Amino acid dipepetide frequency for Candidatus Sodalis pierantonius str. SOPE

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.192AlaAla: 11.192 ± 0.171
1.326AlaCys: 1.326 ± 0.045
5.304AlaAsp: 5.304 ± 0.099
6.082AlaGlu: 6.082 ± 0.105
3.271AlaPhe: 3.271 ± 0.08
7.446AlaGly: 7.446 ± 0.134
1.966AlaHis: 1.966 ± 0.057
5.931AlaIle: 5.931 ± 0.103
3.89AlaLys: 3.89 ± 0.075
13.662AlaLeu: 13.662 ± 0.173
3.359AlaMet: 3.359 ± 0.073
3.333AlaAsn: 3.333 ± 0.081
3.765AlaPro: 3.765 ± 0.081
4.656AlaGln: 4.656 ± 0.093
6.72AlaArg: 6.72 ± 0.116
4.936AlaSer: 4.936 ± 0.087
4.578AlaThr: 4.578 ± 0.084
7.238AlaVal: 7.238 ± 0.116
1.455AlaTrp: 1.455 ± 0.049
2.612AlaTyr: 2.612 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
1.291CysAla: 1.291 ± 0.041
0.13CysCys: 0.13 ± 0.015
0.531CysAsp: 0.531 ± 0.027
0.535CysGlu: 0.535 ± 0.03
0.29CysPhe: 0.29 ± 0.021
1.01CysGly: 1.01 ± 0.044
0.47CysHis: 0.47 ± 0.025
0.783CysIle: 0.783 ± 0.036
0.244CysLys: 0.244 ± 0.021
1.007CysLeu: 1.007 ± 0.036
0.182CysMet: 0.182 ± 0.017
0.233CysAsn: 0.233 ± 0.02
0.604CysPro: 0.604 ± 0.029
0.499CysGln: 0.499 ± 0.028
0.87CysArg: 0.87 ± 0.038
0.567CysSer: 0.567 ± 0.031
0.523CysThr: 0.523 ± 0.031
0.799CysVal: 0.799 ± 0.029
0.168CysTrp: 0.168 ± 0.017
0.342CysTyr: 0.342 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
6.079AspAla: 6.079 ± 0.09
0.595AspCys: 0.595 ± 0.031
2.921AspAsp: 2.921 ± 0.081
3.301AspGlu: 3.301 ± 0.074
1.799AspPhe: 1.799 ± 0.05
4.325AspGly: 4.325 ± 0.082
0.923AspHis: 0.923 ± 0.034
3.792AspIle: 3.792 ± 0.072
2.352AspLys: 2.352 ± 0.071
4.817AspLeu: 4.817 ± 0.093
1.587AspMet: 1.587 ± 0.044
2.053AspAsn: 2.053 ± 0.062
2.026AspPro: 2.026 ± 0.061
1.451AspGln: 1.451 ± 0.05
3.507AspArg: 3.507 ± 0.067
2.952AspSer: 2.952 ± 0.074
2.56AspThr: 2.56 ± 0.069
3.612AspVal: 3.612 ± 0.085
0.865AspTrp: 0.865 ± 0.035
2.223AspTyr: 2.223 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
5.687GluAla: 5.687 ± 0.102
0.372GluCys: 0.372 ± 0.024
2.34GluAsp: 2.34 ± 0.072
2.874GluGlu: 2.874 ± 0.083
1.57GluPhe: 1.57 ± 0.055
3.457GluGly: 3.457 ± 0.079
1.487GluHis: 1.487 ± 0.048
3.187GluIle: 3.187 ± 0.071
2.776GluLys: 2.776 ± 0.072
6.23GluLeu: 6.23 ± 0.122
1.635GluMet: 1.635 ± 0.047
2.009GluAsn: 2.009 ± 0.066
1.878GluPro: 1.878 ± 0.046
3.489GluGln: 3.489 ± 0.082
4.326GluArg: 4.326 ± 0.092
3.011GluSer: 3.011 ± 0.079
2.836GluThr: 2.836 ± 0.067
3.46GluVal: 3.46 ± 0.084
0.778GluTrp: 0.778 ± 0.034
1.204GluTyr: 1.204 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.15PheAla: 3.15 ± 0.074
0.558PheCys: 0.558 ± 0.03
2.021PheAsp: 2.021 ± 0.061
1.722PheGlu: 1.722 ± 0.049
1.338PhePhe: 1.338 ± 0.059
2.721PheGly: 2.721 ± 0.064
0.787PheHis: 0.787 ± 0.032
2.229PheIle: 2.229 ± 0.069
1.538PheLys: 1.538 ± 0.056
2.747PheLeu: 2.747 ± 0.078
0.931PheMet: 0.931 ± 0.036
1.394PheAsn: 1.394 ± 0.043
1.437PhePro: 1.437 ± 0.044
0.941PheGln: 0.941 ± 0.039
1.873PheArg: 1.873 ± 0.055
2.401PheSer: 2.401 ± 0.064
1.91PheThr: 1.91 ± 0.053
2.349PheVal: 2.349 ± 0.065
0.56PheTrp: 0.56 ± 0.027
1.022PheTyr: 1.022 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
6.322GlyAla: 6.322 ± 0.118
0.979GlyCys: 0.979 ± 0.043
3.895GlyAsp: 3.895 ± 0.087
4.988GlyGlu: 4.988 ± 0.098
2.958GlyPhe: 2.958 ± 0.065
5.226GlyGly: 5.226 ± 0.114
1.786GlyHis: 1.786 ± 0.05
4.206GlyIle: 4.206 ± 0.093
3.585GlyLys: 3.585 ± 0.078
7.501GlyLeu: 7.501 ± 0.097
2.578GlyMet: 2.578 ± 0.061
2.302GlyAsn: 2.302 ± 0.06
2.273GlyPro: 2.273 ± 0.058
3.207GlyGln: 3.207 ± 0.077
4.194GlyArg: 4.194 ± 0.085
3.663GlySer: 3.663 ± 0.079
3.643GlyThr: 3.643 ± 0.073
5.403GlyVal: 5.403 ± 0.114
0.998GlyTrp: 0.998 ± 0.039
2.615GlyTyr: 2.615 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
2.024HisAla: 2.024 ± 0.054
0.342HisCys: 0.342 ± 0.022
1.474HisAsp: 1.474 ± 0.05
1.385HisGlu: 1.385 ± 0.053
1.231HisPhe: 1.231 ± 0.044
1.744HisGly: 1.744 ± 0.05
0.897HisHis: 0.897 ± 0.037
1.259HisIle: 1.259 ± 0.04
0.816HisLys: 0.816 ± 0.041
2.949HisLeu: 2.949 ± 0.072
0.74HisMet: 0.74 ± 0.034
0.68HisAsn: 0.68 ± 0.037
1.509HisPro: 1.509 ± 0.054
1.219HisGln: 1.219 ± 0.042
1.873HisArg: 1.873 ± 0.061
0.95HisSer: 0.95 ± 0.041
0.992HisThr: 0.992 ± 0.04
1.136HisVal: 1.136 ± 0.045
0.317HisTrp: 0.317 ± 0.021
1.063HisTyr: 1.063 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.21IleAla: 6.21 ± 0.098
0.746IleCys: 0.746 ± 0.035
3.484IleAsp: 3.484 ± 0.079
3.265IleGlu: 3.265 ± 0.074
1.734IlePhe: 1.734 ± 0.047
3.936IleGly: 3.936 ± 0.092
1.124IleHis: 1.124 ± 0.045
3.178IleIle: 3.178 ± 0.087
2.442IleLys: 2.442 ± 0.064
4.674IleLeu: 4.674 ± 0.095
1.205IleMet: 1.205 ± 0.042
2.68IleAsn: 2.68 ± 0.08
2.314IlePro: 2.314 ± 0.058
1.651IleGln: 1.651 ± 0.052
3.438IleArg: 3.438 ± 0.061
3.591IleSer: 3.591 ± 0.084
3.594IleThr: 3.594 ± 0.083
3.548IleVal: 3.548 ± 0.085
0.465IleTrp: 0.465 ± 0.027
1.446IleTyr: 1.446 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.03LysAla: 4.03 ± 0.082
0.186LysCys: 0.186 ± 0.017
1.715LysAsp: 1.715 ± 0.063
2.084LysGlu: 2.084 ± 0.065
1.219LysPhe: 1.219 ± 0.035
2.804LysGly: 2.804 ± 0.082
0.805LysHis: 0.805 ± 0.036
2.667LysIle: 2.667 ± 0.073
2.982LysLys: 2.982 ± 0.087
3.747LysLeu: 3.747 ± 0.074
0.889LysMet: 0.889 ± 0.036
1.82LysAsn: 1.82 ± 0.068
2.038LysPro: 2.038 ± 0.053
2.282LysGln: 2.282 ± 0.05
2.613LysArg: 2.613 ± 0.062
2.197LysSer: 2.197 ± 0.055
2.725LysThr: 2.725 ± 0.065
3.458LysVal: 3.458 ± 0.081
0.551LysTrp: 0.551 ± 0.025
0.833LysTyr: 0.833 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
12.459LeuAla: 12.459 ± 0.172
1.388LeuCys: 1.388 ± 0.049
5.933LeuAsp: 5.933 ± 0.097
5.599LeuGlu: 5.599 ± 0.107
3.496LeuPhe: 3.496 ± 0.094
7.653LeuGly: 7.653 ± 0.103
2.79LeuHis: 2.79 ± 0.067
5.6LeuIle: 5.6 ± 0.099
4.72LeuLys: 4.72 ± 0.098
12.183LeuLeu: 12.183 ± 0.204
3.254LeuMet: 3.254 ± 0.076
4.252LeuAsn: 4.252 ± 0.095
5.824LeuPro: 5.824 ± 0.118
4.468LeuGln: 4.468 ± 0.077
7.705LeuArg: 7.705 ± 0.118
7.844LeuSer: 7.844 ± 0.13
5.841LeuThr: 5.841 ± 0.101
7.2LeuVal: 7.2 ± 0.12
1.19LeuTrp: 1.19 ± 0.048
2.624LeuTyr: 2.624 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
3.504MetAla: 3.504 ± 0.071
0.224MetCys: 0.224 ± 0.018
1.384MetAsp: 1.384 ± 0.051
1.373MetGlu: 1.373 ± 0.045
0.862MetPhe: 0.862 ± 0.038
1.835MetGly: 1.835 ± 0.054
0.416MetHis: 0.416 ± 0.024
1.439MetIle: 1.439 ± 0.047
1.144MetLys: 1.144 ± 0.044
2.918MetLeu: 2.918 ± 0.071
0.9MetMet: 0.9 ± 0.041
0.859MetAsn: 0.859 ± 0.037
1.42MetPro: 1.42 ± 0.039
1.077MetGln: 1.077 ± 0.039
1.76MetArg: 1.76 ± 0.056
1.576MetSer: 1.576 ± 0.049
1.844MetThr: 1.844 ± 0.054
2.154MetVal: 2.154 ± 0.048
0.284MetTrp: 0.284 ± 0.02
0.383MetTyr: 0.383 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.652AsnAla: 3.652 ± 0.081
0.236AsnCys: 0.236 ± 0.018
1.957AsnAsp: 1.957 ± 0.056
1.593AsnGlu: 1.593 ± 0.053
0.926AsnPhe: 0.926 ± 0.035
2.366AsnGly: 2.366 ± 0.07
1.083AsnHis: 1.083 ± 0.04
1.768AsnIle: 1.768 ± 0.06
1.246AsnLys: 1.246 ± 0.051
3.573AsnLeu: 3.573 ± 0.077
0.697AsnMet: 0.697 ± 0.037
1.422AsnAsn: 1.422 ± 0.053
1.669AsnPro: 1.669 ± 0.051
2.021AsnGln: 2.021 ± 0.063
2.303AsnArg: 2.303 ± 0.052
1.803AsnSer: 1.803 ± 0.05
1.51AsnThr: 1.51 ± 0.047
2.145AsnVal: 2.145 ± 0.059
0.741AsnTrp: 0.741 ± 0.028
0.789AsnTyr: 0.789 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
5.362ProAla: 5.362 ± 0.098
0.358ProCys: 0.358 ± 0.025
2.927ProAsp: 2.927 ± 0.068
3.336ProGlu: 3.336 ± 0.064
1.435ProPhe: 1.435 ± 0.046
3.393ProGly: 3.393 ± 0.068
0.943ProHis: 0.943 ± 0.037
1.747ProIle: 1.747 ± 0.051
1.318ProLys: 1.318 ± 0.049
5.425ProLeu: 5.425 ± 0.086
1.071ProMet: 1.071 ± 0.036
1.101ProAsn: 1.101 ± 0.037
2.151ProPro: 2.151 ± 0.062
2.008ProGln: 2.008 ± 0.055
2.398ProArg: 2.398 ± 0.059
2.314ProSer: 2.314 ± 0.066
2.644ProThr: 2.644 ± 0.064
3.38ProVal: 3.38 ± 0.072
0.63ProTrp: 0.63 ± 0.035
1.039ProTyr: 1.039 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
5.791GlnAla: 5.791 ± 0.101
0.426GlnCys: 0.426 ± 0.027
2.035GlnAsp: 2.035 ± 0.062
1.905GlnGlu: 1.905 ± 0.066
1.286GlnPhe: 1.286 ± 0.042
3.149GlnGly: 3.149 ± 0.078
1.373GlnHis: 1.373 ± 0.05
2.151GlnIle: 2.151 ± 0.058
1.799GlnLys: 1.799 ± 0.052
5.325GlnLeu: 5.325 ± 0.101
1.251GlnMet: 1.251 ± 0.053
1.117GlnAsn: 1.117 ± 0.039
2.123GlnPro: 2.123 ± 0.06
2.985GlnGln: 2.985 ± 0.089
3.6GlnArg: 3.6 ± 0.073
2.291GlnSer: 2.291 ± 0.057
2.291GlnThr: 2.291 ± 0.058
3.263GlnVal: 3.263 ± 0.065
0.686GlnTrp: 0.686 ± 0.042
1.28GlnTyr: 1.28 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
5.397ArgAla: 5.397 ± 0.105
0.853ArgCys: 0.853 ± 0.033
3.622ArgAsp: 3.622 ± 0.076
3.951ArgGlu: 3.951 ± 0.085
2.9ArgPhe: 2.9 ± 0.066
4.326ArgGly: 4.326 ± 0.082
1.977ArgHis: 1.977 ± 0.059
3.596ArgIle: 3.596 ± 0.082
3.251ArgLys: 3.251 ± 0.075
7.92ArgLeu: 7.92 ± 0.144
1.783ArgMet: 1.783 ± 0.048
1.995ArgAsn: 1.995 ± 0.063
2.734ArgPro: 2.734 ± 0.073
4.328ArgGln: 4.328 ± 0.083
5.185ArgArg: 5.185 ± 0.118
3.301ArgSer: 3.301 ± 0.081
2.447ArgThr: 2.447 ± 0.06
4.372ArgVal: 4.372 ± 0.083
0.914ArgTrp: 0.914 ± 0.042
2.862ArgTyr: 2.862 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
5.893SerAla: 5.893 ± 0.095
0.52SerCys: 0.52 ± 0.028
2.511SerAsp: 2.511 ± 0.065
2.5SerGlu: 2.5 ± 0.07
1.782SerPhe: 1.782 ± 0.05
4.773SerGly: 4.773 ± 0.093
1.451SerHis: 1.451 ± 0.045
2.822SerIle: 2.822 ± 0.073
1.635SerLys: 1.635 ± 0.048
7.101SerLeu: 7.101 ± 0.124
1.291SerMet: 1.291 ± 0.041
1.374SerAsn: 1.374 ± 0.055
2.415SerPro: 2.415 ± 0.062
2.517SerGln: 2.517 ± 0.054
3.959SerArg: 3.959 ± 0.081
2.895SerSer: 2.895 ± 0.073
2.837SerThr: 2.837 ± 0.066
4.277SerVal: 4.277 ± 0.072
1.079SerTrp: 1.079 ± 0.047
1.577SerTyr: 1.577 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
4.593ThrAla: 4.593 ± 0.099
0.424ThrCys: 0.424 ± 0.026
3.011ThrAsp: 3.011 ± 0.069
2.645ThrGlu: 2.645 ± 0.063
1.652ThrPhe: 1.652 ± 0.047
4.486ThrGly: 4.486 ± 0.081
1.455ThrHis: 1.455 ± 0.054
2.184ThrIle: 2.184 ± 0.062
1.355ThrLys: 1.355 ± 0.053
7.35ThrLeu: 7.35 ± 0.117
1.075ThrMet: 1.075 ± 0.044
1.486ThrAsn: 1.486 ± 0.053
3.35ThrPro: 3.35 ± 0.068
2.127ThrGln: 2.127 ± 0.061
3.622ThrArg: 3.622 ± 0.077
2.075ThrSer: 2.075 ± 0.059
3.283ThrThr: 3.283 ± 0.069
4.357ThrVal: 4.357 ± 0.081
0.769ThrTrp: 0.769 ± 0.03
0.981ThrTyr: 0.981 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
6.965ValAla: 6.965 ± 0.115
0.751ValCys: 0.751 ± 0.037
4.16ValAsp: 4.16 ± 0.073
3.901ValGlu: 3.901 ± 0.083
2.52ValPhe: 2.52 ± 0.069
4.962ValGly: 4.962 ± 0.084
1.411ValHis: 1.411 ± 0.047
4.398ValIle: 4.398 ± 0.087
3.008ValLys: 3.008 ± 0.075
7.133ValLeu: 7.133 ± 0.114
2.105ValMet: 2.105 ± 0.058
2.252ValAsn: 2.252 ± 0.062
2.857ValPro: 2.857 ± 0.063
2.242ValGln: 2.242 ± 0.054
4.273ValArg: 4.273 ± 0.082
4.407ValSer: 4.407 ± 0.081
4.12ValThr: 4.12 ± 0.082
5.222ValVal: 5.222 ± 0.118
1.199ValTrp: 1.199 ± 0.045
1.718ValTyr: 1.718 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.946TrpAla: 0.946 ± 0.035
0.148TrpCys: 0.148 ± 0.017
0.572TrpAsp: 0.572 ± 0.024
0.493TrpGlu: 0.493 ± 0.025
0.473TrpPhe: 0.473 ± 0.026
0.59TrpGly: 0.59 ± 0.033
0.374TrpHis: 0.374 ± 0.024
0.516TrpIle: 0.516 ± 0.027
0.807TrpLys: 0.807 ± 0.04
2.599TrpLeu: 2.599 ± 0.068
0.358TrpMet: 0.358 ± 0.025
0.273TrpAsn: 0.273 ± 0.021
0.938TrpPro: 0.938 ± 0.04
1.207TrpGln: 1.207 ± 0.045
1.379TrpArg: 1.379 ± 0.047
0.543TrpSer: 0.543 ± 0.028
0.696TrpThr: 0.696 ± 0.028
0.827TrpVal: 0.827 ± 0.032
0.162TrpTrp: 0.162 ± 0.017
0.465TrpTyr: 0.465 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.175TyrAla: 2.175 ± 0.059
0.514TyrCys: 0.514 ± 0.029
1.943TyrAsp: 1.943 ± 0.06
1.074TyrGlu: 1.074 ± 0.047
0.889TyrPhe: 0.889 ± 0.039
2.117TyrGly: 2.117 ± 0.064
1.08TyrHis: 1.08 ± 0.046
1.277TyrIle: 1.277 ± 0.045
0.735TyrLys: 0.735 ± 0.031
3.161TyrLeu: 3.161 ± 0.072
0.464TyrMet: 0.464 ± 0.028
0.865TyrAsn: 0.865 ± 0.034
1.655TyrPro: 1.655 ± 0.057
1.754TyrGln: 1.754 ± 0.05
2.114TyrArg: 2.114 ± 0.059
1.893TyrSer: 1.893 ± 0.056
1.406TyrThr: 1.406 ± 0.044
1.402TyrVal: 1.402 ± 0.053
0.555TyrTrp: 0.555 ± 0.029
0.694TyrTyr: 0.694 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2189 proteins (655530 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski