Amino acid dipepetide frequency for Actinokineospora terrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.284AlaAla: 21.284 ± 0.168	1.058AlaCys: 1.058 ± 0.022	8.773AlaAsp: 8.773 ± 0.075	8.483AlaGlu: 8.483 ± 0.077	3.416AlaPhe: 3.416 ± 0.045	12.532AlaGly: 12.532 ± 0.087	2.883AlaHis: 2.883 ± 0.041	4.399AlaIle: 4.399 ± 0.05	2.912AlaLys: 2.912 ± 0.049	14.673AlaLeu: 14.673 ± 0.123	2.335AlaMet: 2.335 ± 0.037	2.37AlaAsn: 2.37 ± 0.035	6.384AlaPro: 6.384 ± 0.067	3.581AlaGln: 3.581 ± 0.035	9.743AlaArg: 9.743 ± 0.088	5.501AlaSer: 5.501 ± 0.049	8.214AlaThr: 8.214 ± 0.079	13.297AlaVal: 13.297 ± 0.096	1.83AlaTrp: 1.83 ± 0.031	2.331AlaTyr: 2.331 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.021	0.085CysCys: 0.085 ± 0.007	0.474CysAsp: 0.474 ± 0.016	0.336CysGlu: 0.336 ± 0.013	0.202CysPhe: 0.202 ± 0.009	0.885CysGly: 0.885 ± 0.019	0.174CysHis: 0.174 ± 0.009	0.107CysIle: 0.107 ± 0.007	0.115CysLys: 0.115 ± 0.008	0.717CysLeu: 0.717 ± 0.021	0.093CysMet: 0.093 ± 0.007	0.113CysAsn: 0.113 ± 0.008	0.482CysPro: 0.482 ± 0.015	0.19CysGln: 0.19 ± 0.008	0.549CysArg: 0.549 ± 0.018	0.424CysSer: 0.424 ± 0.014	0.485CysThr: 0.485 ± 0.018	0.718CysVal: 0.718 ± 0.017	0.12CysTrp: 0.12 ± 0.008	0.16CysTyr: 0.16 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.409AspAla: 7.409 ± 0.062	0.41AspCys: 0.41 ± 0.014	3.906AspAsp: 3.906 ± 0.046	3.712AspGlu: 3.712 ± 0.044	1.521AspPhe: 1.521 ± 0.03	6.032AspGly: 6.032 ± 0.064	1.613AspHis: 1.613 ± 0.03	2.039AspIle: 2.039 ± 0.033	1.157AspLys: 1.157 ± 0.029	7.402AspLeu: 7.402 ± 0.067	0.748AspMet: 0.748 ± 0.021	1.198AspAsn: 1.198 ± 0.023	4.778AspPro: 4.778 ± 0.046	1.821AspGln: 1.821 ± 0.03	5.157AspArg: 5.157 ± 0.053	2.735AspSer: 2.735 ± 0.034	3.619AspThr: 3.619 ± 0.037	5.0AspVal: 5.0 ± 0.055	0.988AspTrp: 0.988 ± 0.023	1.237AspTyr: 1.237 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.033GluAla: 6.033 ± 0.066	0.354GluCys: 0.354 ± 0.014	2.426GluAsp: 2.426 ± 0.039	2.207GluGlu: 2.207 ± 0.041	1.662GluPhe: 1.662 ± 0.027	3.293GluGly: 3.293 ± 0.047	1.619GluHis: 1.619 ± 0.028	2.094GluIle: 2.094 ± 0.033	0.973GluLys: 0.973 ± 0.027	6.474GluLeu: 6.474 ± 0.071	0.741GluMet: 0.741 ± 0.018	0.86GluAsn: 0.86 ± 0.021	3.21GluPro: 3.21 ± 0.053	2.199GluGln: 2.199 ± 0.037	4.716GluArg: 4.716 ± 0.05	2.605GluSer: 2.605 ± 0.033	2.504GluThr: 2.504 ± 0.033	5.228GluVal: 5.228 ± 0.055	0.758GluTrp: 0.758 ± 0.019	0.987GluTyr: 0.987 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.929PheAla: 3.929 ± 0.045	0.236PheCys: 0.236 ± 0.01	2.205PheAsp: 2.205 ± 0.034	1.286PheGlu: 1.286 ± 0.025	0.794PhePhe: 0.794 ± 0.021	3.026PheGly: 3.026 ± 0.044	0.612PheHis: 0.612 ± 0.016	0.682PheIle: 0.682 ± 0.018	0.383PheLys: 0.383 ± 0.015	2.472PheLeu: 2.472 ± 0.035	0.287PheMet: 0.287 ± 0.012	0.512PheAsn: 0.512 ± 0.016	1.428PhePro: 1.428 ± 0.025	0.636PheGln: 0.636 ± 0.019	1.713PheArg: 1.713 ± 0.03	1.444PheSer: 1.444 ± 0.029	2.292PheThr: 2.292 ± 0.035	2.35PheVal: 2.35 ± 0.034	0.365PheTrp: 0.365 ± 0.014	0.552PheTyr: 0.552 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.297GlyAla: 10.297 ± 0.085	0.79GlyCys: 0.79 ± 0.019	5.247GlyAsp: 5.247 ± 0.056	4.647GlyGlu: 4.647 ± 0.044	2.844GlyPhe: 2.844 ± 0.035	8.172GlyGly: 8.172 ± 0.097	2.167GlyHis: 2.167 ± 0.036	3.412GlyIle: 3.412 ± 0.04	2.413GlyLys: 2.413 ± 0.046	9.278GlyLeu: 9.278 ± 0.068	1.853GlyMet: 1.853 ± 0.029	1.786GlyAsn: 1.786 ± 0.036	4.729GlyPro: 4.729 ± 0.053	2.758GlyGln: 2.758 ± 0.046	6.719GlyArg: 6.719 ± 0.056	5.182GlySer: 5.182 ± 0.056	6.254GlyThr: 6.254 ± 0.074	8.607GlyVal: 8.607 ± 0.083	1.688GlyTrp: 1.688 ± 0.027	2.182GlyTyr: 2.182 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.621HisAla: 2.621 ± 0.04	0.194HisCys: 0.194 ± 0.009	1.367HisAsp: 1.367 ± 0.027	1.08HisGlu: 1.08 ± 0.024	0.566HisPhe: 0.566 ± 0.016	2.199HisGly: 2.199 ± 0.033	0.734HisHis: 0.734 ± 0.02	0.645HisIle: 0.645 ± 0.018	0.308HisLys: 0.308 ± 0.012	2.551HisLeu: 2.551 ± 0.041	0.278HisMet: 0.278 ± 0.01	0.424HisAsn: 0.424 ± 0.012	1.755HisPro: 1.755 ± 0.034	0.663HisGln: 0.663 ± 0.017	2.071HisArg: 2.071 ± 0.034	1.033HisSer: 1.033 ± 0.022	1.362HisThr: 1.362 ± 0.031	1.802HisVal: 1.802 ± 0.031	0.359HisTrp: 0.359 ± 0.014	0.495HisTyr: 0.495 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.289IleAla: 5.289 ± 0.051	0.235IleCys: 0.235 ± 0.01	2.443IleAsp: 2.443 ± 0.037	1.822IleGlu: 1.822 ± 0.031	0.611IlePhe: 0.611 ± 0.019	3.63IleGly: 3.63 ± 0.048	0.585IleHis: 0.585 ± 0.017	0.916IleIle: 0.916 ± 0.024	0.672IleLys: 0.672 ± 0.02	2.14IleLeu: 2.14 ± 0.029	0.371IleMet: 0.371 ± 0.012	0.719IleAsn: 0.719 ± 0.021	1.966IlePro: 1.966 ± 0.033	0.683IleGln: 0.683 ± 0.019	2.204IleArg: 2.204 ± 0.031	1.795IleSer: 1.795 ± 0.032	2.871IleThr: 2.871 ± 0.038	2.67IleVal: 2.67 ± 0.037	0.359IleTrp: 0.359 ± 0.012	0.511IleTyr: 0.511 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.588LysAla: 2.588 ± 0.044	0.09LysCys: 0.09 ± 0.006	0.954LysAsp: 0.954 ± 0.026	0.782LysGlu: 0.782 ± 0.024	0.44LysPhe: 0.44 ± 0.015	1.412LysGly: 1.412 ± 0.032	0.411LysHis: 0.411 ± 0.014	0.776LysIle: 0.776 ± 0.022	0.486LysLys: 0.486 ± 0.019	1.867LysLeu: 1.867 ± 0.035	0.303LysMet: 0.303 ± 0.013	0.398LysAsn: 0.398 ± 0.014	1.356LysPro: 1.356 ± 0.032	0.609LysGln: 0.609 ± 0.019	1.419LysArg: 1.419 ± 0.029	1.124LysSer: 1.124 ± 0.026	1.218LysThr: 1.218 ± 0.026	1.924LysVal: 1.924 ± 0.038	0.28LysTrp: 0.28 ± 0.013	0.379LysTyr: 0.379 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.965LeuAla: 15.965 ± 0.114	0.769LeuCys: 0.769 ± 0.02	7.193LeuAsp: 7.193 ± 0.074	4.007LeuGlu: 4.007 ± 0.049	2.643LeuPhe: 2.643 ± 0.038	9.434LeuGly: 9.434 ± 0.073	2.225LeuHis: 2.225 ± 0.033	3.069LeuIle: 3.069 ± 0.038	1.442LeuLys: 1.442 ± 0.031	11.17LeuLeu: 11.17 ± 0.1	1.3LeuMet: 1.3 ± 0.024	1.63LeuAsn: 1.63 ± 0.031	6.548LeuPro: 6.548 ± 0.063	1.842LeuGln: 1.842 ± 0.032	9.092LeuArg: 9.092 ± 0.087	5.645LeuSer: 5.645 ± 0.052	7.051LeuThr: 7.051 ± 0.064	10.669LeuVal: 10.669 ± 0.084	1.343LeuTrp: 1.343 ± 0.027	1.57LeuTyr: 1.57 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.089MetAla: 2.089 ± 0.033	0.101MetCys: 0.101 ± 0.007	0.728MetAsp: 0.728 ± 0.02	0.488MetGlu: 0.488 ± 0.015	0.4MetPhe: 0.4 ± 0.013	1.144MetGly: 1.144 ± 0.023	0.28MetHis: 0.28 ± 0.011	0.557MetIle: 0.557 ± 0.016	0.267MetLys: 0.267 ± 0.011	1.492MetLeu: 1.492 ± 0.029	0.204MetMet: 0.204 ± 0.01	0.33MetAsn: 0.33 ± 0.013	0.965MetPro: 0.965 ± 0.019	0.333MetGln: 0.333 ± 0.013	1.325MetArg: 1.325 ± 0.024	1.237MetSer: 1.237 ± 0.025	1.461MetThr: 1.461 ± 0.024	1.369MetVal: 1.369 ± 0.028	0.165MetTrp: 0.165 ± 0.008	0.225MetTyr: 0.225 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.378AsnAla: 2.378 ± 0.036	0.174AsnCys: 0.174 ± 0.009	0.951AsnAsp: 0.951 ± 0.024	0.723AsnGlu: 0.723 ± 0.02	0.463AsnPhe: 0.463 ± 0.016	2.022AsnGly: 2.022 ± 0.041	0.403AsnHis: 0.403 ± 0.014	0.591AsnIle: 0.591 ± 0.017	0.357AsnLys: 0.357 ± 0.015	1.805AsnLeu: 1.805 ± 0.032	0.237AsnMet: 0.237 ± 0.01	0.491AsnAsn: 0.491 ± 0.021	1.591AsnPro: 1.591 ± 0.031	0.585AsnGln: 0.585 ± 0.018	1.405AsnArg: 1.405 ± 0.027	0.977AsnSer: 0.977 ± 0.027	1.298AsnThr: 1.298 ± 0.031	1.272AsnVal: 1.272 ± 0.029	0.26AsnTrp: 0.26 ± 0.012	0.415AsnTyr: 0.415 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.959ProAla: 7.959 ± 0.075	0.332ProCys: 0.332 ± 0.014	4.633ProAsp: 4.633 ± 0.049	3.683ProGlu: 3.683 ± 0.048	1.558ProPhe: 1.558 ± 0.024	6.218ProGly: 6.218 ± 0.06	1.242ProHis: 1.242 ± 0.026	1.688ProIle: 1.688 ± 0.028	1.04ProLys: 1.04 ± 0.027	5.208ProLeu: 5.208 ± 0.055	0.905ProMet: 0.905 ± 0.019	1.171ProAsn: 1.171 ± 0.029	3.587ProPro: 3.587 ± 0.059	1.53ProGln: 1.53 ± 0.029	3.967ProArg: 3.967 ± 0.048	3.139ProSer: 3.139 ± 0.042	4.269ProThr: 4.269 ± 0.051	5.938ProVal: 5.938 ± 0.065	0.932ProTrp: 0.932 ± 0.025	1.069ProTyr: 1.069 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.745GlnAla: 3.745 ± 0.047	0.185GlnCys: 0.185 ± 0.008	1.356GlnAsp: 1.356 ± 0.023	1.151GlnGlu: 1.151 ± 0.025	0.711GlnPhe: 0.711 ± 0.018	2.066GlnGly: 2.066 ± 0.036	0.639GlnHis: 0.639 ± 0.017	0.93GlnIle: 0.93 ± 0.022	0.444GlnLys: 0.444 ± 0.018	2.824GlnLeu: 2.824 ± 0.041	0.369GlnMet: 0.369 ± 0.012	0.468GlnAsn: 0.468 ± 0.015	1.773GlnPro: 1.773 ± 0.037	1.138GlnGln: 1.138 ± 0.037	2.492GlnArg: 2.492 ± 0.033	1.281GlnSer: 1.281 ± 0.028	1.414GlnThr: 1.414 ± 0.031	2.975GlnVal: 2.975 ± 0.04	0.492GlnTrp: 0.492 ± 0.015	0.51GlnTyr: 0.51 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.137ArgAla: 10.137 ± 0.094	0.586ArgCys: 0.586 ± 0.016	4.46ArgAsp: 4.46 ± 0.052	4.208ArgGlu: 4.208 ± 0.05	2.497ArgPhe: 2.497 ± 0.032	5.828ArgGly: 5.828 ± 0.059	1.87ArgHis: 1.87 ± 0.029	2.617ArgIle: 2.617 ± 0.034	1.634ArgLys: 1.634 ± 0.035	8.603ArgLeu: 8.603 ± 0.089	1.633ArgMet: 1.633 ± 0.03	1.284ArgAsn: 1.284 ± 0.028	4.421ArgPro: 4.421 ± 0.048	2.273ArgGln: 2.273 ± 0.033	6.844ArgArg: 6.844 ± 0.078	3.984ArgSer: 3.984 ± 0.045	4.833ArgThr: 4.833 ± 0.048	7.172ArgVal: 7.172 ± 0.064	1.489ArgTrp: 1.489 ± 0.029	1.767ArgTyr: 1.767 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.98SerAla: 6.98 ± 0.063	0.409SerCys: 0.409 ± 0.014	2.719SerAsp: 2.719 ± 0.04	2.099SerGlu: 2.099 ± 0.031	1.465SerPhe: 1.465 ± 0.026	5.847SerGly: 5.847 ± 0.063	0.958SerHis: 0.958 ± 0.019	1.657SerIle: 1.657 ± 0.03	0.86SerLys: 0.86 ± 0.022	4.834SerLeu: 4.834 ± 0.054	0.957SerMet: 0.957 ± 0.022	0.933SerAsn: 0.933 ± 0.026	3.197SerPro: 3.197 ± 0.046	1.257SerGln: 1.257 ± 0.026	3.661SerArg: 3.661 ± 0.044	2.872SerSer: 2.872 ± 0.043	3.934SerThr: 3.934 ± 0.051	4.637SerVal: 4.637 ± 0.049	0.92SerTrp: 0.92 ± 0.021	1.105SerTyr: 1.105 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.491ThrAla: 9.491 ± 0.088	0.502ThrCys: 0.502 ± 0.019	3.928ThrAsp: 3.928 ± 0.047	3.363ThrGlu: 3.363 ± 0.044	1.719ThrPhe: 1.719 ± 0.034	6.892ThrGly: 6.892 ± 0.081	1.296ThrHis: 1.296 ± 0.027	2.151ThrIle: 2.151 ± 0.04	1.253ThrLys: 1.253 ± 0.027	5.978ThrLeu: 5.978 ± 0.055	0.897ThrMet: 0.897 ± 0.022	1.225ThrAsn: 1.225 ± 0.032	4.543ThrPro: 4.543 ± 0.059	1.57ThrGln: 1.57 ± 0.031	4.437ThrArg: 4.437 ± 0.049	3.503ThrSer: 3.503 ± 0.048	5.331ThrThr: 5.331 ± 0.106	6.435ThrVal: 6.435 ± 0.086	1.069ThrTrp: 1.069 ± 0.024	1.308ThrTyr: 1.308 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	12.759ValAla: 12.759 ± 0.092	0.724ValCys: 0.724 ± 0.018	6.708ValAsp: 6.708 ± 0.062	5.338ValGlu: 5.338 ± 0.06	2.615ValPhe: 2.615 ± 0.035	7.57ValGly: 7.57 ± 0.079	2.011ValHis: 2.011 ± 0.029	3.202ValIle: 3.202 ± 0.04	1.535ValLys: 1.535 ± 0.03	10.948ValLeu: 10.948 ± 0.079	1.205ValMet: 1.205 ± 0.024	1.782ValAsn: 1.782 ± 0.033	5.34ValPro: 5.34 ± 0.049	2.062ValGln: 2.062 ± 0.03	7.432ValArg: 7.432 ± 0.063	4.836ValSer: 4.836 ± 0.059	6.173ValThr: 6.173 ± 0.078	10.432ValVal: 10.432 ± 0.088	1.102ValTrp: 1.102 ± 0.024	1.478ValTyr: 1.478 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.62TrpAla: 1.62 ± 0.031	0.146TrpCys: 0.146 ± 0.008	0.798TrpAsp: 0.798 ± 0.02	0.618TrpGlu: 0.618 ± 0.016	0.502TrpPhe: 0.502 ± 0.015	1.037TrpGly: 1.037 ± 0.024	0.393TrpHis: 0.393 ± 0.013	0.515TrpIle: 0.515 ± 0.015	0.261TrpLys: 0.261 ± 0.012	1.855TrpLeu: 1.855 ± 0.035	0.255TrpMet: 0.255 ± 0.011	0.318TrpAsn: 0.318 ± 0.013	0.848TrpPro: 0.848 ± 0.021	0.619TrpGln: 0.619 ± 0.025	1.396TrpArg: 1.396 ± 0.028	1.03TrpSer: 1.03 ± 0.023	1.07TrpThr: 1.07 ± 0.024	1.254TrpVal: 1.254 ± 0.026	0.355TrpTrp: 0.355 ± 0.012	0.305TrpTyr: 0.305 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.311TyrAla: 2.311 ± 0.031	0.161TyrCys: 0.161 ± 0.007	1.213TyrAsp: 1.213 ± 0.026	0.909TyrGlu: 0.909 ± 0.026	0.576TyrPhe: 0.576 ± 0.016	1.784TyrGly: 1.784 ± 0.032	0.394TyrHis: 0.394 ± 0.013	0.443TyrIle: 0.443 ± 0.019	0.305TyrLys: 0.305 ± 0.013	2.317TyrLeu: 2.317 ± 0.038	0.192TyrMet: 0.192 ± 0.009	0.384TyrAsn: 0.384 ± 0.015	1.166TyrPro: 1.166 ± 0.023	0.614TyrGln: 0.614 ± 0.019	1.8TyrArg: 1.8 ± 0.033	0.954TyrSer: 0.954 ± 0.024	1.235TyrThr: 1.235 ± 0.027	1.502TyrVal: 1.502 ± 0.029	0.323TyrTrp: 0.323 ± 0.013	0.436TyrTyr: 0.436 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6615 proteins (2246422 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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