Amino acid dipepetide frequency for Lysinibacillus composti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.435AlaAla: 5.435 ± 0.1	0.574AlaCys: 0.574 ± 0.023	3.19AlaAsp: 3.19 ± 0.06	4.606AlaGlu: 4.606 ± 0.072	3.278AlaPhe: 3.278 ± 0.054	4.845AlaGly: 4.845 ± 0.077	1.168AlaHis: 1.168 ± 0.038	6.426AlaIle: 6.426 ± 0.08	4.812AlaLys: 4.812 ± 0.078	7.083AlaLeu: 7.083 ± 0.097	1.975AlaMet: 1.975 ± 0.047	3.093AlaAsn: 3.093 ± 0.05	2.053AlaPro: 2.053 ± 0.042	2.328AlaGln: 2.328 ± 0.046	2.443AlaArg: 2.443 ± 0.058	4.051AlaSer: 4.051 ± 0.059	3.848AlaThr: 3.848 ± 0.067	5.103AlaVal: 5.103 ± 0.075	0.561AlaTrp: 0.561 ± 0.024	2.263AlaTyr: 2.263 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.449CysAla: 0.449 ± 0.018	0.105CysCys: 0.105 ± 0.01	0.375CysAsp: 0.375 ± 0.02	0.485CysGlu: 0.485 ± 0.022	0.312CysPhe: 0.312 ± 0.017	0.638CysGly: 0.638 ± 0.024	0.183CysHis: 0.183 ± 0.014	0.568CysIle: 0.568 ± 0.021	0.34CysLys: 0.34 ± 0.016	0.595CysLeu: 0.595 ± 0.022	0.154CysMet: 0.154 ± 0.013	0.293CysAsn: 0.293 ± 0.016	0.317CysPro: 0.317 ± 0.018	0.22CysGln: 0.22 ± 0.014	0.26CysArg: 0.26 ± 0.015	0.506CysSer: 0.506 ± 0.024	0.379CysThr: 0.379 ± 0.021	0.407CysVal: 0.407 ± 0.02	0.066CysTrp: 0.066 ± 0.007	0.244CysTyr: 0.244 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.361AspAla: 3.361 ± 0.06	0.356AspCys: 0.356 ± 0.017	2.454AspAsp: 2.454 ± 0.06	4.606AspGlu: 4.606 ± 0.075	2.514AspPhe: 2.514 ± 0.054	3.394AspGly: 3.394 ± 0.068	1.093AspHis: 1.093 ± 0.031	3.987AspIle: 3.987 ± 0.065	2.634AspLys: 2.634 ± 0.052	4.975AspLeu: 4.975 ± 0.071	1.206AspMet: 1.206 ± 0.031	1.682AspAsn: 1.682 ± 0.039	1.814AspPro: 1.814 ± 0.042	2.012AspGln: 2.012 ± 0.039	1.968AspArg: 1.968 ± 0.043	2.655AspSer: 2.655 ± 0.051	2.302AspThr: 2.302 ± 0.048	3.817AspVal: 3.817 ± 0.062	0.545AspTrp: 0.545 ± 0.021	2.126AspTyr: 2.126 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.222GluAla: 5.222 ± 0.08	0.365GluCys: 0.365 ± 0.019	3.761GluAsp: 3.761 ± 0.063	7.177GluGlu: 7.177 ± 0.1	2.816GluPhe: 2.816 ± 0.049	4.28GluGly: 4.28 ± 0.062	1.55GluHis: 1.55 ± 0.042	6.2GluIle: 6.2 ± 0.074	6.235GluLys: 6.235 ± 0.094	7.487GluLeu: 7.487 ± 0.093	2.22GluMet: 2.22 ± 0.047	3.946GluAsn: 3.946 ± 0.061	1.969GluPro: 1.969 ± 0.038	3.646GluGln: 3.646 ± 0.063	3.352GluArg: 3.352 ± 0.053	3.67GluSer: 3.67 ± 0.065	3.999GluThr: 3.999 ± 0.063	5.595GluVal: 5.595 ± 0.077	0.74GluTrp: 0.74 ± 0.031	2.268GluTyr: 2.268 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.17PheAla: 3.17 ± 0.069	0.368PheCys: 0.368 ± 0.02	2.519PheAsp: 2.519 ± 0.048	3.277PheGlu: 3.277 ± 0.064	2.238PhePhe: 2.238 ± 0.054	3.435PheGly: 3.435 ± 0.068	0.895PheHis: 0.895 ± 0.029	4.191PheIle: 4.191 ± 0.063	2.617PheLys: 2.617 ± 0.049	4.268PheLeu: 4.268 ± 0.067	1.179PheMet: 1.179 ± 0.032	2.17PheAsn: 2.17 ± 0.047	1.587PhePro: 1.587 ± 0.041	1.465PheGln: 1.465 ± 0.038	1.462PheArg: 1.462 ± 0.033	3.104PheSer: 3.104 ± 0.058	2.728PheThr: 2.728 ± 0.059	3.358PheVal: 3.358 ± 0.062	0.464PheTrp: 0.464 ± 0.02	1.722PheTyr: 1.722 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.853GlyAla: 4.853 ± 0.082	0.55GlyCys: 0.55 ± 0.022	3.105GlyAsp: 3.105 ± 0.05	4.583GlyGlu: 4.583 ± 0.063	3.295GlyPhe: 3.295 ± 0.062	4.649GlyGly: 4.649 ± 0.08	1.331GlyHis: 1.331 ± 0.041	6.094GlyIle: 6.094 ± 0.087	4.724GlyLys: 4.724 ± 0.063	6.324GlyLeu: 6.324 ± 0.081	1.933GlyMet: 1.933 ± 0.047	2.817GlyAsn: 2.817 ± 0.06	1.697GlyPro: 1.697 ± 0.051	2.229GlyGln: 2.229 ± 0.043	2.512GlyArg: 2.512 ± 0.05	3.892GlySer: 3.892 ± 0.064	4.013GlyThr: 4.013 ± 0.058	5.142GlyVal: 5.142 ± 0.083	0.715GlyTrp: 0.715 ± 0.027	2.738GlyTyr: 2.738 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.209HisAla: 1.209 ± 0.031	0.179HisCys: 0.179 ± 0.015	0.958HisAsp: 0.958 ± 0.034	1.336HisGlu: 1.336 ± 0.035	1.013HisPhe: 1.013 ± 0.029	1.314HisGly: 1.314 ± 0.038	0.664HisHis: 0.664 ± 0.032	1.517HisIle: 1.517 ± 0.04	1.017HisLys: 1.017 ± 0.032	2.061HisLeu: 2.061 ± 0.041	0.452HisMet: 0.452 ± 0.019	0.801HisAsn: 0.801 ± 0.026	1.1HisPro: 1.1 ± 0.036	0.808HisGln: 0.808 ± 0.028	0.76HisArg: 0.76 ± 0.028	1.146HisSer: 1.146 ± 0.033	1.004HisThr: 1.004 ± 0.033	1.325HisVal: 1.325 ± 0.029	0.185HisTrp: 0.185 ± 0.013	0.838HisTyr: 0.838 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.402IleAla: 6.402 ± 0.076	0.63IleCys: 0.63 ± 0.024	4.49IleAsp: 4.49 ± 0.064	6.43IleGlu: 6.43 ± 0.084	3.564IlePhe: 3.564 ± 0.07	6.165IleGly: 6.165 ± 0.089	1.609IleHis: 1.609 ± 0.038	6.503IleIle: 6.503 ± 0.099	4.572IleLys: 4.572 ± 0.071	7.79IleLeu: 7.79 ± 0.105	1.881IleMet: 1.881 ± 0.042	3.574IleAsn: 3.574 ± 0.062	3.452IlePro: 3.452 ± 0.054	3.153IleGln: 3.153 ± 0.055	3.125IleArg: 3.125 ± 0.048	5.5IleSer: 5.5 ± 0.074	4.665IleThr: 4.665 ± 0.066	6.296IleVal: 6.296 ± 0.084	0.703IleTrp: 0.703 ± 0.025	2.598IleTyr: 2.598 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.3LysAla: 4.3 ± 0.076	0.339LysCys: 0.339 ± 0.019	3.545LysAsp: 3.545 ± 0.048	6.581LysGlu: 6.581 ± 0.075	2.263LysPhe: 2.263 ± 0.045	4.177LysGly: 4.177 ± 0.054	1.261LysHis: 1.261 ± 0.032	4.858LysIle: 4.858 ± 0.069	5.337LysLys: 5.337 ± 0.086	5.99LysLeu: 5.99 ± 0.071	2.094LysMet: 2.094 ± 0.05	3.429LysAsn: 3.429 ± 0.058	2.167LysPro: 2.167 ± 0.045	2.816LysGln: 2.816 ± 0.054	2.97LysArg: 2.97 ± 0.055	3.707LysSer: 3.707 ± 0.055	3.624LysThr: 3.624 ± 0.052	4.81LysVal: 4.81 ± 0.073	0.782LysTrp: 0.782 ± 0.03	2.258LysTyr: 2.258 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	7.075LeuAla: 7.075 ± 0.086	0.681LeuCys: 0.681 ± 0.024	4.633LeuAsp: 4.633 ± 0.062	6.729LeuGlu: 6.729 ± 0.081	4.825LeuPhe: 4.825 ± 0.083	6.271LeuGly: 6.271 ± 0.092	1.83LeuHis: 1.83 ± 0.044	7.719LeuIle: 7.719 ± 0.103	6.679LeuLys: 6.679 ± 0.08	9.888LeuLeu: 9.888 ± 0.122	2.41LeuMet: 2.41 ± 0.049	4.78LeuAsn: 4.78 ± 0.072	3.771LeuPro: 3.771 ± 0.073	3.704LeuGln: 3.704 ± 0.066	3.455LeuArg: 3.455 ± 0.061	6.653LeuSer: 6.653 ± 0.087	5.792LeuThr: 5.792 ± 0.077	6.551LeuVal: 6.551 ± 0.077	0.702LeuTrp: 0.702 ± 0.028	3.077LeuTyr: 3.077 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.855MetAla: 1.855 ± 0.046	0.153MetCys: 0.153 ± 0.013	1.324MetAsp: 1.324 ± 0.037	1.827MetGlu: 1.827 ± 0.04	1.056MetPhe: 1.056 ± 0.037	1.722MetGly: 1.722 ± 0.042	0.435MetHis: 0.435 ± 0.022	2.132MetIle: 2.132 ± 0.056	2.326MetLys: 2.326 ± 0.044	2.369MetLeu: 2.369 ± 0.047	0.785MetMet: 0.785 ± 0.027	1.587MetAsn: 1.587 ± 0.034	0.969MetPro: 0.969 ± 0.028	0.904MetGln: 0.904 ± 0.032	1.068MetArg: 1.068 ± 0.028	1.673MetSer: 1.673 ± 0.038	1.614MetThr: 1.614 ± 0.038	1.666MetVal: 1.666 ± 0.041	0.156MetTrp: 0.156 ± 0.011	0.744MetTyr: 0.744 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.098AsnAla: 3.098 ± 0.058	0.309AsnCys: 0.309 ± 0.016	2.314AsnAsp: 2.314 ± 0.053	3.946AsnGlu: 3.946 ± 0.068	1.992AsnPhe: 1.992 ± 0.042	3.464AsnGly: 3.464 ± 0.062	1.022AsnHis: 1.022 ± 0.027	3.738AsnIle: 3.738 ± 0.06	3.09AsnLys: 3.09 ± 0.05	4.281AsnLeu: 4.281 ± 0.058	1.217AsnMet: 1.217 ± 0.036	2.355AsnAsn: 2.355 ± 0.055	2.179AsnPro: 2.179 ± 0.048	1.943AsnGln: 1.943 ± 0.044	2.056AsnArg: 2.056 ± 0.041	2.619AsnSer: 2.619 ± 0.054	2.33AsnThr: 2.33 ± 0.051	3.264AsnVal: 3.264 ± 0.056	0.516AsnTrp: 0.516 ± 0.023	1.728AsnTyr: 1.728 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.121ProAla: 2.121 ± 0.044	0.194ProCys: 0.194 ± 0.015	1.753ProAsp: 1.753 ± 0.043	2.812ProGlu: 2.812 ± 0.055	1.973ProPhe: 1.973 ± 0.043	2.188ProGly: 2.188 ± 0.045	0.747ProHis: 0.747 ± 0.03	3.125ProIle: 3.125 ± 0.056	2.276ProLys: 2.276 ± 0.046	3.29ProLeu: 3.29 ± 0.048	0.821ProMet: 0.821 ± 0.027	1.901ProAsn: 1.901 ± 0.042	0.95ProPro: 0.95 ± 0.032	1.185ProGln: 1.185 ± 0.033	0.957ProArg: 0.957 ± 0.029	2.305ProSer: 2.305 ± 0.049	2.264ProThr: 2.264 ± 0.049	2.651ProVal: 2.651 ± 0.053	0.355ProTrp: 0.355 ± 0.019	1.405ProTyr: 1.405 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.532GlnAla: 2.532 ± 0.053	0.207GlnCys: 0.207 ± 0.015	1.592GlnAsp: 1.592 ± 0.04	2.651GlnGlu: 2.651 ± 0.05	1.743GlnPhe: 1.743 ± 0.043	2.024GlnGly: 2.024 ± 0.042	0.787GlnHis: 0.787 ± 0.029	2.977GlnIle: 2.977 ± 0.058	2.625GlnLys: 2.625 ± 0.053	4.231GlnLeu: 4.231 ± 0.072	1.121GlnMet: 1.121 ± 0.038	1.807GlnAsn: 1.807 ± 0.045	1.182GlnPro: 1.182 ± 0.035	1.876GlnGln: 1.876 ± 0.052	1.4GlnArg: 1.4 ± 0.035	2.287GlnSer: 2.287 ± 0.051	2.078GlnThr: 2.078 ± 0.046	2.466GlnVal: 2.466 ± 0.05	0.377GlnTrp: 0.377 ± 0.017	1.445GlnTyr: 1.445 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.397ArgAla: 2.397 ± 0.047	0.239ArgCys: 0.239 ± 0.015	1.971ArgAsp: 1.971 ± 0.043	3.052ArgGlu: 3.052 ± 0.056	1.836ArgPhe: 1.836 ± 0.045	2.289ArgGly: 2.289 ± 0.051	0.724ArgHis: 0.724 ± 0.027	3.039ArgIle: 3.039 ± 0.053	2.949ArgLys: 2.949 ± 0.049	3.695ArgLeu: 3.695 ± 0.071	1.094ArgMet: 1.094 ± 0.033	1.918ArgAsn: 1.918 ± 0.044	1.263ArgPro: 1.263 ± 0.037	1.477ArgGln: 1.477 ± 0.036	1.666ArgArg: 1.666 ± 0.049	2.035ArgSer: 2.035 ± 0.045	1.943ArgThr: 1.943 ± 0.042	2.576ArgVal: 2.576 ± 0.045	0.346ArgTrp: 0.346 ± 0.016	1.404ArgTyr: 1.404 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.709SerAla: 3.709 ± 0.058	0.354SerCys: 0.354 ± 0.018	2.756SerAsp: 2.756 ± 0.054	4.01SerGlu: 4.01 ± 0.057	3.278SerPhe: 3.278 ± 0.053	4.294SerGly: 4.294 ± 0.071	1.171SerHis: 1.171 ± 0.032	5.599SerIle: 5.599 ± 0.07	4.107SerLys: 4.107 ± 0.064	6.136SerLeu: 6.136 ± 0.078	1.599SerMet: 1.599 ± 0.037	3.037SerAsn: 3.037 ± 0.057	2.108SerPro: 2.108 ± 0.044	1.971SerGln: 1.971 ± 0.043	2.107SerArg: 2.107 ± 0.041	3.908SerSer: 3.908 ± 0.082	3.445SerThr: 3.445 ± 0.066	4.172SerVal: 4.172 ± 0.061	0.544SerTrp: 0.544 ± 0.023	2.239SerTyr: 2.239 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	3.97ThrAla: 3.97 ± 0.066	0.34ThrCys: 0.34 ± 0.017	2.676ThrAsp: 2.676 ± 0.051	3.736ThrGlu: 3.736 ± 0.052	2.672ThrPhe: 2.672 ± 0.052	3.972ThrGly: 3.972 ± 0.067	0.996ThrHis: 0.996 ± 0.027	5.071ThrIle: 5.071 ± 0.068	3.536ThrLys: 3.536 ± 0.06	5.356ThrLeu: 5.356 ± 0.067	1.255ThrMet: 1.255 ± 0.037	2.788ThrAsn: 2.788 ± 0.053	2.43ThrPro: 2.43 ± 0.045	1.544ThrGln: 1.544 ± 0.039	1.797ThrArg: 1.797 ± 0.043	3.504ThrSer: 3.504 ± 0.056	3.281ThrThr: 3.281 ± 0.065	4.336ThrVal: 4.336 ± 0.061	0.545ThrTrp: 0.545 ± 0.021	2.057ThrTyr: 2.057 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.231ValAla: 5.231 ± 0.083	0.567ValCys: 0.567 ± 0.022	3.652ValAsp: 3.652 ± 0.062	5.395ValGlu: 5.395 ± 0.071	3.149ValPhe: 3.149 ± 0.054	4.989ValGly: 4.989 ± 0.068	1.274ValHis: 1.274 ± 0.037	5.932ValIle: 5.932 ± 0.085	4.665ValLys: 4.665 ± 0.064	6.912ValLeu: 6.912 ± 0.079	1.862ValMet: 1.862 ± 0.043	3.353ValAsn: 3.353 ± 0.055	2.681ValPro: 2.681 ± 0.047	2.443ValGln: 2.443 ± 0.049	2.701ValArg: 2.701 ± 0.052	4.55ValSer: 4.55 ± 0.072	4.252ValThr: 4.252 ± 0.058	5.427ValVal: 5.427 ± 0.076	0.56ValTrp: 0.56 ± 0.021	2.283ValTyr: 2.283 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.559TrpAla: 0.559 ± 0.024	0.081TrpCys: 0.081 ± 0.008	0.468TrpAsp: 0.468 ± 0.019	0.584TrpGlu: 0.584 ± 0.025	0.505TrpPhe: 0.505 ± 0.024	0.66TrpGly: 0.66 ± 0.026	0.199TrpHis: 0.199 ± 0.014	0.807TrpIle: 0.807 ± 0.025	0.635TrpLys: 0.635 ± 0.025	0.994TrpLeu: 0.994 ± 0.034	0.298TrpMet: 0.298 ± 0.017	0.519TrpAsn: 0.519 ± 0.019	0.235TrpPro: 0.235 ± 0.014	0.347TrpGln: 0.347 ± 0.019	0.334TrpArg: 0.334 ± 0.016	0.564TrpSer: 0.564 ± 0.022	0.509TrpThr: 0.509 ± 0.024	0.623TrpVal: 0.623 ± 0.024	0.113TrpTrp: 0.113 ± 0.01	0.309TrpTyr: 0.309 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.188TyrAla: 2.188 ± 0.051	0.305TyrCys: 0.305 ± 0.018	1.966TyrAsp: 1.966 ± 0.044	2.676TyrGlu: 2.676 ± 0.052	1.895TyrPhe: 1.895 ± 0.039	2.427TyrGly: 2.427 ± 0.051	0.75TyrHis: 0.75 ± 0.025	2.618TyrIle: 2.618 ± 0.054	2.13TyrLys: 2.13 ± 0.048	3.503TyrLeu: 3.503 ± 0.058	0.809TyrMet: 0.809 ± 0.026	1.606TyrAsn: 1.606 ± 0.04	1.35TyrPro: 1.35 ± 0.036	1.337TyrGln: 1.337 ± 0.035	1.522TyrArg: 1.522 ± 0.038	2.214TyrSer: 2.214 ± 0.042	1.791TyrThr: 1.791 ± 0.04	2.291TyrVal: 2.291 ± 0.041	0.367TyrTrp: 0.367 ± 0.017	1.432TyrTyr: 1.432 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3831 proteins (1145423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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