Amino acid dipepetide frequency for Streptomyces phage phiHau3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.134AlaAla: 14.134 ± 1.141
1.259AlaCys: 1.259 ± 0.33
7.767AlaAsp: 7.767 ± 0.871
9.516AlaGlu: 9.516 ± 0.75
3.359AlaPhe: 3.359 ± 0.486
8.816AlaGly: 8.816 ± 0.761
1.959AlaHis: 1.959 ± 0.329
4.618AlaIle: 4.618 ± 0.688
5.668AlaLys: 5.668 ± 0.751
11.685AlaLeu: 11.685 ± 1.054
3.289AlaMet: 3.289 ± 0.405
3.498AlaAsn: 3.498 ± 0.442
5.877AlaPro: 5.877 ± 0.831
3.638AlaGln: 3.638 ± 0.561
6.997AlaArg: 6.997 ± 0.897
5.248AlaSer: 5.248 ± 0.63
6.787AlaThr: 6.787 ± 0.76
7.137AlaVal: 7.137 ± 0.79
2.099AlaTrp: 2.099 ± 0.34
3.149AlaTyr: 3.149 ± 0.591
0.0AlaXaa: 0.0 ± 0.0
Cys
0.77CysAla: 0.77 ± 0.295
0.07CysCys: 0.07 ± 0.061
0.7CysAsp: 0.7 ± 0.256
0.63CysGlu: 0.63 ± 0.184
0.21CysPhe: 0.21 ± 0.128
1.399CysGly: 1.399 ± 0.335
0.28CysHis: 0.28 ± 0.15
0.28CysIle: 0.28 ± 0.15
0.42CysLys: 0.42 ± 0.195
0.42CysLeu: 0.42 ± 0.169
0.0CysMet: 0.0 ± 0.0
0.07CysAsn: 0.07 ± 0.072
1.12CysPro: 1.12 ± 0.352
0.28CysGln: 0.28 ± 0.169
0.7CysArg: 0.7 ± 0.257
0.56CysSer: 0.56 ± 0.218
0.63CysThr: 0.63 ± 0.248
0.63CysVal: 0.63 ± 0.26
0.14CysTrp: 0.14 ± 0.108
0.28CysTyr: 0.28 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
7.697AspAla: 7.697 ± 0.865
0.56AspCys: 0.56 ± 0.239
4.198AspAsp: 4.198 ± 0.485
4.828AspGlu: 4.828 ± 0.636
2.099AspPhe: 2.099 ± 0.308
5.598AspGly: 5.598 ± 0.618
0.84AspHis: 0.84 ± 0.322
2.379AspIle: 2.379 ± 0.45
2.519AspLys: 2.519 ± 0.345
6.507AspLeu: 6.507 ± 0.702
1.05AspMet: 1.05 ± 0.299
1.12AspAsn: 1.12 ± 0.236
4.198AspPro: 4.198 ± 0.587
1.609AspGln: 1.609 ± 0.322
3.778AspArg: 3.778 ± 0.415
3.149AspSer: 3.149 ± 0.366
3.848AspThr: 3.848 ± 0.436
4.548AspVal: 4.548 ± 0.669
1.679AspTrp: 1.679 ± 0.376
1.819AspTyr: 1.819 ± 0.394
0.0AspXaa: 0.0 ± 0.0
Glu
8.396GluAla: 8.396 ± 1.102
0.77GluCys: 0.77 ± 0.216
4.408GluAsp: 4.408 ± 0.431
6.227GluGlu: 6.227 ± 0.944
1.889GluPhe: 1.889 ± 0.372
4.898GluGly: 4.898 ± 0.498
1.539GluHis: 1.539 ± 0.332
3.289GluIle: 3.289 ± 0.535
2.519GluLys: 2.519 ± 0.348
7.697GluLeu: 7.697 ± 0.827
1.609GluMet: 1.609 ± 0.361
0.98GluAsn: 0.98 ± 0.256
3.009GluPro: 3.009 ± 0.545
3.918GluGln: 3.918 ± 0.524
5.668GluArg: 5.668 ± 0.754
2.729GluSer: 2.729 ± 0.386
3.638GluThr: 3.638 ± 0.58
5.528GluVal: 5.528 ± 0.665
0.63GluTrp: 0.63 ± 0.202
1.889GluTyr: 1.889 ± 0.445
0.0GluXaa: 0.0 ± 0.0
Phe
3.009PheAla: 3.009 ± 0.379
0.28PheCys: 0.28 ± 0.138
1.959PheAsp: 1.959 ± 0.368
2.379PheGlu: 2.379 ± 0.414
1.12PhePhe: 1.12 ± 0.311
2.869PheGly: 2.869 ± 0.41
0.35PheHis: 0.35 ± 0.132
1.259PheIle: 1.259 ± 0.296
1.05PheLys: 1.05 ± 0.301
2.029PheLeu: 2.029 ± 0.517
0.49PheMet: 0.49 ± 0.21
1.189PheAsn: 1.189 ± 0.265
1.259PhePro: 1.259 ± 0.299
1.05PheGln: 1.05 ± 0.24
1.679PheArg: 1.679 ± 0.41
1.819PheSer: 1.819 ± 0.335
2.169PheThr: 2.169 ± 0.37
1.539PheVal: 1.539 ± 0.314
0.63PheTrp: 0.63 ± 0.201
0.56PheTyr: 0.56 ± 0.206
0.0PheXaa: 0.0 ± 0.0
Gly
6.857GlyAla: 6.857 ± 0.779
0.7GlyCys: 0.7 ± 0.211
5.178GlyAsp: 5.178 ± 0.692
4.898GlyGlu: 4.898 ± 0.5
3.219GlyPhe: 3.219 ± 0.521
7.067GlyGly: 7.067 ± 0.925
1.889GlyHis: 1.889 ± 0.418
3.359GlyIle: 3.359 ± 0.737
3.289GlyLys: 3.289 ± 0.487
7.067GlyLeu: 7.067 ± 0.71
1.539GlyMet: 1.539 ± 0.282
2.309GlyAsn: 2.309 ± 0.332
4.548GlyPro: 4.548 ± 1.261
3.359GlyGln: 3.359 ± 0.391
5.737GlyArg: 5.737 ± 0.759
4.618GlySer: 4.618 ± 0.647
5.458GlyThr: 5.458 ± 0.478
6.297GlyVal: 6.297 ± 0.674
2.659GlyTrp: 2.659 ± 0.49
2.589GlyTyr: 2.589 ± 0.546
0.0GlyXaa: 0.0 ± 0.0
His
2.029HisAla: 2.029 ± 0.426
0.42HisCys: 0.42 ± 0.163
1.259HisAsp: 1.259 ± 0.294
1.259HisGlu: 1.259 ± 0.339
0.77HisPhe: 0.77 ± 0.245
1.889HisGly: 1.889 ± 0.375
0.56HisHis: 0.56 ± 0.218
0.63HisIle: 0.63 ± 0.21
0.14HisLys: 0.14 ± 0.102
1.609HisLeu: 1.609 ± 0.401
0.28HisMet: 0.28 ± 0.143
0.56HisAsn: 0.56 ± 0.196
0.91HisPro: 0.91 ± 0.28
0.91HisGln: 0.91 ± 0.25
1.679HisArg: 1.679 ± 0.407
1.189HisSer: 1.189 ± 0.435
0.63HisThr: 0.63 ± 0.23
1.609HisVal: 1.609 ± 0.363
0.63HisTrp: 0.63 ± 0.223
0.49HisTyr: 0.49 ± 0.172
0.0HisXaa: 0.0 ± 0.0
Ile
4.898IleAla: 4.898 ± 0.599
0.56IleCys: 0.56 ± 0.184
3.498IleAsp: 3.498 ± 0.538
4.128IleGlu: 4.128 ± 0.62
1.189IlePhe: 1.189 ± 0.399
3.009IleGly: 3.009 ± 0.547
0.84IleHis: 0.84 ± 0.287
1.189IleIle: 1.189 ± 0.315
1.609IleLys: 1.609 ± 0.494
2.939IleLeu: 2.939 ± 0.757
0.56IleMet: 0.56 ± 0.184
1.189IleAsn: 1.189 ± 0.285
1.679IlePro: 1.679 ± 0.369
1.05IleGln: 1.05 ± 0.258
2.309IleArg: 2.309 ± 0.375
2.309IleSer: 2.309 ± 0.394
2.519IleThr: 2.519 ± 0.489
3.219IleVal: 3.219 ± 0.509
0.49IleTrp: 0.49 ± 0.177
1.05IleTyr: 1.05 ± 0.258
0.0IleXaa: 0.0 ± 0.0
Lys
4.478LysAla: 4.478 ± 0.619
0.21LysCys: 0.21 ± 0.102
2.659LysAsp: 2.659 ± 0.457
1.959LysGlu: 1.959 ± 0.291
1.12LysPhe: 1.12 ± 0.297
5.318LysGly: 5.318 ± 0.616
0.56LysHis: 0.56 ± 0.184
1.329LysIle: 1.329 ± 0.353
1.679LysLys: 1.679 ± 0.417
3.079LysLeu: 3.079 ± 0.506
0.42LysMet: 0.42 ± 0.171
0.84LysAsn: 0.84 ± 0.294
2.379LysPro: 2.379 ± 0.478
1.05LysGln: 1.05 ± 0.254
4.198LysArg: 4.198 ± 0.744
1.399LysSer: 1.399 ± 0.298
2.379LysThr: 2.379 ± 0.447
3.428LysVal: 3.428 ± 0.691
0.7LysTrp: 0.7 ± 0.272
1.12LysTyr: 1.12 ± 0.275
0.0LysXaa: 0.0 ± 0.0
Leu
11.405LeuAla: 11.405 ± 1.049
0.98LeuCys: 0.98 ± 0.351
6.157LeuAsp: 6.157 ± 0.664
4.898LeuGlu: 4.898 ± 0.572
1.259LeuPhe: 1.259 ± 0.273
6.927LeuGly: 6.927 ± 0.877
1.539LeuHis: 1.539 ± 0.294
4.128LeuIle: 4.128 ± 0.48
3.708LeuLys: 3.708 ± 0.953
6.367LeuLeu: 6.367 ± 0.716
1.469LeuMet: 1.469 ± 0.281
2.799LeuAsn: 2.799 ± 0.441
5.318LeuPro: 5.318 ± 0.587
2.589LeuGln: 2.589 ± 0.367
6.507LeuArg: 6.507 ± 0.789
6.017LeuSer: 6.017 ± 0.627
6.017LeuThr: 6.017 ± 0.776
5.668LeuVal: 5.668 ± 0.667
1.469LeuTrp: 1.469 ± 0.263
1.749LeuTyr: 1.749 ± 0.291
0.0LeuXaa: 0.0 ± 0.0
Met
3.359MetAla: 3.359 ± 0.502
0.07MetCys: 0.07 ± 0.084
0.63MetAsp: 0.63 ± 0.17
1.12MetGlu: 1.12 ± 0.255
0.35MetPhe: 0.35 ± 0.148
1.469MetGly: 1.469 ± 0.249
0.35MetHis: 0.35 ± 0.167
1.12MetIle: 1.12 ± 0.265
0.7MetLys: 0.7 ± 0.235
1.819MetLeu: 1.819 ± 0.451
0.49MetMet: 0.49 ± 0.165
0.63MetAsn: 0.63 ± 0.23
1.539MetPro: 1.539 ± 0.305
0.49MetGln: 0.49 ± 0.21
1.189MetArg: 1.189 ± 0.435
2.169MetSer: 2.169 ± 0.358
1.679MetThr: 1.679 ± 0.482
1.12MetVal: 1.12 ± 0.27
0.28MetTrp: 0.28 ± 0.11
0.21MetTyr: 0.21 ± 0.12
0.0MetXaa: 0.0 ± 0.0
Asn
3.289AsnAla: 3.289 ± 0.51
0.28AsnCys: 0.28 ± 0.169
1.05AsnAsp: 1.05 ± 0.249
2.379AsnGlu: 2.379 ± 0.463
0.56AsnPhe: 0.56 ± 0.214
2.729AsnGly: 2.729 ± 0.424
0.42AsnHis: 0.42 ± 0.188
0.98AsnIle: 0.98 ± 0.233
0.98AsnLys: 0.98 ± 0.205
2.099AsnLeu: 2.099 ± 0.333
0.28AsnMet: 0.28 ± 0.13
0.63AsnAsn: 0.63 ± 0.219
1.609AsnPro: 1.609 ± 0.339
0.84AsnGln: 0.84 ± 0.279
1.05AsnArg: 1.05 ± 0.25
1.259AsnSer: 1.259 ± 0.296
1.259AsnThr: 1.259 ± 0.263
1.819AsnVal: 1.819 ± 0.381
0.63AsnTrp: 0.63 ± 0.181
1.05AsnTyr: 1.05 ± 0.224
0.0AsnXaa: 0.0 ± 0.0
Pro
7.067ProAla: 7.067 ± 1.041
0.77ProCys: 0.77 ± 0.275
3.079ProAsp: 3.079 ± 0.489
3.778ProGlu: 3.778 ± 0.605
1.259ProPhe: 1.259 ± 0.377
4.478ProGly: 4.478 ± 0.641
0.77ProHis: 0.77 ± 0.249
2.029ProIle: 2.029 ± 0.433
2.449ProLys: 2.449 ± 0.545
3.289ProLeu: 3.289 ± 0.457
1.749ProMet: 1.749 ± 0.374
0.91ProAsn: 0.91 ± 0.28
3.568ProPro: 3.568 ± 0.695
2.939ProGln: 2.939 ± 0.394
2.519ProArg: 2.519 ± 0.416
3.568ProSer: 3.568 ± 0.615
3.638ProThr: 3.638 ± 0.718
3.778ProVal: 3.778 ± 0.548
0.56ProTrp: 0.56 ± 0.183
1.469ProTyr: 1.469 ± 0.296
0.0ProXaa: 0.0 ± 0.0
Gln
5.598GlnAla: 5.598 ± 0.714
0.28GlnCys: 0.28 ± 0.172
1.959GlnAsp: 1.959 ± 0.445
2.099GlnGlu: 2.099 ± 0.45
1.259GlnPhe: 1.259 ± 0.232
2.659GlnGly: 2.659 ± 0.495
0.63GlnHis: 0.63 ± 0.216
1.959GlnIle: 1.959 ± 0.371
1.12GlnLys: 1.12 ± 0.271
2.449GlnLeu: 2.449 ± 0.402
0.91GlnMet: 0.91 ± 0.248
0.63GlnAsn: 0.63 ± 0.207
1.609GlnPro: 1.609 ± 0.421
0.84GlnGln: 0.84 ± 0.284
2.519GlnArg: 2.519 ± 0.477
2.309GlnSer: 2.309 ± 0.443
1.889GlnThr: 1.889 ± 0.399
3.149GlnVal: 3.149 ± 0.564
0.49GlnTrp: 0.49 ± 0.154
0.7GlnTyr: 0.7 ± 0.258
0.0GlnXaa: 0.0 ± 0.0
Arg
6.297ArgAla: 6.297 ± 0.757
0.7ArgCys: 0.7 ± 0.25
4.268ArgAsp: 4.268 ± 0.654
5.877ArgGlu: 5.877 ± 0.711
2.729ArgPhe: 2.729 ± 0.438
4.408ArgGly: 4.408 ± 0.563
2.099ArgHis: 2.099 ± 0.566
2.659ArgIle: 2.659 ± 0.473
4.058ArgLys: 4.058 ± 0.587
7.067ArgLeu: 7.067 ± 0.823
1.749ArgMet: 1.749 ± 0.325
1.609ArgAsn: 1.609 ± 0.38
2.799ArgPro: 2.799 ± 0.544
2.379ArgGln: 2.379 ± 0.53
6.717ArgArg: 6.717 ± 0.92
3.359ArgSer: 3.359 ± 0.481
3.638ArgThr: 3.638 ± 0.517
5.178ArgVal: 5.178 ± 0.578
1.12ArgTrp: 1.12 ± 0.3
2.169ArgTyr: 2.169 ± 0.343
0.0ArgXaa: 0.0 ± 0.0
Ser
7.207SerAla: 7.207 ± 0.634
0.35SerCys: 0.35 ± 0.173
2.939SerAsp: 2.939 ± 0.54
3.079SerGlu: 3.079 ± 0.438
1.889SerPhe: 1.889 ± 0.396
5.248SerGly: 5.248 ± 0.572
1.329SerHis: 1.329 ± 0.532
2.379SerIle: 2.379 ± 0.491
1.539SerLys: 1.539 ± 0.457
5.108SerLeu: 5.108 ± 0.591
0.91SerMet: 0.91 ± 0.263
1.749SerAsn: 1.749 ± 0.324
2.169SerPro: 2.169 ± 0.37
1.329SerGln: 1.329 ± 0.279
4.058SerArg: 4.058 ± 0.567
3.708SerSer: 3.708 ± 0.843
3.918SerThr: 3.918 ± 0.665
4.338SerVal: 4.338 ± 0.58
1.259SerTrp: 1.259 ± 0.24
1.819SerTyr: 1.819 ± 0.404
0.0SerXaa: 0.0 ± 0.0
Thr
6.647ThrAla: 6.647 ± 0.675
0.63ThrCys: 0.63 ± 0.306
3.568ThrAsp: 3.568 ± 0.461
3.498ThrGlu: 3.498 ± 0.49
2.239ThrPhe: 2.239 ± 0.389
5.528ThrGly: 5.528 ± 1.004
1.05ThrHis: 1.05 ± 0.338
2.379ThrIle: 2.379 ± 0.476
1.749ThrLys: 1.749 ± 0.279
6.717ThrLeu: 6.717 ± 0.628
0.77ThrMet: 0.77 ± 0.221
0.98ThrAsn: 0.98 ± 0.276
4.828ThrPro: 4.828 ± 0.782
2.169ThrGln: 2.169 ± 0.326
3.848ThrArg: 3.848 ± 0.648
3.918ThrSer: 3.918 ± 0.832
3.498ThrThr: 3.498 ± 0.515
5.528ThrVal: 5.528 ± 0.582
0.84ThrTrp: 0.84 ± 0.248
1.609ThrTyr: 1.609 ± 0.376
0.0ThrXaa: 0.0 ± 0.0
Val
8.116ValAla: 8.116 ± 0.62
0.21ValCys: 0.21 ± 0.107
4.968ValAsp: 4.968 ± 0.629
4.898ValGlu: 4.898 ± 0.694
1.329ValPhe: 1.329 ± 0.297
4.688ValGly: 4.688 ± 0.459
1.329ValHis: 1.329 ± 0.396
3.079ValIle: 3.079 ± 0.42
3.568ValLys: 3.568 ± 0.469
5.668ValLeu: 5.668 ± 0.755
2.309ValMet: 2.309 ± 0.437
1.819ValAsn: 1.819 ± 0.435
3.988ValPro: 3.988 ± 0.522
2.869ValGln: 2.869 ± 0.464
6.087ValArg: 6.087 ± 0.569
4.128ValSer: 4.128 ± 0.56
5.388ValThr: 5.388 ± 0.536
5.038ValVal: 5.038 ± 0.542
1.329ValTrp: 1.329 ± 0.302
1.399ValTyr: 1.399 ± 0.36
0.0ValXaa: 0.0 ± 0.0
Trp
2.029TrpAla: 2.029 ± 0.451
0.21TrpCys: 0.21 ± 0.125
1.329TrpAsp: 1.329 ± 0.275
1.12TrpGlu: 1.12 ± 0.225
0.21TrpPhe: 0.21 ± 0.131
1.469TrpGly: 1.469 ± 0.344
0.63TrpHis: 0.63 ± 0.186
0.49TrpIle: 0.49 ± 0.219
0.77TrpLys: 0.77 ± 0.218
1.399TrpLeu: 1.399 ± 0.321
0.49TrpMet: 0.49 ± 0.154
0.77TrpAsn: 0.77 ± 0.258
0.49TrpPro: 0.49 ± 0.156
0.7TrpGln: 0.7 ± 0.241
1.679TrpArg: 1.679 ± 0.388
1.329TrpSer: 1.329 ± 0.287
1.329TrpThr: 1.329 ± 0.283
1.399TrpVal: 1.399 ± 0.26
0.21TrpTrp: 0.21 ± 0.163
0.21TrpTyr: 0.21 ± 0.115
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.219TyrAla: 3.219 ± 0.51
0.28TyrCys: 0.28 ± 0.134
2.449TyrAsp: 2.449 ± 0.399
2.659TyrGlu: 2.659 ± 0.486
0.63TyrPhe: 0.63 ± 0.238
2.169TyrGly: 2.169 ± 0.378
0.49TyrHis: 0.49 ± 0.195
0.7TyrIle: 0.7 ± 0.25
0.77TyrLys: 0.77 ± 0.222
1.959TyrLeu: 1.959 ± 0.421
0.35TyrMet: 0.35 ± 0.171
0.91TyrAsn: 0.91 ± 0.267
0.77TyrPro: 0.77 ± 0.252
1.05TyrGln: 1.05 ± 0.295
1.959TyrArg: 1.959 ± 0.459
1.539TyrSer: 1.539 ± 0.483
1.679TyrThr: 1.679 ± 0.321
1.329TyrVal: 1.329 ± 0.361
0.42TyrTrp: 0.42 ± 0.166
0.7TyrTyr: 0.7 ± 0.222
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (14293 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski