Amino acid dipepetide frequency for Klebsiella phage 3LV2017

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.4AlaAla: 14.4 ± 1.467
1.036AlaCys: 1.036 ± 0.329
6.423AlaAsp: 6.423 ± 0.958
6.526AlaGlu: 6.526 ± 1.024
4.247AlaPhe: 4.247 ± 0.889
9.013AlaGly: 9.013 ± 2.038
2.072AlaHis: 2.072 ± 0.521
5.283AlaIle: 5.283 ± 0.624
4.765AlaLys: 4.765 ± 0.788
9.634AlaLeu: 9.634 ± 1.48
2.693AlaMet: 2.693 ± 0.546
3.729AlaAsn: 3.729 ± 0.473
4.04AlaPro: 4.04 ± 0.611
4.144AlaGln: 4.144 ± 0.72
6.112AlaArg: 6.112 ± 0.883
5.283AlaSer: 5.283 ± 1.212
5.698AlaThr: 5.698 ± 0.731
8.184AlaVal: 8.184 ± 1.003
1.658AlaTrp: 1.658 ± 0.376
1.865AlaTyr: 1.865 ± 0.516
0.0AlaXaa: 0.0 ± 0.0
Cys
0.725CysAla: 0.725 ± 0.279
0.207CysCys: 0.207 ± 0.159
0.518CysAsp: 0.518 ± 0.31
0.518CysGlu: 0.518 ± 0.227
0.622CysPhe: 0.622 ± 0.229
0.725CysGly: 0.725 ± 0.289
0.207CysHis: 0.207 ± 0.125
0.104CysIle: 0.104 ± 0.087
0.414CysLys: 0.414 ± 0.207
0.725CysLeu: 0.725 ± 0.266
0.104CysMet: 0.104 ± 0.109
0.0CysAsn: 0.0 ± 0.0
0.622CysPro: 0.622 ± 0.205
0.104CysGln: 0.104 ± 0.112
0.311CysArg: 0.311 ± 0.164
0.622CysSer: 0.622 ± 0.276
0.622CysThr: 0.622 ± 0.262
0.207CysVal: 0.207 ± 0.128
0.207CysTrp: 0.207 ± 0.142
0.104CysTyr: 0.104 ± 0.102
0.0CysXaa: 0.0 ± 0.0
Asp
5.905AspAla: 5.905 ± 0.475
0.622AspCys: 0.622 ± 0.258
3.833AspAsp: 3.833 ± 0.814
4.455AspGlu: 4.455 ± 0.644
2.486AspPhe: 2.486 ± 0.495
5.698AspGly: 5.698 ± 0.786
1.243AspHis: 1.243 ± 0.428
2.797AspIle: 2.797 ± 0.429
3.004AspLys: 3.004 ± 0.474
4.455AspLeu: 4.455 ± 0.781
1.865AspMet: 1.865 ± 0.469
3.004AspAsn: 3.004 ± 0.591
2.693AspPro: 2.693 ± 0.519
1.865AspGln: 1.865 ± 0.355
2.175AspArg: 2.175 ± 0.494
2.901AspSer: 2.901 ± 0.39
3.833AspThr: 3.833 ± 0.708
4.455AspVal: 4.455 ± 0.855
1.14AspTrp: 1.14 ± 0.319
2.072AspTyr: 2.072 ± 0.432
0.0AspXaa: 0.0 ± 0.0
Glu
6.941GluAla: 6.941 ± 0.848
0.104GluCys: 0.104 ± 0.105
2.175GluAsp: 2.175 ± 0.545
3.626GluGlu: 3.626 ± 0.653
2.279GluPhe: 2.279 ± 0.522
3.522GluGly: 3.522 ± 0.623
0.829GluHis: 0.829 ± 0.274
3.937GluIle: 3.937 ± 0.687
3.419GluLys: 3.419 ± 0.638
5.491GluLeu: 5.491 ± 1.025
2.59GluMet: 2.59 ± 0.362
2.279GluAsn: 2.279 ± 0.569
1.658GluPro: 1.658 ± 0.35
2.59GluGln: 2.59 ± 0.534
4.351GluArg: 4.351 ± 0.623
3.522GluSer: 3.522 ± 0.805
4.04GluThr: 4.04 ± 0.64
3.419GluVal: 3.419 ± 0.601
1.347GluTrp: 1.347 ± 0.299
1.968GluTyr: 1.968 ± 0.53
0.0GluXaa: 0.0 ± 0.0
Phe
2.901PheAla: 2.901 ± 0.426
0.0PheCys: 0.0 ± 0.0
2.383PheAsp: 2.383 ± 0.487
1.658PheGlu: 1.658 ± 0.389
1.45PhePhe: 1.45 ± 0.434
2.175PheGly: 2.175 ± 0.487
0.414PheHis: 0.414 ± 0.194
2.383PheIle: 2.383 ± 0.475
1.865PheLys: 1.865 ± 0.424
2.383PheLeu: 2.383 ± 0.443
1.036PheMet: 1.036 ± 0.346
2.486PheAsn: 2.486 ± 0.555
1.036PhePro: 1.036 ± 0.326
0.932PheGln: 0.932 ± 0.292
2.383PheArg: 2.383 ± 0.345
3.419PheSer: 3.419 ± 0.461
2.486PheThr: 2.486 ± 0.599
1.45PheVal: 1.45 ± 0.334
0.622PheTrp: 0.622 ± 0.307
0.518PheTyr: 0.518 ± 0.205
0.0PheXaa: 0.0 ± 0.0
Gly
8.08GlyAla: 8.08 ± 1.467
0.725GlyCys: 0.725 ± 0.271
6.112GlyAsp: 6.112 ± 0.826
5.698GlyGlu: 5.698 ± 0.707
3.419GlyPhe: 3.419 ± 0.677
8.08GlyGly: 8.08 ± 1.143
0.622GlyHis: 0.622 ± 0.215
3.937GlyIle: 3.937 ± 0.728
4.558GlyLys: 4.558 ± 0.754
4.973GlyLeu: 4.973 ± 0.664
2.486GlyMet: 2.486 ± 0.373
3.004GlyAsn: 3.004 ± 0.499
2.072GlyPro: 2.072 ± 0.527
3.004GlyGln: 3.004 ± 0.556
4.765GlyArg: 4.765 ± 0.836
4.247GlySer: 4.247 ± 0.535
4.662GlyThr: 4.662 ± 0.762
4.765GlyVal: 4.765 ± 0.693
1.14GlyTrp: 1.14 ± 0.284
1.761GlyTyr: 1.761 ± 0.464
0.0GlyXaa: 0.0 ± 0.0
His
1.036HisAla: 1.036 ± 0.359
0.104HisCys: 0.104 ± 0.106
0.829HisAsp: 0.829 ± 0.341
1.243HisGlu: 1.243 ± 0.371
0.725HisPhe: 0.725 ± 0.311
1.968HisGly: 1.968 ± 0.398
0.311HisHis: 0.311 ± 0.201
0.829HisIle: 0.829 ± 0.273
0.829HisLys: 0.829 ± 0.282
1.658HisLeu: 1.658 ± 0.478
0.622HisMet: 0.622 ± 0.281
0.622HisAsn: 0.622 ± 0.275
0.414HisPro: 0.414 ± 0.183
1.14HisGln: 1.14 ± 0.398
1.45HisArg: 1.45 ± 0.337
1.036HisSer: 1.036 ± 0.406
0.932HisThr: 0.932 ± 0.363
1.036HisVal: 1.036 ± 0.376
0.207HisTrp: 0.207 ± 0.121
0.518HisTyr: 0.518 ± 0.218
0.0HisXaa: 0.0 ± 0.0
Ile
6.008IleAla: 6.008 ± 0.877
0.414IleCys: 0.414 ± 0.284
4.662IleAsp: 4.662 ± 0.651
3.626IleGlu: 3.626 ± 0.749
0.932IlePhe: 0.932 ± 0.287
4.973IleGly: 4.973 ± 0.935
0.518IleHis: 0.518 ± 0.288
2.383IleIle: 2.383 ± 0.548
1.968IleLys: 1.968 ± 0.385
3.833IleLeu: 3.833 ± 0.539
1.14IleMet: 1.14 ± 0.235
3.004IleAsn: 3.004 ± 0.729
1.761IlePro: 1.761 ± 0.399
1.554IleGln: 1.554 ± 0.433
2.901IleArg: 2.901 ± 0.648
3.937IleSer: 3.937 ± 0.526
4.869IleThr: 4.869 ± 0.88
1.865IleVal: 1.865 ± 0.372
0.725IleTrp: 0.725 ± 0.262
1.968IleTyr: 1.968 ± 0.57
0.0IleXaa: 0.0 ± 0.0
Lys
6.008LysAla: 6.008 ± 1.092
0.207LysCys: 0.207 ± 0.14
2.279LysAsp: 2.279 ± 0.455
2.175LysGlu: 2.175 ± 0.654
1.243LysPhe: 1.243 ± 0.33
3.108LysGly: 3.108 ± 0.576
0.829LysHis: 0.829 ± 0.328
2.901LysIle: 2.901 ± 0.529
4.765LysLys: 4.765 ± 0.937
3.522LysLeu: 3.522 ± 0.897
1.243LysMet: 1.243 ± 0.388
2.59LysAsn: 2.59 ± 0.399
2.797LysPro: 2.797 ± 0.465
1.658LysGln: 1.658 ± 0.419
3.729LysArg: 3.729 ± 0.819
2.072LysSer: 2.072 ± 0.422
3.522LysThr: 3.522 ± 0.425
3.004LysVal: 3.004 ± 0.693
0.518LysTrp: 0.518 ± 0.229
1.865LysTyr: 1.865 ± 0.414
0.0LysXaa: 0.0 ± 0.0
Leu
8.288LeuAla: 8.288 ± 1.237
1.14LeuCys: 1.14 ± 0.344
4.455LeuAsp: 4.455 ± 0.667
4.558LeuGlu: 4.558 ± 0.74
2.486LeuPhe: 2.486 ± 0.508
4.973LeuGly: 4.973 ± 1.005
1.554LeuHis: 1.554 ± 0.393
4.247LeuIle: 4.247 ± 0.933
4.351LeuLys: 4.351 ± 0.661
7.148LeuLeu: 7.148 ± 0.82
3.108LeuMet: 3.108 ± 0.453
3.419LeuAsn: 3.419 ± 0.434
4.04LeuPro: 4.04 ± 0.757
2.901LeuGln: 2.901 ± 0.584
8.184LeuArg: 8.184 ± 1.25
6.216LeuSer: 6.216 ± 1.157
7.148LeuThr: 7.148 ± 0.999
2.901LeuVal: 2.901 ± 0.603
1.036LeuTrp: 1.036 ± 0.388
2.901LeuTyr: 2.901 ± 0.499
0.0LeuXaa: 0.0 ± 0.0
Met
3.419MetAla: 3.419 ± 0.551
0.207MetCys: 0.207 ± 0.142
1.347MetAsp: 1.347 ± 0.439
1.45MetGlu: 1.45 ± 0.355
1.036MetPhe: 1.036 ± 0.249
1.968MetGly: 1.968 ± 0.393
0.414MetHis: 0.414 ± 0.262
1.658MetIle: 1.658 ± 0.353
1.554MetLys: 1.554 ± 0.392
3.211MetLeu: 3.211 ± 0.691
0.725MetMet: 0.725 ± 0.333
1.036MetAsn: 1.036 ± 0.288
1.243MetPro: 1.243 ± 0.413
0.518MetGln: 0.518 ± 0.348
2.175MetArg: 2.175 ± 0.447
1.761MetSer: 1.761 ± 0.403
1.968MetThr: 1.968 ± 0.465
1.347MetVal: 1.347 ± 0.407
0.207MetTrp: 0.207 ± 0.174
0.414MetTyr: 0.414 ± 0.208
0.0MetXaa: 0.0 ± 0.0
Asn
2.486AsnAla: 2.486 ± 0.481
0.104AsnCys: 0.104 ± 0.099
2.693AsnAsp: 2.693 ± 0.485
2.175AsnGlu: 2.175 ± 0.571
1.658AsnPhe: 1.658 ± 0.381
3.937AsnGly: 3.937 ± 0.612
0.932AsnHis: 0.932 ± 0.348
2.693AsnIle: 2.693 ± 0.809
1.658AsnLys: 1.658 ± 0.436
3.419AsnLeu: 3.419 ± 0.651
1.14AsnMet: 1.14 ± 0.315
1.865AsnAsn: 1.865 ± 0.394
2.383AsnPro: 2.383 ± 0.636
1.036AsnGln: 1.036 ± 0.275
3.419AsnArg: 3.419 ± 0.644
2.279AsnSer: 2.279 ± 0.556
2.175AsnThr: 2.175 ± 0.471
2.175AsnVal: 2.175 ± 0.523
0.518AsnTrp: 0.518 ± 0.233
1.243AsnTyr: 1.243 ± 0.359
0.0AsnXaa: 0.0 ± 0.0
Pro
4.558ProAla: 4.558 ± 0.825
0.414ProCys: 0.414 ± 0.226
3.004ProAsp: 3.004 ± 0.512
3.626ProGlu: 3.626 ± 0.703
1.14ProPhe: 1.14 ± 0.368
2.279ProGly: 2.279 ± 0.384
1.14ProHis: 1.14 ± 0.411
1.554ProIle: 1.554 ± 0.33
1.761ProLys: 1.761 ± 0.503
3.729ProLeu: 3.729 ± 0.434
0.932ProMet: 0.932 ± 0.26
1.347ProAsn: 1.347 ± 0.34
2.072ProPro: 2.072 ± 0.49
1.554ProGln: 1.554 ± 0.343
2.901ProArg: 2.901 ± 0.539
2.072ProSer: 2.072 ± 0.406
1.347ProThr: 1.347 ± 0.401
3.315ProVal: 3.315 ± 0.909
0.414ProTrp: 0.414 ± 0.19
2.072ProTyr: 2.072 ± 0.544
0.0ProXaa: 0.0 ± 0.0
Gln
5.18GlnAla: 5.18 ± 0.892
0.104GlnCys: 0.104 ± 0.098
1.658GlnAsp: 1.658 ± 0.436
1.761GlnGlu: 1.761 ± 0.342
1.243GlnPhe: 1.243 ± 0.424
2.279GlnGly: 2.279 ± 0.411
0.518GlnHis: 0.518 ± 0.234
2.072GlnIle: 2.072 ± 0.531
1.968GlnLys: 1.968 ± 0.538
5.387GlnLeu: 5.387 ± 0.862
0.932GlnMet: 0.932 ± 0.412
0.622GlnAsn: 0.622 ± 0.237
1.45GlnPro: 1.45 ± 0.35
2.175GlnGln: 2.175 ± 0.519
3.729GlnArg: 3.729 ± 0.626
3.108GlnSer: 3.108 ± 0.498
1.968GlnThr: 1.968 ± 0.43
1.865GlnVal: 1.865 ± 0.51
0.414GlnTrp: 0.414 ± 0.212
0.932GlnTyr: 0.932 ± 0.277
0.0GlnXaa: 0.0 ± 0.0
Arg
7.044ArgAla: 7.044 ± 0.945
0.104ArgCys: 0.104 ± 0.112
2.486ArgAsp: 2.486 ± 0.453
4.247ArgGlu: 4.247 ± 0.981
1.761ArgPhe: 1.761 ± 0.378
4.351ArgGly: 4.351 ± 0.587
2.279ArgHis: 2.279 ± 0.511
3.315ArgIle: 3.315 ± 0.612
3.108ArgLys: 3.108 ± 0.596
6.734ArgLeu: 6.734 ± 0.739
1.761ArgMet: 1.761 ± 0.502
2.693ArgAsn: 2.693 ± 0.526
1.761ArgPro: 1.761 ± 0.369
3.937ArgGln: 3.937 ± 0.691
5.283ArgArg: 5.283 ± 1.173
4.144ArgSer: 4.144 ± 0.778
3.937ArgThr: 3.937 ± 0.613
5.801ArgVal: 5.801 ± 0.738
1.554ArgTrp: 1.554 ± 0.477
2.383ArgTyr: 2.383 ± 0.396
0.0ArgXaa: 0.0 ± 0.0
Ser
7.977SerAla: 7.977 ± 1.353
0.311SerCys: 0.311 ± 0.139
4.973SerAsp: 4.973 ± 0.594
3.108SerGlu: 3.108 ± 0.781
2.072SerPhe: 2.072 ± 0.454
6.423SerGly: 6.423 ± 0.876
1.45SerHis: 1.45 ± 0.408
3.108SerIle: 3.108 ± 0.516
2.383SerLys: 2.383 ± 0.479
5.18SerLeu: 5.18 ± 0.649
1.14SerMet: 1.14 ± 0.307
1.865SerAsn: 1.865 ± 0.451
2.693SerPro: 2.693 ± 0.535
2.901SerGln: 2.901 ± 0.474
2.797SerArg: 2.797 ± 0.468
3.833SerSer: 3.833 ± 0.646
3.626SerThr: 3.626 ± 0.702
4.144SerVal: 4.144 ± 0.491
0.932SerTrp: 0.932 ± 0.302
1.45SerTyr: 1.45 ± 0.373
0.0SerXaa: 0.0 ± 0.0
Thr
6.526ThrAla: 6.526 ± 1.043
0.0ThrCys: 0.0 ± 0.0
4.662ThrAsp: 4.662 ± 0.773
3.937ThrGlu: 3.937 ± 0.704
1.658ThrPhe: 1.658 ± 0.428
5.698ThrGly: 5.698 ± 0.629
0.518ThrHis: 0.518 ± 0.223
3.833ThrIle: 3.833 ± 0.756
2.175ThrLys: 2.175 ± 0.6
5.698ThrLeu: 5.698 ± 0.588
1.036ThrMet: 1.036 ± 0.331
1.761ThrAsn: 1.761 ± 0.528
4.351ThrPro: 4.351 ± 0.563
2.175ThrGln: 2.175 ± 0.529
4.662ThrArg: 4.662 ± 0.637
4.04ThrSer: 4.04 ± 0.591
3.108ThrThr: 3.108 ± 0.522
5.076ThrVal: 5.076 ± 0.708
0.725ThrTrp: 0.725 ± 0.291
1.658ThrTyr: 1.658 ± 0.429
0.0ThrXaa: 0.0 ± 0.0
Val
5.801ValAla: 5.801 ± 0.862
0.725ValCys: 0.725 ± 0.215
3.626ValAsp: 3.626 ± 0.605
3.108ValGlu: 3.108 ± 0.557
2.072ValPhe: 2.072 ± 0.393
3.626ValGly: 3.626 ± 0.854
0.518ValHis: 0.518 ± 0.27
4.04ValIle: 4.04 ± 0.581
3.522ValLys: 3.522 ± 0.716
4.455ValLeu: 4.455 ± 0.587
2.175ValMet: 2.175 ± 0.438
2.901ValAsn: 2.901 ± 0.521
1.658ValPro: 1.658 ± 0.41
2.279ValGln: 2.279 ± 0.503
3.626ValArg: 3.626 ± 0.67
4.662ValSer: 4.662 ± 0.695
5.18ValThr: 5.18 ± 0.951
2.175ValVal: 2.175 ± 0.467
1.554ValTrp: 1.554 ± 0.454
1.554ValTyr: 1.554 ± 0.328
0.0ValXaa: 0.0 ± 0.0
Trp
1.243TrpAla: 1.243 ± 0.324
0.311TrpCys: 0.311 ± 0.171
0.518TrpAsp: 0.518 ± 0.238
1.14TrpGlu: 1.14 ± 0.346
0.725TrpPhe: 0.725 ± 0.264
0.725TrpGly: 0.725 ± 0.256
0.725TrpHis: 0.725 ± 0.215
1.036TrpIle: 1.036 ± 0.307
0.518TrpLys: 0.518 ± 0.307
1.347TrpLeu: 1.347 ± 0.366
0.207TrpMet: 0.207 ± 0.163
0.622TrpAsn: 0.622 ± 0.288
1.036TrpPro: 1.036 ± 0.254
1.243TrpGln: 1.243 ± 0.303
1.554TrpArg: 1.554 ± 0.401
0.725TrpSer: 0.725 ± 0.283
0.518TrpThr: 0.518 ± 0.293
0.932TrpVal: 0.932 ± 0.309
0.414TrpTrp: 0.414 ± 0.181
0.518TrpTyr: 0.518 ± 0.238
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.383TyrAla: 2.383 ± 0.35
0.829TyrCys: 0.829 ± 0.335
1.865TyrAsp: 1.865 ± 0.666
1.45TyrGlu: 1.45 ± 0.332
0.725TyrPhe: 0.725 ± 0.34
2.59TyrGly: 2.59 ± 0.606
0.414TyrHis: 0.414 ± 0.185
0.932TyrIle: 0.932 ± 0.295
1.45TyrLys: 1.45 ± 0.327
2.072TyrLeu: 2.072 ± 0.566
0.622TyrMet: 0.622 ± 0.241
1.14TyrAsn: 1.14 ± 0.292
1.45TyrPro: 1.45 ± 0.455
1.658TyrGln: 1.658 ± 0.414
2.175TyrArg: 2.175 ± 0.562
2.486TyrSer: 2.486 ± 0.441
1.658TyrThr: 1.658 ± 0.463
1.14TyrVal: 1.14 ± 0.412
0.725TyrTrp: 0.725 ± 0.22
1.554TyrTyr: 1.554 ± 0.508
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 36 proteins (9654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski