Amino acid dipepetide frequency for Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.872AlaAla: 9.872 ± 0.134	1.02AlaCys: 1.02 ± 0.035	5.459AlaAsp: 5.459 ± 0.068	5.679AlaGlu: 5.679 ± 0.09	3.19AlaPhe: 3.19 ± 0.051	7.327AlaGly: 7.327 ± 0.093	1.957AlaHis: 1.957 ± 0.038	5.798AlaIle: 5.798 ± 0.073	3.731AlaLys: 3.731 ± 0.079	10.622AlaLeu: 10.622 ± 0.145	2.417AlaMet: 2.417 ± 0.042	3.868AlaAsn: 3.868 ± 0.076	3.88AlaPro: 3.88 ± 0.062	4.846AlaGln: 4.846 ± 0.076	5.525AlaArg: 5.525 ± 0.073	6.224AlaSer: 6.224 ± 0.086	4.888AlaThr: 4.888 ± 0.077	6.238AlaVal: 6.238 ± 0.08	1.297AlaTrp: 1.297 ± 0.037	2.894AlaTyr: 2.894 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.944CysAla: 0.944 ± 0.03	0.17CysCys: 0.17 ± 0.012	0.555CysAsp: 0.555 ± 0.033	0.507CysGlu: 0.507 ± 0.021	0.369CysPhe: 0.369 ± 0.015	0.83CysGly: 0.83 ± 0.026	0.306CysHis: 0.306 ± 0.017	0.512CysIle: 0.512 ± 0.02	0.323CysLys: 0.323 ± 0.017	0.99CysLeu: 0.99 ± 0.027	0.182CysMet: 0.182 ± 0.013	0.344CysAsn: 0.344 ± 0.019	0.478CysPro: 0.478 ± 0.029	0.386CysGln: 0.386 ± 0.017	0.541CysArg: 0.541 ± 0.021	0.625CysSer: 0.625 ± 0.024	0.48CysThr: 0.48 ± 0.019	0.625CysVal: 0.625 ± 0.023	0.163CysTrp: 0.163 ± 0.011	0.331CysTyr: 0.331 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.145AspAla: 5.145 ± 0.066	0.47AspCys: 0.47 ± 0.02	2.84AspAsp: 2.84 ± 0.055	3.294AspGlu: 3.294 ± 0.061	2.382AspPhe: 2.382 ± 0.045	4.267AspGly: 4.267 ± 0.102	1.142AspHis: 1.142 ± 0.031	3.69AspIle: 3.69 ± 0.061	2.575AspLys: 2.575 ± 0.049	5.296AspLeu: 5.296 ± 0.064	1.292AspMet: 1.292 ± 0.034	2.464AspAsn: 2.464 ± 0.065	2.515AspPro: 2.515 ± 0.053	2.232AspGln: 2.232 ± 0.046	2.564AspArg: 2.564 ± 0.046	3.234AspSer: 3.234 ± 0.058	2.969AspThr: 2.969 ± 0.065	3.621AspVal: 3.621 ± 0.062	1.039AspTrp: 1.039 ± 0.032	2.251AspTyr: 2.251 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.223GluAla: 5.223 ± 0.072	0.417GluCys: 0.417 ± 0.018	2.611GluAsp: 2.611 ± 0.052	3.019GluGlu: 3.019 ± 0.07	2.192GluPhe: 2.192 ± 0.044	3.402GluGly: 3.402 ± 0.059	1.349GluHis: 1.349 ± 0.036	3.084GluIle: 3.084 ± 0.05	2.778GluLys: 2.778 ± 0.058	6.182GluLeu: 6.182 ± 0.086	1.17GluMet: 1.17 ± 0.032	2.065GluAsn: 2.065 ± 0.04	2.323GluPro: 2.323 ± 0.046	3.508GluGln: 3.508 ± 0.075	3.702GluArg: 3.702 ± 0.072	3.144GluSer: 3.144 ± 0.056	2.875GluThr: 2.875 ± 0.046	3.496GluVal: 3.496 ± 0.054	0.802GluTrp: 0.802 ± 0.026	1.671GluTyr: 1.671 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.447PheAla: 3.447 ± 0.06	0.453PheCys: 0.453 ± 0.021	2.512PheAsp: 2.512 ± 0.047	2.0PheGlu: 2.0 ± 0.042	1.75PhePhe: 1.75 ± 0.04	2.86PheGly: 2.86 ± 0.054	0.814PheHis: 0.814 ± 0.025	2.29PheIle: 2.29 ± 0.042	1.383PheLys: 1.383 ± 0.035	3.326PheLeu: 3.326 ± 0.056	0.932PheMet: 0.932 ± 0.032	1.889PheAsn: 1.889 ± 0.043	1.498PhePro: 1.498 ± 0.036	1.204PheGln: 1.204 ± 0.035	1.772PheArg: 1.772 ± 0.037	2.964PheSer: 2.964 ± 0.053	2.262PheThr: 2.262 ± 0.044	2.551PheVal: 2.551 ± 0.048	0.62PheTrp: 0.62 ± 0.023	1.409PheTyr: 1.409 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	6.141GlyAla: 6.141 ± 0.088	0.867GlyCys: 0.867 ± 0.027	4.2GlyAsp: 4.2 ± 0.082	4.216GlyGlu: 4.216 ± 0.062	3.324GlyPhe: 3.324 ± 0.054	5.435GlyGly: 5.435 ± 0.095	1.612GlyHis: 1.612 ± 0.036	4.652GlyIle: 4.652 ± 0.074	3.613GlyLys: 3.613 ± 0.06	7.421GlyLeu: 7.421 ± 0.086	1.785GlyMet: 1.785 ± 0.037	3.202GlyAsn: 3.202 ± 0.078	1.91GlyPro: 1.91 ± 0.043	3.111GlyGln: 3.111 ± 0.055	3.808GlyArg: 3.808 ± 0.058	4.856GlySer: 4.856 ± 0.087	3.892GlyThr: 3.892 ± 0.086	5.387GlyVal: 5.387 ± 0.078	1.258GlyTrp: 1.258 ± 0.034	2.723GlyTyr: 2.723 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.732HisAla: 1.732 ± 0.036	0.299HisCys: 0.299 ± 0.014	0.99HisAsp: 0.99 ± 0.03	1.13HisGlu: 1.13 ± 0.031	1.052HisPhe: 1.052 ± 0.03	1.49HisGly: 1.49 ± 0.037	0.753HisHis: 0.753 ± 0.029	1.394HisIle: 1.394 ± 0.037	0.937HisLys: 0.937 ± 0.025	2.522HisLeu: 2.522 ± 0.051	0.558HisMet: 0.558 ± 0.021	0.975HisAsn: 0.975 ± 0.024	1.347HisPro: 1.347 ± 0.033	1.247HisGln: 1.247 ± 0.033	1.289HisArg: 1.289 ± 0.036	1.386HisSer: 1.386 ± 0.03	1.163HisThr: 1.163 ± 0.03	1.26HisVal: 1.26 ± 0.028	0.543HisTrp: 0.543 ± 0.021	1.017HisTyr: 1.017 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.297IleAla: 6.297 ± 0.072	0.527IleCys: 0.527 ± 0.018	3.71IleAsp: 3.71 ± 0.061	3.457IleGlu: 3.457 ± 0.051	1.905IlePhe: 1.905 ± 0.045	4.209IleGly: 4.209 ± 0.072	1.43IleHis: 1.43 ± 0.034	2.824IleIle: 2.824 ± 0.059	2.512IleLys: 2.512 ± 0.049	4.67IleLeu: 4.67 ± 0.073	0.952IleMet: 0.952 ± 0.034	2.786IleAsn: 2.786 ± 0.05	2.812IlePro: 2.812 ± 0.05	2.236IleGln: 2.236 ± 0.041	3.119IleArg: 3.119 ± 0.05	3.881IleSer: 3.881 ± 0.062	3.506IleThr: 3.506 ± 0.068	3.417IleVal: 3.417 ± 0.062	0.643IleTrp: 0.643 ± 0.025	1.757IleTyr: 1.757 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.073LysAla: 4.073 ± 0.074	0.221LysCys: 0.221 ± 0.013	2.0LysAsp: 2.0 ± 0.041	1.967LysGlu: 1.967 ± 0.046	1.155LysPhe: 1.155 ± 0.031	2.658LysGly: 2.658 ± 0.049	0.963LysHis: 0.963 ± 0.027	2.275LysIle: 2.275 ± 0.05	1.991LysLys: 1.991 ± 0.059	3.964LysLeu: 3.964 ± 0.062	0.846LysMet: 0.846 ± 0.028	1.717LysAsn: 1.717 ± 0.044	2.43LysPro: 2.43 ± 0.046	1.88LysGln: 1.88 ± 0.042	2.401LysArg: 2.401 ± 0.048	2.391LysSer: 2.391 ± 0.044	2.66LysThr: 2.66 ± 0.052	2.725LysVal: 2.725 ± 0.047	0.384LysTrp: 0.384 ± 0.019	1.123LysTyr: 1.123 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.404LeuAla: 11.404 ± 0.111	1.112LeuCys: 1.112 ± 0.03	6.039LeuAsp: 6.039 ± 0.073	5.617LeuGlu: 5.617 ± 0.077	3.806LeuPhe: 3.806 ± 0.068	7.748LeuGly: 7.748 ± 0.09	2.398LeuHis: 2.398 ± 0.046	5.391LeuIle: 5.391 ± 0.077	4.226LeuLys: 4.226 ± 0.068	11.923LeuLeu: 11.923 ± 0.164	2.328LeuMet: 2.328 ± 0.044	4.08LeuAsn: 4.08 ± 0.062	5.415LeuPro: 5.415 ± 0.081	4.803LeuGln: 4.803 ± 0.065	6.075LeuArg: 6.075 ± 0.081	7.018LeuSer: 7.018 ± 0.087	5.34LeuThr: 5.34 ± 0.076	7.892LeuVal: 7.892 ± 0.106	1.446LeuTrp: 1.446 ± 0.034	2.73LeuTyr: 2.73 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.393MetAla: 2.393 ± 0.046	0.151MetCys: 0.151 ± 0.011	1.186MetAsp: 1.186 ± 0.031	1.113MetGlu: 1.113 ± 0.03	0.662MetPhe: 0.662 ± 0.026	1.625MetGly: 1.625 ± 0.035	0.466MetHis: 0.466 ± 0.018	1.102MetIle: 1.102 ± 0.033	0.956MetLys: 0.956 ± 0.029	2.294MetLeu: 2.294 ± 0.056	0.513MetMet: 0.513 ± 0.021	0.879MetAsn: 0.879 ± 0.024	1.202MetPro: 1.202 ± 0.031	0.963MetGln: 0.963 ± 0.031	1.273MetArg: 1.273 ± 0.029	1.557MetSer: 1.557 ± 0.037	1.258MetThr: 1.258 ± 0.034	1.494MetVal: 1.494 ± 0.036	0.181MetTrp: 0.181 ± 0.012	0.434MetTyr: 0.434 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.689AsnAla: 3.689 ± 0.059	0.411AsnCys: 0.411 ± 0.028	1.997AsnAsp: 1.997 ± 0.046	1.731AsnGlu: 1.731 ± 0.036	1.385AsnPhe: 1.385 ± 0.035	3.167AsnGly: 3.167 ± 0.098	1.031AsnHis: 1.031 ± 0.026	2.417AsnIle: 2.417 ± 0.044	1.586AsnLys: 1.586 ± 0.042	4.321AsnLeu: 4.321 ± 0.076	0.794AsnMet: 0.794 ± 0.024	2.064AsnAsn: 2.064 ± 0.062	2.614AsnPro: 2.614 ± 0.043	1.965AsnGln: 1.965 ± 0.04	2.313AsnArg: 2.313 ± 0.046	2.545AsnSer: 2.545 ± 0.058	2.653AsnThr: 2.653 ± 0.056	2.14AsnVal: 2.14 ± 0.047	0.682AsnTrp: 0.682 ± 0.025	1.454AsnTyr: 1.454 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.903ProAla: 4.903 ± 0.086	0.386ProCys: 0.386 ± 0.017	2.879ProAsp: 2.879 ± 0.045	3.359ProGlu: 3.359 ± 0.061	1.665ProPhe: 1.665 ± 0.038	3.67ProGly: 3.67 ± 0.06	1.015ProHis: 1.015 ± 0.029	2.288ProIle: 2.288 ± 0.045	1.464ProLys: 1.464 ± 0.033	5.077ProLeu: 5.077 ± 0.069	0.993ProMet: 0.993 ± 0.028	1.672ProAsn: 1.672 ± 0.04	1.76ProPro: 1.76 ± 0.044	2.031ProGln: 2.031 ± 0.051	2.049ProArg: 2.049 ± 0.046	2.655ProSer: 2.655 ± 0.048	2.166ProThr: 2.166 ± 0.043	3.787ProVal: 3.787 ± 0.056	0.694ProTrp: 0.694 ± 0.025	1.312ProTyr: 1.312 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.056GlnAla: 5.056 ± 0.083	0.376GlnCys: 0.376 ± 0.016	2.104GlnAsp: 2.104 ± 0.039	2.329GlnGlu: 2.329 ± 0.051	1.614GlnPhe: 1.614 ± 0.036	3.434GlnGly: 3.434 ± 0.057	1.21GlnHis: 1.21 ± 0.037	2.336GlnIle: 2.336 ± 0.043	1.688GlnLys: 1.688 ± 0.044	6.051GlnLeu: 6.051 ± 0.092	0.981GlnMet: 0.981 ± 0.027	1.268GlnAsn: 1.268 ± 0.031	2.196GlnPro: 2.196 ± 0.045	3.473GlnGln: 3.473 ± 0.067	3.0GlnArg: 3.0 ± 0.056	2.488GlnSer: 2.488 ± 0.043	2.275GlnThr: 2.275 ± 0.04	3.595GlnVal: 3.595 ± 0.061	0.813GlnTrp: 0.813 ± 0.023	1.259GlnTyr: 1.259 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	4.805ArgAla: 4.805 ± 0.064	0.519ArgCys: 0.519 ± 0.02	3.259ArgAsp: 3.259 ± 0.056	3.588ArgGlu: 3.588 ± 0.061	2.433ArgPhe: 2.433 ± 0.04	3.335ArgGly: 3.335 ± 0.058	1.424ArgHis: 1.424 ± 0.039	3.501ArgIle: 3.501 ± 0.055	2.099ArgLys: 2.099 ± 0.043	6.409ArgLeu: 6.409 ± 0.077	1.298ArgMet: 1.298 ± 0.028	2.145ArgAsn: 2.145 ± 0.035	2.145ArgPro: 2.145 ± 0.051	3.039ArgGln: 3.039 ± 0.052	3.106ArgArg: 3.106 ± 0.06	2.945ArgSer: 2.945 ± 0.049	2.561ArgThr: 2.561 ± 0.044	3.908ArgVal: 3.908 ± 0.064	0.984ArgTrp: 0.984 ± 0.027	2.155ArgTyr: 2.155 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.15SerAla: 6.15 ± 0.09	0.578SerCys: 0.578 ± 0.023	3.336SerAsp: 3.336 ± 0.071	3.151SerGlu: 3.151 ± 0.061	2.486SerPhe: 2.486 ± 0.049	5.361SerGly: 5.361 ± 0.098	1.425SerHis: 1.425 ± 0.032	3.588SerIle: 3.588 ± 0.062	1.979SerLys: 1.979 ± 0.044	7.523SerLeu: 7.523 ± 0.083	1.247SerMet: 1.247 ± 0.033	2.446SerAsn: 2.446 ± 0.05	3.068SerPro: 3.068 ± 0.05	2.636SerGln: 2.636 ± 0.048	3.275SerArg: 3.275 ± 0.054	6.265SerSer: 6.265 ± 0.277	3.397SerThr: 3.397 ± 0.066	4.486SerVal: 4.486 ± 0.088	0.921SerTrp: 0.921 ± 0.026	2.065SerTyr: 2.065 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.141ThrAla: 5.141 ± 0.081	0.486ThrCys: 0.486 ± 0.022	2.874ThrAsp: 2.874 ± 0.061	2.662ThrGlu: 2.662 ± 0.05	1.818ThrPhe: 1.818 ± 0.039	4.819ThrGly: 4.819 ± 0.069	1.328ThrHis: 1.328 ± 0.033	2.78ThrIle: 2.78 ± 0.062	1.57ThrLys: 1.57 ± 0.038	6.188ThrLeu: 6.188 ± 0.074	0.883ThrMet: 0.883 ± 0.03	2.071ThrAsn: 2.071 ± 0.052	3.166ThrPro: 3.166 ± 0.065	2.534ThrGln: 2.534 ± 0.042	3.031ThrArg: 3.031 ± 0.048	3.519ThrSer: 3.519 ± 0.077	3.103ThrThr: 3.103 ± 0.091	3.273ThrVal: 3.273 ± 0.086	0.788ThrTrp: 0.788 ± 0.024	1.8ThrTyr: 1.8 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	6.505ValAla: 6.505 ± 0.078	0.663ValCys: 0.663 ± 0.022	4.233ValAsp: 4.233 ± 0.061	3.907ValGlu: 3.907 ± 0.069	2.725ValPhe: 2.725 ± 0.055	4.422ValGly: 4.422 ± 0.06	1.254ValHis: 1.254 ± 0.031	4.385ValIle: 4.385 ± 0.067	2.785ValLys: 2.785 ± 0.047	6.681ValLeu: 6.681 ± 0.094	1.598ValMet: 1.598 ± 0.038	3.098ValAsn: 3.098 ± 0.06	2.961ValPro: 2.961 ± 0.059	2.617ValGln: 2.617 ± 0.041	3.6ValArg: 3.6 ± 0.066	4.693ValSer: 4.693 ± 0.086	3.916ValThr: 3.916 ± 0.08	5.118ValVal: 5.118 ± 0.079	0.788ValTrp: 0.788 ± 0.024	1.974ValTyr: 1.974 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.118TrpAla: 1.118 ± 0.028	0.17TrpCys: 0.17 ± 0.011	0.713TrpAsp: 0.713 ± 0.024	0.66TrpGlu: 0.66 ± 0.024	0.605TrpPhe: 0.605 ± 0.024	0.98TrpGly: 0.98 ± 0.029	0.437TrpHis: 0.437 ± 0.019	0.822TrpIle: 0.822 ± 0.025	0.483TrpLys: 0.483 ± 0.019	1.92TrpLeu: 1.92 ± 0.046	0.368TrpMet: 0.368 ± 0.016	0.666TrpAsn: 0.666 ± 0.025	0.635TrpPro: 0.635 ± 0.025	1.068TrpGln: 1.068 ± 0.031	0.958TrpArg: 0.958 ± 0.031	0.902TrpSer: 0.902 ± 0.029	0.657TrpThr: 0.657 ± 0.029	1.022TrpVal: 1.022 ± 0.029	0.282TrpTrp: 0.282 ± 0.017	0.447TrpTyr: 0.447 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.694TyrAla: 2.694 ± 0.049	0.366TyrCys: 0.366 ± 0.019	1.785TyrAsp: 1.785 ± 0.059	1.627TyrGlu: 1.627 ± 0.041	1.418TyrPhe: 1.418 ± 0.033	2.374TyrGly: 2.374 ± 0.054	0.771TyrHis: 0.771 ± 0.027	1.521TyrIle: 1.521 ± 0.039	1.141TyrLys: 1.141 ± 0.032	3.412TyrLeu: 3.412 ± 0.052	0.569TyrMet: 0.569 ± 0.022	1.26TyrAsn: 1.26 ± 0.037	1.471TyrPro: 1.471 ± 0.035	1.766TyrGln: 1.766 ± 0.035	2.259TyrArg: 2.259 ± 0.039	2.09TyrSer: 2.09 ± 0.043	1.813TyrThr: 1.813 ± 0.048	1.888TyrVal: 1.888 ± 0.039	0.584TyrTrp: 0.584 ± 0.02	1.063TyrTyr: 1.063 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3711 proteins (1367215 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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