Amino acid dipepetide frequency for Thermoproteus spherical piliferous virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.335AlaAla: 14.335 ± 2.763
0.956AlaCys: 0.956 ± 0.476
3.823AlaAsp: 3.823 ± 1.118
3.44AlaGlu: 3.44 ± 0.773
2.102AlaPhe: 2.102 ± 0.57
7.645AlaGly: 7.645 ± 1.263
0.765AlaHis: 0.765 ± 0.323
10.13AlaIle: 10.13 ± 1.83
3.058AlaLys: 3.058 ± 0.885
15.291AlaLeu: 15.291 ± 3.701
3.823AlaMet: 3.823 ± 0.813
3.058AlaAsn: 3.058 ± 0.981
3.249AlaPro: 3.249 ± 0.748
2.102AlaGln: 2.102 ± 0.575
4.014AlaArg: 4.014 ± 0.861
6.498AlaSer: 6.498 ± 1.012
6.498AlaThr: 6.498 ± 0.877
11.277AlaVal: 11.277 ± 1.396
1.529AlaTrp: 1.529 ± 0.585
5.734AlaTyr: 5.734 ± 0.878
0.0AlaXaa: 0.0 ± 0.0
Cys
1.147CysAla: 1.147 ± 0.53
0.0CysCys: 0.0 ± 0.0
1.147CysAsp: 1.147 ± 0.391
0.765CysGlu: 0.765 ± 0.37
0.0CysPhe: 0.0 ± 0.0
1.147CysGly: 1.147 ± 0.444
0.0CysHis: 0.0 ± 0.0
0.765CysIle: 0.765 ± 0.333
0.573CysLys: 0.573 ± 0.455
0.573CysLeu: 0.573 ± 0.323
0.573CysMet: 0.573 ± 0.297
0.191CysAsn: 0.191 ± 0.182
1.911CysPro: 1.911 ± 0.519
0.573CysGln: 0.573 ± 0.321
1.338CysArg: 1.338 ± 0.622
0.573CysSer: 0.573 ± 0.274
0.382CysThr: 0.382 ± 0.258
0.765CysVal: 0.765 ± 0.365
0.191CysTrp: 0.191 ± 0.19
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.676AspAla: 2.676 ± 0.678
0.382AspCys: 0.382 ± 0.278
0.573AspAsp: 0.573 ± 0.434
0.382AspGlu: 0.382 ± 0.236
1.147AspPhe: 1.147 ± 0.399
3.058AspGly: 3.058 ± 0.995
0.0AspHis: 0.0 ± 0.0
4.396AspIle: 4.396 ± 0.751
1.72AspLys: 1.72 ± 0.596
3.44AspLeu: 3.44 ± 0.757
1.529AspMet: 1.529 ± 0.474
1.338AspAsn: 1.338 ± 0.498
1.911AspPro: 1.911 ± 0.495
0.765AspGln: 0.765 ± 0.355
2.294AspArg: 2.294 ± 0.995
1.529AspSer: 1.529 ± 0.559
2.676AspThr: 2.676 ± 0.556
3.44AspVal: 3.44 ± 0.952
0.191AspTrp: 0.191 ± 0.205
1.529AspTyr: 1.529 ± 0.501
0.0AspXaa: 0.0 ± 0.0
Glu
3.44GluAla: 3.44 ± 0.703
0.573GluCys: 0.573 ± 0.316
0.573GluAsp: 0.573 ± 0.421
1.911GluGlu: 1.911 ± 0.617
1.147GluPhe: 1.147 ± 0.457
4.396GluGly: 4.396 ± 1.204
0.191GluHis: 0.191 ± 0.209
2.294GluIle: 2.294 ± 0.585
0.765GluLys: 0.765 ± 0.359
2.485GluLeu: 2.485 ± 0.778
0.382GluMet: 0.382 ± 0.254
1.338GluAsn: 1.338 ± 0.454
1.529GluPro: 1.529 ± 0.599
0.573GluGln: 0.573 ± 0.356
2.867GluArg: 2.867 ± 0.798
1.147GluSer: 1.147 ± 0.435
0.956GluThr: 0.956 ± 0.525
4.014GluVal: 4.014 ± 0.772
0.765GluTrp: 0.765 ± 0.491
2.102GluTyr: 2.102 ± 0.5
0.0GluXaa: 0.0 ± 0.0
Phe
3.249PheAla: 3.249 ± 0.897
0.191PheCys: 0.191 ± 0.215
1.529PheAsp: 1.529 ± 0.62
0.191PheGlu: 0.191 ± 0.187
1.338PhePhe: 1.338 ± 0.507
3.249PheGly: 3.249 ± 0.619
0.0PheHis: 0.0 ± 0.0
4.014PheIle: 4.014 ± 1.346
1.911PheLys: 1.911 ± 0.623
3.631PheLeu: 3.631 ± 0.655
0.956PheMet: 0.956 ± 0.385
1.911PheAsn: 1.911 ± 0.803
1.147PhePro: 1.147 ± 0.444
1.338PheGln: 1.338 ± 0.411
1.147PheArg: 1.147 ± 0.476
1.911PheSer: 1.911 ± 0.502
1.911PheThr: 1.911 ± 0.537
2.867PheVal: 2.867 ± 0.821
0.382PheTrp: 0.382 ± 0.244
1.529PheTyr: 1.529 ± 0.574
0.0PheXaa: 0.0 ± 0.0
Gly
7.072GlyAla: 7.072 ± 1.436
0.765GlyCys: 0.765 ± 0.366
2.294GlyAsp: 2.294 ± 0.652
2.102GlyGlu: 2.102 ± 0.497
2.294GlyPhe: 2.294 ± 0.607
5.543GlyGly: 5.543 ± 1.147
1.529GlyHis: 1.529 ± 0.585
4.587GlyIle: 4.587 ± 1.151
2.294GlyLys: 2.294 ± 0.604
8.601GlyLeu: 8.601 ± 1.364
1.911GlyMet: 1.911 ± 0.683
3.631GlyAsn: 3.631 ± 1.01
3.058GlyPro: 3.058 ± 0.731
0.956GlyGln: 0.956 ± 0.527
4.587GlyArg: 4.587 ± 0.941
4.969GlySer: 4.969 ± 1.497
7.263GlyThr: 7.263 ± 1.331
8.41GlyVal: 8.41 ± 1.234
0.956GlyTrp: 0.956 ± 0.423
5.161GlyTyr: 5.161 ± 1.198
0.0GlyXaa: 0.0 ± 0.0
His
1.147HisAla: 1.147 ± 0.451
0.0HisCys: 0.0 ± 0.0
0.765HisAsp: 0.765 ± 0.314
0.573HisGlu: 0.573 ± 0.306
0.191HisPhe: 0.191 ± 0.172
1.911HisGly: 1.911 ± 0.619
0.191HisHis: 0.191 ± 0.194
0.573HisIle: 0.573 ± 0.381
0.573HisLys: 0.573 ± 0.466
0.573HisLeu: 0.573 ± 0.324
0.191HisMet: 0.191 ± 0.186
0.382HisAsn: 0.382 ± 0.266
0.382HisPro: 0.382 ± 0.233
0.0HisGln: 0.0 ± 0.0
1.338HisArg: 1.338 ± 0.495
0.0HisSer: 0.0 ± 0.0
0.573HisThr: 0.573 ± 0.416
1.529HisVal: 1.529 ± 0.562
0.191HisTrp: 0.191 ± 0.186
0.382HisTyr: 0.382 ± 0.254
0.0HisXaa: 0.0 ± 0.0
Ile
9.174IleAla: 9.174 ± 1.559
1.338IleCys: 1.338 ± 0.557
2.102IleAsp: 2.102 ± 0.492
3.631IleGlu: 3.631 ± 0.907
3.249IlePhe: 3.249 ± 1.017
6.116IleGly: 6.116 ± 1.48
0.765IleHis: 0.765 ± 0.372
5.161IleIle: 5.161 ± 0.793
1.529IleLys: 1.529 ± 0.458
6.116IleLeu: 6.116 ± 1.105
2.485IleMet: 2.485 ± 0.635
2.294IleAsn: 2.294 ± 0.803
4.778IlePro: 4.778 ± 1.172
2.485IleGln: 2.485 ± 0.722
2.867IleArg: 2.867 ± 0.662
4.205IleSer: 4.205 ± 0.777
4.014IleThr: 4.014 ± 0.965
3.44IleVal: 3.44 ± 0.863
1.147IleTrp: 1.147 ± 0.429
3.823IleTyr: 3.823 ± 0.984
0.0IleXaa: 0.0 ± 0.0
