Amino acid dipepetide frequency for Kocuria sp. HSID16901

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.262AlaAla: 13.262 ± 0.178
0.754AlaCys: 0.754 ± 0.034
6.154AlaAsp: 6.154 ± 0.106
7.706AlaGlu: 7.706 ± 0.107
3.26AlaPhe: 3.26 ± 0.069
9.445AlaGly: 9.445 ± 0.136
2.35AlaHis: 2.35 ± 0.072
5.022AlaIle: 5.022 ± 0.089
3.373AlaLys: 3.373 ± 0.076
10.737AlaLeu: 10.737 ± 0.139
2.799AlaMet: 2.799 ± 0.057
2.486AlaAsn: 2.486 ± 0.053
5.111AlaPro: 5.111 ± 0.104
4.127AlaGln: 4.127 ± 0.088
7.068AlaArg: 7.068 ± 0.118
7.098AlaSer: 7.098 ± 0.098
6.147AlaThr: 6.147 ± 0.088
9.159AlaVal: 9.159 ± 0.126
1.563AlaTrp: 1.563 ± 0.045
2.237AlaTyr: 2.237 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.7CysAla: 0.7 ± 0.034
0.076CysCys: 0.076 ± 0.012
0.379CysAsp: 0.379 ± 0.023
0.341CysGlu: 0.341 ± 0.022
0.211CysPhe: 0.211 ± 0.016
0.727CysGly: 0.727 ± 0.035
0.181CysHis: 0.181 ± 0.015
0.296CysIle: 0.296 ± 0.021
0.123CysLys: 0.123 ± 0.015
0.641CysLeu: 0.641 ± 0.033
0.105CysMet: 0.105 ± 0.013
0.14CysAsn: 0.14 ± 0.014
0.372CysPro: 0.372 ± 0.023
0.181CysGln: 0.181 ± 0.015
0.417CysArg: 0.417 ± 0.029
0.476CysSer: 0.476 ± 0.029
0.401CysThr: 0.401 ± 0.025
0.518CysVal: 0.518 ± 0.027
0.09CysTrp: 0.09 ± 0.012
0.135CysTyr: 0.135 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.971AspAla: 6.971 ± 0.098
0.299AspCys: 0.299 ± 0.022
3.96AspAsp: 3.96 ± 0.082
4.335AspGlu: 4.335 ± 0.072
1.828AspPhe: 1.828 ± 0.053
5.169AspGly: 5.169 ± 0.089
1.664AspHis: 1.664 ± 0.053
2.63AspIle: 2.63 ± 0.057
1.438AspLys: 1.438 ± 0.05
6.007AspLeu: 6.007 ± 0.089
1.099AspMet: 1.099 ± 0.037
1.187AspAsn: 1.187 ± 0.047
3.809AspPro: 3.809 ± 0.079
2.283AspGln: 2.283 ± 0.059
3.946AspArg: 3.946 ± 0.07
3.609AspSer: 3.609 ± 0.07
2.664AspThr: 2.664 ± 0.063
5.194AspVal: 5.194 ± 0.092
0.821AspTrp: 0.821 ± 0.039
1.384AspTyr: 1.384 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
7.394GluAla: 7.394 ± 0.124
0.338GluCys: 0.338 ± 0.025
3.822GluAsp: 3.822 ± 0.079
4.463GluGlu: 4.463 ± 0.093
2.058GluPhe: 2.058 ± 0.057
4.707GluGly: 4.707 ± 0.077
1.712GluHis: 1.712 ± 0.05
3.231GluIle: 3.231 ± 0.064
2.403GluLys: 2.403 ± 0.064
6.067GluLeu: 6.067 ± 0.109
1.196GluMet: 1.196 ± 0.044
1.968GluAsn: 1.968 ± 0.059
3.005GluPro: 3.005 ± 0.065
2.315GluGln: 2.315 ± 0.064
4.982GluArg: 4.982 ± 0.099
4.208GluSer: 4.208 ± 0.091
3.64GluThr: 3.64 ± 0.075
4.542GluVal: 4.542 ± 0.089
0.824GluTrp: 0.824 ± 0.037
1.429GluTyr: 1.429 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.417PheAla: 3.417 ± 0.08
0.248PheCys: 0.248 ± 0.019
2.178PheAsp: 2.178 ± 0.058
1.758PheGlu: 1.758 ± 0.053
1.131PhePhe: 1.131 ± 0.043
3.381PheGly: 3.381 ± 0.078
0.69PheHis: 0.69 ± 0.037
1.41PheIle: 1.41 ± 0.046
0.765PheLys: 0.765 ± 0.035
2.962PheLeu: 2.962 ± 0.079
0.694PheMet: 0.694 ± 0.033
0.893PheAsn: 0.893 ± 0.035
1.454PhePro: 1.454 ± 0.043
0.861PheGln: 0.861 ± 0.034
1.734PheArg: 1.734 ± 0.045
2.189PheSer: 2.189 ± 0.053
2.092PheThr: 2.092 ± 0.056
2.609PheVal: 2.609 ± 0.066
0.498PheTrp: 0.498 ± 0.026
0.75PheTyr: 0.75 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
8.769GlyAla: 8.769 ± 0.122
0.629GlyCys: 0.629 ± 0.028
4.464GlyAsp: 4.464 ± 0.07
4.965GlyGlu: 4.965 ± 0.087
3.112GlyPhe: 3.112 ± 0.076
7.077GlyGly: 7.077 ± 0.127
2.099GlyHis: 2.099 ± 0.052
4.721GlyIle: 4.721 ± 0.099
3.05GlyLys: 3.05 ± 0.069
8.473GlyLeu: 8.473 ± 0.117
2.066GlyMet: 2.066 ± 0.054
2.321GlyAsn: 2.321 ± 0.067
3.722GlyPro: 3.722 ± 0.072
3.279GlyGln: 3.279 ± 0.076
5.749GlyArg: 5.749 ± 0.094
6.003GlySer: 6.003 ± 0.103
5.186GlyThr: 5.186 ± 0.088
7.061GlyVal: 7.061 ± 0.107
1.424GlyTrp: 1.424 ± 0.042
2.342GlyTyr: 2.342 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.275HisAla: 2.275 ± 0.063
0.172HisCys: 0.172 ± 0.016
1.492HisAsp: 1.492 ± 0.046
1.544HisGlu: 1.544 ± 0.046
0.704HisPhe: 0.704 ± 0.034
2.195HisGly: 2.195 ± 0.059
0.805HisHis: 0.805 ± 0.038
0.934HisIle: 0.934 ± 0.033
0.524HisLys: 0.524 ± 0.028
2.182HisLeu: 2.182 ± 0.049
0.443HisMet: 0.443 ± 0.024
0.507HisAsn: 0.507 ± 0.027
1.552HisPro: 1.552 ± 0.039
0.854HisGln: 0.854 ± 0.034
1.956HisArg: 1.956 ± 0.052
1.358HisSer: 1.358 ± 0.045
1.204HisThr: 1.204 ± 0.041
1.86HisVal: 1.86 ± 0.043
0.312HisTrp: 0.312 ± 0.021
0.484HisTyr: 0.484 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.618IleAla: 5.618 ± 0.097
0.361IleCys: 0.361 ± 0.022
3.224IleAsp: 3.224 ± 0.07
2.871IleGlu: 2.871 ± 0.059
1.578IlePhe: 1.578 ± 0.057
4.281IleGly: 4.281 ± 0.098
1.045IleHis: 1.045 ± 0.038
2.169IleIle: 2.169 ± 0.068
1.215IleLys: 1.215 ± 0.044
4.496IleLeu: 4.496 ± 0.098
0.981IleMet: 0.981 ± 0.035
1.371IleAsn: 1.371 ± 0.041
2.635IlePro: 2.635 ± 0.063
1.371IleGln: 1.371 ± 0.038
3.063IleArg: 3.063 ± 0.07
3.175IleSer: 3.175 ± 0.073
2.732IleThr: 2.732 ± 0.062
4.084IleVal: 4.084 ± 0.086
0.473IleTrp: 0.473 ± 0.029
0.922IleTyr: 0.922 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.419LysAla: 3.419 ± 0.092
0.135LysCys: 0.135 ± 0.012
2.039LysAsp: 2.039 ± 0.062
1.659LysGlu: 1.659 ± 0.054
0.833LysPhe: 0.833 ± 0.037
2.132LysGly: 2.132 ± 0.066
0.69LysHis: 0.69 ± 0.027
1.678LysIle: 1.678 ± 0.054
1.536LysLys: 1.536 ± 0.061
2.544LysLeu: 2.544 ± 0.065
0.657LysMet: 0.657 ± 0.033
1.193LysAsn: 1.193 ± 0.044
1.697LysPro: 1.697 ± 0.053
0.911LysGln: 0.911 ± 0.036
1.833LysArg: 1.833 ± 0.06
1.959LysSer: 1.959 ± 0.056
1.982LysThr: 1.982 ± 0.049
2.53LysVal: 2.53 ± 0.064
0.293LysTrp: 0.293 ± 0.02
0.753LysTyr: 0.753 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
11.112LeuAla: 11.112 ± 0.147
0.652LeuCys: 0.652 ± 0.031
5.994LeuAsp: 5.994 ± 0.111
5.483LeuGlu: 5.483 ± 0.102
2.848LeuPhe: 2.848 ± 0.071
8.519LeuGly: 8.519 ± 0.133
1.976LeuHis: 1.976 ± 0.059
4.587LeuIle: 4.587 ± 0.104
2.807LeuLys: 2.807 ± 0.062
8.346LeuLeu: 8.346 ± 0.129
2.121LeuMet: 2.121 ± 0.063
2.695LeuAsn: 2.695 ± 0.066
4.939LeuPro: 4.939 ± 0.072
2.361LeuGln: 2.361 ± 0.059
6.454LeuArg: 6.454 ± 0.11
6.224LeuSer: 6.224 ± 0.092
6.029LeuThr: 6.029 ± 0.089
7.687LeuVal: 7.687 ± 0.118
1.174LeuTrp: 1.174 ± 0.046
1.769LeuTyr: 1.769 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.511MetAla: 2.511 ± 0.054
0.157MetCys: 0.157 ± 0.015
1.238MetAsp: 1.238 ± 0.049
1.031MetGlu: 1.031 ± 0.035
0.649MetPhe: 0.649 ± 0.028
1.817MetGly: 1.817 ± 0.049
0.419MetHis: 0.419 ± 0.025
1.187MetIle: 1.187 ± 0.044
0.702MetLys: 0.702 ± 0.032
1.856MetLeu: 1.856 ± 0.046
0.537MetMet: 0.537 ± 0.027
0.726MetAsn: 0.726 ± 0.031
1.189MetPro: 1.189 ± 0.039
0.561MetGln: 0.561 ± 0.025
1.387MetArg: 1.387 ± 0.036
1.95MetSer: 1.95 ± 0.05
1.925MetThr: 1.925 ± 0.052
1.766MetVal: 1.766 ± 0.04
0.269MetTrp: 0.269 ± 0.018
0.447MetTyr: 0.447 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.803AsnAla: 2.803 ± 0.057
0.172AsnCys: 0.172 ± 0.015
1.596AsnAsp: 1.596 ± 0.048
1.41AsnGlu: 1.41 ± 0.039
0.884AsnPhe: 0.884 ± 0.034
2.491AsnGly: 2.491 ± 0.074
0.637AsnHis: 0.637 ± 0.027
1.279AsnIle: 1.279 ± 0.041
0.663AsnLys: 0.663 ± 0.038
2.608AsnLeu: 2.608 ± 0.064
0.54AsnMet: 0.54 ± 0.028
0.712AsnAsn: 0.712 ± 0.037
1.938AsnPro: 1.938 ± 0.055
0.888AsnGln: 0.888 ± 0.034
1.749AsnArg: 1.749 ± 0.057
1.784AsnSer: 1.784 ± 0.053
1.465AsnThr: 1.465 ± 0.048
2.035AsnVal: 2.035 ± 0.056
0.342AsnTrp: 0.342 ± 0.024
0.633AsnTyr: 0.633 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
5.059ProAla: 5.059 ± 0.085
0.232ProCys: 0.232 ± 0.018
3.366ProAsp: 3.366 ± 0.077
4.766ProGlu: 4.766 ± 0.08
1.465ProPhe: 1.465 ± 0.043
4.621ProGly: 4.621 ± 0.089
1.342ProHis: 1.342 ± 0.047
2.036ProIle: 2.036 ± 0.047
1.579ProLys: 1.579 ± 0.051
4.336ProLeu: 4.336 ± 0.081
1.027ProMet: 1.027 ± 0.041
1.372ProAsn: 1.372 ± 0.048
1.62ProPro: 1.62 ± 0.057
1.961ProGln: 1.961 ± 0.059
3.121ProArg: 3.121 ± 0.079
3.548ProSer: 3.548 ± 0.081
3.226ProThr: 3.226 ± 0.07
4.395ProVal: 4.395 ± 0.075
0.837ProTrp: 0.837 ± 0.037
1.072ProTyr: 1.072 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.938GlnAla: 3.938 ± 0.083
0.206GlnCys: 0.206 ± 0.017
1.858GlnAsp: 1.858 ± 0.054
2.133GlnGlu: 2.133 ± 0.055
0.91GlnPhe: 0.91 ± 0.036
2.75GlnGly: 2.75 ± 0.064
0.825GlnHis: 0.825 ± 0.033
1.485GlnIle: 1.485 ± 0.045
1.247GlnLys: 1.247 ± 0.046
3.111GlnLeu: 3.111 ± 0.067
0.757GlnMet: 0.757 ± 0.03
1.002GlnAsn: 1.002 ± 0.043
1.683GlnPro: 1.683 ± 0.056
1.429GlnGln: 1.429 ± 0.057
2.671GlnArg: 2.671 ± 0.064
1.901GlnSer: 1.901 ± 0.051
1.754GlnThr: 1.754 ± 0.053
2.45GlnVal: 2.45 ± 0.064
0.526GlnTrp: 0.526 ± 0.027
0.764GlnTyr: 0.764 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
6.776ArgAla: 6.776 ± 0.117
0.401ArgCys: 0.401 ± 0.026
3.968ArgAsp: 3.968 ± 0.076
4.812ArgGlu: 4.812 ± 0.099
2.27ArgPhe: 2.27 ± 0.061
5.149ArgGly: 5.149 ± 0.098
1.72ArgHis: 1.72 ± 0.05
3.357ArgIle: 3.357 ± 0.068
2.092ArgLys: 2.092 ± 0.057
6.457ArgLeu: 6.457 ± 0.118
1.601ArgMet: 1.601 ± 0.048
1.705ArgAsn: 1.705 ± 0.056
3.406ArgPro: 3.406 ± 0.075
2.341ArgGln: 2.341 ± 0.057
6.041ArgArg: 6.041 ± 0.126
4.224ArgSer: 4.224 ± 0.084
3.823ArgThr: 3.823 ± 0.068
4.861ArgVal: 4.861 ± 0.089
1.143ArgTrp: 1.143 ± 0.045
1.585ArgTyr: 1.585 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
7.121SerAla: 7.121 ± 0.093
0.381SerCys: 0.381 ± 0.025
3.698SerAsp: 3.698 ± 0.079
4.242SerGlu: 4.242 ± 0.081
2.087SerPhe: 2.087 ± 0.048
6.464SerGly: 6.464 ± 0.101
1.439SerHis: 1.439 ± 0.045
2.856SerIle: 2.856 ± 0.069
1.889SerLys: 1.889 ± 0.046
6.074SerLeu: 6.074 ± 0.093
1.802SerMet: 1.802 ± 0.051
1.627SerAsn: 1.627 ± 0.049
3.453SerPro: 3.453 ± 0.069
2.261SerGln: 2.261 ± 0.054
4.268SerArg: 4.268 ± 0.082
5.364SerSer: 5.364 ± 0.115
4.235SerThr: 4.235 ± 0.079
5.169SerVal: 5.169 ± 0.089
1.042SerTrp: 1.042 ± 0.04
1.464SerTyr: 1.464 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.108ThrAla: 6.108 ± 0.089
0.371ThrCys: 0.371 ± 0.024
3.452ThrAsp: 3.452 ± 0.074
3.583ThrGlu: 3.583 ± 0.075
1.882ThrPhe: 1.882 ± 0.059
5.641ThrGly: 5.641 ± 0.096
1.293ThrHis: 1.293 ± 0.047
2.822ThrIle: 2.822 ± 0.062
1.657ThrLys: 1.657 ± 0.043
5.253ThrLeu: 5.253 ± 0.08
1.309ThrMet: 1.309 ± 0.042
1.558ThrAsn: 1.558 ± 0.046
3.647ThrPro: 3.647 ± 0.078
1.937ThrGln: 1.937 ± 0.05
3.504ThrArg: 3.504 ± 0.073
4.163ThrSer: 4.163 ± 0.082
3.674ThrThr: 3.674 ± 0.07
5.408ThrVal: 5.408 ± 0.086
0.88ThrTrp: 0.88 ± 0.036
1.384ThrTyr: 1.384 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
8.945ValAla: 8.945 ± 0.125
0.644ValCys: 0.644 ± 0.032
5.145ValAsp: 5.145 ± 0.085
5.173ValGlu: 5.173 ± 0.1
2.594ValPhe: 2.594 ± 0.059
6.731ValGly: 6.731 ± 0.099
1.731ValHis: 1.731 ± 0.049
4.333ValIle: 4.333 ± 0.103
2.336ValLys: 2.336 ± 0.065
7.893ValLeu: 7.893 ± 0.133
1.851ValMet: 1.851 ± 0.055
2.173ValAsn: 2.173 ± 0.054
4.04ValPro: 4.04 ± 0.081
2.231ValGln: 2.231 ± 0.054
5.187ValArg: 5.187 ± 0.094
5.325ValSer: 5.325 ± 0.094
5.34ValThr: 5.34 ± 0.094
7.929ValVal: 7.929 ± 0.127
0.906ValTrp: 0.906 ± 0.035
1.53ValTyr: 1.53 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.458TrpAla: 1.458 ± 0.044
0.12TrpCys: 0.12 ± 0.012
0.798TrpAsp: 0.798 ± 0.033
0.741TrpGlu: 0.741 ± 0.03
0.576TrpPhe: 0.576 ± 0.03
1.135TrpGly: 1.135 ± 0.042
0.326TrpHis: 0.326 ± 0.02
0.805TrpIle: 0.805 ± 0.03
0.492TrpLys: 0.492 ± 0.028
1.442TrpLeu: 1.442 ± 0.054
0.338TrpMet: 0.338 ± 0.023
0.45TrpAsn: 0.45 ± 0.023
0.58TrpPro: 0.58 ± 0.023
0.496TrpGln: 0.496 ± 0.027
0.892TrpArg: 0.892 ± 0.037
0.902TrpSer: 0.902 ± 0.04
0.794TrpThr: 0.794 ± 0.029
1.099TrpVal: 1.099 ± 0.046
0.34TrpTrp: 0.34 ± 0.02
0.28TrpTyr: 0.28 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.204TyrAla: 2.204 ± 0.053
0.165TyrCys: 0.165 ± 0.013
1.47TyrAsp: 1.47 ± 0.056
1.289TyrGlu: 1.289 ± 0.034
0.836TyrPhe: 0.836 ± 0.034
2.08TyrGly: 2.08 ± 0.062
0.415TyrHis: 0.415 ± 0.023
0.828TyrIle: 0.828 ± 0.035
0.581TyrLys: 0.581 ± 0.031
2.294TyrLeu: 2.294 ± 0.064
0.398TyrMet: 0.398 ± 0.024
0.54TyrAsn: 0.54 ± 0.03
1.128TyrPro: 1.128 ± 0.045
0.752TyrGln: 0.752 ± 0.036
1.709TyrArg: 1.709 ± 0.05
1.476TyrSer: 1.476 ± 0.048
1.214TyrThr: 1.214 ± 0.042
1.682TyrVal: 1.682 ± 0.059
0.304TyrTrp: 0.304 ± 0.022
0.539TyrTyr: 0.539 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2178 proteins (733174 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski