Amino acid dipepetide frequency for Alteromonas lipolytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.277AlaAla: 9.277 ± 0.101	0.997AlaCys: 0.997 ± 0.025	5.515AlaAsp: 5.515 ± 0.057	6.268AlaGlu: 6.268 ± 0.071	3.649AlaPhe: 3.649 ± 0.058	7.176AlaGly: 7.176 ± 0.08	1.685AlaHis: 1.685 ± 0.033	6.011AlaIle: 6.011 ± 0.064	4.471AlaLys: 4.471 ± 0.062	10.845AlaLeu: 10.845 ± 0.1	2.858AlaMet: 2.858 ± 0.047	3.642AlaAsn: 3.642 ± 0.048	3.453AlaPro: 3.453 ± 0.059	4.139AlaGln: 4.139 ± 0.054	4.473AlaArg: 4.473 ± 0.063	5.962AlaSer: 5.962 ± 0.071	5.061AlaThr: 5.061 ± 0.061	6.56AlaVal: 6.56 ± 0.069	1.03AlaTrp: 1.03 ± 0.032	2.695AlaTyr: 2.695 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.888CysAla: 0.888 ± 0.026	0.179CysCys: 0.179 ± 0.012	0.593CysAsp: 0.593 ± 0.024	0.627CysGlu: 0.627 ± 0.022	0.423CysPhe: 0.423 ± 0.016	0.801CysGly: 0.801 ± 0.026	0.316CysHis: 0.316 ± 0.017	0.552CysIle: 0.552 ± 0.021	0.398CysLys: 0.398 ± 0.018	0.962CysLeu: 0.962 ± 0.027	0.213CysMet: 0.213 ± 0.011	0.374CysAsn: 0.374 ± 0.017	0.461CysPro: 0.461 ± 0.022	0.495CysGln: 0.495 ± 0.02	0.509CysArg: 0.509 ± 0.021	0.647CysSer: 0.647 ± 0.02	0.476CysThr: 0.476 ± 0.02	0.658CysVal: 0.658 ± 0.023	0.14CysTrp: 0.14 ± 0.011	0.339CysTyr: 0.339 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.066AspAla: 5.066 ± 0.063	0.578AspCys: 0.578 ± 0.019	3.491AspAsp: 3.491 ± 0.051	4.023AspGlu: 4.023 ± 0.049	2.615AspPhe: 2.615 ± 0.051	3.931AspGly: 3.931 ± 0.075	1.001AspHis: 1.001 ± 0.026	4.165AspIle: 4.165 ± 0.056	3.093AspLys: 3.093 ± 0.046	4.834AspLeu: 4.834 ± 0.056	1.498AspMet: 1.498 ± 0.03	2.686AspAsn: 2.686 ± 0.052	2.173AspPro: 2.173 ± 0.04	1.719AspGln: 1.719 ± 0.037	2.188AspArg: 2.188 ± 0.035	3.441AspSer: 3.441 ± 0.045	3.118AspThr: 3.118 ± 0.05	3.973AspVal: 3.973 ± 0.054	0.961AspTrp: 0.961 ± 0.026	2.273AspTyr: 2.273 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.549GluAla: 5.549 ± 0.06	0.476GluCys: 0.476 ± 0.019	2.979GluAsp: 2.979 ± 0.052	3.525GluGlu: 3.525 ± 0.057	2.521GluPhe: 2.521 ± 0.044	3.504GluGly: 3.504 ± 0.052	1.555GluHis: 1.555 ± 0.033	3.618GluIle: 3.618 ± 0.052	3.089GluLys: 3.089 ± 0.052	6.538GluLeu: 6.538 ± 0.079	1.586GluMet: 1.586 ± 0.033	2.447GluAsn: 2.447 ± 0.041	2.164GluPro: 2.164 ± 0.042	4.096GluGln: 4.096 ± 0.052	3.286GluArg: 3.286 ± 0.054	3.633GluSer: 3.633 ± 0.057	3.025GluThr: 3.025 ± 0.043	4.146GluVal: 4.146 ± 0.058	0.753GluTrp: 0.753 ± 0.024	1.803GluTyr: 1.803 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.167PheAla: 4.167 ± 0.058	0.505PheCys: 0.505 ± 0.019	2.832PheAsp: 2.832 ± 0.045	2.378PheGlu: 2.378 ± 0.042	1.719PhePhe: 1.719 ± 0.037	3.129PheGly: 3.129 ± 0.05	0.775PheHis: 0.775 ± 0.024	2.728PheIle: 2.728 ± 0.045	1.856PheLys: 1.856 ± 0.037	3.229PheLeu: 3.229 ± 0.05	1.002PheMet: 1.002 ± 0.033	2.101PheAsn: 2.101 ± 0.044	1.42PhePro: 1.42 ± 0.036	1.113PheGln: 1.113 ± 0.031	1.605PheArg: 1.605 ± 0.032	3.286PheSer: 3.286 ± 0.054	2.656PheThr: 2.656 ± 0.044	2.807PheVal: 2.807 ± 0.052	0.563PheTrp: 0.563 ± 0.02	1.463PheTyr: 1.463 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.686GlyAla: 5.686 ± 0.078	0.845GlyCys: 0.845 ± 0.025	3.923GlyAsp: 3.923 ± 0.051	4.34GlyGlu: 4.34 ± 0.064	3.406GlyPhe: 3.406 ± 0.057	4.956GlyGly: 4.956 ± 0.076	1.553GlyHis: 1.553 ± 0.036	4.653GlyIle: 4.653 ± 0.061	3.802GlyLys: 3.802 ± 0.061	7.194GlyLeu: 7.194 ± 0.072	2.062GlyMet: 2.062 ± 0.043	2.757GlyAsn: 2.757 ± 0.056	1.932GlyPro: 1.932 ± 0.04	2.948GlyGln: 2.948 ± 0.039	3.05GlyArg: 3.05 ± 0.044	4.086GlySer: 4.086 ± 0.065	3.5GlyThr: 3.5 ± 0.065	5.151GlyVal: 5.151 ± 0.062	1.032GlyTrp: 1.032 ± 0.024	2.697GlyTyr: 2.697 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.657HisAla: 1.657 ± 0.037	0.305HisCys: 0.305 ± 0.014	1.074HisAsp: 1.074 ± 0.03	1.134HisGlu: 1.134 ± 0.03	1.061HisPhe: 1.061 ± 0.028	1.577HisGly: 1.577 ± 0.038	0.658HisHis: 0.658 ± 0.024	1.305HisIle: 1.305 ± 0.031	0.952HisLys: 0.952 ± 0.027	2.119HisLeu: 2.119 ± 0.038	0.502HisMet: 0.502 ± 0.018	0.881HisAsn: 0.881 ± 0.023	1.197HisPro: 1.197 ± 0.031	1.093HisGln: 1.093 ± 0.025	1.081HisArg: 1.081 ± 0.028	1.343HisSer: 1.343 ± 0.031	1.113HisThr: 1.113 ± 0.028	1.209HisVal: 1.209 ± 0.032	0.392HisTrp: 0.392 ± 0.018	0.943HisTyr: 0.943 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.403IleAla: 6.403 ± 0.059	0.658IleCys: 0.658 ± 0.022	4.085IleAsp: 4.085 ± 0.057	4.161IleGlu: 4.161 ± 0.057	2.032IlePhe: 2.032 ± 0.043	4.317IleGly: 4.317 ± 0.058	1.154IleHis: 1.154 ± 0.028	3.261IleIle: 3.261 ± 0.052	2.815IleLys: 2.815 ± 0.046	4.866IleLeu: 4.866 ± 0.06	1.237IleMet: 1.237 ± 0.031	2.995IleAsn: 2.995 ± 0.053	2.549IlePro: 2.549 ± 0.044	2.038IleGln: 2.038 ± 0.039	2.698IleArg: 2.698 ± 0.044	4.217IleSer: 4.217 ± 0.06	3.838IleThr: 3.838 ± 0.05	3.942IleVal: 3.942 ± 0.061	0.599IleTrp: 0.599 ± 0.02	1.635IleTyr: 1.635 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.818LysAla: 4.818 ± 0.072	0.289LysCys: 0.289 ± 0.018	2.289LysAsp: 2.289 ± 0.04	2.637LysGlu: 2.637 ± 0.052	1.394LysPhe: 1.394 ± 0.029	2.879LysGly: 2.879 ± 0.047	1.093LysHis: 1.093 ± 0.027	2.439LysIle: 2.439 ± 0.041	2.186LysLys: 2.186 ± 0.045	4.746LysLeu: 4.746 ± 0.059	1.168LysMet: 1.168 ± 0.032	1.702LysAsn: 1.702 ± 0.038	2.249LysPro: 2.249 ± 0.046	2.705LysGln: 2.705 ± 0.05	2.57LysArg: 2.57 ± 0.04	2.731LysSer: 2.731 ± 0.044	2.648LysThr: 2.648 ± 0.04	3.393LysVal: 3.393 ± 0.049	0.485LysTrp: 0.485 ± 0.02	1.251LysTyr: 1.251 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.843LeuAla: 10.843 ± 0.102	1.089LeuCys: 1.089 ± 0.031	5.585LeuAsp: 5.585 ± 0.066	5.374LeuGlu: 5.374 ± 0.072	4.196LeuPhe: 4.196 ± 0.065	6.776LeuGly: 6.776 ± 0.086	2.05LeuHis: 2.05 ± 0.035	5.885LeuIle: 5.885 ± 0.076	4.805LeuLys: 4.805 ± 0.065	10.833LeuLeu: 10.833 ± 0.134	2.532LeuMet: 2.532 ± 0.038	4.636LeuAsn: 4.636 ± 0.059	5.004LeuPro: 5.004 ± 0.057	4.15LeuGln: 4.15 ± 0.064	4.509LeuArg: 4.509 ± 0.062	7.77LeuSer: 7.77 ± 0.076	6.551LeuThr: 6.551 ± 0.081	6.829LeuVal: 6.829 ± 0.085	1.081LeuTrp: 1.081 ± 0.031	2.707LeuTyr: 2.707 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.694MetAla: 2.694 ± 0.044	0.187MetCys: 0.187 ± 0.01	1.266MetAsp: 1.266 ± 0.03	1.248MetGlu: 1.248 ± 0.028	0.867MetPhe: 0.867 ± 0.024	1.7MetGly: 1.7 ± 0.031	0.523MetHis: 0.523 ± 0.019	1.216MetIle: 1.216 ± 0.033	1.193MetLys: 1.193 ± 0.028	2.779MetLeu: 2.779 ± 0.05	0.703MetMet: 0.703 ± 0.022	0.978MetAsn: 0.978 ± 0.026	1.273MetPro: 1.273 ± 0.028	1.295MetGln: 1.295 ± 0.033	1.199MetArg: 1.199 ± 0.028	1.852MetSer: 1.852 ± 0.037	1.66MetThr: 1.66 ± 0.036	1.708MetVal: 1.708 ± 0.04	0.236MetTrp: 0.236 ± 0.014	0.544MetTyr: 0.544 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.835AsnAla: 3.835 ± 0.053	0.423AsnCys: 0.423 ± 0.016	2.278AsnAsp: 2.278 ± 0.045	2.348AsnGlu: 2.348 ± 0.04	1.522AsnPhe: 1.522 ± 0.038	3.113AsnGly: 3.113 ± 0.057	0.882AsnHis: 0.882 ± 0.024	2.564AsnIle: 2.564 ± 0.045	1.832AsnLys: 1.832 ± 0.035	3.867AsnLeu: 3.867 ± 0.057	0.962AsnMet: 0.962 ± 0.023	1.803AsnAsn: 1.803 ± 0.042	2.057AsnPro: 2.057 ± 0.037	2.103AsnGln: 2.103 ± 0.041	1.981AsnArg: 1.981 ± 0.039	2.446AsnSer: 2.446 ± 0.043	2.325AsnThr: 2.325 ± 0.048	2.665AsnVal: 2.665 ± 0.048	0.631AsnTrp: 0.631 ± 0.022	1.325AsnTyr: 1.325 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.357ProAla: 4.357 ± 0.07	0.297ProCys: 0.297 ± 0.015	2.839ProAsp: 2.839 ± 0.05	3.296ProGlu: 3.296 ± 0.055	1.819ProPhe: 1.819 ± 0.04	3.071ProGly: 3.071 ± 0.054	0.865ProHis: 0.865 ± 0.025	2.009ProIle: 2.009 ± 0.036	1.62ProLys: 1.62 ± 0.035	4.26ProLeu: 4.26 ± 0.06	0.967ProMet: 0.967 ± 0.024	1.406ProAsn: 1.406 ± 0.032	1.457ProPro: 1.457 ± 0.035	1.881ProGln: 1.881 ± 0.039	1.528ProArg: 1.528 ± 0.033	2.16ProSer: 2.16 ± 0.039	2.092ProThr: 2.092 ± 0.037	3.823ProVal: 3.823 ± 0.051	0.514ProTrp: 0.514 ± 0.021	1.285ProTyr: 1.285 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.838GlnAla: 4.838 ± 0.065	0.405GlnCys: 0.405 ± 0.019	2.048GlnAsp: 2.048 ± 0.037	2.198GlnGlu: 2.198 ± 0.039	1.861GlnPhe: 1.861 ± 0.033	2.873GlnGly: 2.873 ± 0.041	1.258GlnHis: 1.258 ± 0.027	2.45GlnIle: 2.45 ± 0.045	1.815GlnLys: 1.815 ± 0.037	5.314GlnLeu: 5.314 ± 0.07	1.053GlnMet: 1.053 ± 0.026	1.617GlnAsn: 1.617 ± 0.032	2.089GlnPro: 2.089 ± 0.038	3.704GlnGln: 3.704 ± 0.09	2.664GlnArg: 2.664 ± 0.046	2.97GlnSer: 2.97 ± 0.048	2.525GlnThr: 2.525 ± 0.044	3.056GlnVal: 3.056 ± 0.049	0.715GlnTrp: 0.715 ± 0.024	1.446GlnTyr: 1.446 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	3.758ArgAla: 3.758 ± 0.052	0.451ArgCys: 0.451 ± 0.019	2.57ArgAsp: 2.57 ± 0.041	3.058ArgGlu: 3.058 ± 0.048	2.371ArgPhe: 2.371 ± 0.039	2.735ArgGly: 2.735 ± 0.044	1.199ArgHis: 1.199 ± 0.028	3.031ArgIle: 3.031 ± 0.051	2.122ArgLys: 2.122 ± 0.041	5.226ArgLeu: 5.226 ± 0.067	1.193ArgMet: 1.193 ± 0.028	1.843ArgAsn: 1.843 ± 0.036	1.727ArgPro: 1.727 ± 0.039	2.585ArgGln: 2.585 ± 0.049	2.443ArgArg: 2.443 ± 0.038	2.466ArgSer: 2.466 ± 0.044	2.132ArgThr: 2.132 ± 0.04	3.223ArgVal: 3.223 ± 0.044	0.705ArgTrp: 0.705 ± 0.021	1.953ArgTyr: 1.953 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.278SerAla: 6.278 ± 0.072	0.593SerCys: 0.593 ± 0.023	3.703SerAsp: 3.703 ± 0.055	4.011SerGlu: 4.011 ± 0.056	2.654SerPhe: 2.654 ± 0.047	5.066SerGly: 5.066 ± 0.071	1.416SerHis: 1.416 ± 0.034	3.541SerIle: 3.541 ± 0.048	2.658SerLys: 2.658 ± 0.048	7.0SerLeu: 7.0 ± 0.071	1.583SerMet: 1.583 ± 0.034	2.236SerAsn: 2.236 ± 0.045	2.637SerPro: 2.637 ± 0.049	3.048SerGln: 3.048 ± 0.049	3.054SerArg: 3.054 ± 0.048	4.043SerSer: 4.043 ± 0.068	3.174SerThr: 3.174 ± 0.055	4.845SerVal: 4.845 ± 0.063	0.892SerTrp: 0.892 ± 0.024	2.067SerTyr: 2.067 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.251ThrAla: 5.251 ± 0.072	0.5ThrCys: 0.5 ± 0.019	3.28ThrAsp: 3.28 ± 0.052	3.301ThrGlu: 3.301 ± 0.046	2.248ThrPhe: 2.248 ± 0.043	4.454ThrGly: 4.454 ± 0.068	1.174ThrHis: 1.174 ± 0.025	3.253ThrIle: 3.253 ± 0.05	1.867ThrLys: 1.867 ± 0.041	6.487ThrLeu: 6.487 ± 0.072	1.15ThrMet: 1.15 ± 0.026	2.037ThrAsn: 2.037 ± 0.038	2.962ThrPro: 2.962 ± 0.047	2.429ThrGln: 2.429 ± 0.038	2.49ThrArg: 2.49 ± 0.04	3.43ThrSer: 3.43 ± 0.057	3.23ThrThr: 3.23 ± 0.051	4.123ThrVal: 4.123 ± 0.064	0.607ThrTrp: 0.607 ± 0.02	1.59ThrTyr: 1.59 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.861ValAla: 6.861 ± 0.078	0.769ValCys: 0.769 ± 0.023	4.091ValAsp: 4.091 ± 0.052	4.139ValGlu: 4.139 ± 0.054	2.851ValPhe: 2.851 ± 0.04	4.47ValGly: 4.47 ± 0.061	1.242ValHis: 1.242 ± 0.03	4.596ValIle: 4.596 ± 0.054	3.454ValLys: 3.454 ± 0.045	6.823ValLeu: 6.823 ± 0.074	1.916ValMet: 1.916 ± 0.037	3.193ValAsn: 3.193 ± 0.053	2.795ValPro: 2.795 ± 0.043	2.278ValGln: 2.278 ± 0.041	2.912ValArg: 2.912 ± 0.048	5.207ValSer: 5.207 ± 0.072	4.53ValThr: 4.53 ± 0.063	5.351ValVal: 5.351 ± 0.062	0.773ValTrp: 0.773 ± 0.021	1.934ValTyr: 1.934 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.852TrpAla: 0.852 ± 0.03	0.138TrpCys: 0.138 ± 0.009	0.636TrpAsp: 0.636 ± 0.021	0.55TrpGlu: 0.55 ± 0.02	0.604TrpPhe: 0.604 ± 0.023	0.814TrpGly: 0.814 ± 0.026	0.394TrpHis: 0.394 ± 0.016	0.629TrpIle: 0.629 ± 0.022	0.393TrpLys: 0.393 ± 0.019	1.889TrpLeu: 1.889 ± 0.043	0.358TrpMet: 0.358 ± 0.015	0.425TrpAsn: 0.425 ± 0.015	0.505TrpPro: 0.505 ± 0.02	1.188TrpGln: 1.188 ± 0.034	0.725TrpArg: 0.725 ± 0.023	0.71TrpSer: 0.71 ± 0.024	0.525TrpThr: 0.525 ± 0.02	0.831TrpVal: 0.831 ± 0.023	0.191TrpTrp: 0.191 ± 0.014	0.415TrpTyr: 0.415 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.687TyrAla: 2.687 ± 0.044	0.369TyrCys: 0.369 ± 0.018	1.752TyrAsp: 1.752 ± 0.034	1.677TyrGlu: 1.677 ± 0.032	1.52TyrPhe: 1.52 ± 0.036	2.23TyrGly: 2.23 ± 0.052	0.805TyrHis: 0.805 ± 0.024	1.592TyrIle: 1.592 ± 0.03	1.252TyrLys: 1.252 ± 0.029	3.396TyrLeu: 3.396 ± 0.058	0.574TyrMet: 0.574 ± 0.022	1.203TyrAsn: 1.203 ± 0.03	1.44TyrPro: 1.44 ± 0.032	1.893TyrGln: 1.893 ± 0.041	1.824TyrArg: 1.824 ± 0.037	2.1TyrSer: 2.1 ± 0.045	1.685TyrThr: 1.685 ± 0.032	1.89TyrVal: 1.89 ± 0.04	0.474TyrTrp: 0.474 ± 0.02	1.182TyrTyr: 1.182 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4316 proteins (1473345 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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