Amino acid dipepetide frequency for Edwardsiella phage GF-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.576AlaAla: 10.576 ± 1.207
0.67AlaCys: 0.67 ± 0.25
5.362AlaAsp: 5.362 ± 0.651
7.522AlaGlu: 7.522 ± 1.259
3.054AlaPhe: 3.054 ± 0.511
6.852AlaGly: 6.852 ± 0.802
1.043AlaHis: 1.043 ± 0.308
6.926AlaIle: 6.926 ± 0.77
4.99AlaLys: 4.99 ± 0.741
7.15AlaLeu: 7.15 ± 0.762
2.681AlaMet: 2.681 ± 0.465
3.5AlaAsn: 3.5 ± 0.613
3.351AlaPro: 3.351 ± 0.413
4.692AlaGln: 4.692 ± 0.787
5.213AlaArg: 5.213 ± 1.199
6.479AlaSer: 6.479 ± 0.691
4.841AlaThr: 4.841 ± 0.718
5.064AlaVal: 5.064 ± 0.657
1.713AlaTrp: 1.713 ± 0.313
2.905AlaTyr: 2.905 ± 0.443
0.0AlaXaa: 0.0 ± 0.0
Cys
1.117CysAla: 1.117 ± 0.303
0.372CysCys: 0.372 ± 0.176
0.894CysAsp: 0.894 ± 0.275
0.596CysGlu: 0.596 ± 0.216
0.223CysPhe: 0.223 ± 0.134
1.043CysGly: 1.043 ± 0.285
0.447CysHis: 0.447 ± 0.198
0.67CysIle: 0.67 ± 0.244
0.298CysLys: 0.298 ± 0.185
0.596CysLeu: 0.596 ± 0.22
0.149CysMet: 0.149 ± 0.107
0.596CysAsn: 0.596 ± 0.181
0.521CysPro: 0.521 ± 0.222
0.372CysGln: 0.372 ± 0.153
0.968CysArg: 0.968 ± 0.21
0.819CysSer: 0.819 ± 0.27
0.596CysThr: 0.596 ± 0.218
0.521CysVal: 0.521 ± 0.194
0.223CysTrp: 0.223 ± 0.125
0.968CysTyr: 0.968 ± 0.25
0.0CysXaa: 0.0 ± 0.0
Asp
5.809AspAla: 5.809 ± 0.706
0.521AspCys: 0.521 ± 0.195
4.99AspAsp: 4.99 ± 0.661
3.575AspGlu: 3.575 ± 0.458
3.203AspPhe: 3.203 ± 0.43
5.213AspGly: 5.213 ± 0.656
0.745AspHis: 0.745 ± 0.278
3.873AspIle: 3.873 ± 0.513
4.022AspLys: 4.022 ± 0.712
4.692AspLeu: 4.692 ± 0.475
1.936AspMet: 1.936 ± 0.282
2.383AspAsn: 2.383 ± 0.437
2.085AspPro: 2.085 ± 0.522
1.936AspGln: 1.936 ± 0.34
2.756AspArg: 2.756 ± 0.496
4.022AspSer: 4.022 ± 0.663
2.383AspThr: 2.383 ± 0.427
3.724AspVal: 3.724 ± 0.645
1.043AspTrp: 1.043 ± 0.292
1.415AspTyr: 1.415 ± 0.281
0.0AspXaa: 0.0 ± 0.0
Glu
6.554GluAla: 6.554 ± 0.989
0.894GluCys: 0.894 ± 0.287
2.383GluAsp: 2.383 ± 0.393
4.394GluGlu: 4.394 ± 1.125
2.681GluPhe: 2.681 ± 0.375
3.054GluGly: 3.054 ± 0.515
1.49GluHis: 1.49 ± 0.302
4.32GluIle: 4.32 ± 0.778
4.767GluLys: 4.767 ± 0.82
5.213GluLeu: 5.213 ± 0.557
1.862GluMet: 1.862 ± 0.38
3.203GluAsn: 3.203 ± 0.487
1.787GluPro: 1.787 ± 0.349
2.458GluGln: 2.458 ± 0.565
4.99GluArg: 4.99 ± 0.914
3.575GluSer: 3.575 ± 0.567
2.756GluThr: 2.756 ± 0.411
4.171GluVal: 4.171 ± 0.657
1.341GluTrp: 1.341 ± 0.327
2.011GluTyr: 2.011 ± 0.43
0.0GluXaa: 0.0 ± 0.0
Phe
2.532PheAla: 2.532 ± 0.439
0.521PheCys: 0.521 ± 0.182
2.458PheAsp: 2.458 ± 0.429
2.085PheGlu: 2.085 ± 0.315
1.192PhePhe: 1.192 ± 0.376
2.905PheGly: 2.905 ± 0.431
0.223PheHis: 0.223 ± 0.134
2.085PheIle: 2.085 ± 0.42
1.787PheLys: 1.787 ± 0.284
2.011PheLeu: 2.011 ± 0.394
0.968PheMet: 0.968 ± 0.291
2.681PheAsn: 2.681 ± 0.454
1.49PhePro: 1.49 ± 0.331
0.968PheGln: 0.968 ± 0.302
1.862PheArg: 1.862 ± 0.343
2.383PheSer: 2.383 ± 0.391
2.458PheThr: 2.458 ± 0.475
2.011PheVal: 2.011 ± 0.415
0.67PheTrp: 0.67 ± 0.249
1.117PheTyr: 1.117 ± 0.339
0.0PheXaa: 0.0 ± 0.0
Gly
5.288GlyAla: 5.288 ± 0.751
1.043GlyCys: 1.043 ± 0.292
5.735GlyAsp: 5.735 ± 1.016
4.171GlyGlu: 4.171 ± 0.568
2.979GlyPhe: 2.979 ± 0.496
4.915GlyGly: 4.915 ± 0.734
1.117GlyHis: 1.117 ± 0.229
3.798GlyIle: 3.798 ± 0.521
4.096GlyLys: 4.096 ± 0.558
5.511GlyLeu: 5.511 ± 0.57
3.128GlyMet: 3.128 ± 0.473
3.798GlyAsn: 3.798 ± 0.794
0.745GlyPro: 0.745 ± 0.211
2.532GlyGln: 2.532 ± 0.414
2.83GlyArg: 2.83 ± 0.383
6.479GlySer: 6.479 ± 1.836
3.649GlyThr: 3.649 ± 0.559
6.182GlyVal: 6.182 ± 0.781
0.894GlyTrp: 0.894 ± 0.24
3.277GlyTyr: 3.277 ± 0.574
0.0GlyXaa: 0.0 ± 0.0
His
1.192HisAla: 1.192 ± 0.285
0.223HisCys: 0.223 ± 0.121
0.521HisAsp: 0.521 ± 0.178
0.819HisGlu: 0.819 ± 0.269
0.149HisPhe: 0.149 ± 0.095
0.894HisGly: 0.894 ± 0.266
0.298HisHis: 0.298 ± 0.148
0.894HisIle: 0.894 ± 0.221
0.67HisLys: 0.67 ± 0.23
1.192HisLeu: 1.192 ± 0.333
0.596HisMet: 0.596 ± 0.237
0.372HisAsn: 0.372 ± 0.198
0.596HisPro: 0.596 ± 0.243
0.67HisGln: 0.67 ± 0.215
0.447HisArg: 0.447 ± 0.208
0.968HisSer: 0.968 ± 0.252
0.968HisThr: 0.968 ± 0.298
0.894HisVal: 0.894 ± 0.262
0.298HisTrp: 0.298 ± 0.138
0.745HisTyr: 0.745 ± 0.222
0.0HisXaa: 0.0 ± 0.0
Ile
7.075IleAla: 7.075 ± 0.744
0.894IleCys: 0.894 ± 0.257
4.394IleAsp: 4.394 ± 0.571
4.171IleGlu: 4.171 ± 0.587
1.49IlePhe: 1.49 ± 0.304
5.213IleGly: 5.213 ± 1.776
0.894IleHis: 0.894 ± 0.238
3.351IleIle: 3.351 ± 0.524
4.915IleLys: 4.915 ± 0.618
3.426IleLeu: 3.426 ± 0.406
1.415IleMet: 1.415 ± 0.358
3.128IleAsn: 3.128 ± 0.379
2.905IlePro: 2.905 ± 0.447
3.128IleGln: 3.128 ± 0.462
3.203IleArg: 3.203 ± 0.476
4.171IleSer: 4.171 ± 0.488
4.841IleThr: 4.841 ± 0.607
3.277IleVal: 3.277 ± 0.442
0.745IleTrp: 0.745 ± 0.25
2.011IleTyr: 2.011 ± 0.363
0.0IleXaa: 0.0 ± 0.0
Lys
4.915LysAla: 4.915 ± 0.696
0.521LysCys: 0.521 ± 0.196
2.681LysAsp: 2.681 ± 0.641
4.618LysGlu: 4.618 ± 0.649
2.085LysPhe: 2.085 ± 0.313
3.426LysGly: 3.426 ± 0.549
0.894LysHis: 0.894 ± 0.23
3.5LysIle: 3.5 ± 0.51
3.873LysLys: 3.873 ± 0.56
5.735LysLeu: 5.735 ± 0.528
1.266LysMet: 1.266 ± 0.257
1.564LysAsn: 1.564 ± 0.335
3.128LysPro: 3.128 ± 0.608
3.798LysGln: 3.798 ± 0.581
4.022LysArg: 4.022 ± 0.644
3.724LysSer: 3.724 ± 0.635
2.905LysThr: 2.905 ± 0.4
3.277LysVal: 3.277 ± 0.476
0.968LysTrp: 0.968 ± 0.378
2.234LysTyr: 2.234 ± 0.453
0.0LysXaa: 0.0 ± 0.0
Leu
7.075LeuAla: 7.075 ± 0.656
1.117LeuCys: 1.117 ± 0.261
4.171LeuAsp: 4.171 ± 0.516
4.469LeuGlu: 4.469 ± 0.48
2.234LeuPhe: 2.234 ± 0.353
4.32LeuGly: 4.32 ± 0.58
0.298LeuHis: 0.298 ± 0.176
5.437LeuIle: 5.437 ± 0.596
4.171LeuLys: 4.171 ± 0.626
4.99LeuLeu: 4.99 ± 0.66
2.383LeuMet: 2.383 ± 0.488
4.171LeuAsn: 4.171 ± 0.618
2.756LeuPro: 2.756 ± 0.438
2.83LeuGln: 2.83 ± 0.487
5.139LeuArg: 5.139 ± 0.612
6.182LeuSer: 6.182 ± 0.747
5.064LeuThr: 5.064 ± 0.612
5.362LeuVal: 5.362 ± 0.602
1.117LeuTrp: 1.117 ± 0.326
2.234LeuTyr: 2.234 ± 0.413
0.0LeuXaa: 0.0 ± 0.0
Met
2.085MetAla: 2.085 ± 0.425
0.223MetCys: 0.223 ± 0.127
1.043MetAsp: 1.043 ± 0.278
1.192MetGlu: 1.192 ± 0.237
0.745MetPhe: 0.745 ± 0.201
1.936MetGly: 1.936 ± 0.466
0.372MetHis: 0.372 ± 0.167
2.234MetIle: 2.234 ± 0.411
2.681MetLys: 2.681 ± 0.431
1.564MetLeu: 1.564 ± 0.337
0.745MetMet: 0.745 ± 0.261
2.458MetAsn: 2.458 ± 0.425
1.564MetPro: 1.564 ± 0.32
1.415MetGln: 1.415 ± 0.289
1.49MetArg: 1.49 ± 0.371
1.49MetSer: 1.49 ± 0.306
3.128MetThr: 3.128 ± 0.424
1.341MetVal: 1.341 ± 0.3
0.372MetTrp: 0.372 ± 0.162
0.596MetTyr: 0.596 ± 0.219
0.0MetXaa: 0.0 ± 0.0
Asn
4.692AsnAla: 4.692 ± 0.743
0.298AsnCys: 0.298 ± 0.145
3.203AsnAsp: 3.203 ± 0.78
2.309AsnGlu: 2.309 ± 0.348
1.49AsnPhe: 1.49 ± 0.282
4.915AsnGly: 4.915 ± 0.546
0.521AsnHis: 0.521 ± 0.192
2.309AsnIle: 2.309 ± 0.467
2.681AsnLys: 2.681 ± 0.404
3.351AsnLeu: 3.351 ± 0.453
0.745AsnMet: 0.745 ± 0.283
1.713AsnAsn: 1.713 ± 0.396
2.309AsnPro: 2.309 ± 0.376
2.383AsnGln: 2.383 ± 0.446
2.458AsnArg: 2.458 ± 0.434
3.054AsnSer: 3.054 ± 0.589
2.458AsnThr: 2.458 ± 0.438
2.383AsnVal: 2.383 ± 0.456
0.372AsnTrp: 0.372 ± 0.189
1.564AsnTyr: 1.564 ± 0.32
0.0AsnXaa: 0.0 ± 0.0
Pro
2.756ProAla: 2.756 ± 0.456
0.596ProCys: 0.596 ± 0.217
3.203ProAsp: 3.203 ± 0.503
3.054ProGlu: 3.054 ± 0.432
1.713ProPhe: 1.713 ± 0.382
2.979ProGly: 2.979 ± 0.677
0.67ProHis: 0.67 ± 0.22
1.862ProIle: 1.862 ± 0.396
2.011ProLys: 2.011 ± 0.475
3.128ProLeu: 3.128 ± 0.476
1.266ProMet: 1.266 ± 0.349
1.862ProAsn: 1.862 ± 0.379
1.49ProPro: 1.49 ± 0.281
1.117ProGln: 1.117 ± 0.213
1.713ProArg: 1.713 ± 0.354
3.575ProSer: 3.575 ± 0.588
2.234ProThr: 2.234 ± 0.463
3.203ProVal: 3.203 ± 0.49
0.67ProTrp: 0.67 ± 0.251
1.117ProTyr: 1.117 ± 0.286
0.0ProXaa: 0.0 ± 0.0
Gln
3.798GlnAla: 3.798 ± 0.55
0.372GlnCys: 0.372 ± 0.152
1.713GlnAsp: 1.713 ± 0.345
2.607GlnGlu: 2.607 ± 0.533
1.117GlnPhe: 1.117 ± 0.219
2.234GlnGly: 2.234 ± 0.399
0.819GlnHis: 0.819 ± 0.226
2.681GlnIle: 2.681 ± 0.751
1.936GlnLys: 1.936 ± 0.419
3.203GlnLeu: 3.203 ± 0.549
1.415GlnMet: 1.415 ± 0.293
2.234GlnAsn: 2.234 ± 0.392
1.787GlnPro: 1.787 ± 0.306
2.681GlnGln: 2.681 ± 0.525
2.681GlnArg: 2.681 ± 0.519
3.426GlnSer: 3.426 ± 0.493
1.787GlnThr: 1.787 ± 0.408
2.979GlnVal: 2.979 ± 0.426
0.894GlnTrp: 0.894 ± 0.24
1.117GlnTyr: 1.117 ± 0.275
0.0GlnXaa: 0.0 ± 0.0
Arg
4.767ArgAla: 4.767 ± 0.941
0.67ArgCys: 0.67 ± 0.219
3.649ArgAsp: 3.649 ± 0.57
4.022ArgGlu: 4.022 ± 0.784
2.234ArgPhe: 2.234 ± 0.416
2.607ArgGly: 2.607 ± 0.416
0.447ArgHis: 0.447 ± 0.208
4.915ArgIle: 4.915 ± 1.16
5.511ArgLys: 5.511 ± 0.849
4.692ArgLeu: 4.692 ± 0.587
1.638ArgMet: 1.638 ± 0.396
1.638ArgAsn: 1.638 ± 0.319
2.085ArgPro: 2.085 ± 0.402
1.638ArgGln: 1.638 ± 0.339
3.649ArgArg: 3.649 ± 0.585
3.724ArgSer: 3.724 ± 0.576
1.862ArgThr: 1.862 ± 0.333
3.873ArgVal: 3.873 ± 0.529
1.341ArgTrp: 1.341 ± 0.36
0.968ArgTyr: 0.968 ± 0.304
0.0ArgXaa: 0.0 ± 0.0
Ser
7.597SerAla: 7.597 ± 0.813
0.745SerCys: 0.745 ± 0.211
3.575SerAsp: 3.575 ± 0.486
4.543SerGlu: 4.543 ± 0.706
1.936SerPhe: 1.936 ± 0.382
7.15SerGly: 7.15 ± 1.928
0.596SerHis: 0.596 ± 0.215
5.213SerIle: 5.213 ± 0.669
2.681SerLys: 2.681 ± 0.453
6.331SerLeu: 6.331 ± 0.671
2.234SerMet: 2.234 ± 0.353
3.054SerAsn: 3.054 ± 0.468
2.979SerPro: 2.979 ± 0.492
2.532SerGln: 2.532 ± 0.473
3.649SerArg: 3.649 ± 0.506
6.033SerSer: 6.033 ± 1.682
3.351SerThr: 3.351 ± 0.606
4.245SerVal: 4.245 ± 0.594
0.968SerTrp: 0.968 ± 0.27
2.309SerTyr: 2.309 ± 0.477
0.0SerXaa: 0.0 ± 0.0
Thr
5.362ThrAla: 5.362 ± 0.648
0.596ThrCys: 0.596 ± 0.244
3.277ThrAsp: 3.277 ± 0.49
3.054ThrGlu: 3.054 ± 0.416
1.787ThrPhe: 1.787 ± 0.428
4.543ThrGly: 4.543 ± 0.632
0.67ThrHis: 0.67 ± 0.217
3.873ThrIle: 3.873 ± 0.598
2.681ThrLys: 2.681 ± 0.584
4.394ThrLeu: 4.394 ± 0.517
1.341ThrMet: 1.341 ± 0.399
1.862ThrAsn: 1.862 ± 0.417
3.277ThrPro: 3.277 ± 0.397
2.16ThrGln: 2.16 ± 0.382
2.905ThrArg: 2.905 ± 0.474
4.096ThrSer: 4.096 ± 0.556
2.905ThrThr: 2.905 ± 0.518
3.277ThrVal: 3.277 ± 0.6
0.745ThrTrp: 0.745 ± 0.26
2.085ThrTyr: 2.085 ± 0.421
0.0ThrXaa: 0.0 ± 0.0
Val
6.628ValAla: 6.628 ± 0.714
0.67ValCys: 0.67 ± 0.24
4.096ValAsp: 4.096 ± 0.588
3.724ValGlu: 3.724 ± 0.511
2.011ValPhe: 2.011 ± 0.422
4.394ValGly: 4.394 ± 0.666
1.117ValHis: 1.117 ± 0.235
4.022ValIle: 4.022 ± 0.625
2.979ValLys: 2.979 ± 0.517
3.649ValLeu: 3.649 ± 0.483
1.713ValMet: 1.713 ± 0.402
3.277ValAsn: 3.277 ± 0.445
2.905ValPro: 2.905 ± 0.407
2.309ValGln: 2.309 ± 0.479
3.054ValArg: 3.054 ± 0.498
4.767ValSer: 4.767 ± 0.577
4.394ValThr: 4.394 ± 0.762
4.245ValVal: 4.245 ± 0.819
0.67ValTrp: 0.67 ± 0.208
2.085ValTyr: 2.085 ± 0.548
0.0ValXaa: 0.0 ± 0.0
Trp
1.266TrpAla: 1.266 ± 0.324
0.67TrpCys: 0.67 ± 0.207
1.192TrpAsp: 1.192 ± 0.277
1.117TrpGlu: 1.117 ± 0.245
0.67TrpPhe: 0.67 ± 0.234
1.117TrpGly: 1.117 ± 0.328
0.298TrpHis: 0.298 ± 0.174
0.968TrpIle: 0.968 ± 0.257
0.968TrpLys: 0.968 ± 0.27
1.787TrpLeu: 1.787 ± 0.461
0.521TrpMet: 0.521 ± 0.164
0.67TrpAsn: 0.67 ± 0.236
0.447TrpPro: 0.447 ± 0.188
0.447TrpGln: 0.447 ± 0.19
0.298TrpArg: 0.298 ± 0.167
0.819TrpSer: 0.819 ± 0.239
0.894TrpThr: 0.894 ± 0.254
1.117TrpVal: 1.117 ± 0.303
0.447TrpTrp: 0.447 ± 0.211
0.372TrpTyr: 0.372 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.5TyrAla: 3.5 ± 0.674
0.372TyrCys: 0.372 ± 0.183
1.787TyrAsp: 1.787 ± 0.37
1.862TyrGlu: 1.862 ± 0.367
1.415TyrPhe: 1.415 ± 0.277
2.458TyrGly: 2.458 ± 0.482
0.447TyrHis: 0.447 ± 0.19
1.713TyrIle: 1.713 ± 0.358
1.415TyrLys: 1.415 ± 0.284
2.905TyrLeu: 2.905 ± 0.568
0.596TyrMet: 0.596 ± 0.219
1.043TyrAsn: 1.043 ± 0.268
2.011TyrPro: 2.011 ± 0.361
1.49TyrGln: 1.49 ± 0.296
2.607TyrArg: 2.607 ± 0.481
1.936TyrSer: 1.936 ± 0.431
1.415TyrThr: 1.415 ± 0.333
1.564TyrVal: 1.564 ± 0.382
0.596TyrTrp: 0.596 ± 0.212
1.862TyrTyr: 1.862 ± 0.499
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 82 proteins (13428 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski