Amino acid dipepetide frequency for Embleya scabrispora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.909AlaAla: 21.909 ± 0.144	1.18AlaCys: 1.18 ± 0.022	9.341AlaAsp: 9.341 ± 0.067	8.871AlaGlu: 8.871 ± 0.075	3.539AlaPhe: 3.539 ± 0.042	14.019AlaGly: 14.019 ± 0.084	3.208AlaHis: 3.208 ± 0.04	4.243AlaIle: 4.243 ± 0.042	2.429AlaLys: 2.429 ± 0.04	14.35AlaLeu: 14.35 ± 0.101	2.595AlaMet: 2.595 ± 0.031	2.092AlaAsn: 2.092 ± 0.031	7.716AlaPro: 7.716 ± 0.07	3.182AlaGln: 3.182 ± 0.034	11.482AlaArg: 11.482 ± 0.077	5.759AlaSer: 5.759 ± 0.046	7.247AlaThr: 7.247 ± 0.056	11.847AlaVal: 11.847 ± 0.078	2.064AlaTrp: 2.064 ± 0.03	2.675AlaTyr: 2.675 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.221CysAla: 1.221 ± 0.017	0.094CysCys: 0.094 ± 0.007	0.507CysAsp: 0.507 ± 0.015	0.388CysGlu: 0.388 ± 0.011	0.217CysPhe: 0.217 ± 0.008	0.997CysGly: 0.997 ± 0.019	0.201CysHis: 0.201 ± 0.008	0.154CysIle: 0.154 ± 0.007	0.1CysLys: 0.1 ± 0.006	0.757CysLeu: 0.757 ± 0.015	0.122CysMet: 0.122 ± 0.007	0.129CysAsn: 0.129 ± 0.007	0.545CysPro: 0.545 ± 0.015	0.133CysGln: 0.133 ± 0.007	0.7CysArg: 0.7 ± 0.016	0.444CysSer: 0.444 ± 0.014	0.516CysThr: 0.516 ± 0.015	0.745CysVal: 0.745 ± 0.016	0.107CysTrp: 0.107 ± 0.006	0.149CysTyr: 0.149 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.395AspAla: 8.395 ± 0.06	0.444AspCys: 0.444 ± 0.014	3.809AspAsp: 3.809 ± 0.041	3.824AspGlu: 3.824 ± 0.038	1.585AspPhe: 1.585 ± 0.022	6.231AspGly: 6.231 ± 0.062	1.531AspHis: 1.531 ± 0.026	1.891AspIle: 1.891 ± 0.027	1.069AspLys: 1.069 ± 0.022	6.732AspLeu: 6.732 ± 0.053	0.848AspMet: 0.848 ± 0.018	0.952AspAsn: 0.952 ± 0.02	5.319AspPro: 5.319 ± 0.051	1.212AspGln: 1.212 ± 0.017	5.74AspArg: 5.74 ± 0.058	2.202AspSer: 2.202 ± 0.028	3.59AspThr: 3.59 ± 0.036	5.099AspVal: 5.099 ± 0.046	0.977AspTrp: 0.977 ± 0.02	1.109AspTyr: 1.109 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.941GluAla: 6.941 ± 0.071	0.371GluCys: 0.371 ± 0.011	2.608GluAsp: 2.608 ± 0.029	2.74GluGlu: 2.74 ± 0.039	1.505GluPhe: 1.505 ± 0.021	3.766GluGly: 3.766 ± 0.04	1.742GluHis: 1.742 ± 0.025	2.188GluIle: 2.188 ± 0.024	0.93GluLys: 0.93 ± 0.018	6.369GluLeu: 6.369 ± 0.053	0.821GluMet: 0.821 ± 0.018	0.892GluAsn: 0.892 ± 0.02	3.578GluPro: 3.578 ± 0.042	1.937GluGln: 1.937 ± 0.029	5.602GluArg: 5.602 ± 0.048	2.506GluSer: 2.506 ± 0.029	2.752GluThr: 2.752 ± 0.03	4.436GluVal: 4.436 ± 0.044	0.757GluTrp: 0.757 ± 0.016	1.064GluTyr: 1.064 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	4.074PheAla: 4.074 ± 0.038	0.257PheCys: 0.257 ± 0.01	2.08PheAsp: 2.08 ± 0.03	1.43PheGlu: 1.43 ± 0.022	0.747PhePhe: 0.747 ± 0.018	3.138PheGly: 3.138 ± 0.032	0.632PheHis: 0.632 ± 0.014	0.594PheIle: 0.594 ± 0.014	0.414PheLys: 0.414 ± 0.012	2.45PheLeu: 2.45 ± 0.032	0.361PheMet: 0.361 ± 0.01	0.465PheAsn: 0.465 ± 0.014	1.394PhePro: 1.394 ± 0.022	0.535PheGln: 0.535 ± 0.012	1.945PheArg: 1.945 ± 0.027	1.131PheSer: 1.131 ± 0.021	1.884PheThr: 1.884 ± 0.027	2.512PheVal: 2.512 ± 0.03	0.37PheTrp: 0.37 ± 0.01	0.487PheTyr: 0.487 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	11.719GlyAla: 11.719 ± 0.07	0.885GlyCys: 0.885 ± 0.018	5.282GlyAsp: 5.282 ± 0.039	4.743GlyGlu: 4.743 ± 0.039	2.855GlyPhe: 2.855 ± 0.035	8.964GlyGly: 8.964 ± 0.082	2.243GlyHis: 2.243 ± 0.027	3.526GlyIle: 3.526 ± 0.04	2.037GlyLys: 2.037 ± 0.032	9.121GlyLeu: 9.121 ± 0.065	2.054GlyMet: 2.054 ± 0.03	1.805GlyAsn: 1.805 ± 0.033	5.773GlyPro: 5.773 ± 0.051	2.096GlyGln: 2.096 ± 0.03	8.689GlyArg: 8.689 ± 0.066	5.194GlySer: 5.194 ± 0.049	6.341GlyThr: 6.341 ± 0.057	7.864GlyVal: 7.864 ± 0.064	1.683GlyTrp: 1.683 ± 0.025	2.144GlyTyr: 2.144 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.997HisAla: 2.997 ± 0.035	0.21HisCys: 0.21 ± 0.008	1.542HisAsp: 1.542 ± 0.025	1.289HisGlu: 1.289 ± 0.021	0.581HisPhe: 0.581 ± 0.015	2.392HisGly: 2.392 ± 0.031	0.744HisHis: 0.744 ± 0.02	0.709HisIle: 0.709 ± 0.018	0.294HisLys: 0.294 ± 0.012	2.479HisLeu: 2.479 ± 0.028	0.345HisMet: 0.345 ± 0.011	0.391HisAsn: 0.391 ± 0.011	2.001HisPro: 2.001 ± 0.029	0.51HisGln: 0.51 ± 0.013	2.261HisArg: 2.261 ± 0.03	0.904HisSer: 0.904 ± 0.018	1.487HisThr: 1.487 ± 0.023	1.884HisVal: 1.884 ± 0.029	0.362HisTrp: 0.362 ± 0.011	0.451HisTyr: 0.451 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.388IleAla: 5.388 ± 0.046	0.262IleCys: 0.262 ± 0.01	2.468IleAsp: 2.468 ± 0.029	2.213IleGlu: 2.213 ± 0.028	0.658IlePhe: 0.658 ± 0.014	3.825IleGly: 3.825 ± 0.046	0.698IleHis: 0.698 ± 0.016	0.755IleIle: 0.755 ± 0.017	0.635IleLys: 0.635 ± 0.016	2.663IleLeu: 2.663 ± 0.031	0.417IleMet: 0.417 ± 0.012	0.644IleAsn: 0.644 ± 0.016	1.963IlePro: 1.963 ± 0.027	0.648IleGln: 0.648 ± 0.015	2.705IleArg: 2.705 ± 0.034	1.451IleSer: 1.451 ± 0.021	2.297IleThr: 2.297 ± 0.032	3.133IleVal: 3.133 ± 0.038	0.341IleTrp: 0.341 ± 0.012	0.46IleTyr: 0.46 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	2.305LysAla: 2.305 ± 0.038	0.103LysCys: 0.103 ± 0.007	0.992LysAsp: 0.992 ± 0.022	0.78LysGlu: 0.78 ± 0.018	0.384LysPhe: 0.384 ± 0.012	1.47LysGly: 1.47 ± 0.025	0.373LysHis: 0.373 ± 0.012	0.641LysIle: 0.641 ± 0.015	0.503LysLys: 0.503 ± 0.019	1.589LysLeu: 1.589 ± 0.028	0.313LysMet: 0.313 ± 0.011	0.404LysAsn: 0.404 ± 0.014	1.291LysPro: 1.291 ± 0.027	0.523LysGln: 0.523 ± 0.015	1.251LysArg: 1.251 ± 0.023	1.027LysSer: 1.027 ± 0.021	1.109LysThr: 1.109 ± 0.022	1.558LysVal: 1.558 ± 0.025	0.238LysTrp: 0.238 ± 0.009	0.374LysTyr: 0.374 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.39LeuAla: 15.39 ± 0.096	0.837LeuCys: 0.837 ± 0.017	7.049LeuAsp: 7.049 ± 0.055	4.173LeuGlu: 4.173 ± 0.042	2.614LeuPhe: 2.614 ± 0.033	9.302LeuGly: 9.302 ± 0.066	2.215LeuHis: 2.215 ± 0.029	3.521LeuIle: 3.521 ± 0.039	1.457LeuLys: 1.457 ± 0.028	10.66LeuLeu: 10.66 ± 0.092	1.478LeuMet: 1.478 ± 0.026	1.522LeuAsn: 1.522 ± 0.024	6.476LeuPro: 6.476 ± 0.054	1.659LeuGln: 1.659 ± 0.028	8.993LeuArg: 8.993 ± 0.062	4.677LeuSer: 4.677 ± 0.044	6.721LeuThr: 6.721 ± 0.05	8.867LeuVal: 8.867 ± 0.074	1.25LeuTrp: 1.25 ± 0.022	1.796LeuTyr: 1.796 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.159MetAla: 2.159 ± 0.031	0.154MetCys: 0.154 ± 0.006	0.87MetAsp: 0.87 ± 0.016	0.621MetGlu: 0.621 ± 0.016	0.535MetPhe: 0.535 ± 0.013	1.28MetGly: 1.28 ± 0.023	0.373MetHis: 0.373 ± 0.012	0.682MetIle: 0.682 ± 0.014	0.324MetLys: 0.324 ± 0.01	1.655MetLeu: 1.655 ± 0.027	0.277MetMet: 0.277 ± 0.011	0.399MetAsn: 0.399 ± 0.013	1.146MetPro: 1.146 ± 0.019	0.38MetGln: 0.38 ± 0.012	1.626MetArg: 1.626 ± 0.023	1.329MetSer: 1.329 ± 0.023	1.482MetThr: 1.482 ± 0.025	1.351MetVal: 1.351 ± 0.023	0.237MetTrp: 0.237 ± 0.008	0.359MetTyr: 0.359 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.242AsnAla: 2.242 ± 0.028	0.161AsnCys: 0.161 ± 0.007	0.942AsnAsp: 0.942 ± 0.018	0.726AsnGlu: 0.726 ± 0.017	0.426AsnPhe: 0.426 ± 0.014	1.811AsnGly: 1.811 ± 0.03	0.392AsnHis: 0.392 ± 0.011	0.593AsnIle: 0.593 ± 0.016	0.356AsnLys: 0.356 ± 0.014	1.697AsnLeu: 1.697 ± 0.028	0.276AsnMet: 0.276 ± 0.01	0.4AsnAsn: 0.4 ± 0.014	1.443AsnPro: 1.443 ± 0.025	0.415AsnGln: 0.415 ± 0.012	1.373AsnArg: 1.373 ± 0.024	0.812AsnSer: 0.812 ± 0.017	1.151AsnThr: 1.151 ± 0.022	1.352AsnVal: 1.352 ± 0.025	0.261AsnTrp: 0.261 ± 0.01	0.353AsnTyr: 0.353 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.518ProAla: 9.518 ± 0.075	0.404ProCys: 0.404 ± 0.012	5.199ProAsp: 5.199 ± 0.051	4.244ProGlu: 4.244 ± 0.042	1.542ProPhe: 1.542 ± 0.023	7.111ProGly: 7.111 ± 0.064	1.495ProHis: 1.495 ± 0.026	1.937ProIle: 1.937 ± 0.025	1.081ProLys: 1.081 ± 0.022	5.083ProLeu: 5.083 ± 0.045	1.12ProMet: 1.12 ± 0.021	1.158ProAsn: 1.158 ± 0.023	4.34ProPro: 4.34 ± 0.064	1.479ProGln: 1.479 ± 0.027	4.561ProArg: 4.561 ± 0.044	3.072ProSer: 3.072 ± 0.035	4.268ProThr: 4.268 ± 0.04	5.328ProVal: 5.328 ± 0.049	0.961ProTrp: 0.961 ± 0.021	1.241ProTyr: 1.241 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.217GlnAla: 3.217 ± 0.039	0.158GlnCys: 0.158 ± 0.007	1.115GlnAsp: 1.115 ± 0.02	1.01GlnGlu: 1.01 ± 0.022	0.574GlnPhe: 0.574 ± 0.013	1.938GlnGly: 1.938 ± 0.028	0.471GlnHis: 0.471 ± 0.013	0.91GlnIle: 0.91 ± 0.018	0.385GlnLys: 0.385 ± 0.013	2.31GlnLeu: 2.31 ± 0.028	0.374GlnMet: 0.374 ± 0.011	0.407GlnAsn: 0.407 ± 0.012	1.446GlnPro: 1.446 ± 0.027	0.818GlnGln: 0.818 ± 0.024	2.025GlnArg: 2.025 ± 0.029	1.062GlnSer: 1.062 ± 0.02	1.152GlnThr: 1.152 ± 0.02	2.015GlnVal: 2.015 ± 0.034	0.404GlnTrp: 0.404 ± 0.012	0.463GlnTyr: 0.463 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	11.348ArgAla: 11.348 ± 0.082	0.683ArgCys: 0.683 ± 0.017	4.851ArgAsp: 4.851 ± 0.041	4.982ArgGlu: 4.982 ± 0.047	2.498ArgPhe: 2.498 ± 0.032	6.207ArgGly: 6.207 ± 0.052	2.415ArgHis: 2.415 ± 0.033	3.733ArgIle: 3.733 ± 0.037	1.347ArgLys: 1.347 ± 0.023	9.272ArgLeu: 9.272 ± 0.073	1.894ArgMet: 1.894 ± 0.027	1.43ArgAsn: 1.43 ± 0.022	5.733ArgPro: 5.733 ± 0.053	2.001ArgGln: 2.001 ± 0.025	8.926ArgArg: 8.926 ± 0.076	4.025ArgSer: 4.025 ± 0.04	5.337ArgThr: 5.337 ± 0.044	7.071ArgVal: 7.071 ± 0.051	1.42ArgTrp: 1.42 ± 0.026	1.795ArgTyr: 1.795 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.613SerAla: 6.613 ± 0.053	0.401SerCys: 0.401 ± 0.013	2.428SerAsp: 2.428 ± 0.029	1.975SerGlu: 1.975 ± 0.029	1.38SerPhe: 1.38 ± 0.025	5.601SerGly: 5.601 ± 0.051	0.907SerHis: 0.907 ± 0.016	1.598SerIle: 1.598 ± 0.026	0.808SerLys: 0.808 ± 0.018	4.189SerLeu: 4.189 ± 0.039	1.042SerMet: 1.042 ± 0.02	0.791SerAsn: 0.791 ± 0.017	3.106SerPro: 3.106 ± 0.039	0.889SerGln: 0.889 ± 0.017	3.727SerArg: 3.727 ± 0.042	2.427SerSer: 2.427 ± 0.037	3.159SerThr: 3.159 ± 0.035	4.029SerVal: 4.029 ± 0.042	0.837SerTrp: 0.837 ± 0.019	0.96SerTyr: 0.96 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.543ThrAla: 8.543 ± 0.063	0.487ThrCys: 0.487 ± 0.015	3.694ThrAsp: 3.694 ± 0.037	3.009ThrGlu: 3.009 ± 0.037	1.679ThrPhe: 1.679 ± 0.028	6.667ThrGly: 6.667 ± 0.058	1.365ThrHis: 1.365 ± 0.022	2.106ThrIle: 2.106 ± 0.027	1.073ThrLys: 1.073 ± 0.023	5.892ThrLeu: 5.892 ± 0.044	1.076ThrMet: 1.076 ± 0.02	1.04ThrAsn: 1.04 ± 0.022	4.548ThrPro: 4.548 ± 0.051	1.132ThrGln: 1.132 ± 0.021	4.691ThrArg: 4.691 ± 0.041	3.004ThrSer: 3.004 ± 0.035	4.233ThrThr: 4.233 ± 0.052	5.85ThrVal: 5.85 ± 0.05	1.017ThrTrp: 1.017 ± 0.021	1.244ThrTyr: 1.244 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.491ValAla: 11.491 ± 0.074	0.804ValCys: 0.804 ± 0.018	5.58ValAsp: 5.58 ± 0.048	4.813ValGlu: 4.813 ± 0.049	2.505ValPhe: 2.505 ± 0.029	7.29ValGly: 7.29 ± 0.055	2.023ValHis: 2.023 ± 0.03	2.728ValIle: 2.728 ± 0.033	1.39ValLys: 1.39 ± 0.025	9.633ValLeu: 9.633 ± 0.065	1.314ValMet: 1.314 ± 0.019	1.528ValAsn: 1.528 ± 0.024	5.385ValPro: 5.385 ± 0.044	1.716ValGln: 1.716 ± 0.024	7.358ValArg: 7.358 ± 0.057	3.98ValSer: 3.98 ± 0.043	5.292ValThr: 5.292 ± 0.047	8.625ValVal: 8.625 ± 0.072	1.15ValTrp: 1.15 ± 0.017	1.544ValTyr: 1.544 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.707TrpAla: 1.707 ± 0.025	0.162TrpCys: 0.162 ± 0.008	0.848TrpAsp: 0.848 ± 0.021	0.65TrpGlu: 0.65 ± 0.013	0.508TrpPhe: 0.508 ± 0.013	1.034TrpGly: 1.034 ± 0.02	0.403TrpHis: 0.403 ± 0.011	0.626TrpIle: 0.626 ± 0.015	0.29TrpLys: 0.29 ± 0.011	1.669TrpLeu: 1.669 ± 0.028	0.285TrpMet: 0.285 ± 0.009	0.388TrpAsn: 0.388 ± 0.011	0.828TrpPro: 0.828 ± 0.017	0.501TrpGln: 0.501 ± 0.013	1.394TrpArg: 1.394 ± 0.026	1.002TrpSer: 1.002 ± 0.019	1.092TrpThr: 1.092 ± 0.02	1.034TrpVal: 1.034 ± 0.021	0.387TrpTrp: 0.387 ± 0.011	0.346TrpTyr: 0.346 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.573TyrAla: 2.573 ± 0.032	0.168TyrCys: 0.168 ± 0.008	1.351TyrAsp: 1.351 ± 0.028	1.025TyrGlu: 1.025 ± 0.02	0.568TyrPhe: 0.568 ± 0.015	1.976TyrGly: 1.976 ± 0.027	0.401TyrHis: 0.401 ± 0.01	0.488TyrIle: 0.488 ± 0.013	0.307TyrLys: 0.307 ± 0.011	2.087TyrLeu: 2.087 ± 0.027	0.228TyrMet: 0.228 ± 0.01	0.346TyrAsn: 0.346 ± 0.012	1.111TyrPro: 1.111 ± 0.02	0.489TyrGln: 0.489 ± 0.013	1.918TyrArg: 1.918 ± 0.027	0.857TyrSer: 0.857 ± 0.017	1.239TyrThr: 1.239 ± 0.021	1.548TyrVal: 1.548 ± 0.026	0.333TyrTrp: 0.333 ± 0.013	0.378TyrTyr: 0.378 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9009 proteins (2957195 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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