Lys
3.44LysAla: 3.44 ± 0.886
1.529LysCys: 1.529 ± 0.765
1.147LysAsp: 1.147 ± 0.478
0.765LysGlu: 0.765 ± 0.344
1.338LysPhe: 1.338 ± 0.626
1.911LysGly: 1.911 ± 0.809
0.956LysHis: 0.956 ± 0.487
1.147LysIle: 1.147 ± 0.467
1.338LysLys: 1.338 ± 0.595
2.485LysLeu: 2.485 ± 0.787
0.382LysMet: 0.382 ± 0.265
0.956LysAsn: 0.956 ± 0.444
2.102LysPro: 2.102 ± 0.681
0.191LysGln: 0.191 ± 0.215
1.338LysArg: 1.338 ± 0.597
2.102LysSer: 2.102 ± 0.747
1.72LysThr: 1.72 ± 0.736
3.058LysVal: 3.058 ± 0.82
0.573LysTrp: 0.573 ± 0.341
1.338LysTyr: 1.338 ± 0.538
0.0LysXaa: 0.0 ± 0.0
Leu
14.526LeuAla: 14.526 ± 2.213
0.956LeuCys: 0.956 ± 0.434
2.867LeuAsp: 2.867 ± 0.831
4.014LeuGlu: 4.014 ± 0.969
5.352LeuPhe: 5.352 ± 1.355
7.836LeuGly: 7.836 ± 1.166
1.147LeuHis: 1.147 ± 0.525
6.881LeuIle: 6.881 ± 1.347
2.485LeuLys: 2.485 ± 0.856
7.836LeuLeu: 7.836 ± 1.361
4.396LeuMet: 4.396 ± 1.145
2.485LeuAsn: 2.485 ± 0.572
4.014LeuPro: 4.014 ± 1.034
1.338LeuGln: 1.338 ± 0.525
4.587LeuArg: 4.587 ± 1.086
6.498LeuSer: 6.498 ± 1.479
6.307LeuThr: 6.307 ± 1.024
11.659LeuVal: 11.659 ± 1.916
1.911LeuTrp: 1.911 ± 0.752
5.352LeuTyr: 5.352 ± 1.027
0.0LeuXaa: 0.0 ± 0.0
Met
4.396MetAla: 4.396 ± 0.817
0.382MetCys: 0.382 ± 0.249
1.72MetAsp: 1.72 ± 0.72
0.956MetGlu: 0.956 ± 0.401
0.573MetPhe: 0.573 ± 0.312
1.338MetGly: 1.338 ± 0.513
0.382MetHis: 0.382 ± 0.265
1.338MetIle: 1.338 ± 0.491
0.191MetLys: 0.191 ± 0.215
2.867MetLeu: 2.867 ± 0.605
0.0MetMet: 0.0 ± 0.0
0.573MetAsn: 0.573 ± 0.266
2.485MetPro: 2.485 ± 0.706
0.573MetGln: 0.573 ± 0.321
2.294MetArg: 2.294 ± 0.65
2.676MetSer: 2.676 ± 0.582
0.956MetThr: 0.956 ± 0.439
4.205MetVal: 4.205 ± 0.823
0.765MetTrp: 0.765 ± 0.42
2.102MetTyr: 2.102 ± 0.59
0.0MetXaa: 0.0 ± 0.0
Asn
2.676AsnAla: 2.676 ± 0.721
0.382AsnCys: 0.382 ± 0.272
0.765AsnAsp: 0.765 ± 0.357
1.338AsnGlu: 1.338 ± 0.62
1.911AsnPhe: 1.911 ± 0.661
3.249AsnGly: 3.249 ± 1.038
0.0AsnHis: 0.0 ± 0.0
1.529AsnIle: 1.529 ± 0.554
0.191AsnLys: 0.191 ± 0.21
2.867AsnLeu: 2.867 ± 0.624
1.529AsnMet: 1.529 ± 0.511
1.911AsnAsn: 1.911 ± 0.698
2.676AsnPro: 2.676 ± 0.625
0.573AsnGln: 0.573 ± 0.287
0.956AsnArg: 0.956 ± 0.35
1.338AsnSer: 1.338 ± 0.533
3.44AsnThr: 3.44 ± 1.023
2.676AsnVal: 2.676 ± 0.668
0.191AsnTrp: 0.191 ± 0.179
1.529AsnTyr: 1.529 ± 0.547
0.0AsnXaa: 0.0 ± 0.0
Pro
5.543ProAla: 5.543 ± 1.154
1.147ProCys: 1.147 ± 0.436
2.294ProAsp: 2.294 ± 0.638
1.147ProGlu: 1.147 ± 0.493
1.529ProPhe: 1.529 ± 0.402
2.294ProGly: 2.294 ± 0.525
0.765ProHis: 0.765 ± 0.435
3.631ProIle: 3.631 ± 0.628
2.294ProLys: 2.294 ± 0.616
6.307ProLeu: 6.307 ± 1.203
3.249ProMet: 3.249 ± 0.992
1.338ProAsn: 1.338 ± 0.561
3.249ProPro: 3.249 ± 0.952
1.529ProGln: 1.529 ± 0.489
1.147ProArg: 1.147 ± 0.5
3.631ProSer: 3.631 ± 0.734
4.205ProThr: 4.205 ± 0.852
3.058ProVal: 3.058 ± 0.881
0.956ProTrp: 0.956 ± 0.408
2.867ProTyr: 2.867 ± 0.668
0.0ProXaa: 0.0 ± 0.0
Gln
2.676GlnAla: 2.676 ± 0.715
0.191GlnCys: 0.191 ± 0.205
0.382GlnAsp: 0.382 ± 0.257
0.573GlnGlu: 0.573 ± 0.329
0.382GlnPhe: 0.382 ± 0.245
1.911GlnGly: 1.911 ± 0.68
0.573GlnHis: 0.573 ± 0.303
2.102GlnIle: 2.102 ± 0.654
0.573GlnLys: 0.573 ± 0.422
3.249GlnLeu: 3.249 ± 0.804
0.0GlnMet: 0.0 ± 0.0
0.191GlnAsn: 0.191 ± 0.182
0.956GlnPro: 0.956 ± 0.543
0.382GlnGln: 0.382 ± 0.241
0.382GlnArg: 0.382 ± 0.418
0.573GlnSer: 0.573 ± 0.258
1.529GlnThr: 1.529 ± 0.658
2.294GlnVal: 2.294 ± 0.668
0.191GlnTrp: 0.191 ± 0.194
1.911GlnTyr: 1.911 ± 0.842
0.0GlnXaa: 0.0 ± 0.0
Arg
5.352ArgAla: 5.352 ± 1.251
0.382ArgCys: 0.382 ± 0.243
1.72ArgAsp: 1.72 ± 0.659
2.102ArgGlu: 2.102 ± 0.581
1.338ArgPhe: 1.338 ± 0.691
3.249ArgGly: 3.249 ± 0.712
0.956ArgHis: 0.956 ± 0.431
1.72ArgIle: 1.72 ± 0.501
2.485ArgLys: 2.485 ± 0.703
5.352ArgLeu: 5.352 ± 0.977
1.529ArgMet: 1.529 ± 0.64
1.147ArgAsn: 1.147 ± 0.463
3.058ArgPro: 3.058 ± 0.82
0.956ArgGln: 0.956 ± 0.367
4.587ArgArg: 4.587 ± 1.109
2.294ArgSer: 2.294 ± 0.721
0.956ArgThr: 0.956 ± 0.487
7.263ArgVal: 7.263 ± 1.309
0.765ArgTrp: 0.765 ± 0.413
2.867ArgTyr: 2.867 ± 0.702
0.0ArgXaa: 0.0 ± 0.0
Ser
5.161SerAla: 5.161 ± 1.501
1.147SerCys: 1.147 ± 0.42
1.911SerAsp: 1.911 ± 0.541
2.102SerGlu: 2.102 ± 0.548
2.102SerPhe: 2.102 ± 0.644
5.161SerGly: 5.161 ± 1.559
0.191SerHis: 0.191 ± 0.151
3.44SerIle: 3.44 ± 1.037
1.529SerLys: 1.529 ± 0.708
7.454SerLeu: 7.454 ± 0.945
1.338SerMet: 1.338 ± 0.513
0.765SerAsn: 0.765 ± 0.34
4.014SerPro: 4.014 ± 0.821
1.529SerGln: 1.529 ± 0.557
3.823SerArg: 3.823 ± 0.747
4.014SerSer: 4.014 ± 1.179
3.631SerThr: 3.631 ± 0.854
5.543SerVal: 5.543 ± 0.903
1.72SerTrp: 1.72 ± 0.505
1.911SerTyr: 1.911 ± 0.518
0.0SerXaa: 0.0 ± 0.0
Thr
6.881ThrAla: 6.881 ± 0.915
1.147ThrCys: 1.147 ± 0.448
2.102ThrAsp: 2.102 ± 0.558
2.485ThrGlu: 2.485 ± 0.632
1.72ThrPhe: 1.72 ± 0.572
3.44ThrGly: 3.44 ± 0.732
0.956ThrHis: 0.956 ± 0.398
4.778ThrIle: 4.778 ± 1.701
0.573ThrLys: 0.573 ± 0.315
4.587ThrLeu: 4.587 ± 0.773
1.338ThrMet: 1.338 ± 0.49
1.911ThrAsn: 1.911 ± 0.709
4.778ThrPro: 4.778 ± 0.957
1.529ThrGln: 1.529 ± 0.568
1.72ThrArg: 1.72 ± 0.777
4.587ThrSer: 4.587 ± 1.413
4.205ThrThr: 4.205 ± 1.471
7.836ThrVal: 7.836 ± 0.793
1.147ThrTrp: 1.147 ± 0.348
4.778ThrTyr: 4.778 ± 1.165
0.0ThrXaa: 0.0 ± 0.0
Val
8.792ValAla: 8.792 ± 1.538
0.573ValCys: 0.573 ± 0.319
4.396ValAsp: 4.396 ± 0.837
3.249ValGlu: 3.249 ± 0.79
4.014ValPhe: 4.014 ± 0.824
8.983ValGly: 8.983 ± 1.05
1.529ValHis: 1.529 ± 0.599
5.925ValIle: 5.925 ± 1.147
4.205ValLys: 4.205 ± 0.996
11.086ValLeu: 11.086 ± 1.635
2.867ValMet: 2.867 ± 0.565
3.44ValAsn: 3.44 ± 1.004
4.969ValPro: 4.969 ± 0.934
1.72ValGln: 1.72 ± 0.58
5.543ValArg: 5.543 ± 1.11
6.307ValSer: 6.307 ± 0.944
7.836ValThr: 7.836 ± 1.427
12.232ValVal: 12.232 ± 1.73
1.72ValTrp: 1.72 ± 0.589
4.587ValTyr: 4.587 ± 1.117
0.0ValXaa: 0.0 ± 0.0
Trp
2.102TrpAla: 2.102 ± 0.638
0.191TrpCys: 0.191 ± 0.194
1.529TrpAsp: 1.529 ± 0.741
0.573TrpGlu: 0.573 ± 0.322
0.191TrpPhe: 0.191 ± 0.194
1.147TrpGly: 1.147 ± 0.448
0.191TrpHis: 0.191 ± 0.186
0.956TrpIle: 0.956 ± 0.392
0.191TrpLys: 0.191 ± 0.188
2.102TrpLeu: 2.102 ± 0.603
0.191TrpMet: 0.191 ± 0.199
0.0TrpAsn: 0.0 ± 0.0
0.765TrpPro: 0.765 ± 0.334
0.573TrpGln: 0.573 ± 0.266
0.765TrpArg: 0.765 ± 0.457
0.956TrpSer: 0.956 ± 0.396
0.765TrpThr: 0.765 ± 0.288
1.529TrpVal: 1.529 ± 0.39
0.191TrpTrp: 0.191 ± 0.172
0.956TrpTyr: 0.956 ± 0.454
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.543TyrAla: 5.543 ± 1.236
0.382TyrCys: 0.382 ± 0.275
1.338TyrAsp: 1.338 ± 0.526
1.147TyrGlu: 1.147 ± 0.531
2.485TyrPhe: 2.485 ± 0.696
4.396TyrGly: 4.396 ± 0.742
0.382TyrHis: 0.382 ± 0.258
5.352TyrIle: 5.352 ± 1.112
1.338TyrLys: 1.338 ± 0.494
5.543TyrLeu: 5.543 ± 0.951
1.911TyrMet: 1.911 ± 0.519
2.867TyrAsn: 2.867 ± 0.87
1.338TyrPro: 1.338 ± 0.41
1.338TyrGln: 1.338 ± 0.47
2.485TyrArg: 2.485 ± 0.85
2.676TyrSer: 2.676 ± 0.592
2.676TyrThr: 2.676 ± 0.714
6.881TyrVal: 6.881 ± 1.789
0.382TyrTrp: 0.382 ± 0.243
5.734TyrTyr: 5.734 ± 1.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 31 proteins (5233 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski