Amino acid dipepetide frequency for Luteimonas sp. JM171

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.337AlaAla: 18.337 ± 0.264
1.196AlaCys: 1.196 ± 0.037
7.378AlaAsp: 7.378 ± 0.111
7.638AlaGlu: 7.638 ± 0.133
3.957AlaPhe: 3.957 ± 0.07
12.883AlaGly: 12.883 ± 0.147
2.55AlaHis: 2.55 ± 0.062
5.474AlaIle: 5.474 ± 0.085
2.348AlaLys: 2.348 ± 0.069
15.131AlaLeu: 15.131 ± 0.19
3.434AlaMet: 3.434 ± 0.065
2.728AlaAsn: 2.728 ± 0.062
6.477AlaPro: 6.477 ± 0.116
4.692AlaGln: 4.692 ± 0.084
10.946AlaArg: 10.946 ± 0.141
6.285AlaSer: 6.285 ± 0.089
5.786AlaThr: 5.786 ± 0.109
8.962AlaVal: 8.962 ± 0.113
2.244AlaTrp: 2.244 ± 0.064
2.275AlaTyr: 2.275 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.935CysAla: 0.935 ± 0.035
0.08CysCys: 0.08 ± 0.01
0.419CysAsp: 0.419 ± 0.023
0.409CysGlu: 0.409 ± 0.025
0.221CysPhe: 0.221 ± 0.016
0.82CysGly: 0.82 ± 0.031
0.228CysHis: 0.228 ± 0.016
0.313CysIle: 0.313 ± 0.023
0.144CysLys: 0.144 ± 0.012
0.692CysLeu: 0.692 ± 0.032
0.144CysMet: 0.144 ± 0.013
0.193CysAsn: 0.193 ± 0.019
0.424CysPro: 0.424 ± 0.025
0.23CysGln: 0.23 ± 0.016
0.571CysArg: 0.571 ± 0.025
0.42CysSer: 0.42 ± 0.024
0.352CysThr: 0.352 ± 0.02
0.561CysVal: 0.561 ± 0.027
0.102CysTrp: 0.102 ± 0.011
0.178CysTyr: 0.178 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
8.662AspAla: 8.662 ± 0.121
0.406AspCys: 0.406 ± 0.025
3.638AspAsp: 3.638 ± 0.076
3.666AspGlu: 3.666 ± 0.07
2.018AspPhe: 2.018 ± 0.052
6.463AspGly: 6.463 ± 0.117
1.182AspHis: 1.182 ± 0.04
2.358AspIle: 2.358 ± 0.056
1.125AspLys: 1.125 ± 0.041
5.608AspLeu: 5.608 ± 0.087
1.229AspMet: 1.229 ± 0.041
1.291AspAsn: 1.291 ± 0.046
4.273AspPro: 4.273 ± 0.086
1.763AspGln: 1.763 ± 0.05
4.466AspArg: 4.466 ± 0.064
2.581AspSer: 2.581 ± 0.059
2.612AspThr: 2.612 ± 0.051
4.141AspVal: 4.141 ± 0.073
1.09AspTrp: 1.09 ± 0.038
1.536AspTyr: 1.536 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
8.29GluAla: 8.29 ± 0.121
0.37GluCys: 0.37 ± 0.02
3.206GluAsp: 3.206 ± 0.073
3.409GluGlu: 3.409 ± 0.074
2.024GluPhe: 2.024 ± 0.043
5.028GluGly: 5.028 ± 0.079
1.433GluHis: 1.433 ± 0.038
2.686GluIle: 2.686 ± 0.061
1.43GluLys: 1.43 ± 0.05
6.6GluLeu: 6.6 ± 0.096
1.299GluMet: 1.299 ± 0.044
1.205GluAsn: 1.205 ± 0.037
3.181GluPro: 3.181 ± 0.073
2.67GluGln: 2.67 ± 0.073
6.191GluArg: 6.191 ± 0.114
2.81GluSer: 2.81 ± 0.058
2.629GluThr: 2.629 ± 0.058
4.669GluVal: 4.669 ± 0.061
0.792GluTrp: 0.792 ± 0.035
1.294GluTyr: 1.294 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
4.015PheAla: 4.015 ± 0.074
0.278PheCys: 0.278 ± 0.016
2.65PheAsp: 2.65 ± 0.054
2.208PheGlu: 2.208 ± 0.054
1.195PhePhe: 1.195 ± 0.044
3.364PheGly: 3.364 ± 0.068
0.742PheHis: 0.742 ± 0.031
1.294PheIle: 1.294 ± 0.042
0.69PheLys: 0.69 ± 0.034
2.892PheLeu: 2.892 ± 0.066
0.683PheMet: 0.683 ± 0.03
1.056PheAsn: 1.056 ± 0.034
1.468PhePro: 1.468 ± 0.043
1.026PheGln: 1.026 ± 0.037
2.268PheArg: 2.268 ± 0.052
1.934PheSer: 1.934 ± 0.048
1.615PheThr: 1.615 ± 0.043
2.402PheVal: 2.402 ± 0.045
0.504PheTrp: 0.504 ± 0.026
0.723PheTyr: 0.723 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
9.812GlyAla: 9.812 ± 0.138
0.757GlyCys: 0.757 ± 0.033
5.405GlyAsp: 5.405 ± 0.087
5.966GlyGlu: 5.966 ± 0.091
3.458GlyPhe: 3.458 ± 0.069
8.075GlyGly: 8.075 ± 0.123
2.249GlyHis: 2.249 ± 0.05
4.087GlyIle: 4.087 ± 0.078
2.439GlyLys: 2.439 ± 0.067
9.36GlyLeu: 9.36 ± 0.122
2.533GlyMet: 2.533 ± 0.056
2.412GlyAsn: 2.412 ± 0.062
3.808GlyPro: 3.808 ± 0.067
3.291GlyGln: 3.291 ± 0.066
7.298GlyArg: 7.298 ± 0.084
5.019GlySer: 5.019 ± 0.106
4.55GlyThr: 4.55 ± 0.091
6.769GlyVal: 6.769 ± 0.1
1.721GlyTrp: 1.721 ± 0.048
2.309GlyTyr: 2.309 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
3.086HisAla: 3.086 ± 0.069
0.239HisCys: 0.239 ± 0.016
1.31HisAsp: 1.31 ± 0.043
1.193HisGlu: 1.193 ± 0.043
0.765HisPhe: 0.765 ± 0.032
2.325HisGly: 2.325 ± 0.054
0.57HisHis: 0.57 ± 0.029
0.767HisIle: 0.767 ± 0.025
0.398HisLys: 0.398 ± 0.021
2.126HisLeu: 2.126 ± 0.05
0.423HisMet: 0.423 ± 0.022
0.445HisAsn: 0.445 ± 0.024
1.492HisPro: 1.492 ± 0.042
0.646HisGln: 0.646 ± 0.023
1.679HisArg: 1.679 ± 0.044
0.943HisSer: 0.943 ± 0.036
0.961HisThr: 0.961 ± 0.039
1.605HisVal: 1.605 ± 0.044
0.372HisTrp: 0.372 ± 0.021
0.579HisTyr: 0.579 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.826IleAla: 5.826 ± 0.081
0.272IleCys: 0.272 ± 0.017
3.266IleAsp: 3.266 ± 0.068
3.067IleGlu: 3.067 ± 0.067
1.045IlePhe: 1.045 ± 0.036
4.286IleGly: 4.286 ± 0.081
0.854IleHis: 0.854 ± 0.032
1.41IleIle: 1.41 ± 0.056
0.912IleLys: 0.912 ± 0.037
3.18IleLeu: 3.18 ± 0.056
0.607IleMet: 0.607 ± 0.025
1.24IleAsn: 1.24 ± 0.041
2.078IlePro: 2.078 ± 0.053
1.244IleGln: 1.244 ± 0.04
2.926IleArg: 2.926 ± 0.057
2.149IleSer: 2.149 ± 0.051
2.114IleThr: 2.114 ± 0.054
3.015IleVal: 3.015 ± 0.076
0.444IleTrp: 0.444 ± 0.021
0.743IleTyr: 0.743 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
2.66LysAla: 2.66 ± 0.066
0.104LysCys: 0.104 ± 0.012
1.107LysAsp: 1.107 ± 0.041
1.043LysGlu: 1.043 ± 0.047
0.603LysPhe: 0.603 ± 0.027
1.694LysGly: 1.694 ± 0.048
0.437LysHis: 0.437 ± 0.023
0.87LysIle: 0.87 ± 0.036
0.753LysLys: 0.753 ± 0.036
2.336LysLeu: 2.336 ± 0.057
0.505LysMet: 0.505 ± 0.03
0.437LysAsn: 0.437 ± 0.023
1.396LysPro: 1.396 ± 0.047
0.847LysGln: 0.847 ± 0.037
1.794LysArg: 1.794 ± 0.055
1.086LysSer: 1.086 ± 0.041
1.071LysThr: 1.071 ± 0.039
1.806LysVal: 1.806 ± 0.057
0.261LysTrp: 0.261 ± 0.019
0.478LysTyr: 0.478 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
15.438LeuAla: 15.438 ± 0.192
0.809LeuCys: 0.809 ± 0.031
6.726LeuAsp: 6.726 ± 0.089
6.886LeuGlu: 6.886 ± 0.125
3.336LeuPhe: 3.336 ± 0.065
8.99LeuGly: 8.99 ± 0.11
2.276LeuHis: 2.276 ± 0.05
3.32LeuIle: 3.32 ± 0.059
2.26LeuLys: 2.26 ± 0.066
11.47LeuLeu: 11.47 ± 0.164
2.25LeuMet: 2.25 ± 0.05
2.038LeuAsn: 2.038 ± 0.051
6.133LeuPro: 6.133 ± 0.086
3.774LeuGln: 3.774 ± 0.061
8.949LeuArg: 8.949 ± 0.123
5.151LeuSer: 5.151 ± 0.077
4.256LeuThr: 4.256 ± 0.071
8.587LeuVal: 8.587 ± 0.099
1.311LeuTrp: 1.311 ± 0.046
2.047LeuTyr: 2.047 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.938MetAla: 2.938 ± 0.064
0.155MetCys: 0.155 ± 0.012
1.305MetAsp: 1.305 ± 0.039
1.24MetGlu: 1.24 ± 0.035
0.687MetPhe: 0.687 ± 0.03
1.746MetGly: 1.746 ± 0.04
0.474MetHis: 0.474 ± 0.024
0.93MetIle: 0.93 ± 0.035
0.73MetLys: 0.73 ± 0.031
2.556MetLeu: 2.556 ± 0.061
0.512MetMet: 0.512 ± 0.025
0.588MetAsn: 0.588 ± 0.027
1.41MetPro: 1.41 ± 0.039
0.898MetGln: 0.898 ± 0.034
1.895MetArg: 1.895 ± 0.054
1.493MetSer: 1.493 ± 0.038
1.327MetThr: 1.327 ± 0.041
1.664MetVal: 1.664 ± 0.046
0.223MetTrp: 0.223 ± 0.016
0.375MetTyr: 0.375 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.989AsnAla: 2.989 ± 0.072
0.188AsnCys: 0.188 ± 0.015
1.214AsnAsp: 1.214 ± 0.044
1.12AsnGlu: 1.12 ± 0.041
0.85AsnPhe: 0.85 ± 0.033
2.052AsnGly: 2.052 ± 0.055
0.481AsnHis: 0.481 ± 0.022
1.03AsnIle: 1.03 ± 0.045
0.449AsnLys: 0.449 ± 0.023
2.355AsnLeu: 2.355 ± 0.058
0.496AsnMet: 0.496 ± 0.024
0.57AsnAsn: 0.57 ± 0.03
1.726AsnPro: 1.726 ± 0.039
0.733AsnGln: 0.733 ± 0.031
1.806AsnArg: 1.806 ± 0.045
0.979AsnSer: 0.979 ± 0.04
1.132AsnThr: 1.132 ± 0.044
1.75AsnVal: 1.75 ± 0.049
0.367AsnTrp: 0.367 ± 0.024
0.534AsnTyr: 0.534 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
7.751ProAla: 7.751 ± 0.132
0.287ProCys: 0.287 ± 0.02
4.065ProAsp: 4.065 ± 0.078
4.059ProGlu: 4.059 ± 0.077
1.583ProPhe: 1.583 ± 0.049
5.888ProGly: 5.888 ± 0.087
1.089ProHis: 1.089 ± 0.034
1.729ProIle: 1.729 ± 0.051
1.014ProLys: 1.014 ± 0.037
5.279ProLeu: 5.279 ± 0.074
1.335ProMet: 1.335 ± 0.041
1.03ProAsn: 1.03 ± 0.036
3.241ProPro: 3.241 ± 0.09
1.949ProGln: 1.949 ± 0.046
3.868ProArg: 3.868 ± 0.077
2.461ProSer: 2.461 ± 0.063
2.117ProThr: 2.117 ± 0.05
4.593ProVal: 4.593 ± 0.077
0.877ProTrp: 0.877 ± 0.032
1.057ProTyr: 1.057 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
5.57GlnAla: 5.57 ± 0.091
0.21GlnCys: 0.21 ± 0.014
1.662GlnAsp: 1.662 ± 0.048
1.779GlnGlu: 1.779 ± 0.055
1.048GlnPhe: 1.048 ± 0.034
2.705GlnGly: 2.705 ± 0.066
0.738GlnHis: 0.738 ± 0.029
1.353GlnIle: 1.353 ± 0.044
0.711GlnLys: 0.711 ± 0.03
3.822GlnLeu: 3.822 ± 0.072
0.868GlnMet: 0.868 ± 0.029
0.575GlnAsn: 0.575 ± 0.028
2.13GlnPro: 2.13 ± 0.051
1.669GlnGln: 1.669 ± 0.05
3.189GlnArg: 3.189 ± 0.065
1.564GlnSer: 1.564 ± 0.044
1.316GlnThr: 1.316 ± 0.045
3.257GlnVal: 3.257 ± 0.065
0.575GlnTrp: 0.575 ± 0.023
0.701GlnTyr: 0.701 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
9.168ArgAla: 9.168 ± 0.131
0.542ArgCys: 0.542 ± 0.026
4.806ArgAsp: 4.806 ± 0.072
5.816ArgGlu: 5.816 ± 0.093
3.105ArgPhe: 3.105 ± 0.06
6.04ArgGly: 6.04 ± 0.088
1.994ArgHis: 1.994 ± 0.047
4.145ArgIle: 4.145 ± 0.067
1.883ArgLys: 1.883 ± 0.052
9.213ArgLeu: 9.213 ± 0.123
2.219ArgMet: 2.219 ± 0.049
1.996ArgAsn: 1.996 ± 0.052
4.092ArgPro: 4.092 ± 0.075
3.196ArgGln: 3.196 ± 0.069
7.167ArgArg: 7.167 ± 0.132
3.843ArgSer: 3.843 ± 0.074
3.486ArgThr: 3.486 ± 0.072
5.697ArgVal: 5.697 ± 0.09
1.475ArgTrp: 1.475 ± 0.042
2.164ArgTyr: 2.164 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
6.038SerAla: 6.038 ± 0.102
0.35SerCys: 0.35 ± 0.021
2.721SerAsp: 2.721 ± 0.054
2.604SerGlu: 2.604 ± 0.064
1.691SerPhe: 1.691 ± 0.043
5.311SerGly: 5.311 ± 0.096
1.095SerHis: 1.095 ± 0.035
2.098SerIle: 2.098 ± 0.05
0.984SerLys: 0.984 ± 0.035
5.036SerLeu: 5.036 ± 0.077
1.105SerMet: 1.105 ± 0.033
1.272SerAsn: 1.272 ± 0.041
2.781SerPro: 2.781 ± 0.061
1.677SerGln: 1.677 ± 0.047
4.007SerArg: 4.007 ± 0.078
2.531SerSer: 2.531 ± 0.073
2.472SerThr: 2.472 ± 0.059
3.606SerVal: 3.606 ± 0.074
0.76SerTrp: 0.76 ± 0.044
1.174SerTyr: 1.174 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.513ThrAla: 5.513 ± 0.104
0.313ThrCys: 0.313 ± 0.019
2.386ThrAsp: 2.386 ± 0.056
2.01ThrGlu: 2.01 ± 0.053
1.503ThrPhe: 1.503 ± 0.042
4.894ThrGly: 4.894 ± 0.095
0.992ThrHis: 0.992 ± 0.034
2.047ThrIle: 2.047 ± 0.058
0.699ThrLys: 0.699 ± 0.03
5.442ThrLeu: 5.442 ± 0.08
0.961ThrMet: 0.961 ± 0.033
0.931ThrAsn: 0.931 ± 0.04
3.033ThrPro: 3.033 ± 0.058
1.237ThrGln: 1.237 ± 0.036
3.647ThrArg: 3.647 ± 0.076
2.2ThrSer: 2.2 ± 0.066
2.209ThrThr: 2.209 ± 0.06
3.93ThrVal: 3.93 ± 0.078
0.716ThrTrp: 0.716 ± 0.029
0.87ThrTyr: 0.87 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
9.702ValAla: 9.702 ± 0.118
0.574ValCys: 0.574 ± 0.025
4.836ValAsp: 4.836 ± 0.089
5.148ValGlu: 5.148 ± 0.08
2.498ValPhe: 2.498 ± 0.059
5.837ValGly: 5.837 ± 0.096
1.721ValHis: 1.721 ± 0.042
3.323ValIle: 3.323 ± 0.073
1.516ValLys: 1.516 ± 0.048
8.441ValLeu: 8.441 ± 0.126
1.639ValMet: 1.639 ± 0.042
1.8ValAsn: 1.8 ± 0.056
4.21ValPro: 4.21 ± 0.074
2.447ValGln: 2.447 ± 0.053
5.908ValArg: 5.908 ± 0.099
3.898ValSer: 3.898 ± 0.067
3.691ValThr: 3.691 ± 0.078
6.412ValVal: 6.412 ± 0.1
0.877ValTrp: 0.877 ± 0.036
1.473ValTyr: 1.473 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.386TrpAla: 1.386 ± 0.042
0.137TrpCys: 0.137 ± 0.012
0.734TrpAsp: 0.734 ± 0.029
0.743TrpGlu: 0.743 ± 0.03
0.628TrpPhe: 0.628 ± 0.028
0.924TrpGly: 0.924 ± 0.033
0.357TrpHis: 0.357 ± 0.021
0.716TrpIle: 0.716 ± 0.027
0.417TrpLys: 0.417 ± 0.021
2.259TrpLeu: 2.259 ± 0.065
0.476TrpMet: 0.476 ± 0.025
0.445TrpAsn: 0.445 ± 0.022
0.821TrpPro: 0.821 ± 0.034
0.702TrpGln: 0.702 ± 0.028
1.415TrpArg: 1.415 ± 0.052
0.826TrpSer: 0.826 ± 0.039
0.774TrpThr: 0.774 ± 0.034
0.962TrpVal: 0.962 ± 0.036
0.316TrpTrp: 0.316 ± 0.021
0.363TrpTyr: 0.363 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.607TyrAla: 2.607 ± 0.064
0.169TyrCys: 0.169 ± 0.014
1.272TyrAsp: 1.272 ± 0.042
1.214TyrGlu: 1.214 ± 0.04
0.793TyrPhe: 0.793 ± 0.032
1.992TyrGly: 1.992 ± 0.051
0.46TyrHis: 0.46 ± 0.023
0.728TyrIle: 0.728 ± 0.026
0.387TyrLys: 0.387 ± 0.025
2.209TyrLeu: 2.209 ± 0.054
0.427TyrMet: 0.427 ± 0.022
0.566TyrAsn: 0.566 ± 0.028
1.094TyrPro: 1.094 ± 0.037
0.752TyrGln: 0.752 ± 0.031
2.057TyrArg: 2.057 ± 0.053
1.142TyrSer: 1.142 ± 0.038
1.063TyrThr: 1.063 ± 0.036
1.563TyrVal: 1.563 ± 0.043
0.374TyrTrp: 0.374 ± 0.023
0.512TyrTyr: 0.512 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2668 proteins (882712 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski