Amino acid dipepetide frequency for Gordonia phage Kenna

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.592AlaAla: 13.592 ± 1.206
0.715AlaCys: 0.715 ± 0.224
7.213AlaAsp: 7.213 ± 0.693
8.703AlaGlu: 8.703 ± 0.857
2.981AlaPhe: 2.981 ± 0.7
8.405AlaGly: 8.405 ± 0.972
1.967AlaHis: 1.967 ± 0.42
5.246AlaIle: 5.246 ± 0.579
3.159AlaLys: 3.159 ± 0.561
9.657AlaLeu: 9.657 ± 0.808
3.636AlaMet: 3.636 ± 0.513
2.921AlaAsn: 2.921 ± 0.439
5.425AlaPro: 5.425 ± 0.648
4.829AlaGln: 4.829 ± 0.693
7.273AlaArg: 7.273 ± 0.784
5.782AlaSer: 5.782 ± 0.578
5.961AlaThr: 5.961 ± 0.67
8.048AlaVal: 8.048 ± 1.127
1.848AlaTrp: 1.848 ± 0.369
2.623AlaTyr: 2.623 ± 0.391
0.0AlaXaa: 0.0 ± 0.0
Cys
0.775CysAla: 0.775 ± 0.24
0.119CysCys: 0.119 ± 0.094
1.133CysAsp: 1.133 ± 0.271
0.656CysGlu: 0.656 ± 0.256
0.417CysPhe: 0.417 ± 0.169
1.073CysGly: 1.073 ± 0.26
0.656CysHis: 0.656 ± 0.204
0.298CysIle: 0.298 ± 0.145
0.358CysLys: 0.358 ± 0.162
0.715CysLeu: 0.715 ± 0.197
0.119CysMet: 0.119 ± 0.081
0.358CysAsn: 0.358 ± 0.148
0.715CysPro: 0.715 ± 0.228
0.358CysGln: 0.358 ± 0.172
0.596CysArg: 0.596 ± 0.222
0.715CysSer: 0.715 ± 0.246
0.298CysThr: 0.298 ± 0.137
0.894CysVal: 0.894 ± 0.253
0.358CysTrp: 0.358 ± 0.145
0.238CysTyr: 0.238 ± 0.138
0.0CysXaa: 0.0 ± 0.0
Asp
7.809AspAla: 7.809 ± 0.675
0.596AspCys: 0.596 ± 0.221
4.531AspAsp: 4.531 ± 0.768
4.829AspGlu: 4.829 ± 0.694
1.848AspPhe: 1.848 ± 0.304
5.604AspGly: 5.604 ± 0.626
1.311AspHis: 1.311 ± 0.274
2.861AspIle: 2.861 ± 0.424
2.206AspLys: 2.206 ± 0.333
4.829AspLeu: 4.829 ± 0.556
1.073AspMet: 1.073 ± 0.209
1.49AspAsn: 1.49 ± 0.33
4.471AspPro: 4.471 ± 0.406
1.49AspGln: 1.49 ± 0.309
4.292AspArg: 4.292 ± 0.477
3.756AspSer: 3.756 ± 0.422
3.815AspThr: 3.815 ± 0.496
5.544AspVal: 5.544 ± 0.537
1.371AspTrp: 1.371 ± 0.281
2.027AspTyr: 2.027 ± 0.351
0.0AspXaa: 0.0 ± 0.0
Glu
7.094GluAla: 7.094 ± 0.751
0.835GluCys: 0.835 ± 0.276
3.279GluAsp: 3.279 ± 0.46
3.1GluGlu: 3.1 ± 0.691
2.325GluPhe: 2.325 ± 0.34
4.054GluGly: 4.054 ± 0.487
1.788GluHis: 1.788 ± 0.327
2.206GluIle: 2.206 ± 0.344
2.265GluLys: 2.265 ± 0.414
5.544GluLeu: 5.544 ± 0.826
1.073GluMet: 1.073 ± 0.25
0.954GluAsn: 0.954 ± 0.23
3.636GluPro: 3.636 ± 0.635
2.742GluGln: 2.742 ± 0.386
5.186GluArg: 5.186 ± 0.709
2.981GluSer: 2.981 ± 0.447
3.577GluThr: 3.577 ± 0.428
4.292GluVal: 4.292 ± 0.554
1.848GluTrp: 1.848 ± 0.394
1.252GluTyr: 1.252 ± 0.302
0.0GluXaa: 0.0 ± 0.0
Phe
2.802PheAla: 2.802 ± 0.4
0.298PheCys: 0.298 ± 0.136
1.848PheAsp: 1.848 ± 0.317
1.55PheGlu: 1.55 ± 0.249
0.835PhePhe: 0.835 ± 0.218
3.1PheGly: 3.1 ± 0.466
0.537PheHis: 0.537 ± 0.171
0.596PheIle: 0.596 ± 0.185
1.192PheLys: 1.192 ± 0.267
1.49PheLeu: 1.49 ± 0.313
1.073PheMet: 1.073 ± 0.284
0.894PheAsn: 0.894 ± 0.249
1.192PhePro: 1.192 ± 0.299
1.013PheGln: 1.013 ± 0.21
2.086PheArg: 2.086 ± 0.352
1.49PheSer: 1.49 ± 0.292
1.669PheThr: 1.669 ± 0.246
2.086PheVal: 2.086 ± 0.332
0.477PheTrp: 0.477 ± 0.199
1.013PheTyr: 1.013 ± 0.243
0.0PheXaa: 0.0 ± 0.0
Gly
7.392GlyAla: 7.392 ± 1.18
0.656GlyCys: 0.656 ± 0.266
5.544GlyAsp: 5.544 ± 0.617
3.398GlyGlu: 3.398 ± 0.441
3.1GlyPhe: 3.1 ± 0.614
7.511GlyGly: 7.511 ± 1.188
1.61GlyHis: 1.61 ± 0.364
3.815GlyIle: 3.815 ± 0.602
3.159GlyLys: 3.159 ± 0.519
6.498GlyLeu: 6.498 ± 0.56
2.325GlyMet: 2.325 ± 0.329
2.504GlyAsn: 2.504 ± 0.388
3.398GlyPro: 3.398 ± 0.395
2.981GlyGln: 2.981 ± 0.413
6.259GlyArg: 6.259 ± 0.595
4.352GlySer: 4.352 ± 0.587
5.902GlyThr: 5.902 ± 0.679
6.915GlyVal: 6.915 ± 0.774
2.265GlyTrp: 2.265 ± 0.3
2.206GlyTyr: 2.206 ± 0.361
0.0GlyXaa: 0.0 ± 0.0
His
1.669HisAla: 1.669 ± 0.333
0.596HisCys: 0.596 ± 0.19
1.013HisAsp: 1.013 ± 0.222
1.192HisGlu: 1.192 ± 0.31
0.715HisPhe: 0.715 ± 0.209
1.788HisGly: 1.788 ± 0.321
0.358HisHis: 0.358 ± 0.152
1.073HisIle: 1.073 ± 0.253
0.298HisLys: 0.298 ± 0.172
2.206HisLeu: 2.206 ± 0.443
0.715HisMet: 0.715 ± 0.211
0.537HisAsn: 0.537 ± 0.196
1.252HisPro: 1.252 ± 0.214
0.775HisGln: 0.775 ± 0.211
1.729HisArg: 1.729 ± 0.326
1.013HisSer: 1.013 ± 0.249
1.967HisThr: 1.967 ± 0.368
2.265HisVal: 2.265 ± 0.368
0.656HisTrp: 0.656 ± 0.238
0.656HisTyr: 0.656 ± 0.237
0.0HisXaa: 0.0 ± 0.0
Ile
5.782IleAla: 5.782 ± 0.644
0.358IleCys: 0.358 ± 0.158
3.398IleAsp: 3.398 ± 0.419
2.861IleGlu: 2.861 ± 0.462
0.656IlePhe: 0.656 ± 0.294
4.888IleGly: 4.888 ± 0.419
1.073IleHis: 1.073 ± 0.313
1.311IleIle: 1.311 ± 0.315
1.908IleLys: 1.908 ± 0.526
2.742IleLeu: 2.742 ± 0.349
0.656IleMet: 0.656 ± 0.215
1.49IleAsn: 1.49 ± 0.362
2.623IlePro: 2.623 ± 0.384
1.848IleGln: 1.848 ± 0.299
3.279IleArg: 3.279 ± 0.384
1.967IleSer: 1.967 ± 0.308
3.159IleThr: 3.159 ± 0.405
3.577IleVal: 3.577 ± 0.473
0.656IleTrp: 0.656 ± 0.205
1.013IleTyr: 1.013 ± 0.315
0.0IleXaa: 0.0 ± 0.0
Lys
4.471LysAla: 4.471 ± 0.653
0.298LysCys: 0.298 ± 0.139
2.623LysAsp: 2.623 ± 0.521
1.61LysGlu: 1.61 ± 0.301
1.073LysPhe: 1.073 ± 0.214
2.742LysGly: 2.742 ± 0.614
0.835LysHis: 0.835 ± 0.233
1.431LysIle: 1.431 ± 0.247
2.325LysLys: 2.325 ± 0.508
2.802LysLeu: 2.802 ± 0.312
0.358LysMet: 0.358 ± 0.123
1.073LysAsn: 1.073 ± 0.259
1.61LysPro: 1.61 ± 0.298
1.311LysGln: 1.311 ± 0.33
2.504LysArg: 2.504 ± 0.412
2.086LysSer: 2.086 ± 0.393
2.921LysThr: 2.921 ± 0.424
2.086LysVal: 2.086 ± 0.409
1.133LysTrp: 1.133 ± 0.286
0.596LysTyr: 0.596 ± 0.198
0.0LysXaa: 0.0 ± 0.0
Leu
9.419LeuAla: 9.419 ± 0.886
0.894LeuCys: 0.894 ± 0.254
5.306LeuAsp: 5.306 ± 0.747
3.517LeuGlu: 3.517 ± 0.518
1.788LeuPhe: 1.788 ± 0.398
5.902LeuGly: 5.902 ± 0.647
1.431LeuHis: 1.431 ± 0.241
3.458LeuIle: 3.458 ± 0.446
2.563LeuLys: 2.563 ± 0.362
5.484LeuLeu: 5.484 ± 0.763
1.192LeuMet: 1.192 ± 0.256
1.967LeuAsn: 1.967 ± 0.276
4.59LeuPro: 4.59 ± 0.423
2.265LeuGln: 2.265 ± 0.367
6.259LeuArg: 6.259 ± 0.734
4.232LeuSer: 4.232 ± 0.472
5.663LeuThr: 5.663 ± 0.553
6.379LeuVal: 6.379 ± 0.764
1.729LeuTrp: 1.729 ± 0.355
1.669LeuTyr: 1.669 ± 0.301
0.0LeuXaa: 0.0 ± 0.0
Met
2.861MetAla: 2.861 ± 0.485
0.298MetCys: 0.298 ± 0.132
0.775MetAsp: 0.775 ± 0.231
0.537MetGlu: 0.537 ± 0.185
0.358MetPhe: 0.358 ± 0.154
1.61MetGly: 1.61 ± 0.298
0.477MetHis: 0.477 ± 0.18
1.013MetIle: 1.013 ± 0.29
0.954MetLys: 0.954 ± 0.221
1.371MetLeu: 1.371 ± 0.242
0.417MetMet: 0.417 ± 0.148
0.715MetAsn: 0.715 ± 0.183
1.729MetPro: 1.729 ± 0.353
0.656MetGln: 0.656 ± 0.164
2.086MetArg: 2.086 ± 0.476
2.742MetSer: 2.742 ± 0.403
2.444MetThr: 2.444 ± 0.381
1.61MetVal: 1.61 ± 0.284
0.417MetTrp: 0.417 ± 0.156
0.298MetTyr: 0.298 ± 0.125
0.0MetXaa: 0.0 ± 0.0
Asn
3.934AsnAla: 3.934 ± 0.58
0.179AsnCys: 0.179 ± 0.102
1.788AsnAsp: 1.788 ± 0.314
1.073AsnGlu: 1.073 ± 0.229
0.477AsnPhe: 0.477 ± 0.143
3.159AsnGly: 3.159 ± 0.449
0.656AsnHis: 0.656 ± 0.198
1.252AsnIle: 1.252 ± 0.302
0.417AsnLys: 0.417 ± 0.145
2.206AsnLeu: 2.206 ± 0.388
0.596AsnMet: 0.596 ± 0.147
0.775AsnAsn: 0.775 ± 0.219
2.504AsnPro: 2.504 ± 0.397
1.192AsnGln: 1.192 ± 0.312
2.385AsnArg: 2.385 ± 0.409
1.61AsnSer: 1.61 ± 0.42
1.729AsnThr: 1.729 ± 0.33
1.848AsnVal: 1.848 ± 0.357
0.238AsnTrp: 0.238 ± 0.104
0.656AsnTyr: 0.656 ± 0.171
0.0AsnXaa: 0.0 ± 0.0
Pro
6.021ProAla: 6.021 ± 0.549
0.954ProCys: 0.954 ± 0.262
4.709ProAsp: 4.709 ± 0.615
4.829ProGlu: 4.829 ± 0.649
1.133ProPhe: 1.133 ± 0.284
4.471ProGly: 4.471 ± 0.446
0.835ProHis: 0.835 ± 0.205
2.683ProIle: 2.683 ± 0.437
2.802ProLys: 2.802 ± 0.395
3.338ProLeu: 3.338 ± 0.47
1.252ProMet: 1.252 ± 0.231
1.49ProAsn: 1.49 ± 0.312
2.683ProPro: 2.683 ± 0.498
1.431ProGln: 1.431 ± 0.303
3.219ProArg: 3.219 ± 0.417
3.1ProSer: 3.1 ± 0.424
3.875ProThr: 3.875 ± 0.414
4.292ProVal: 4.292 ± 0.475
0.894ProTrp: 0.894 ± 0.219
1.252ProTyr: 1.252 ± 0.294
0.0ProXaa: 0.0 ± 0.0
Gln
4.054GlnAla: 4.054 ± 0.679
0.656GlnCys: 0.656 ± 0.236
1.311GlnAsp: 1.311 ± 0.303
1.908GlnGlu: 1.908 ± 0.31
0.894GlnPhe: 0.894 ± 0.215
2.444GlnGly: 2.444 ± 0.353
1.013GlnHis: 1.013 ± 0.3
1.908GlnIle: 1.908 ± 0.297
1.073GlnLys: 1.073 ± 0.25
2.742GlnLeu: 2.742 ± 0.419
1.013GlnMet: 1.013 ± 0.235
1.013GlnAsn: 1.013 ± 0.214
1.967GlnPro: 1.967 ± 0.279
1.908GlnGln: 1.908 ± 0.335
3.1GlnArg: 3.1 ± 0.49
2.027GlnSer: 2.027 ± 0.291
1.848GlnThr: 1.848 ± 0.351
2.802GlnVal: 2.802 ± 0.436
1.371GlnTrp: 1.371 ± 0.305
0.894GlnTyr: 0.894 ± 0.24
0.0GlnXaa: 0.0 ± 0.0
Arg
6.975ArgAla: 6.975 ± 0.708
0.835ArgCys: 0.835 ± 0.227
4.65ArgAsp: 4.65 ± 0.574
4.888ArgGlu: 4.888 ± 0.574
1.729ArgPhe: 1.729 ± 0.322
4.292ArgGly: 4.292 ± 0.55
2.504ArgHis: 2.504 ± 0.501
4.054ArgIle: 4.054 ± 0.522
2.981ArgLys: 2.981 ± 0.497
6.319ArgLeu: 6.319 ± 0.467
1.967ArgMet: 1.967 ± 0.312
2.444ArgAsn: 2.444 ± 0.369
3.696ArgPro: 3.696 ± 0.585
3.159ArgGln: 3.159 ± 0.408
6.557ArgArg: 6.557 ± 1.016
4.173ArgSer: 4.173 ± 0.602
3.875ArgThr: 3.875 ± 0.457
4.471ArgVal: 4.471 ± 0.554
2.086ArgTrp: 2.086 ± 0.306
2.444ArgTyr: 2.444 ± 0.388
0.0ArgXaa: 0.0 ± 0.0
Ser
5.723SerAla: 5.723 ± 0.556
0.417SerCys: 0.417 ± 0.194
3.159SerAsp: 3.159 ± 0.504
3.815SerGlu: 3.815 ± 0.473
1.49SerPhe: 1.49 ± 0.295
6.855SerGly: 6.855 ± 0.781
1.311SerHis: 1.311 ± 0.296
2.623SerIle: 2.623 ± 0.459
1.669SerLys: 1.669 ± 0.317
3.756SerLeu: 3.756 ± 0.607
2.086SerMet: 2.086 ± 0.386
1.49SerAsn: 1.49 ± 0.367
2.325SerPro: 2.325 ± 0.303
1.49SerGln: 1.49 ± 0.331
4.352SerArg: 4.352 ± 0.629
4.232SerSer: 4.232 ± 0.555
4.471SerThr: 4.471 ± 0.608
4.292SerVal: 4.292 ± 0.668
1.192SerTrp: 1.192 ± 0.222
0.954SerTyr: 0.954 ± 0.249
0.0SerXaa: 0.0 ± 0.0
Thr
7.154ThrAla: 7.154 ± 0.877
0.775ThrCys: 0.775 ± 0.232
4.531ThrAsp: 4.531 ± 0.495
3.696ThrGlu: 3.696 ± 0.472
1.669ThrPhe: 1.669 ± 0.294
4.769ThrGly: 4.769 ± 0.538
1.49ThrHis: 1.49 ± 0.267
4.411ThrIle: 4.411 ± 0.498
1.55ThrLys: 1.55 ± 0.267
5.604ThrLeu: 5.604 ± 0.571
0.596ThrMet: 0.596 ± 0.168
2.385ThrAsn: 2.385 ± 0.423
4.531ThrPro: 4.531 ± 0.471
1.967ThrGln: 1.967 ± 0.373
3.815ThrArg: 3.815 ± 0.391
3.875ThrSer: 3.875 ± 0.544
4.352ThrThr: 4.352 ± 0.621
5.782ThrVal: 5.782 ± 0.627
1.49ThrTrp: 1.49 ± 0.321
1.61ThrTyr: 1.61 ± 0.327
0.0ThrXaa: 0.0 ± 0.0
Val
8.346ValAla: 8.346 ± 0.738
0.715ValCys: 0.715 ± 0.228
4.829ValAsp: 4.829 ± 0.535
4.888ValGlu: 4.888 ± 0.615
2.444ValPhe: 2.444 ± 0.309
5.961ValGly: 5.961 ± 0.699
1.55ValHis: 1.55 ± 0.308
3.517ValIle: 3.517 ± 0.448
3.1ValLys: 3.1 ± 0.486
4.829ValLeu: 4.829 ± 0.55
1.848ValMet: 1.848 ± 0.341
2.325ValAsn: 2.325 ± 0.349
4.352ValPro: 4.352 ± 0.55
2.504ValGln: 2.504 ± 0.388
5.544ValArg: 5.544 ± 0.773
4.829ValSer: 4.829 ± 0.682
4.531ValThr: 4.531 ± 0.704
6.557ValVal: 6.557 ± 0.765
2.086ValTrp: 2.086 ± 0.374
1.729ValTyr: 1.729 ± 0.346
0.0ValXaa: 0.0 ± 0.0
Trp
1.848TrpAla: 1.848 ± 0.407
0.298TrpCys: 0.298 ± 0.143
1.848TrpAsp: 1.848 ± 0.257
1.431TrpGlu: 1.431 ± 0.335
0.537TrpPhe: 0.537 ± 0.165
1.431TrpGly: 1.431 ± 0.262
0.477TrpHis: 0.477 ± 0.199
0.954TrpIle: 0.954 ± 0.2
0.715TrpLys: 0.715 ± 0.219
2.444TrpLeu: 2.444 ± 0.362
0.715TrpMet: 0.715 ± 0.181
1.133TrpAsn: 1.133 ± 0.279
1.192TrpPro: 1.192 ± 0.267
1.311TrpGln: 1.311 ± 0.243
1.788TrpArg: 1.788 ± 0.351
1.073TrpSer: 1.073 ± 0.255
1.55TrpThr: 1.55 ± 0.253
1.192TrpVal: 1.192 ± 0.289
0.417TrpTrp: 0.417 ± 0.166
0.537TrpTyr: 0.537 ± 0.154
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.265TyrAla: 2.265 ± 0.482
0.358TyrCys: 0.358 ± 0.142
2.265TyrAsp: 2.265 ± 0.339
1.55TyrGlu: 1.55 ± 0.292
0.775TyrPhe: 0.775 ± 0.201
1.729TyrGly: 1.729 ± 0.289
0.656TyrHis: 0.656 ± 0.193
0.537TyrIle: 0.537 ± 0.2
1.192TyrLys: 1.192 ± 0.281
1.133TyrLeu: 1.133 ± 0.326
0.596TyrMet: 0.596 ± 0.161
0.715TyrAsn: 0.715 ± 0.191
1.371TyrPro: 1.371 ± 0.317
0.715TyrGln: 0.715 ± 0.215
1.788TyrArg: 1.788 ± 0.343
1.669TyrSer: 1.669 ± 0.315
2.444TyrThr: 2.444 ± 0.44
1.55TyrVal: 1.55 ± 0.302
0.358TyrTrp: 0.358 ± 0.144
0.894TyrTyr: 0.894 ± 0.22
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 98 proteins (16776 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski