Amino acid dipepetide frequency for Nocardioides daphniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.287AlaAla: 19.287 ± 0.237	0.953AlaCys: 0.953 ± 0.033	7.97AlaAsp: 7.97 ± 0.102	8.179AlaGlu: 8.179 ± 0.127	3.346AlaPhe: 3.346 ± 0.063	11.936AlaGly: 11.936 ± 0.128	2.641AlaHis: 2.641 ± 0.063	3.791AlaIle: 3.791 ± 0.075	2.817AlaLys: 2.817 ± 0.08	13.699AlaLeu: 13.699 ± 0.189	2.792AlaMet: 2.792 ± 0.062	1.906AlaAsn: 1.906 ± 0.05	6.778AlaPro: 6.778 ± 0.135	3.772AlaGln: 3.772 ± 0.081	9.545AlaArg: 9.545 ± 0.117	6.757AlaSer: 6.757 ± 0.093	7.924AlaThr: 7.924 ± 0.111	11.932AlaVal: 11.932 ± 0.145	2.201AlaTrp: 2.201 ± 0.059	2.393AlaTyr: 2.393 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.908CysAla: 0.908 ± 0.036	0.112CysCys: 0.112 ± 0.013	0.43CysAsp: 0.43 ± 0.023	0.332CysGlu: 0.332 ± 0.023	0.224CysPhe: 0.224 ± 0.015	0.833CysGly: 0.833 ± 0.038	0.17CysHis: 0.17 ± 0.014	0.161CysIle: 0.161 ± 0.014	0.105CysLys: 0.105 ± 0.012	0.619CysLeu: 0.619 ± 0.029	0.102CysMet: 0.102 ± 0.01	0.114CysAsn: 0.114 ± 0.011	0.448CysPro: 0.448 ± 0.025	0.155CysGln: 0.155 ± 0.014	0.608CysArg: 0.608 ± 0.029	0.483CysSer: 0.483 ± 0.025	0.449CysThr: 0.449 ± 0.024	0.659CysVal: 0.659 ± 0.025	0.138CysTrp: 0.138 ± 0.012	0.106CysTyr: 0.106 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.846AspAla: 7.846 ± 0.109	0.359AspCys: 0.359 ± 0.019	4.552AspAsp: 4.552 ± 0.094	4.574AspGlu: 4.574 ± 0.082	1.627AspPhe: 1.627 ± 0.048	5.998AspGly: 5.998 ± 0.091	1.571AspHis: 1.571 ± 0.047	1.563AspIle: 1.563 ± 0.049	1.137AspLys: 1.137 ± 0.048	7.112AspLeu: 7.112 ± 0.102	0.92AspMet: 0.92 ± 0.036	0.992AspAsn: 0.992 ± 0.034	4.302AspPro: 4.302 ± 0.082	1.781AspGln: 1.781 ± 0.05	4.497AspArg: 4.497 ± 0.065	2.564AspSer: 2.564 ± 0.046	2.702AspThr: 2.702 ± 0.058	6.134AspVal: 6.134 ± 0.097	0.936AspTrp: 0.936 ± 0.032	1.02AspTyr: 1.02 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.717GluAla: 7.717 ± 0.132	0.346GluCys: 0.346 ± 0.022	2.776GluAsp: 2.776 ± 0.062	3.721GluGlu: 3.721 ± 0.083	1.628GluPhe: 1.628 ± 0.046	4.658GluGly: 4.658 ± 0.08	1.569GluHis: 1.569 ± 0.044	2.318GluIle: 2.318 ± 0.057	1.67GluLys: 1.67 ± 0.046	6.317GluLeu: 6.317 ± 0.089	1.174GluMet: 1.174 ± 0.039	0.925GluAsn: 0.925 ± 0.04	2.973GluPro: 2.973 ± 0.074	2.372GluGln: 2.372 ± 0.052	5.212GluArg: 5.212 ± 0.084	2.865GluSer: 2.865 ± 0.057	3.059GluThr: 3.059 ± 0.06	6.2GluVal: 6.2 ± 0.102	0.987GluTrp: 0.987 ± 0.036	0.88GluTyr: 0.88 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.536PheAla: 3.536 ± 0.064	0.236PheCys: 0.236 ± 0.017	2.075PheAsp: 2.075 ± 0.051	1.577PheGlu: 1.577 ± 0.043	0.912PhePhe: 0.912 ± 0.036	2.975PheGly: 2.975 ± 0.066	0.614PheHis: 0.614 ± 0.028	0.762PheIle: 0.762 ± 0.035	0.534PheLys: 0.534 ± 0.025	2.501PheLeu: 2.501 ± 0.069	0.479PheMet: 0.479 ± 0.026	0.584PheAsn: 0.584 ± 0.027	1.252PhePro: 1.252 ± 0.037	0.548PheGln: 0.548 ± 0.023	1.707PheArg: 1.707 ± 0.047	1.643PheSer: 1.643 ± 0.046	1.968PheThr: 1.968 ± 0.046	2.717PheVal: 2.717 ± 0.057	0.411PheTrp: 0.411 ± 0.022	0.521PheTyr: 0.521 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.703GlyAla: 10.703 ± 0.136	0.774GlyCys: 0.774 ± 0.03	5.428GlyAsp: 5.428 ± 0.087	5.327GlyGlu: 5.327 ± 0.082	2.832GlyPhe: 2.832 ± 0.059	7.672GlyGly: 7.672 ± 0.117	2.183GlyHis: 2.183 ± 0.051	3.297GlyIle: 3.297 ± 0.064	2.283GlyLys: 2.283 ± 0.069	9.187GlyLeu: 9.187 ± 0.133	1.916GlyMet: 1.916 ± 0.049	1.669GlyAsn: 1.669 ± 0.056	4.343GlyPro: 4.343 ± 0.07	2.797GlyGln: 2.797 ± 0.066	7.222GlyArg: 7.222 ± 0.095	5.12GlySer: 5.12 ± 0.092	5.542GlyThr: 5.542 ± 0.108	8.099GlyVal: 8.099 ± 0.111	1.799GlyTrp: 1.799 ± 0.049	1.824GlyTyr: 1.824 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.672HisAla: 2.672 ± 0.056	0.201HisCys: 0.201 ± 0.017	1.526HisAsp: 1.526 ± 0.046	1.231HisGlu: 1.231 ± 0.037	0.581HisPhe: 0.581 ± 0.026	2.203HisGly: 2.203 ± 0.061	0.788HisHis: 0.788 ± 0.034	0.489HisIle: 0.489 ± 0.027	0.325HisLys: 0.325 ± 0.021	2.612HisLeu: 2.612 ± 0.047	0.338HisMet: 0.338 ± 0.019	0.344HisAsn: 0.344 ± 0.02	1.706HisPro: 1.706 ± 0.046	0.661HisGln: 0.661 ± 0.029	2.027HisArg: 2.027 ± 0.055	0.914HisSer: 0.914 ± 0.036	1.106HisThr: 1.106 ± 0.039	2.163HisVal: 2.163 ± 0.056	0.311HisTrp: 0.311 ± 0.021	0.381HisTyr: 0.381 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.371IleAla: 4.371 ± 0.081	0.269IleCys: 0.269 ± 0.021	2.359IleAsp: 2.359 ± 0.063	2.152IleGlu: 2.152 ± 0.056	0.843IlePhe: 0.843 ± 0.033	3.298IleGly: 3.298 ± 0.076	0.655IleHis: 0.655 ± 0.025	0.944IleIle: 0.944 ± 0.038	0.792IleLys: 0.792 ± 0.032	2.285IleLeu: 2.285 ± 0.051	0.454IleMet: 0.454 ± 0.024	0.724IleAsn: 0.724 ± 0.03	1.566IlePro: 1.566 ± 0.043	0.676IleGln: 0.676 ± 0.026	1.897IleArg: 1.897 ± 0.046	1.856IleSer: 1.856 ± 0.048	2.059IleThr: 2.059 ± 0.057	2.814IleVal: 2.814 ± 0.056	0.377IleTrp: 0.377 ± 0.022	0.536IleTyr: 0.536 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.033LysAla: 3.033 ± 0.085	0.113LysCys: 0.113 ± 0.013	1.127LysAsp: 1.127 ± 0.036	1.252LysGlu: 1.252 ± 0.04	0.571LysPhe: 0.571 ± 0.025	1.941LysGly: 1.941 ± 0.067	0.442LysHis: 0.442 ± 0.025	0.872LysIle: 0.872 ± 0.039	1.019LysLys: 1.019 ± 0.057	1.827LysLeu: 1.827 ± 0.051	0.419LysMet: 0.419 ± 0.026	0.538LysAsn: 0.538 ± 0.029	1.222LysPro: 1.222 ± 0.042	0.7LysGln: 0.7 ± 0.031	1.493LysArg: 1.493 ± 0.049	1.236LysSer: 1.236 ± 0.044	1.174LysThr: 1.174 ± 0.043	2.362LysVal: 2.362 ± 0.066	0.273LysTrp: 0.273 ± 0.019	0.467LysTyr: 0.467 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.424LeuAla: 14.424 ± 0.182	0.646LeuCys: 0.646 ± 0.024	6.936LeuAsp: 6.936 ± 0.11	5.513LeuGlu: 5.513 ± 0.096	2.533LeuPhe: 2.533 ± 0.066	9.302LeuGly: 9.302 ± 0.129	2.14LeuHis: 2.14 ± 0.048	2.572LeuIle: 2.572 ± 0.062	1.927LeuLys: 1.927 ± 0.058	10.726LeuLeu: 10.726 ± 0.178	1.662LeuMet: 1.662 ± 0.044	1.626LeuAsn: 1.626 ± 0.051	5.599LeuPro: 5.599 ± 0.096	2.271LeuGln: 2.271 ± 0.05	7.711LeuArg: 7.711 ± 0.101	5.164LeuSer: 5.164 ± 0.084	6.553LeuThr: 6.553 ± 0.092	10.831LeuVal: 10.831 ± 0.15	1.295LeuTrp: 1.295 ± 0.039	1.383LeuTyr: 1.383 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.446MetAla: 2.446 ± 0.06	0.119MetCys: 0.119 ± 0.013	0.925MetAsp: 0.925 ± 0.035	0.876MetGlu: 0.876 ± 0.036	0.448MetPhe: 0.448 ± 0.023	1.457MetGly: 1.457 ± 0.051	0.392MetHis: 0.392 ± 0.022	0.6MetIle: 0.6 ± 0.029	0.515MetLys: 0.515 ± 0.026	1.925MetLeu: 1.925 ± 0.049	0.343MetMet: 0.343 ± 0.022	0.445MetAsn: 0.445 ± 0.023	1.144MetPro: 1.144 ± 0.034	0.509MetGln: 0.509 ± 0.025	1.406MetArg: 1.406 ± 0.041	1.518MetSer: 1.518 ± 0.041	1.652MetThr: 1.652 ± 0.045	1.813MetVal: 1.813 ± 0.049	0.224MetTrp: 0.224 ± 0.016	0.25MetTyr: 0.25 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.202AsnAla: 2.202 ± 0.056	0.142AsnCys: 0.142 ± 0.012	1.061AsnAsp: 1.061 ± 0.045	0.864AsnGlu: 0.864 ± 0.036	0.49AsnPhe: 0.49 ± 0.024	1.7AsnGly: 1.7 ± 0.061	0.398AsnHis: 0.398 ± 0.021	0.608AsnIle: 0.608 ± 0.027	0.413AsnLys: 0.413 ± 0.023	1.631AsnLeu: 1.631 ± 0.043	0.284AsnMet: 0.284 ± 0.017	0.445AsnAsn: 0.445 ± 0.027	1.388AsnPro: 1.388 ± 0.046	0.544AsnGln: 0.544 ± 0.027	1.25AsnArg: 1.25 ± 0.041	0.843AsnSer: 0.843 ± 0.037	0.974AsnThr: 0.974 ± 0.036	1.515AsnVal: 1.515 ± 0.047	0.269AsnTrp: 0.269 ± 0.019	0.363AsnTyr: 0.363 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.306ProAla: 7.306 ± 0.137	0.355ProCys: 0.355 ± 0.023	4.109ProAsp: 4.109 ± 0.086	3.992ProGlu: 3.992 ± 0.067	1.496ProPhe: 1.496 ± 0.039	5.577ProGly: 5.577 ± 0.088	1.308ProHis: 1.308 ± 0.047	1.411ProIle: 1.411 ± 0.04	1.115ProLys: 1.115 ± 0.041	4.692ProLeu: 4.692 ± 0.08	1.038ProMet: 1.038 ± 0.036	0.769ProAsn: 0.769 ± 0.031	2.829ProPro: 2.829 ± 0.068	1.525ProGln: 1.525 ± 0.047	4.051ProArg: 4.051 ± 0.077	3.465ProSer: 3.465 ± 0.075	3.957ProThr: 3.957 ± 0.112	5.279ProVal: 5.279 ± 0.078	0.963ProTrp: 0.963 ± 0.032	1.019ProTyr: 1.019 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.585GlnAla: 3.585 ± 0.067	0.149GlnCys: 0.149 ± 0.014	1.202GlnAsp: 1.202 ± 0.045	1.455GlnGlu: 1.455 ± 0.045	0.764GlnPhe: 0.764 ± 0.032	2.269GlnGly: 2.269 ± 0.062	0.689GlnHis: 0.689 ± 0.029	0.974GlnIle: 0.974 ± 0.034	0.624GlnLys: 0.624 ± 0.029	3.029GlnLeu: 3.029 ± 0.062	0.593GlnMet: 0.593 ± 0.027	0.434GlnAsn: 0.434 ± 0.024	1.578GlnPro: 1.578 ± 0.051	1.153GlnGln: 1.153 ± 0.039	2.621GlnArg: 2.621 ± 0.062	1.278GlnSer: 1.278 ± 0.039	1.365GlnThr: 1.365 ± 0.04	3.246GlnVal: 3.246 ± 0.06	0.503GlnTrp: 0.503 ± 0.022	0.458GlnTyr: 0.458 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.138ArgAla: 9.138 ± 0.12	0.546ArgCys: 0.546 ± 0.028	4.371ArgAsp: 4.371 ± 0.069	4.412ArgGlu: 4.412 ± 0.077	2.153ArgPhe: 2.153 ± 0.057	5.966ArgGly: 5.966 ± 0.076	1.94ArgHis: 1.94 ± 0.054	2.89ArgIle: 2.89 ± 0.057	1.655ArgLys: 1.655 ± 0.057	7.757ArgLeu: 7.757 ± 0.118	1.835ArgMet: 1.835 ± 0.047	1.341ArgAsn: 1.341 ± 0.041	4.489ArgPro: 4.489 ± 0.077	2.159ArgGln: 2.159 ± 0.053	7.971ArgArg: 7.971 ± 0.139	4.566ArgSer: 4.566 ± 0.082	4.945ArgThr: 4.945 ± 0.081	6.496ArgVal: 6.496 ± 0.105	1.52ArgTrp: 1.52 ± 0.041	1.34ArgTyr: 1.34 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.545SerAla: 6.545 ± 0.111	0.431SerCys: 0.431 ± 0.026	3.058SerAsp: 3.058 ± 0.06	2.694SerGlu: 2.694 ± 0.054	1.695SerPhe: 1.695 ± 0.047	5.672SerGly: 5.672 ± 0.097	1.152SerHis: 1.152 ± 0.042	1.76SerIle: 1.76 ± 0.047	1.133SerLys: 1.133 ± 0.045	5.102SerLeu: 5.102 ± 0.082	1.241SerMet: 1.241 ± 0.04	0.999SerAsn: 0.999 ± 0.035	3.444SerPro: 3.444 ± 0.084	1.503SerGln: 1.503 ± 0.047	4.04SerArg: 4.04 ± 0.08	3.66SerSer: 3.66 ± 0.082	3.816SerThr: 3.816 ± 0.081	4.545SerVal: 4.545 ± 0.079	0.982SerTrp: 0.982 ± 0.037	1.231SerTyr: 1.231 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.456ThrAla: 7.456 ± 0.107	0.482ThrCys: 0.482 ± 0.027	3.605ThrAsp: 3.605 ± 0.066	3.102ThrGlu: 3.102 ± 0.059	1.835ThrPhe: 1.835 ± 0.05	5.737ThrGly: 5.737 ± 0.085	1.314ThrHis: 1.314 ± 0.037	1.974ThrIle: 1.974 ± 0.059	1.291ThrLys: 1.291 ± 0.045	6.09ThrLeu: 6.09 ± 0.087	1.097ThrMet: 1.097 ± 0.038	1.067ThrAsn: 1.067 ± 0.039	4.28ThrPro: 4.28 ± 0.111	1.6ThrGln: 1.6 ± 0.05	4.158ThrArg: 4.158 ± 0.076	3.816ThrSer: 3.816 ± 0.076	4.484ThrThr: 4.484 ± 0.105	6.234ThrVal: 6.234 ± 0.107	1.139ThrTrp: 1.139 ± 0.04	1.42ThrTyr: 1.42 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	13.262ValAla: 13.262 ± 0.174	0.626ValCys: 0.626 ± 0.029	6.498ValAsp: 6.498 ± 0.099	6.217ValGlu: 6.217 ± 0.101	2.428ValPhe: 2.428 ± 0.055	7.991ValGly: 7.991 ± 0.122	1.979ValHis: 1.979 ± 0.05	2.97ValIle: 2.97 ± 0.064	2.039ValLys: 2.039 ± 0.054	10.0ValLeu: 10.0 ± 0.131	1.747ValMet: 1.747 ± 0.052	1.787ValAsn: 1.787 ± 0.053	5.308ValPro: 5.308 ± 0.084	2.294ValGln: 2.294 ± 0.052	7.33ValArg: 7.33 ± 0.113	4.804ValSer: 4.804 ± 0.081	6.497ValThr: 6.497 ± 0.123	11.516ValVal: 11.516 ± 0.19	1.265ValTrp: 1.265 ± 0.048	1.306ValTyr: 1.306 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.746TrpAla: 1.746 ± 0.048	0.158TrpCys: 0.158 ± 0.015	0.769TrpAsp: 0.769 ± 0.029	0.758TrpGlu: 0.758 ± 0.029	0.605TrpPhe: 0.605 ± 0.028	1.13TrpGly: 1.13 ± 0.034	0.346TrpHis: 0.346 ± 0.021	0.59TrpIle: 0.59 ± 0.029	0.344TrpLys: 0.344 ± 0.022	1.945TrpLeu: 1.945 ± 0.05	0.354TrpMet: 0.354 ± 0.02	0.331TrpAsn: 0.331 ± 0.021	0.792TrpPro: 0.792 ± 0.027	0.532TrpGln: 0.532 ± 0.022	1.436TrpArg: 1.436 ± 0.047	1.215TrpSer: 1.215 ± 0.048	1.058TrpThr: 1.058 ± 0.038	1.433TrpVal: 1.433 ± 0.044	0.451TrpTrp: 0.451 ± 0.025	0.299TrpTyr: 0.299 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.434TyrAla: 2.434 ± 0.066	0.138TyrCys: 0.138 ± 0.012	1.411TyrAsp: 1.411 ± 0.041	1.138TyrGlu: 1.138 ± 0.036	0.539TyrPhe: 0.539 ± 0.031	1.701TyrGly: 1.701 ± 0.049	0.286TyrHis: 0.286 ± 0.019	0.381TyrIle: 0.381 ± 0.024	0.342TyrLys: 0.342 ± 0.023	1.759TyrLeu: 1.759 ± 0.053	0.215TyrMet: 0.215 ± 0.017	0.344TyrAsn: 0.344 ± 0.02	0.814TyrPro: 0.814 ± 0.033	0.419TyrGln: 0.419 ± 0.023	1.311TyrArg: 1.311 ± 0.045	0.938TyrSer: 0.938 ± 0.031	0.9TyrThr: 0.9 ± 0.035	1.877TyrVal: 1.877 ± 0.042	0.249TyrTrp: 0.249 ± 0.017	0.367TyrTyr: 0.367 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2853 proteins (840121 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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