Amino acid dipepetide frequency for Coriobacteriaceae bacterium EMTCatB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.708AlaAla: 18.708 ± 0.314
1.562AlaCys: 1.562 ± 0.075
6.927AlaAsp: 6.927 ± 0.115
8.74AlaGlu: 8.74 ± 0.166
4.114AlaPhe: 4.114 ± 0.093
10.539AlaGly: 10.539 ± 0.202
2.424AlaHis: 2.424 ± 0.072
5.933AlaIle: 5.933 ± 0.108
3.567AlaLys: 3.567 ± 0.092
14.677AlaLeu: 14.677 ± 0.203
2.927AlaMet: 2.927 ± 0.077
1.908AlaAsn: 1.908 ± 0.066
5.204AlaPro: 5.204 ± 0.121
3.224AlaGln: 3.224 ± 0.085
10.512AlaArg: 10.512 ± 0.189
7.414AlaSer: 7.414 ± 0.136
5.964AlaThr: 5.964 ± 0.115
11.871AlaVal: 11.871 ± 0.164
1.479AlaTrp: 1.479 ± 0.063
2.986AlaTyr: 2.986 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
1.218CysAla: 1.218 ± 0.049
0.154CysCys: 0.154 ± 0.016
0.695CysAsp: 0.695 ± 0.037
0.637CysGlu: 0.637 ± 0.036
0.288CysPhe: 0.288 ± 0.024
1.233CysGly: 1.233 ± 0.058
0.671CysHis: 0.671 ± 0.111
0.369CysIle: 0.369 ± 0.025
0.281CysLys: 0.281 ± 0.021
0.688CysLeu: 0.688 ± 0.04
0.186CysMet: 0.186 ± 0.017
0.194CysAsn: 0.194 ± 0.019
0.671CysPro: 0.671 ± 0.041
0.224CysGln: 0.224 ± 0.022
0.729CysArg: 0.729 ± 0.038
0.69CysSer: 0.69 ± 0.041
0.55CysThr: 0.55 ± 0.032
0.939CysVal: 0.939 ± 0.047
0.114CysTrp: 0.114 ± 0.013
0.239CysTyr: 0.239 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
8.145AspAla: 8.145 ± 0.138
0.545AspCys: 0.545 ± 0.037
3.147AspAsp: 3.147 ± 0.08
4.443AspGlu: 4.443 ± 0.112
1.692AspPhe: 1.692 ± 0.064
5.289AspGly: 5.289 ± 0.11
0.941AspHis: 0.941 ± 0.036
2.273AspIle: 2.273 ± 0.066
1.325AspLys: 1.325 ± 0.056
5.964AspLeu: 5.964 ± 0.118
1.033AspMet: 1.033 ± 0.041
0.722AspAsn: 0.722 ± 0.038
3.66AspPro: 3.66 ± 0.09
1.068AspGln: 1.068 ± 0.04
4.119AspArg: 4.119 ± 0.093
2.139AspSer: 2.139 ± 0.074
2.346AspThr: 2.346 ± 0.066
5.777AspVal: 5.777 ± 0.112
0.61AspTrp: 0.61 ± 0.035
1.153AspTyr: 1.153 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
9.079GluAla: 9.079 ± 0.172
0.554GluCys: 0.554 ± 0.031
3.097GluAsp: 3.097 ± 0.082
4.7GluGlu: 4.7 ± 0.125
1.73GluPhe: 1.73 ± 0.056
4.831GluGly: 4.831 ± 0.101
1.734GluHis: 1.734 ± 0.05
3.495GluIle: 3.495 ± 0.097
1.919GluLys: 1.919 ± 0.072
6.139GluLeu: 6.139 ± 0.102
1.642GluMet: 1.642 ± 0.049
1.167GluAsn: 1.167 ± 0.056
3.432GluPro: 3.432 ± 0.087
2.346GluGln: 2.346 ± 0.073
7.642GluArg: 7.642 ± 0.143
3.171GluSer: 3.171 ± 0.085
3.247GluThr: 3.247 ± 0.089
5.806GluVal: 5.806 ± 0.105
0.653GluTrp: 0.653 ± 0.036
1.321GluTyr: 1.321 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.714PheAla: 3.714 ± 0.088
0.344PheCys: 0.344 ± 0.029
2.208PheAsp: 2.208 ± 0.067
2.27PheGlu: 2.27 ± 0.067
1.104PhePhe: 1.104 ± 0.049
3.191PheGly: 3.191 ± 0.074
0.472PheHis: 0.472 ± 0.03
1.126PheIle: 1.126 ± 0.051
0.825PheLys: 0.825 ± 0.039
2.547PheLeu: 2.547 ± 0.08
0.595PheMet: 0.595 ± 0.036
0.628PheAsn: 0.628 ± 0.037
1.392PhePro: 1.392 ± 0.058
0.639PheGln: 0.639 ± 0.04
1.812PheArg: 1.812 ± 0.058
1.763PheSer: 1.763 ± 0.056
1.5PheThr: 1.5 ± 0.055
3.175PheVal: 3.175 ± 0.08
0.409PheTrp: 0.409 ± 0.029
0.793PheTyr: 0.793 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
10.099GlyAla: 10.099 ± 0.176
1.131GlyCys: 1.131 ± 0.048
4.389GlyAsp: 4.389 ± 0.095
5.213GlyGlu: 5.213 ± 0.094
2.901GlyPhe: 2.901 ± 0.075
7.158GlyGly: 7.158 ± 0.162
1.689GlyHis: 1.689 ± 0.056
4.342GlyIle: 4.342 ± 0.105
2.816GlyLys: 2.816 ± 0.084
8.286GlyLeu: 8.286 ± 0.131
2.118GlyMet: 2.118 ± 0.063
1.519GlyAsn: 1.519 ± 0.051
3.509GlyPro: 3.509 ± 0.087
2.014GlyGln: 2.014 ± 0.049
6.559GlyArg: 6.559 ± 0.14
5.16GlySer: 5.16 ± 0.109
4.865GlyThr: 4.865 ± 0.097
8.442GlyVal: 8.442 ± 0.13
1.108GlyTrp: 1.108 ± 0.046
2.215GlyTyr: 2.215 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.69HisAla: 2.69 ± 0.078
0.195HisCys: 0.195 ± 0.018
1.372HisAsp: 1.372 ± 0.048
1.401HisGlu: 1.401 ± 0.05
0.545HisPhe: 0.545 ± 0.034
2.127HisGly: 2.127 ± 0.072
0.503HisHis: 0.503 ± 0.035
0.76HisIle: 0.76 ± 0.037
0.496HisLys: 0.496 ± 0.038
1.817HisLeu: 1.817 ± 0.053
0.311HisMet: 0.311 ± 0.026
0.445HisAsn: 0.445 ± 0.032
1.338HisPro: 1.338 ± 0.057
0.481HisGln: 0.481 ± 0.034
1.66HisArg: 1.66 ± 0.075
0.896HisSer: 0.896 ± 0.041
0.961HisThr: 0.961 ± 0.046
1.96HisVal: 1.96 ± 0.067
0.176HisTrp: 0.176 ± 0.016
0.414HisTyr: 0.414 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.679IleAla: 6.679 ± 0.127
0.393IleCys: 0.393 ± 0.025
3.122IleAsp: 3.122 ± 0.08
3.674IleGlu: 3.674 ± 0.1
1.073IlePhe: 1.073 ± 0.044
4.029IleGly: 4.029 ± 0.099
0.795IleHis: 0.795 ± 0.035
1.593IleIle: 1.593 ± 0.062
1.272IleLys: 1.272 ± 0.051
3.195IleLeu: 3.195 ± 0.089
0.753IleMet: 0.753 ± 0.044
0.76IleAsn: 0.76 ± 0.042
2.083IlePro: 2.083 ± 0.067
1.019IleGln: 1.019 ± 0.045
2.892IleArg: 2.892 ± 0.079
2.237IleSer: 2.237 ± 0.064
2.168IleThr: 2.168 ± 0.064
4.728IleVal: 4.728 ± 0.102
0.306IleTrp: 0.306 ± 0.026
0.715IleTyr: 0.715 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
3.39LysAla: 3.39 ± 0.089
0.261LysCys: 0.261 ± 0.027
1.618LysAsp: 1.618 ± 0.057
1.824LysGlu: 1.824 ± 0.073
0.603LysPhe: 0.603 ± 0.034
2.328LysGly: 2.328 ± 0.076
0.686LysHis: 0.686 ± 0.041
1.267LysIle: 1.267 ± 0.046
1.124LysLys: 1.124 ± 0.052
2.232LysLeu: 2.232 ± 0.073
0.67LysMet: 0.67 ± 0.038
0.57LysAsn: 0.57 ± 0.033
1.756LysPro: 1.756 ± 0.063
0.995LysGln: 0.995 ± 0.043
2.918LysArg: 2.918 ± 0.074
1.403LysSer: 1.403 ± 0.052
1.794LysThr: 1.794 ± 0.061
2.407LysVal: 2.407 ± 0.074
0.264LysTrp: 0.264 ± 0.02
0.577LysTyr: 0.577 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
14.727LeuAla: 14.727 ± 0.204
0.872LeuCys: 0.872 ± 0.041
5.866LeuAsp: 5.866 ± 0.099
6.465LeuGlu: 6.465 ± 0.133
2.831LeuPhe: 2.831 ± 0.078
8.626LeuGly: 8.626 ± 0.13
1.732LeuHis: 1.732 ± 0.056
3.381LeuIle: 3.381 ± 0.075
3.227LeuLys: 3.227 ± 0.081
8.963LeuLeu: 8.963 ± 0.159
1.949LeuMet: 1.949 ± 0.063
1.403LeuAsn: 1.403 ± 0.048
5.041LeuPro: 5.041 ± 0.098
2.331LeuGln: 2.331 ± 0.068
6.825LeuArg: 6.825 ± 0.13
5.394LeuSer: 5.394 ± 0.109
4.896LeuThr: 4.896 ± 0.08
9.471LeuVal: 9.471 ± 0.143
0.881LeuTrp: 0.881 ± 0.043
1.911LeuTyr: 1.911 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.646MetAla: 2.646 ± 0.069
0.201MetCys: 0.201 ± 0.02
1.006MetAsp: 1.006 ± 0.039
1.142MetGlu: 1.142 ± 0.044
0.521MetPhe: 0.521 ± 0.03
1.756MetGly: 1.756 ± 0.056
0.458MetHis: 0.458 ± 0.028
0.771MetIle: 0.771 ± 0.036
0.621MetLys: 0.621 ± 0.033
2.407MetLeu: 2.407 ± 0.061
0.512MetMet: 0.512 ± 0.03
0.431MetAsn: 0.431 ± 0.024
1.367MetPro: 1.367 ± 0.054
0.633MetGln: 0.633 ± 0.035
2.143MetArg: 2.143 ± 0.062
1.348MetSer: 1.348 ± 0.045
1.385MetThr: 1.385 ± 0.051
1.609MetVal: 1.609 ± 0.065
0.235MetTrp: 0.235 ± 0.02
0.429MetTyr: 0.429 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.282AsnAla: 2.282 ± 0.066
0.235AsnCys: 0.235 ± 0.024
0.872AsnAsp: 0.872 ± 0.042
0.965AsnGlu: 0.965 ± 0.043
0.414AsnPhe: 0.414 ± 0.028
1.443AsnGly: 1.443 ± 0.056
0.353AsnHis: 0.353 ± 0.022
0.771AsnIle: 0.771 ± 0.038
0.509AsnLys: 0.509 ± 0.036
1.805AsnLeu: 1.805 ± 0.064
0.342AsnMet: 0.342 ± 0.022
0.358AsnAsn: 0.358 ± 0.027
1.249AsnPro: 1.249 ± 0.051
0.443AsnGln: 0.443 ± 0.028
1.269AsnArg: 1.269 ± 0.046
0.675AsnSer: 0.675 ± 0.039
0.923AsnThr: 0.923 ± 0.047
1.645AsnVal: 1.645 ± 0.059
0.215AsnTrp: 0.215 ± 0.023
0.4AsnTyr: 0.4 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
5.928ProAla: 5.928 ± 0.123
0.51ProCys: 0.51 ± 0.031
3.538ProAsp: 3.538 ± 0.11
4.223ProGlu: 4.223 ± 0.099
1.7ProPhe: 1.7 ± 0.053
4.673ProGly: 4.673 ± 0.085
1.204ProHis: 1.204 ± 0.059
1.848ProIle: 1.848 ± 0.059
1.557ProLys: 1.557 ± 0.05
4.463ProLeu: 4.463 ± 0.098
0.961ProMet: 0.961 ± 0.043
0.99ProAsn: 0.99 ± 0.041
2.317ProPro: 2.317 ± 0.081
1.31ProGln: 1.31 ± 0.051
3.399ProArg: 3.399 ± 0.091
3.081ProSer: 3.081 ± 0.083
2.346ProThr: 2.346 ± 0.067
4.816ProVal: 4.816 ± 0.08
0.641ProTrp: 0.641 ± 0.038
1.233ProTyr: 1.233 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.482GlnAla: 3.482 ± 0.094
0.243GlnCys: 0.243 ± 0.025
1.117GlnAsp: 1.117 ± 0.043
1.511GlnGlu: 1.511 ± 0.053
0.74GlnPhe: 0.74 ± 0.042
1.824GlnGly: 1.824 ± 0.068
0.561GlnHis: 0.561 ± 0.037
1.243GlnIle: 1.243 ± 0.047
0.784GlnLys: 0.784 ± 0.038
2.163GlnLeu: 2.163 ± 0.065
0.704GlnMet: 0.704 ± 0.037
0.416GlnAsn: 0.416 ± 0.029
1.443GlnPro: 1.443 ± 0.048
1.071GlnGln: 1.071 ± 0.052
2.273GlnArg: 2.273 ± 0.078
1.263GlnSer: 1.263 ± 0.049
1.377GlnThr: 1.377 ± 0.041
2.29GlnVal: 2.29 ± 0.072
0.309GlnTrp: 0.309 ± 0.024
0.557GlnTyr: 0.557 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
9.433ArgAla: 9.433 ± 0.169
0.89ArgCys: 0.89 ± 0.05
4.367ArgAsp: 4.367 ± 0.101
5.656ArgGlu: 5.656 ± 0.133
2.764ArgPhe: 2.764 ± 0.067
5.754ArgGly: 5.754 ± 0.127
1.703ArgHis: 1.703 ± 0.072
4.253ArgIle: 4.253 ± 0.092
2.138ArgLys: 2.138 ± 0.074
8.244ArgLeu: 8.244 ± 0.145
2.024ArgMet: 2.024 ± 0.059
1.307ArgAsn: 1.307 ± 0.057
3.884ArgPro: 3.884 ± 0.09
2.029ArgGln: 2.029 ± 0.07
7.169ArgArg: 7.169 ± 0.22
4.572ArgSer: 4.572 ± 0.119
3.768ArgThr: 3.768 ± 0.088
7.015ArgVal: 7.015 ± 0.132
0.909ArgTrp: 0.909 ± 0.048
2.199ArgTyr: 2.199 ± 0.073
0.0ArgXaa: 0.0 ± 0.0
Ser
6.67SerAla: 6.67 ± 0.128
0.632SerCys: 0.632 ± 0.036
3.032SerAsp: 3.032 ± 0.078
3.345SerGlu: 3.345 ± 0.073
1.795SerPhe: 1.795 ± 0.056
5.623SerGly: 5.623 ± 0.102
1.055SerHis: 1.055 ± 0.044
2.376SerIle: 2.376 ± 0.069
1.406SerLys: 1.406 ± 0.054
4.845SerLeu: 4.845 ± 0.1
1.195SerMet: 1.195 ± 0.045
0.938SerAsn: 0.938 ± 0.047
2.679SerPro: 2.679 ± 0.07
1.348SerGln: 1.348 ± 0.056
4.107SerArg: 4.107 ± 0.102
3.455SerSer: 3.455 ± 0.09
2.954SerThr: 2.954 ± 0.082
4.947SerVal: 4.947 ± 0.105
0.773SerTrp: 0.773 ± 0.04
1.265SerTyr: 1.265 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.88ThrAla: 5.88 ± 0.127
0.556ThrCys: 0.556 ± 0.039
2.539ThrAsp: 2.539 ± 0.069
2.711ThrGlu: 2.711 ± 0.071
1.652ThrPhe: 1.652 ± 0.058
5.133ThrGly: 5.133 ± 0.109
1.077ThrHis: 1.077 ± 0.045
2.456ThrIle: 2.456 ± 0.071
1.392ThrLys: 1.392 ± 0.054
5.044ThrLeu: 5.044 ± 0.103
1.073ThrMet: 1.073 ± 0.04
0.997ThrAsn: 0.997 ± 0.049
3.05ThrPro: 3.05 ± 0.081
1.198ThrGln: 1.198 ± 0.049
3.473ThrArg: 3.473 ± 0.084
2.691ThrSer: 2.691 ± 0.08
2.881ThrThr: 2.881 ± 0.091
5.019ThrVal: 5.019 ± 0.103
0.552ThrTrp: 0.552 ± 0.039
1.318ThrTyr: 1.318 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
12.067ValAla: 12.067 ± 0.207
1.108ValCys: 1.108 ± 0.05
5.444ValAsp: 5.444 ± 0.106
6.595ValGlu: 6.595 ± 0.104
2.952ValPhe: 2.952 ± 0.088
7.08ValGly: 7.08 ± 0.138
1.783ValHis: 1.783 ± 0.058
4.018ValIle: 4.018 ± 0.09
2.579ValLys: 2.579 ± 0.079
9.77ValLeu: 9.77 ± 0.136
1.993ValMet: 1.993 ± 0.061
1.709ValAsn: 1.709 ± 0.056
4.861ValPro: 4.861 ± 0.092
1.986ValGln: 1.986 ± 0.06
7.719ValArg: 7.719 ± 0.108
5.211ValSer: 5.211 ± 0.097
5.135ValThr: 5.135 ± 0.108
10.349ValVal: 10.349 ± 0.173
0.965ValTrp: 0.965 ± 0.04
1.893ValTyr: 1.893 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
1.169TrpAla: 1.169 ± 0.052
0.129TrpCys: 0.129 ± 0.016
0.579TrpAsp: 0.579 ± 0.037
0.568TrpGlu: 0.568 ± 0.036
0.358TrpPhe: 0.358 ± 0.028
0.811TrpGly: 0.811 ± 0.043
0.214TrpHis: 0.214 ± 0.019
0.452TrpIle: 0.452 ± 0.031
0.348TrpLys: 0.348 ± 0.026
1.229TrpLeu: 1.229 ± 0.05
0.299TrpMet: 0.299 ± 0.022
0.243TrpAsn: 0.243 ± 0.027
0.567TrpPro: 0.567 ± 0.033
0.38TrpGln: 0.38 ± 0.027
1.071TrpArg: 1.071 ± 0.046
0.72TrpSer: 0.72 ± 0.039
0.55TrpThr: 0.55 ± 0.033
0.898TrpVal: 0.898 ± 0.041
0.215TrpTrp: 0.215 ± 0.023
0.246TrpTyr: 0.246 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.671TyrAla: 2.671 ± 0.083
0.257TyrCys: 0.257 ± 0.026
1.457TyrAsp: 1.457 ± 0.06
1.62TyrGlu: 1.62 ± 0.059
0.728TyrPhe: 0.728 ± 0.038
2.087TyrGly: 2.087 ± 0.061
0.494TyrHis: 0.494 ± 0.031
0.757TyrIle: 0.757 ± 0.037
0.501TyrLys: 0.501 ± 0.029
2.317TyrLeu: 2.317 ± 0.071
0.333TyrMet: 0.333 ± 0.023
0.465TyrAsn: 0.465 ± 0.032
1.236TyrPro: 1.236 ± 0.055
0.632TyrGln: 0.632 ± 0.034
1.786TyrArg: 1.786 ± 0.056
1.157TyrSer: 1.157 ± 0.053
1.084TyrThr: 1.084 ± 0.046
2.052TyrVal: 2.052 ± 0.067
0.232TyrTrp: 0.232 ± 0.019
0.659TyrTyr: 0.659 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1659 proteins (552506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski