 ± 0.075
0.677GluTrp: 0.677 ± 0.022
1.729GluTyr: 1.729 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.402PheAla: 3.402 ± 0.054
0.563PheCys: 0.563 ± 0.022
2.33PheAsp: 2.33 ± 0.044
2.082PheGlu: 2.082 ± 0.041
1.914PhePhe: 1.914 ± 0.048
3.287PheGly: 3.287 ± 0.057
0.836PheHis: 0.836 ± 0.031
2.319PheIle: 2.319 ± 0.049
1.47PheLys: 1.47 ± 0.038
4.136PheLeu: 4.136 ± 0.073
0.927PheMet: 0.927 ± 0.027
1.427PheAsn: 1.427 ± 0.034
1.929PhePro: 1.929 ± 0.042
1.079PheGln: 1.079 ± 0.03
2.701PheArg: 2.701 ± 0.059
3.065PheSer: 3.065 ± 0.05
2.443PheThr: 2.443 ± 0.045
2.646PheVal: 2.646 ± 0.05
0.436PheTrp: 0.436 ± 0.02
1.169PheTyr: 1.169 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
6.959GlyAla: 6.959 ± 0.09
1.43GlyCys: 1.43 ± 0.046
3.992GlyAsp: 3.992 ± 0.057
5.587GlyGlu: 5.587 ± 0.064
3.39GlyPhe: 3.39 ± 0.057
6.867GlyGly: 6.867 ± 0.131
1.577GlyHis: 1.577 ± 0.035
5.759GlyIle: 5.759 ± 0.077
4.862GlyLys: 4.862 ± 0.071
6.88GlyLeu: 6.88 ± 0.08
2.327GlyMet: 2.327 ± 0.048
3.127GlyAsn: 3.127 ± 0.084
2.367GlyPro: 2.367 ± 0.052
2.107GlyGln: 2.107 ± 0.04
4.945GlyArg: 4.945 ± 0.075
5.178GlySer: 5.178 ± 0.105
5.367GlyThr: 5.367 ± 0.14
5.952GlyVal: 5.952 ± 0.08
0.958GlyTrp: 0.958 ± 0.031
2.771GlyTyr: 2.771 ± 0.046
0.001GlyXaa: 0.001 ± 0.001
His
1.745HisAla: 1.745 ± 0.046
0.307HisCys: 0.307 ± 0.016
1.239HisAsp: 1.239 ± 0.039
1.235HisGlu: 1.235 ± 0.031
0.938HisPhe: 0.938 ± 0.028
1.906HisGly: 1.906 ± 0.065
0.591HisHis: 0.591 ± 0.024
1.066HisIle: 1.066 ± 0.029
0.708HisLys: 0.708 ± 0.028
2.202HisLeu: 2.202 ± 0.053
0.474HisMet: 0.474 ± 0.021
0.71HisAsn: 0.71 ± 0.034
1.349HisPro: 1.349 ± 0.04
0.645HisGln: 0.645 ± 0.024
1.394HisArg: 1.394 ± 0.037
1.239HisSer: 1.239 ± 0.048
1.037HisThr: 1.037 ± 0.033
1.277HisVal: 1.277 ± 0.037
0.217HisTrp: 0.217 ± 0.015
0.674HisTyr: 0.674 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.615IleAla: 5.615 ± 0.082
0.78IleCys: 0.78 ± 0.028
3.507IleAsp: 3.507 ± 0.065
3.812IleGlu: 3.812 ± 0.061
2.384IlePhe: 2.384 ± 0.047
4.72IleGly: 4.72 ± 0.062
1.169IleHis: 1.169 ± 0.031
3.476IleIle: 3.476 ± 0.069
2.413IleLys: 2.413 ± 0.059
5.52IleLeu: 5.52 ± 0.088
1.243IleMet: 1.243 ± 0.037
2.076IleAsn: 2.076 ± 0.049
2.994IlePro: 2.994 ± 0.049
1.537IleGln: 1.537 ± 0.037
3.766IleArg: 3.766 ± 0.062
3.984IleSer: 3.984 ± 0.06
3.501IleThr: 3.501 ± 0.057
4.068IleVal: 4.068 ± 0.065
0.511IleTrp: 0.511 ± 0.022
1.535IleTyr: 1.535 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.262LysAla: 4.262 ± 0.071
0.494LysCys: 0.494 ± 0.03
2.242LysAsp: 2.242 ± 0.049
3.719LysGlu: 3.719 ± 0.076
1.412LysPhe: 1.412 ± 0.038
3.956LysGly: 3.956 ± 0.069
0.847LysHis: 0.847 ± 0.032
2.823LysIle: 2.823 ± 0.067
3.181LysLys: 3.181 ± 0.07
4.285LysLeu: 4.285 ± 0.072
1.364LysMet: 1.364 ± 0.039
1.71LysAsn: 1.71 ± 0.043
2.212LysPro: 2.212 ± 0.049
1.54LysGln: 1.54 ± 0.042
2.954LysArg: 2.954 ± 0.061
2.523LysSer: 2.523 ± 0.049
2.419LysThr: 2.419 ± 0.052
3.57LysVal: 3.57 ± 0.068
0.413LysTrp: 0.413 ± 0.02
1.243LysTyr: 1.243 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
9.807LeuAla: 9.807 ± 0.115
1.136LeuCys: 1.136 ± 0.035
5.366LeuAsp: 5.366 ± 0.087
6.088LeuGlu: 6.088 ± 0.097
4.061LeuPhe: 4.061 ± 0.072
7.03LeuGly: 7.03 ± 0.098
2.065LeuHis: 2.065 ± 0.046
5.029LeuIle: 5.029 ± 0.071
5.08LeuLys: 5.08 ± 0.082
11.074LeuLeu: 11.074 ± 0.162
2.277LeuMet: 2.277 ± 0.046
3.143LeuAsn: 3.143 ± 0.055
5.125LeuPro: 5.125 ± 0.081
3.301LeuGln: 3.301 ± 0.063
6.443LeuArg: 6.443 ± 0.088
6.718LeuSer: 6.718 ± 0.085
5.168LeuThr: 5.168 ± 0.075
7.112LeuVal: 7.112 ± 0.094
0.944LeuTrp: 0.944 ± 0.032
2.491LeuTyr: 2.491 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.441MetAla: 2.441 ± 0.04
0.207MetCys: 0.207 ± 0.013
1.177MetAsp: 1.177 ± 0.031
1.757MetGlu: 1.757 ± 0.045
0.783MetPhe: 0.783 ± 0.028
1.821MetGly: 1.821 ± 0.039
0.441MetHis: 0.441 ± 0.018
1.32MetIle: 1.32 ± 0.03
1.694MetLys: 1.694 ± 0.036
2.362MetLeu: 2.362 ± 0.05
0.633MetMet: 0.633 ± 0.026
1.001MetAsn: 1.001 ± 0.027
1.15MetPro: 1.15 ± 0.028
0.838MetGln: 0.838 ± 0.028
1.429MetArg: 1.429 ± 0.033
1.438MetSer: 1.438 ± 0.034
1.435MetThr: 1.435 ± 0.041
1.768MetVal: 1.768 ± 0.038
0.161MetTrp: 0.161 ± 0.012
0.464MetTyr: 0.464 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.755AsnAla: 2.755 ± 0.057
0.503AsnCys: 0.503 ± 0.027
1.614AsnAsp: 1.614 ± 0.036
1.714AsnGlu: 1.714 ± 0.044
1.28AsnPhe: 1.28 ± 0.034
2.842AsnGly: 2.842 ± 0.078
0.64AsnHis: 0.64 ± 0.024
2.142AsnIle: 2.142 ± 0.052
1.238AsnLys: 1.238 ± 0.035
3.497AsnLeu: 3.497 ± 0.064
0.703AsnMet: 0.703 ± 0.028
1.188AsnAsn: 1.188 ± 0.042
2.138AsnPro: 2.138 ± 0.048
0.949AsnGln: 0.949 ± 0.027
2.202AsnArg: 2.202 ± 0.045
1.943AsnSer: 1.943 ± 0.054
1.626AsnThr: 1.626 ± 0.05
2.517AsnVal: 2.517 ± 0.049
0.387AsnTrp: 0.387 ± 0.02
1.044AsnTyr: 1.044 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
4.638ProAla: 4.638 ± 0.087
0.46ProCys: 0.46 ± 0.021
2.818ProAsp: 2.818 ± 0.053
3.738ProGlu: 3.738 ± 0.069
2.106ProPhe: 2.106 ± 0.047
4.047ProGly: 4.047 ± 0.068
1.017ProHis: 1.017 ± 0.032
1.98ProIle: 1.98 ± 0.047
1.647ProLys: 1.647 ± 0.043
4.767ProLeu: 4.767 ± 0.074
0.877ProMet: 0.877 ± 0.027
1.241ProAsn: 1.241 ± 0.036
2.321ProPro: 2.321 ± 0.057
1.558ProGln: 1.558 ± 0.043
2.375ProArg: 2.375 ± 0.053
2.621ProSer: 2.621 ± 0.055
2.12ProThr: 2.12 ± 0.051
4.158ProVal: 4.158 ± 0.065
0.497ProTrp: 0.497 ± 0.019
1.322ProTyr: 1.322 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
2.918GlnAla: 2.918 ± 0.052
0.329GlnCys: 0.329 ± 0.022
1.28GlnAsp: 1.28 ± 0.034
2.264GlnGlu: 2.264 ± 0.052
1.065GlnPhe: 1.065 ± 0.034
2.312GlnGly: 2.312 ± 0.044
0.637GlnHis: 0.637 ± 0.024
1.712GlnIle: 1.712 ± 0.039
1.698GlnLys: 1.698 ± 0.046
3.022GlnLeu: 3.022 ± 0.059
0.822GlnMet: 0.822 ± 0.027
1.009GlnAsn: 1.009 ± 0.03
1.308GlnPro: 1.308 ± 0.033
1.293GlnGln: 1.293 ± 0.036
2.041GlnArg: 2.041 ± 0.049
1.515GlnSer: 1.515 ± 0.044
1.451GlnThr: 1.451 ± 0.032
2.521GlnVal: 2.521 ± 0.052
0.381GlnTrp: 0.381 ± 0.018
0.785GlnTyr: 0.785 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
4.532ArgAla: 4.532 ± 0.061
0.798ArgCys: 0.798 ± 0.033
3.27ArgAsp: 3.27 ± 0.06
5.367ArgGlu: 5.367 ± 0.088
2.839ArgPhe: 2.839 ± 0.059
4.414ArgGly: 4.414 ± 0.069
1.52ArgHis: 1.52 ± 0.043
4.295ArgIle: 4.295 ± 0.069
3.386ArgLys: 3.386 ± 0.066
6.908ArgLeu: 6.908 ± 0.085
1.801ArgMet: 1.801 ± 0.045
2.334ArgAsn: 2.334 ± 0.046
2.4ArgPro: 2.4 ± 0.043
2.392ArgGln: 2.392 ± 0.046
4.559ArgArg: 4.559 ± 0.082
3.708ArgSer: 3.708 ± 0.062
3.077ArgThr: 3.077 ± 0.049
4.321ArgVal: 4.321 ± 0.066
0.732ArgTrp: 0.732 ± 0.025
2.11ArgTyr: 2.11 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.582SerAla: 5.582 ± 0.101
0.967SerCys: 0.967 ± 0.043
3.026SerAsp: 3.026 ± 0.057
3.221SerGlu: 3.221 ± 0.06
2.871SerPhe: 2.871 ± 0.057
6.031SerGly: 6.031 ± 0.114
1.35SerHis: 1.35 ± 0.036
3.576SerIle: 3.576 ± 0.06
2.05SerLys: 2.05 ± 0.043
6.208SerLeu: 6.208 ± 0.081
1.37SerMet: 1.37 ± 0.039
1.847SerAsn: 1.847 ± 0.053
3.029SerPro: 3.029 ± 0.058
1.653SerGln: 1.653 ± 0.039
4.013SerArg: 4.013 ± 0.063
4.158SerSer: 4.158 ± 0.096
3.228SerThr: 3.228 ± 0.077
4.239SerVal: 4.239 ± 0.058
0.731SerTrp: 0.731 ± 0.029
1.862SerTyr: 1.862 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
5.486ThrAla: 5.486 ± 0.095
0.815ThrCys: 0.815 ± 0.049
2.736ThrAsp: 2.736 ± 0.061
3.0ThrGlu: 3.0 ± 0.056
2.339ThrPhe: 2.339 ± 0.045
5.733ThrGly: 5.733 ± 0.133
0.949ThrHis: 0.949 ± 0.027
3.291ThrIle: 3.291 ± 0.057
1.975ThrLys: 1.975 ± 0.044
5.194ThrLeu: 5.194 ± 0.064
1.155ThrMet: 1.155 ± 0.035
1.529ThrAsn: 1.529 ± 0.048
3.019ThrPro: 3.019 ± 0.062
1.187ThrGln: 1.187 ± 0.03
2.84ThrArg: 2.84 ± 0.056
3.374ThrSer: 3.374 ± 0.08
3.177ThrThr: 3.177 ± 0.104
4.57ThrVal: 4.57 ± 0.082
0.6ThrTrp: 0.6 ± 0.032
1.472ThrTyr: 1.472 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
7.314ValAla: 7.314 ± 0.085
0.914ValCys: 0.914 ± 0.033
3.845ValAsp: 3.845 ± 0.057
4.988ValGlu: 4.988 ± 0.087
2.691ValPhe: 2.691 ± 0.05
4.956ValGly: 4.956 ± 0.072
1.373ValHis: 1.373 ± 0.033
4.475ValIle: 4.475 ± 0.069
3.656ValLys: 3.656 ± 0.066
6.879ValLeu: 6.879 ± 0.084
1.783ValMet: 1.783 ± 0.043
2.529ValAsn: 2.529 ± 0.05
3.475ValPro: 3.475 ± 0.059
2.119ValGln: 2.119 ± 0.045
4.685ValArg: 4.685 ± 0.071
4.766ValSer: 4.766 ± 0.07
4.859ValThr: 4.859 ± 0.085
6.003ValVal: 6.003 ± 0.082
0.711ValTrp: 0.711 ± 0.029
1.826ValTyr: 1.826 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.692TrpAla: 0.692 ± 0.026
0.137TrpCys: 0.137 ± 0.011
0.551TrpAsp: 0.551 ± 0.025
0.663TrpGlu: 0.663 ± 0.026
0.464TrpPhe: 0.464 ± 0.024
0.945TrpGly: 0.945 ± 0.041
0.263TrpHis: 0.263 ± 0.014
0.541TrpIle: 0.541 ± 0.023
0.503TrpLys: 0.503 ± 0.023
1.092TrpLeu: 1.092 ± 0.033
0.238TrpMet: 0.238 ± 0.016
0.454TrpAsn: 0.454 ± 0.025
0.41TrpPro: 0.41 ± 0.021
0.459TrpGln: 0.459 ± 0.022
0.709TrpArg: 0.709 ± 0.027
0.681TrpSer: 0.681 ± 0.03
0.54TrpThr: 0.54 ± 0.028
0.666TrpVal: 0.666 ± 0.032
0.17TrpTrp: 0.17 ± 0.014
0.333TrpTyr: 0.333 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.237TyrAla: 2.237 ± 0.051
0.422TyrCys: 0.422 ± 0.028
1.639TyrAsp: 1.639 ± 0.036
1.512TyrGlu: 1.512 ± 0.043
1.252TyrPhe: 1.252 ± 0.031
2.36TyrGly: 2.36 ± 0.046
0.635TyrHis: 0.635 ± 0.022
1.331TyrIle: 1.331 ± 0.04
0.99TyrLys: 0.99 ± 0.032
3.024TyrLeu: 3.024 ± 0.056
0.558TyrMet: 0.558 ± 0.021
1.036TyrAsn: 1.036 ± 0.038
1.417TyrPro: 1.417 ± 0.034
0.917TyrGln: 0.917 ± 0.028
2.466TyrArg: 2.466 ± 0.052
1.85TyrSer: 1.85 ± 0.059
1.433TyrThr: 1.433 ± 0.044
1.761TyrVal: 1.761 ± 0.04
0.367TyrTrp: 0.367 ± 0.017
0.899TyrTyr: 0.899 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.001XaaTyr: 0.001 ± 0.001
0.003XaaXaa: 0.003 ± 0.003
Statistics based on 3513 proteins (1189170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski