Amino acid dipepetide frequency for Bifidobacterium scardovii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.458AlaAla: 15.458 ± 0.22	1.201AlaCys: 1.201 ± 0.042	8.22AlaAsp: 8.22 ± 0.13	6.03AlaGlu: 6.03 ± 0.108	3.818AlaPhe: 3.818 ± 0.079	10.111AlaGly: 10.111 ± 0.137	2.148AlaHis: 2.148 ± 0.053	5.786AlaIle: 5.786 ± 0.086	4.534AlaLys: 4.534 ± 0.083	10.719AlaLeu: 10.719 ± 0.127	3.423AlaMet: 3.423 ± 0.068	3.257AlaAsn: 3.257 ± 0.068	4.553AlaPro: 4.553 ± 0.104	3.928AlaGln: 3.928 ± 0.085	6.613AlaArg: 6.613 ± 0.103	6.855AlaSer: 6.855 ± 0.106	5.923AlaThr: 5.923 ± 0.097	9.084AlaVal: 9.084 ± 0.111	1.624AlaTrp: 1.624 ± 0.044	2.833AlaTyr: 2.833 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	1.145CysAla: 1.145 ± 0.039	0.158CysCys: 0.158 ± 0.017	0.564CysAsp: 0.564 ± 0.025	0.516CysGlu: 0.516 ± 0.025	0.342CysPhe: 0.342 ± 0.023	1.06CysGly: 1.06 ± 0.034	0.215CysHis: 0.215 ± 0.018	0.399CysIle: 0.399 ± 0.022	0.204CysLys: 0.204 ± 0.016	0.741CysLeu: 0.741 ± 0.033	0.229CysMet: 0.229 ± 0.015	0.24CysAsn: 0.24 ± 0.018	0.447CysPro: 0.447 ± 0.024	0.226CysGln: 0.226 ± 0.015	0.603CysArg: 0.603 ± 0.029	0.527CysSer: 0.527 ± 0.028	0.503CysThr: 0.503 ± 0.022	0.799CysVal: 0.799 ± 0.034	0.134CysTrp: 0.134 ± 0.013	0.256CysTyr: 0.256 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	8.087AspAla: 8.087 ± 0.11	0.549AspCys: 0.549 ± 0.026	4.883AspAsp: 4.883 ± 0.101	4.62AspGlu: 4.62 ± 0.08	2.207AspPhe: 2.207 ± 0.052	6.618AspGly: 6.618 ± 0.123	1.345AspHis: 1.345 ± 0.045	3.107AspIle: 3.107 ± 0.07	2.317AspLys: 2.317 ± 0.058	5.475AspLeu: 5.475 ± 0.08	1.688AspMet: 1.688 ± 0.041	1.723AspAsn: 1.723 ± 0.049	3.912AspPro: 3.912 ± 0.072	1.97AspGln: 1.97 ± 0.052	4.022AspArg: 4.022 ± 0.096	3.263AspSer: 3.263 ± 0.065	3.331AspThr: 3.331 ± 0.068	4.947AspVal: 4.947 ± 0.078	1.071AspTrp: 1.071 ± 0.035	2.007AspTyr: 2.007 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	6.142GluAla: 6.142 ± 0.089	0.468GluCys: 0.468 ± 0.025	2.926GluAsp: 2.926 ± 0.06	2.848GluGlu: 2.848 ± 0.063	1.762GluPhe: 1.762 ± 0.045	3.798GluGly: 3.798 ± 0.074	1.523GluHis: 1.523 ± 0.044	2.527GluIle: 2.527 ± 0.055	1.735GluLys: 1.735 ± 0.055	5.047GluLeu: 5.047 ± 0.097	1.297GluMet: 1.297 ± 0.038	1.671GluAsn: 1.671 ± 0.049	2.662GluPro: 2.662 ± 0.062	2.281GluGln: 2.281 ± 0.054	4.515GluArg: 4.515 ± 0.092	3.275GluSer: 3.275 ± 0.07	3.094GluThr: 3.094 ± 0.06	3.181GluVal: 3.181 ± 0.062	0.705GluTrp: 0.705 ± 0.032	1.719GluTyr: 1.719 ± 0.047	0.001GluXaa: 0.001 ± 0.001
Phe	4.153PheAla: 4.153 ± 0.069	0.367PheCys: 0.367 ± 0.019	2.743PheAsp: 2.743 ± 0.065	1.683PheGlu: 1.683 ± 0.05	1.259PhePhe: 1.259 ± 0.047	3.438PheGly: 3.438 ± 0.069	0.696PheHis: 0.696 ± 0.028	1.626PheIle: 1.626 ± 0.055	1.078PheLys: 1.078 ± 0.041	2.727PheLeu: 2.727 ± 0.072	0.777PheMet: 0.777 ± 0.034	1.178PheAsn: 1.178 ± 0.034	1.433PhePro: 1.433 ± 0.049	0.873PheGln: 0.873 ± 0.031	1.805PheArg: 1.805 ± 0.058	2.199PheSer: 2.199 ± 0.052	2.28PheThr: 2.28 ± 0.051	2.709PheVal: 2.709 ± 0.059	0.496PheTrp: 0.496 ± 0.027	0.978PheTyr: 0.978 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	8.756GlyAla: 8.756 ± 0.123	0.851GlyCys: 0.851 ± 0.031	5.276GlyAsp: 5.276 ± 0.084	4.918GlyGlu: 4.918 ± 0.082	3.262GlyPhe: 3.262 ± 0.064	6.954GlyGly: 6.954 ± 0.104	1.752GlyHis: 1.752 ± 0.046	4.699GlyIle: 4.699 ± 0.077	3.629GlyLys: 3.629 ± 0.069	7.484GlyLeu: 7.484 ± 0.111	2.343GlyMet: 2.343 ± 0.055	2.739GlyAsn: 2.739 ± 0.065	2.852GlyPro: 2.852 ± 0.063	2.599GlyGln: 2.599 ± 0.065	5.125GlyArg: 5.125 ± 0.086	5.59GlySer: 5.59 ± 0.096	5.503GlyThr: 5.503 ± 0.088	6.708GlyVal: 6.708 ± 0.097	1.322GlyTrp: 1.322 ± 0.041	2.882GlyTyr: 2.882 ± 0.064	0.001GlyXaa: 0.001 ± 0.001
His	2.296HisAla: 2.296 ± 0.058	0.206HisCys: 0.206 ± 0.017	1.594HisAsp: 1.594 ± 0.043	1.19HisGlu: 1.19 ± 0.038	0.583HisPhe: 0.583 ± 0.025	2.033HisGly: 2.033 ± 0.052	0.499HisHis: 0.499 ± 0.026	1.081HisIle: 1.081 ± 0.034	0.519HisLys: 0.519 ± 0.023	1.581HisLeu: 1.581 ± 0.044	0.568HisMet: 0.568 ± 0.028	0.515HisAsn: 0.515 ± 0.024	1.291HisPro: 1.291 ± 0.041	0.589HisGln: 0.589 ± 0.029	1.43HisArg: 1.43 ± 0.049	0.908HisSer: 0.908 ± 0.032	1.115HisThr: 1.115 ± 0.037	1.637HisVal: 1.637 ± 0.044	0.358HisTrp: 0.358 ± 0.022	0.638HisTyr: 0.638 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.759IleAla: 6.759 ± 0.101	0.538IleCys: 0.538 ± 0.024	3.986IleAsp: 3.986 ± 0.074	2.901IleGlu: 2.901 ± 0.061	1.49IlePhe: 1.49 ± 0.053	4.931IleGly: 4.931 ± 0.086	0.861IleHis: 0.861 ± 0.03	2.695IleIle: 2.695 ± 0.067	1.554IleLys: 1.554 ± 0.046	3.734IleLeu: 3.734 ± 0.072	1.2IleMet: 1.2 ± 0.041	1.675IleAsn: 1.675 ± 0.049	2.728IlePro: 2.728 ± 0.07	1.205IleGln: 1.205 ± 0.039	3.018IleArg: 3.018 ± 0.062	2.934IleSer: 2.934 ± 0.062	3.202IleThr: 3.202 ± 0.066	4.677IleVal: 4.677 ± 0.075	0.626IleTrp: 0.626 ± 0.025	1.161IleTyr: 1.161 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.443LysAla: 4.443 ± 0.099	0.138LysCys: 0.138 ± 0.012	2.335LysAsp: 2.335 ± 0.059	1.868LysGlu: 1.868 ± 0.058	0.92LysPhe: 0.92 ± 0.035	2.531LysGly: 2.531 ± 0.063	0.734LysHis: 0.734 ± 0.03	1.583LysIle: 1.583 ± 0.045	1.521LysLys: 1.521 ± 0.052	2.852LysLeu: 2.852 ± 0.066	0.79LysMet: 0.79 ± 0.031	1.268LysAsn: 1.268 ± 0.045	2.065LysPro: 2.065 ± 0.053	1.222LysGln: 1.222 ± 0.042	2.349LysArg: 2.349 ± 0.055	2.024LysSer: 2.024 ± 0.047	2.346LysThr: 2.346 ± 0.05	2.459LysVal: 2.459 ± 0.058	0.474LysTrp: 0.474 ± 0.024	1.021LysTyr: 1.021 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	10.511LeuAla: 10.511 ± 0.124	0.951LeuCys: 0.951 ± 0.04	6.163LeuAsp: 6.163 ± 0.114	4.132LeuGlu: 4.132 ± 0.072	3.134LeuPhe: 3.134 ± 0.069	7.072LeuGly: 7.072 ± 0.099	1.822LeuHis: 1.822 ± 0.046	4.883LeuIle: 4.883 ± 0.09	3.214LeuLys: 3.214 ± 0.07	7.963LeuLeu: 7.963 ± 0.11	2.26LeuMet: 2.26 ± 0.056	2.794LeuAsn: 2.794 ± 0.056	4.602LeuPro: 4.602 ± 0.074	2.36LeuGln: 2.36 ± 0.05	5.466LeuArg: 5.466 ± 0.091	5.645LeuSer: 5.645 ± 0.098	5.424LeuThr: 5.424 ± 0.074	6.441LeuVal: 6.441 ± 0.087	1.099LeuTrp: 1.099 ± 0.04	2.157LeuTyr: 2.157 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.01MetAla: 3.01 ± 0.065	0.236MetCys: 0.236 ± 0.016	1.435MetAsp: 1.435 ± 0.042	1.055MetGlu: 1.055 ± 0.034	0.86MetPhe: 0.86 ± 0.036	1.911MetGly: 1.911 ± 0.049	0.529MetHis: 0.529 ± 0.023	1.416MetIle: 1.416 ± 0.044	0.878MetLys: 0.878 ± 0.032	2.639MetLeu: 2.639 ± 0.054	0.739MetMet: 0.739 ± 0.035	0.921MetAsn: 0.921 ± 0.037	1.498MetPro: 1.498 ± 0.043	0.788MetGln: 0.788 ± 0.03	1.813MetArg: 1.813 ± 0.049	1.861MetSer: 1.861 ± 0.051	2.025MetThr: 2.025 ± 0.044	1.913MetVal: 1.913 ± 0.047	0.35MetTrp: 0.35 ± 0.021	0.552MetTyr: 0.552 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.711AsnAla: 3.711 ± 0.063	0.209AsnCys: 0.209 ± 0.016	2.048AsnAsp: 2.048 ± 0.051	1.608AsnGlu: 1.608 ± 0.044	0.899AsnPhe: 0.899 ± 0.032	3.374AsnGly: 3.374 ± 0.073	0.598AsnHis: 0.598 ± 0.027	1.499AsnIle: 1.499 ± 0.04	1.046AsnLys: 1.046 ± 0.033	2.432AsnLeu: 2.432 ± 0.054	0.733AsnMet: 0.733 ± 0.031	0.988AsnAsn: 0.988 ± 0.044	2.04AsnPro: 2.04 ± 0.045	0.977AsnGln: 0.977 ± 0.031	1.836AsnArg: 1.836 ± 0.045	1.518AsnSer: 1.518 ± 0.045	1.832AsnThr: 1.832 ± 0.046	2.303AsnVal: 2.303 ± 0.043	0.45AsnTrp: 0.45 ± 0.024	0.898AsnTyr: 0.898 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.66ProAla: 5.66 ± 0.097	0.343ProCys: 0.343 ± 0.02	3.826ProAsp: 3.826 ± 0.075	3.218ProGlu: 3.218 ± 0.071	1.776ProPhe: 1.776 ± 0.046	3.994ProGly: 3.994 ± 0.073	1.012ProHis: 1.012 ± 0.036	2.269ProIle: 2.269 ± 0.049	1.634ProLys: 1.634 ± 0.046	3.936ProLeu: 3.936 ± 0.067	1.129ProMet: 1.129 ± 0.039	1.509ProAsn: 1.509 ± 0.044	1.38ProPro: 1.38 ± 0.046	1.792ProGln: 1.792 ± 0.052	2.489ProArg: 2.489 ± 0.067	3.028ProSer: 3.028 ± 0.061	2.77ProThr: 2.77 ± 0.059	4.009ProVal: 4.009 ± 0.075	0.733ProTrp: 0.733 ± 0.033	1.494ProTyr: 1.494 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.693GlnAla: 3.693 ± 0.083	0.243GlnCys: 0.243 ± 0.017	1.512GlnAsp: 1.512 ± 0.048	1.377GlnGlu: 1.377 ± 0.042	1.031GlnPhe: 1.031 ± 0.039	2.317GlnGly: 2.317 ± 0.057	0.682GlnHis: 0.682 ± 0.027	1.741GlnIle: 1.741 ± 0.052	0.962GlnLys: 0.962 ± 0.036	3.15GlnLeu: 3.15 ± 0.073	0.868GlnMet: 0.868 ± 0.035	0.9GlnAsn: 0.9 ± 0.035	1.666GlnPro: 1.666 ± 0.058	1.472GlnGln: 1.472 ± 0.056	2.337GlnArg: 2.337 ± 0.062	2.024GlnSer: 2.024 ± 0.052	1.787GlnThr: 1.787 ± 0.044	2.252GlnVal: 2.252 ± 0.051	0.598GlnTrp: 0.598 ± 0.027	1.081GlnTyr: 1.081 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	5.847ArgAla: 5.847 ± 0.086	0.558ArgCys: 0.558 ± 0.027	3.91ArgAsp: 3.91 ± 0.09	3.81ArgGlu: 3.81 ± 0.077	2.407ArgPhe: 2.407 ± 0.06	4.305ArgGly: 4.305 ± 0.078	1.62ArgHis: 1.62 ± 0.047	3.807ArgIle: 3.807 ± 0.065	2.311ArgLys: 2.311 ± 0.051	5.793ArgLeu: 5.793 ± 0.1	2.076ArgMet: 2.076 ± 0.049	2.016ArgAsn: 2.016 ± 0.054	2.75ArgPro: 2.75 ± 0.056	2.218ArgGln: 2.218 ± 0.056	5.165ArgArg: 5.165 ± 0.108	3.406ArgSer: 3.406 ± 0.068	3.468ArgThr: 3.468 ± 0.072	4.381ArgVal: 4.381 ± 0.076	0.94ArgTrp: 0.94 ± 0.038	2.107ArgTyr: 2.107 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.531SerAla: 6.531 ± 0.108	0.512SerCys: 0.512 ± 0.025	3.915SerAsp: 3.915 ± 0.08	2.784SerGlu: 2.784 ± 0.06	2.182SerPhe: 2.182 ± 0.05	6.208SerGly: 6.208 ± 0.102	1.192SerHis: 1.192 ± 0.036	3.102SerIle: 3.102 ± 0.053	1.987SerLys: 1.987 ± 0.05	5.248SerLeu: 5.248 ± 0.079	1.648SerMet: 1.648 ± 0.042	1.832SerAsn: 1.832 ± 0.044	2.7SerPro: 2.7 ± 0.06	1.911SerGln: 1.911 ± 0.047	3.585SerArg: 3.585 ± 0.069	3.846SerSer: 3.846 ± 0.088	3.545SerThr: 3.545 ± 0.076	4.646SerVal: 4.646 ± 0.082	0.932SerTrp: 0.932 ± 0.032	1.641SerTyr: 1.641 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.614ThrAla: 6.614 ± 0.099	0.456ThrCys: 0.456 ± 0.023	3.764ThrAsp: 3.764 ± 0.075	2.517ThrGlu: 2.517 ± 0.051	2.067ThrPhe: 2.067 ± 0.059	5.419ThrGly: 5.419 ± 0.084	1.163ThrHis: 1.163 ± 0.042	3.384ThrIle: 3.384 ± 0.062	1.867ThrLys: 1.867 ± 0.048	5.635ThrLeu: 5.635 ± 0.076	1.526ThrMet: 1.526 ± 0.036	1.757ThrAsn: 1.757 ± 0.05	3.421ThrPro: 3.421 ± 0.074	1.702ThrGln: 1.702 ± 0.043	3.079ThrArg: 3.079 ± 0.053	3.258ThrSer: 3.258 ± 0.064	3.537ThrThr: 3.537 ± 0.066	5.733ThrVal: 5.733 ± 0.09	0.821ThrTrp: 0.821 ± 0.034	1.552ThrTyr: 1.552 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.717ValAla: 8.717 ± 0.1	0.852ValCys: 0.852 ± 0.04	5.172ValAsp: 5.172 ± 0.085	3.975ValGlu: 3.975 ± 0.082	2.921ValPhe: 2.921 ± 0.067	5.394ValGly: 5.394 ± 0.096	1.361ValHis: 1.361 ± 0.043	4.373ValIle: 4.373 ± 0.07	2.58ValLys: 2.58 ± 0.057	6.979ValLeu: 6.979 ± 0.099	2.059ValMet: 2.059 ± 0.053	2.506ValAsn: 2.506 ± 0.056	4.094ValPro: 4.094 ± 0.077	1.948ValGln: 1.948 ± 0.046	4.488ValArg: 4.488 ± 0.087	5.209ValSer: 5.209 ± 0.081	5.134ValThr: 5.134 ± 0.086	6.142ValVal: 6.142 ± 0.104	1.023ValTrp: 1.023 ± 0.034	1.985ValTyr: 1.985 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.272TrpAla: 1.272 ± 0.04	0.147TrpCys: 0.147 ± 0.012	0.887TrpAsp: 0.887 ± 0.036	0.561TrpGlu: 0.561 ± 0.026	0.595TrpPhe: 0.595 ± 0.028	0.994TrpGly: 0.994 ± 0.032	0.358TrpHis: 0.358 ± 0.021	0.754TrpIle: 0.754 ± 0.031	0.572TrpLys: 0.572 ± 0.026	1.482TrpLeu: 1.482 ± 0.043	0.45TrpMet: 0.45 ± 0.022	0.668TrpAsn: 0.668 ± 0.026	0.595TrpPro: 0.595 ± 0.025	0.679TrpGln: 0.679 ± 0.031	1.102TrpArg: 1.102 ± 0.038	0.97TrpSer: 0.97 ± 0.032	0.833TrpThr: 0.833 ± 0.031	0.853TrpVal: 0.853 ± 0.028	0.291TrpTrp: 0.291 ± 0.018	0.449TrpTyr: 0.449 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.315TyrAla: 3.315 ± 0.063	0.324TyrCys: 0.324 ± 0.018	1.982TyrAsp: 1.982 ± 0.046	1.57TyrGlu: 1.57 ± 0.045	0.982TyrPhe: 0.982 ± 0.034	2.785TyrGly: 2.785 ± 0.063	0.518TyrHis: 0.518 ± 0.026	1.147TyrIle: 1.147 ± 0.038	0.802TyrLys: 0.802 ± 0.034	2.476TyrLeu: 2.476 ± 0.051	0.626TyrMet: 0.626 ± 0.027	0.843TyrAsn: 0.843 ± 0.034	1.315TyrPro: 1.315 ± 0.04	0.954TyrGln: 0.954 ± 0.035	2.05TyrArg: 2.05 ± 0.052	1.603TyrSer: 1.603 ± 0.039	1.617TyrThr: 1.617 ± 0.055	2.037TyrVal: 2.037 ± 0.045	0.466TyrTrp: 0.466 ± 0.026	0.893TyrTyr: 0.893 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2477 proteins (882320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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