Amino acid dipepetide frequency for Richelia intracellularis HH01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.765AlaAla: 5.765 ± 0.109
0.862AlaCys: 0.862 ± 0.039
3.193AlaAsp: 3.193 ± 0.073
4.222AlaGlu: 4.222 ± 0.095
2.41AlaPhe: 2.41 ± 0.067
4.726AlaGly: 4.726 ± 0.096
1.291AlaHis: 1.291 ± 0.048
6.45AlaIle: 6.45 ± 0.103
3.948AlaLys: 3.948 ± 0.094
7.3AlaLeu: 7.3 ± 0.111
1.598AlaMet: 1.598 ± 0.053
3.221AlaAsn: 3.221 ± 0.084
2.173AlaPro: 2.173 ± 0.062
3.044AlaGln: 3.044 ± 0.075
3.372AlaArg: 3.372 ± 0.087
4.355AlaSer: 4.355 ± 0.103
3.684AlaThr: 3.684 ± 0.089
4.856AlaVal: 4.856 ± 0.105
0.838AlaTrp: 0.838 ± 0.039
2.251AlaTyr: 2.251 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.62CysAla: 0.62 ± 0.036
0.187CysCys: 0.187 ± 0.018
0.62CysAsp: 0.62 ± 0.029
0.534CysGlu: 0.534 ± 0.03
0.459CysPhe: 0.459 ± 0.028
0.944CysGly: 0.944 ± 0.046
0.312CysHis: 0.312 ± 0.023
0.862CysIle: 0.862 ± 0.041
0.543CysLys: 0.543 ± 0.032
1.303CysLeu: 1.303 ± 0.051
0.267CysMet: 0.267 ± 0.022
0.59CysAsn: 0.59 ± 0.032
0.588CysPro: 0.588 ± 0.034
0.683CysGln: 0.683 ± 0.033
0.598CysArg: 0.598 ± 0.029
0.832CysSer: 0.832 ± 0.033
0.63CysThr: 0.63 ± 0.037
0.6CysVal: 0.6 ± 0.034
0.182CysTrp: 0.182 ± 0.016
0.421CysTyr: 0.421 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
2.771AspAla: 2.771 ± 0.072
0.65AspCys: 0.65 ± 0.028
1.897AspAsp: 1.897 ± 0.065
2.572AspGlu: 2.572 ± 0.075
2.191AspPhe: 2.191 ± 0.063
2.834AspGly: 2.834 ± 0.086
0.753AspHis: 0.753 ± 0.038
4.152AspIle: 4.152 ± 0.084
2.59AspLys: 2.59 ± 0.071
5.399AspLeu: 5.399 ± 0.108
0.999AspMet: 0.999 ± 0.041
2.316AspAsn: 2.316 ± 0.063
1.941AspPro: 1.941 ± 0.053
1.376AspGln: 1.376 ± 0.051
2.271AspArg: 2.271 ± 0.064
2.887AspSer: 2.887 ± 0.069
2.378AspThr: 2.378 ± 0.06
2.804AspVal: 2.804 ± 0.061
0.757AspTrp: 0.757 ± 0.036
1.9AspTyr: 1.9 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
4.314GluAla: 4.314 ± 0.092
0.544GluCys: 0.544 ± 0.029
2.605GluAsp: 2.605 ± 0.076
4.041GluGlu: 4.041 ± 0.106
2.275GluPhe: 2.275 ± 0.073
3.009GluGly: 3.009 ± 0.069
1.06GluHis: 1.06 ± 0.043
5.488GluIle: 5.488 ± 0.098
4.092GluLys: 4.092 ± 0.092
6.765GluLeu: 6.765 ± 0.133
1.468GluMet: 1.468 ± 0.054
3.068GluAsn: 3.068 ± 0.066
2.059GluPro: 2.059 ± 0.058
2.742GluGln: 2.742 ± 0.076
2.923GluArg: 2.923 ± 0.07
3.216GluSer: 3.216 ± 0.075
3.135GluThr: 3.135 ± 0.074
4.145GluVal: 4.145 ± 0.081
0.785GluTrp: 0.785 ± 0.036
1.999GluTyr: 1.999 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.817PheAla: 2.817 ± 0.064
0.663PheCys: 0.663 ± 0.035
2.091PheAsp: 2.091 ± 0.064
1.847PheGlu: 1.847 ± 0.061
1.563PhePhe: 1.563 ± 0.06
2.879PheGly: 2.879 ± 0.07
0.86PheHis: 0.86 ± 0.048
2.946PheIle: 2.946 ± 0.074
1.712PheLys: 1.712 ± 0.059
4.202PheLeu: 4.202 ± 0.104
0.757PheMet: 0.757 ± 0.04
1.795PheAsn: 1.795 ± 0.06
1.904PhePro: 1.904 ± 0.056
1.774PheGln: 1.774 ± 0.049
1.717PheArg: 1.717 ± 0.055
2.959PheSer: 2.959 ± 0.081
2.335PheThr: 2.335 ± 0.068
2.223PheVal: 2.223 ± 0.066
0.676PheTrp: 0.676 ± 0.039
1.374PheTyr: 1.374 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.254GlyAla: 4.254 ± 0.11
0.924GlyCys: 0.924 ± 0.043
3.18GlyAsp: 3.18 ± 0.083
3.963GlyGlu: 3.963 ± 0.081
3.08GlyPhe: 3.08 ± 0.071
4.646GlyGly: 4.646 ± 0.099
1.346GlyHis: 1.346 ± 0.055
6.092GlyIle: 6.092 ± 0.111
4.866GlyLys: 4.866 ± 0.116
6.889GlyLeu: 6.889 ± 0.111
1.67GlyMet: 1.67 ± 0.056
3.16GlyAsn: 3.16 ± 0.074
1.503GlyPro: 1.503 ± 0.045
2.425GlyGln: 2.425 ± 0.063
3.201GlyArg: 3.201 ± 0.084
3.956GlySer: 3.956 ± 0.085
3.45GlyThr: 3.45 ± 0.076
4.669GlyVal: 4.669 ± 0.093
1.012GlyTrp: 1.012 ± 0.046
2.438GlyTyr: 2.438 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.101HisAla: 1.101 ± 0.045
0.261HisCys: 0.261 ± 0.02
0.693HisAsp: 0.693 ± 0.033
0.892HisGlu: 0.892 ± 0.04
0.942HisPhe: 0.942 ± 0.043
1.348HisGly: 1.348 ± 0.049
0.641HisHis: 0.641 ± 0.036
1.643HisIle: 1.643 ± 0.056
1.075HisLys: 1.075 ± 0.038
2.41HisLeu: 2.41 ± 0.055
0.406HisMet: 0.406 ± 0.032
1.099HisAsn: 1.099 ± 0.047
1.304HisPro: 1.304 ± 0.044
1.156HisGln: 1.156 ± 0.038
1.054HisArg: 1.054 ± 0.041
1.401HisSer: 1.401 ± 0.053
1.112HisThr: 1.112 ± 0.044
1.027HisVal: 1.027 ± 0.041
0.321HisTrp: 0.321 ± 0.021
0.741HisTyr: 0.741 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.855IleAla: 6.855 ± 0.11
1.064IleCys: 1.064 ± 0.045
4.098IleAsp: 4.098 ± 0.086
4.504IleGlu: 4.504 ± 0.095
3.175IlePhe: 3.175 ± 0.083
5.251IleGly: 5.251 ± 0.105
1.668IleHis: 1.668 ± 0.048
6.109IleIle: 6.109 ± 0.122
4.005IleLys: 4.005 ± 0.09
8.292IleLeu: 8.292 ± 0.137
1.461IleMet: 1.461 ± 0.049
4.349IleAsn: 4.349 ± 0.094
4.244IlePro: 4.244 ± 0.082
3.402IleGln: 3.402 ± 0.089
3.682IleArg: 3.682 ± 0.086
6.007IleSer: 6.007 ± 0.11
4.982IleThr: 4.982 ± 0.115
4.719IleVal: 4.719 ± 0.093
0.969IleTrp: 0.969 ± 0.041
2.532IleTyr: 2.532 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
3.866LysAla: 3.866 ± 0.086
0.449LysCys: 0.449 ± 0.025
2.276LysAsp: 2.276 ± 0.076
3.382LysGlu: 3.382 ± 0.081
2.091LysPhe: 2.091 ± 0.075
3.058LysGly: 3.058 ± 0.074
1.03LysHis: 1.03 ± 0.043
4.619LysIle: 4.619 ± 0.102
2.986LysLys: 2.986 ± 0.084
6.498LysLeu: 6.498 ± 0.114
1.224LysMet: 1.224 ± 0.045
2.852LysAsn: 2.852 ± 0.072
2.432LysPro: 2.432 ± 0.065
2.993LysGln: 2.993 ± 0.087
2.555LysArg: 2.555 ± 0.068
3.596LysSer: 3.596 ± 0.088
3.215LysThr: 3.215 ± 0.078
3.876LysVal: 3.876 ± 0.098
0.581LysTrp: 0.581 ± 0.034
2.041LysTyr: 2.041 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
8.173LeuAla: 8.173 ± 0.118
1.129LeuCys: 1.129 ± 0.041
5.018LeuAsp: 5.018 ± 0.103
7.473LeuGlu: 7.473 ± 0.121
3.915LeuPhe: 3.915 ± 0.101
7.851LeuGly: 7.851 ± 0.129
2.101LeuHis: 2.101 ± 0.061
7.996LeuIle: 7.996 ± 0.137
5.93LeuLys: 5.93 ± 0.098
11.268LeuLeu: 11.268 ± 0.185
2.303LeuMet: 2.303 ± 0.067
4.689LeuAsn: 4.689 ± 0.102
5.539LeuPro: 5.539 ± 0.098
5.57LeuGln: 5.57 ± 0.116
5.077LeuArg: 5.077 ± 0.09
7.545LeuSer: 7.545 ± 0.126
5.904LeuThr: 5.904 ± 0.092
7.488LeuVal: 7.488 ± 0.122
1.286LeuTrp: 1.286 ± 0.049
2.861LeuTyr: 2.861 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
1.926MetAla: 1.926 ± 0.054
0.184MetCys: 0.184 ± 0.017
0.908MetAsp: 0.908 ± 0.036
1.271MetGlu: 1.271 ± 0.048
0.698MetPhe: 0.698 ± 0.035
1.862MetGly: 1.862 ± 0.062
0.382MetHis: 0.382 ± 0.027
1.525MetIle: 1.525 ± 0.05
1.136MetLys: 1.136 ± 0.044
2.194MetLeu: 2.194 ± 0.06
0.494MetMet: 0.494 ± 0.031
1.015MetAsn: 1.015 ± 0.043
0.999MetPro: 0.999 ± 0.04
0.967MetGln: 0.967 ± 0.044
1.0MetArg: 1.0 ± 0.041
1.54MetSer: 1.54 ± 0.049
1.294MetThr: 1.294 ± 0.051
1.578MetVal: 1.578 ± 0.051
0.192MetTrp: 0.192 ± 0.019
0.516MetTyr: 0.516 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.806AsnAla: 2.806 ± 0.062
0.62AsnCys: 0.62 ± 0.034
1.764AsnAsp: 1.764 ± 0.05
1.725AsnGlu: 1.725 ± 0.045
2.002AsnPhe: 2.002 ± 0.059
2.592AsnGly: 2.592 ± 0.082
1.276AsnHis: 1.276 ± 0.051
4.198AsnIle: 4.198 ± 0.093
2.592AsnLys: 2.592 ± 0.071
5.962AsnLeu: 5.962 ± 0.142
1.007AsnMet: 1.007 ± 0.048
2.737AsnAsn: 2.737 ± 0.069
2.784AsnPro: 2.784 ± 0.071
2.662AsnGln: 2.662 ± 0.076
2.401AsnArg: 2.401 ± 0.06
3.611AsnSer: 3.611 ± 0.088
2.789AsnThr: 2.789 ± 0.079
2.447AsnVal: 2.447 ± 0.065
0.777AsnTrp: 0.777 ± 0.038
1.949AsnTyr: 1.949 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.293ProAla: 2.293 ± 0.074
0.397ProCys: 0.397 ± 0.028
2.25ProAsp: 2.25 ± 0.061
3.454ProGlu: 3.454 ± 0.084
1.625ProPhe: 1.625 ± 0.052
3.013ProGly: 3.013 ± 0.079
1.017ProHis: 1.017 ± 0.042
3.574ProIle: 3.574 ± 0.07
2.388ProLys: 2.388 ± 0.06
4.486ProLeu: 4.486 ± 0.093
0.807ProMet: 0.807 ± 0.033
2.296ProAsn: 2.296 ± 0.072
1.67ProPro: 1.67 ± 0.056
2.246ProGln: 2.246 ± 0.064
1.73ProArg: 1.73 ± 0.058
2.749ProSer: 2.749 ± 0.076
2.398ProThr: 2.398 ± 0.074
2.787ProVal: 2.787 ± 0.072
0.526ProTrp: 0.526 ± 0.034
1.455ProTyr: 1.455 ± 0.052
0.002ProXaa: 0.002 ± 0.002
Gln
3.502GlnAla: 3.502 ± 0.088
0.382GlnCys: 0.382 ± 0.026
1.941GlnAsp: 1.941 ± 0.06
3.512GlnGlu: 3.512 ± 0.091
1.553GlnPhe: 1.553 ± 0.053
3.123GlnGly: 3.123 ± 0.085
0.882GlnHis: 0.882 ± 0.038
3.778GlnIle: 3.778 ± 0.077
3.103GlnLys: 3.103 ± 0.079
5.296GlnLeu: 5.296 ± 0.109
1.106GlnMet: 1.106 ± 0.038
2.116GlnAsn: 2.116 ± 0.06
1.889GlnPro: 1.889 ± 0.056
2.791GlnGln: 2.791 ± 0.085
2.403GlnArg: 2.403 ± 0.076
2.707GlnSer: 2.707 ± 0.063
2.545GlnThr: 2.545 ± 0.072
3.524GlnVal: 3.524 ± 0.075
0.596GlnTrp: 0.596 ± 0.031
1.358GlnTyr: 1.358 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.869ArgAla: 2.869 ± 0.07
0.549ArgCys: 0.549 ± 0.029
2.246ArgAsp: 2.246 ± 0.058
3.018ArgGlu: 3.018 ± 0.073
1.939ArgPhe: 1.939 ± 0.058
2.911ArgGly: 2.911 ± 0.078
0.985ArgHis: 0.985 ± 0.044
3.748ArgIle: 3.748 ± 0.096
2.657ArgLys: 2.657 ± 0.068
5.428ArgLeu: 5.428 ± 0.098
1.086ArgMet: 1.086 ± 0.043
2.356ArgAsn: 2.356 ± 0.066
1.77ArgPro: 1.77 ± 0.054
2.715ArgGln: 2.715 ± 0.063
2.786ArgArg: 2.786 ± 0.082
2.801ArgSer: 2.801 ± 0.077
2.341ArgThr: 2.341 ± 0.062
3.313ArgVal: 3.313 ± 0.081
0.625ArgTrp: 0.625 ± 0.035
1.688ArgTyr: 1.688 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.088SerAla: 4.088 ± 0.09
0.837SerCys: 0.837 ± 0.043
2.769SerAsp: 2.769 ± 0.066
3.592SerGlu: 3.592 ± 0.081
2.527SerPhe: 2.527 ± 0.075
4.733SerGly: 4.733 ± 0.095
1.538SerHis: 1.538 ± 0.053
5.157SerIle: 5.157 ± 0.097
3.409SerLys: 3.409 ± 0.071
7.547SerLeu: 7.547 ± 0.126
1.516SerMet: 1.516 ± 0.044
3.328SerAsn: 3.328 ± 0.072
3.108SerPro: 3.108 ± 0.074
3.727SerGln: 3.727 ± 0.086
3.195SerArg: 3.195 ± 0.08
4.938SerSer: 4.938 ± 0.114
3.571SerThr: 3.571 ± 0.078
3.679SerVal: 3.679 ± 0.081
0.999SerTrp: 0.999 ± 0.045
2.093SerTyr: 2.093 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.976ThrAla: 3.976 ± 0.081
0.623ThrCys: 0.623 ± 0.035
2.517ThrAsp: 2.517 ± 0.07
2.926ThrGlu: 2.926 ± 0.076
1.947ThrPhe: 1.947 ± 0.064
4.195ThrGly: 4.195 ± 0.08
1.176ThrHis: 1.176 ± 0.038
4.512ThrIle: 4.512 ± 0.101
2.64ThrLys: 2.64 ± 0.074
5.887ThrLeu: 5.887 ± 0.102
1.034ThrMet: 1.034 ± 0.041
2.512ThrAsn: 2.512 ± 0.068
2.836ThrPro: 2.836 ± 0.076
2.365ThrGln: 2.365 ± 0.07
2.348ThrArg: 2.348 ± 0.061
3.98ThrSer: 3.98 ± 0.087
3.116ThrThr: 3.116 ± 0.082
3.452ThrVal: 3.452 ± 0.083
0.675ThrTrp: 0.675 ± 0.037
1.794ThrTyr: 1.794 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
5.013ValAla: 5.013 ± 0.102
0.775ValCys: 0.775 ± 0.042
3.377ValAsp: 3.377 ± 0.086
4.123ValGlu: 4.123 ± 0.09
2.627ValPhe: 2.627 ± 0.07
4.566ValGly: 4.566 ± 0.099
1.106ValHis: 1.106 ± 0.04
5.342ValIle: 5.342 ± 0.101
3.636ValLys: 3.636 ± 0.078
6.316ValLeu: 6.316 ± 0.101
1.49ValMet: 1.49 ± 0.053
3.133ValAsn: 3.133 ± 0.072
2.453ValPro: 2.453 ± 0.066
2.328ValGln: 2.328 ± 0.065
3.051ValArg: 3.051 ± 0.071
4.122ValSer: 4.122 ± 0.086
3.51ValThr: 3.51 ± 0.078
4.698ValVal: 4.698 ± 0.104
0.777ValTrp: 0.777 ± 0.043
1.885ValTyr: 1.885 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.745TrpAla: 0.745 ± 0.038
0.137TrpCys: 0.137 ± 0.018
0.566TrpAsp: 0.566 ± 0.034
0.917TrpGlu: 0.917 ± 0.04
0.598TrpPhe: 0.598 ± 0.03
1.004TrpGly: 1.004 ± 0.041
0.391TrpHis: 0.391 ± 0.026
0.872TrpIle: 0.872 ± 0.04
0.62TrpLys: 0.62 ± 0.033
1.774TrpLeu: 1.774 ± 0.063
0.366TrpMet: 0.366 ± 0.024
0.616TrpAsn: 0.616 ± 0.032
0.235TrpPro: 0.235 ± 0.021
1.136TrpGln: 1.136 ± 0.052
0.663TrpArg: 0.663 ± 0.034
0.825TrpSer: 0.825 ± 0.042
0.473TrpThr: 0.473 ± 0.027
0.833TrpVal: 0.833 ± 0.036
0.217TrpTrp: 0.217 ± 0.02
0.396TrpTyr: 0.396 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.807TyrAla: 1.807 ± 0.056
0.536TyrCys: 0.536 ± 0.032
1.43TyrAsp: 1.43 ± 0.052
1.765TyrGlu: 1.765 ± 0.059
1.476TyrPhe: 1.476 ± 0.047
2.181TyrGly: 2.181 ± 0.059
0.81TyrHis: 0.81 ± 0.036
2.305TyrIle: 2.305 ± 0.058
1.695TyrLys: 1.695 ± 0.049
3.903TyrLeu: 3.903 ± 0.065
0.623TyrMet: 0.623 ± 0.032
1.45TyrAsn: 1.45 ± 0.051
1.732TyrPro: 1.732 ± 0.055
2.004TyrGln: 2.004 ± 0.055
1.804TyrArg: 1.804 ± 0.06
2.323TyrSer: 2.323 ± 0.062
1.648TyrThr: 1.648 ± 0.052
1.608TyrVal: 1.608 ± 0.054
0.593TyrTrp: 0.593 ± 0.033
1.207TyrTyr: 1.207 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.002XaaPhe: 0.002 ± 0.002
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2278 proteins (598795 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski