Amino acid dipepetide frequency for Sinorhizobium fredii (strain NBRC 101917 / NGR234)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.773AlaAla: 16.773 ± 0.155	1.075AlaCys: 1.075 ± 0.027	6.514AlaAsp: 6.514 ± 0.065	8.002AlaGlu: 8.002 ± 0.07	4.523AlaPhe: 4.523 ± 0.058	10.42AlaGly: 10.42 ± 0.082	2.19AlaHis: 2.19 ± 0.042	6.976AlaIle: 6.976 ± 0.067	4.233AlaLys: 4.233 ± 0.056	12.898AlaLeu: 12.898 ± 0.12	3.378AlaMet: 3.378 ± 0.045	3.008AlaAsn: 3.008 ± 0.04	4.766AlaPro: 4.766 ± 0.051	3.322AlaGln: 3.322 ± 0.048	8.259AlaArg: 8.259 ± 0.076	6.537AlaSer: 6.537 ± 0.055	5.85AlaThr: 5.85 ± 0.063	8.778AlaVal: 8.778 ± 0.078	1.387AlaTrp: 1.387 ± 0.026	2.551AlaTyr: 2.551 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.97CysAla: 0.97 ± 0.025	0.145CysCys: 0.145 ± 0.01	0.508CysAsp: 0.508 ± 0.016	0.494CysGlu: 0.494 ± 0.016	0.358CysPhe: 0.358 ± 0.013	0.956CysGly: 0.956 ± 0.025	0.268CysHis: 0.268 ± 0.012	0.409CysIle: 0.409 ± 0.015	0.21CysLys: 0.21 ± 0.011	0.861CysLeu: 0.861 ± 0.021	0.174CysMet: 0.174 ± 0.01	0.219CysAsn: 0.219 ± 0.01	0.428CysPro: 0.428 ± 0.017	0.246CysGln: 0.246 ± 0.012	0.696CysArg: 0.696 ± 0.02	0.507CysSer: 0.507 ± 0.017	0.411CysThr: 0.411 ± 0.014	0.626CysVal: 0.626 ± 0.018	0.121CysTrp: 0.121 ± 0.008	0.21CysTyr: 0.21 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.302AspAla: 6.302 ± 0.069	0.534AspCys: 0.534 ± 0.016	3.023AspAsp: 3.023 ± 0.04	3.591AspGlu: 3.591 ± 0.051	2.284AspPhe: 2.284 ± 0.035	5.054AspGly: 5.054 ± 0.057	1.254AspHis: 1.254 ± 0.029	3.227AspIle: 3.227 ± 0.038	1.698AspLys: 1.698 ± 0.032	5.619AspLeu: 5.619 ± 0.064	1.294AspMet: 1.294 ± 0.027	1.324AspAsn: 1.324 ± 0.031	3.257AspPro: 3.257 ± 0.041	1.687AspGln: 1.687 ± 0.04	4.407AspArg: 4.407 ± 0.047	2.133AspSer: 2.133 ± 0.038	2.426AspThr: 2.426 ± 0.044	4.095AspVal: 4.095 ± 0.052	0.933AspTrp: 0.933 ± 0.022	1.485AspTyr: 1.485 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.911GluAla: 7.911 ± 0.074	0.398GluCys: 0.398 ± 0.016	2.818GluAsp: 2.818 ± 0.039	3.697GluGlu: 3.697 ± 0.053	1.959GluPhe: 1.959 ± 0.033	4.332GluGly: 4.332 ± 0.047	1.253GluHis: 1.253 ± 0.027	3.98GluIle: 3.98 ± 0.047	2.625GluLys: 2.625 ± 0.04	5.621GluLeu: 5.621 ± 0.057	1.564GluMet: 1.564 ± 0.03	1.83GluAsn: 1.83 ± 0.032	2.804GluPro: 2.804 ± 0.04	2.075GluGln: 2.075 ± 0.035	5.289GluArg: 5.289 ± 0.07	2.528GluSer: 2.528 ± 0.038	3.689GluThr: 3.689 ± 0.045	3.883GluVal: 3.883 ± 0.045	0.747GluTrp: 0.747 ± 0.018	1.04GluTyr: 1.04 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.586PheAla: 4.586 ± 0.062	0.432PheCys: 0.432 ± 0.015	2.74PheAsp: 2.74 ± 0.043	2.329PheGlu: 2.329 ± 0.037	1.569PhePhe: 1.569 ± 0.036	3.707PheGly: 3.707 ± 0.05	0.798PheHis: 0.798 ± 0.023	1.796PheIle: 1.796 ± 0.034	1.092PheLys: 1.092 ± 0.026	3.656PheLeu: 3.656 ± 0.042	0.834PheMet: 0.834 ± 0.02	1.052PheAsn: 1.052 ± 0.023	1.652PhePro: 1.652 ± 0.03	1.052PheGln: 1.052 ± 0.021	2.488PheArg: 2.488 ± 0.04	2.415PheSer: 2.415 ± 0.039	1.891PheThr: 1.891 ± 0.034	3.019PheVal: 3.019 ± 0.048	0.541PheTrp: 0.541 ± 0.018	0.962PheTyr: 0.962 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	8.695GlyAla: 8.695 ± 0.073	0.853GlyCys: 0.853 ± 0.022	4.253GlyAsp: 4.253 ± 0.054	4.965GlyGlu: 4.965 ± 0.044	3.59GlyPhe: 3.59 ± 0.045	7.086GlyGly: 7.086 ± 0.083	1.913GlyHis: 1.913 ± 0.033	4.78GlyIle: 4.78 ± 0.049	3.537GlyLys: 3.537 ± 0.05	8.537GlyLeu: 8.537 ± 0.073	2.25GlyMet: 2.25 ± 0.038	2.385GlyAsn: 2.385 ± 0.05	3.266GlyPro: 3.266 ± 0.044	2.608GlyGln: 2.608 ± 0.038	6.158GlyArg: 6.158 ± 0.062	4.923GlySer: 4.923 ± 0.053	4.487GlyThr: 4.487 ± 0.056	5.95GlyVal: 5.95 ± 0.052	1.234GlyTrp: 1.234 ± 0.028	2.34GlyTyr: 2.34 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.306HisAla: 2.306 ± 0.038	0.254HisCys: 0.254 ± 0.011	1.191HisAsp: 1.191 ± 0.025	1.102HisGlu: 1.102 ± 0.029	0.948HisPhe: 0.948 ± 0.023	1.939HisGly: 1.939 ± 0.035	0.582HisHis: 0.582 ± 0.02	0.968HisIle: 0.968 ± 0.028	0.533HisLys: 0.533 ± 0.019	2.101HisLeu: 2.101 ± 0.032	0.545HisMet: 0.545 ± 0.017	0.462HisAsn: 0.462 ± 0.015	1.331HisPro: 1.331 ± 0.028	0.638HisGln: 0.638 ± 0.019	1.574HisArg: 1.574 ± 0.033	1.043HisSer: 1.043 ± 0.022	0.768HisThr: 0.768 ± 0.02	1.598HisVal: 1.598 ± 0.028	0.294HisTrp: 0.294 ± 0.013	0.556HisTyr: 0.556 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.754IleAla: 7.754 ± 0.082	0.575IleCys: 0.575 ± 0.02	3.803IleAsp: 3.803 ± 0.051	3.777IleGlu: 3.777 ± 0.049	1.933IlePhe: 1.933 ± 0.033	5.3IleGly: 5.3 ± 0.053	0.968IleHis: 0.968 ± 0.024	2.464IleIle: 2.464 ± 0.043	1.557IleLys: 1.557 ± 0.027	4.761IleLeu: 4.761 ± 0.053	1.035IleMet: 1.035 ± 0.024	1.516IleAsn: 1.516 ± 0.028	2.379IlePro: 2.379 ± 0.035	1.193IleGln: 1.193 ± 0.023	3.577IleArg: 3.577 ± 0.044	3.159IleSer: 3.159 ± 0.042	2.63IleThr: 2.63 ± 0.037	4.604IleVal: 4.604 ± 0.05	0.581IleTrp: 0.581 ± 0.017	1.198IleTyr: 1.198 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.558LysAla: 4.558 ± 0.05	0.202LysCys: 0.202 ± 0.011	1.843LysAsp: 1.843 ± 0.038	1.921LysGlu: 1.921 ± 0.033	0.98LysPhe: 0.98 ± 0.021	2.835LysGly: 2.835 ± 0.042	0.661LysHis: 0.661 ± 0.019	1.97LysIle: 1.97 ± 0.033	1.417LysLys: 1.417 ± 0.031	3.541LysLeu: 3.541 ± 0.049	0.836LysMet: 0.836 ± 0.022	0.941LysAsn: 0.941 ± 0.024	2.137LysPro: 2.137 ± 0.037	1.096LysGln: 1.096 ± 0.025	2.578LysArg: 2.578 ± 0.038	2.116LysSer: 2.116 ± 0.032	2.114LysThr: 2.114 ± 0.037	2.605LysVal: 2.605 ± 0.042	0.394LysTrp: 0.394 ± 0.016	0.676LysTyr: 0.676 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.114LeuAla: 13.114 ± 0.103	0.893LeuCys: 0.893 ± 0.021	5.831LeuAsp: 5.831 ± 0.054	5.513LeuGlu: 5.513 ± 0.064	3.711LeuPhe: 3.711 ± 0.051	7.974LeuGly: 7.974 ± 0.075	1.821LeuHis: 1.821 ± 0.036	5.139LeuIle: 5.139 ± 0.057	4.044LeuLys: 4.044 ± 0.047	9.288LeuLeu: 9.288 ± 0.088	2.327LeuMet: 2.327 ± 0.034	2.62LeuAsn: 2.62 ± 0.042	5.352LeuPro: 5.352 ± 0.062	2.803LeuGln: 2.803 ± 0.039	6.583LeuArg: 6.583 ± 0.065	6.872LeuSer: 6.872 ± 0.099	5.391LeuThr: 5.391 ± 0.051	7.476LeuVal: 7.476 ± 0.071	1.112LeuTrp: 1.112 ± 0.027	2.155LeuTyr: 2.155 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.964MetAla: 2.964 ± 0.038	0.156MetCys: 0.156 ± 0.009	1.11MetAsp: 1.11 ± 0.023	1.196MetGlu: 1.196 ± 0.026	0.691MetPhe: 0.691 ± 0.021	1.708MetGly: 1.708 ± 0.035	0.475MetHis: 0.475 ± 0.017	1.402MetIle: 1.402 ± 0.027	1.085MetLys: 1.085 ± 0.022	2.516MetLeu: 2.516 ± 0.037	0.683MetMet: 0.683 ± 0.021	0.823MetAsn: 0.823 ± 0.022	1.502MetPro: 1.502 ± 0.03	0.834MetGln: 0.834 ± 0.018	1.888MetArg: 1.888 ± 0.033	1.672MetSer: 1.672 ± 0.03	1.861MetThr: 1.861 ± 0.034	1.675MetVal: 1.675 ± 0.028	0.21MetTrp: 0.21 ± 0.01	0.314MetTyr: 0.314 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.195AsnAla: 3.195 ± 0.038	0.268AsnCys: 0.268 ± 0.012	1.559AsnAsp: 1.559 ± 0.04	1.344AsnGlu: 1.344 ± 0.027	1.014AsnPhe: 1.014 ± 0.023	2.511AsnGly: 2.511 ± 0.048	0.537AsnHis: 0.537 ± 0.018	1.435AsnIle: 1.435 ± 0.028	0.731AsnLys: 0.731 ± 0.019	2.653AsnLeu: 2.653 ± 0.04	0.633AsnMet: 0.633 ± 0.019	0.719AsnAsn: 0.719 ± 0.02	1.835AsnPro: 1.835 ± 0.029	0.776AsnGln: 0.776 ± 0.02	1.984AsnArg: 1.984 ± 0.03	1.374AsnSer: 1.374 ± 0.029	1.245AsnThr: 1.245 ± 0.03	1.995AsnVal: 1.995 ± 0.033	0.465AsnTrp: 0.465 ± 0.016	0.686AsnTyr: 0.686 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.774ProAla: 5.774 ± 0.056	0.325ProCys: 0.325 ± 0.014	3.302ProAsp: 3.302 ± 0.046	3.697ProGlu: 3.697 ± 0.045	2.008ProPhe: 2.008 ± 0.032	4.117ProGly: 4.117 ± 0.047	1.136ProHis: 1.136 ± 0.025	2.414ProIle: 2.414 ± 0.035	1.77ProLys: 1.77 ± 0.032	4.746ProLeu: 4.746 ± 0.052	1.153ProMet: 1.153 ± 0.024	1.279ProAsn: 1.279 ± 0.028	2.321ProPro: 2.321 ± 0.041	1.555ProGln: 1.555 ± 0.031	2.769ProArg: 2.769 ± 0.036	2.78ProSer: 2.78 ± 0.039	2.349ProThr: 2.349 ± 0.037	4.031ProVal: 4.031 ± 0.05	0.668ProTrp: 0.668 ± 0.019	1.174ProTyr: 1.174 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.829GlnAla: 3.829 ± 0.046	0.216GlnCys: 0.216 ± 0.011	1.239GlnAsp: 1.239 ± 0.026	1.594GlnGlu: 1.594 ± 0.029	1.079GlnPhe: 1.079 ± 0.026	2.118GlnGly: 2.118 ± 0.033	0.612GlnHis: 0.612 ± 0.016	1.798GlnIle: 1.798 ± 0.041	1.195GlnLys: 1.195 ± 0.027	2.774GlnLeu: 2.774 ± 0.038	0.916GlnMet: 0.916 ± 0.021	0.827GlnAsn: 0.827 ± 0.022	1.635GlnPro: 1.635 ± 0.034	1.244GlnGln: 1.244 ± 0.035	2.34GlnArg: 2.34 ± 0.03	1.793GlnSer: 1.793 ± 0.032	1.658GlnThr: 1.658 ± 0.027	2.142GlnVal: 2.142 ± 0.048	0.385GlnTrp: 0.385 ± 0.014	0.58GlnTyr: 0.58 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.43ArgAla: 7.43 ± 0.069	0.549ArgCys: 0.549 ± 0.018	3.933ArgAsp: 3.933 ± 0.047	4.211ArgGlu: 4.211 ± 0.052	2.985ArgPhe: 2.985 ± 0.039	4.657ArgGly: 4.657 ± 0.052	1.88ArgHis: 1.88 ± 0.037	4.171ArgIle: 4.171 ± 0.049	2.631ArgLys: 2.631 ± 0.033	7.933ArgLeu: 7.933 ± 0.076	1.932ArgMet: 1.932 ± 0.031	2.082ArgAsn: 2.082 ± 0.034	3.53ArgPro: 3.53 ± 0.046	2.78ArgGln: 2.78 ± 0.044	5.964ArgArg: 5.964 ± 0.07	4.059ArgSer: 4.059 ± 0.046	3.446ArgThr: 3.446 ± 0.041	4.544ArgVal: 4.544 ± 0.058	0.934ArgTrp: 0.934 ± 0.023	1.758ArgTyr: 1.758 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.446SerAla: 6.446 ± 0.07	0.456SerCys: 0.456 ± 0.016	3.094SerAsp: 3.094 ± 0.045	3.219SerGlu: 3.219 ± 0.043	2.479SerPhe: 2.479 ± 0.04	5.726SerGly: 5.726 ± 0.062	1.174SerHis: 1.174 ± 0.026	3.044SerIle: 3.044 ± 0.043	1.804SerLys: 1.804 ± 0.029	5.667SerLeu: 5.667 ± 0.054	1.368SerMet: 1.368 ± 0.029	1.461SerAsn: 1.461 ± 0.027	2.807SerPro: 2.807 ± 0.036	1.624SerGln: 1.624 ± 0.036	3.892SerArg: 3.892 ± 0.045	3.3SerSer: 3.3 ± 0.057	2.908SerThr: 2.908 ± 0.082	4.245SerVal: 4.245 ± 0.041	0.756SerTrp: 0.756 ± 0.018	1.375SerTyr: 1.375 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.036ThrAla: 6.036 ± 0.064	0.444ThrCys: 0.444 ± 0.015	2.733ThrAsp: 2.733 ± 0.05	2.787ThrGlu: 2.787 ± 0.037	2.054ThrPhe: 2.054 ± 0.035	4.967ThrGly: 4.967 ± 0.051	1.007ThrHis: 1.007 ± 0.025	3.087ThrIle: 3.087 ± 0.043	1.591ThrLys: 1.591 ± 0.029	5.554ThrLeu: 5.554 ± 0.059	1.284ThrMet: 1.284 ± 0.027	1.325ThrAsn: 1.325 ± 0.026	2.882ThrPro: 2.882 ± 0.038	1.282ThrGln: 1.282 ± 0.03	3.136ThrArg: 3.136 ± 0.043	2.919ThrSer: 2.919 ± 0.046	2.754ThrThr: 2.754 ± 0.048	4.36ThrVal: 4.36 ± 0.054	0.608ThrTrp: 0.608 ± 0.018	1.2ThrTyr: 1.2 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.177ValAla: 9.177 ± 0.085	0.651ValCys: 0.651 ± 0.017	4.118ValAsp: 4.118 ± 0.046	4.756ValGlu: 4.756 ± 0.051	2.925ValPhe: 2.925 ± 0.04	5.452ValGly: 5.452 ± 0.057	1.383ValHis: 1.383 ± 0.031	4.071ValIle: 4.071 ± 0.042	2.532ValLys: 2.532 ± 0.04	7.385ValLeu: 7.385 ± 0.066	1.761ValMet: 1.761 ± 0.028	2.043ValAsn: 2.043 ± 0.032	3.671ValPro: 3.671 ± 0.048	1.899ValGln: 1.899 ± 0.036	4.874ValArg: 4.874 ± 0.054	4.655ValSer: 4.655 ± 0.049	4.394ValThr: 4.394 ± 0.049	5.914ValVal: 5.914 ± 0.066	0.821ValTrp: 0.821 ± 0.02	1.481ValTyr: 1.481 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.167TrpAla: 1.167 ± 0.027	0.13TrpCys: 0.13 ± 0.009	0.588TrpAsp: 0.588 ± 0.018	0.577TrpGlu: 0.577 ± 0.019	0.526TrpPhe: 0.526 ± 0.019	0.819TrpGly: 0.819 ± 0.019	0.319TrpHis: 0.319 ± 0.012	0.669TrpIle: 0.669 ± 0.02	0.515TrpLys: 0.515 ± 0.018	1.578TrpLeu: 1.578 ± 0.031	0.349TrpMet: 0.349 ± 0.013	0.464TrpAsn: 0.464 ± 0.015	0.685TrpPro: 0.685 ± 0.02	0.537TrpGln: 0.537 ± 0.016	1.039TrpArg: 1.039 ± 0.028	0.801TrpSer: 0.801 ± 0.021	0.717TrpThr: 0.717 ± 0.021	0.755TrpVal: 0.755 ± 0.019	0.224TrpTrp: 0.224 ± 0.011	0.294TrpTyr: 0.294 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.454TyrAla: 2.454 ± 0.035	0.26TyrCys: 0.26 ± 0.012	1.428TyrAsp: 1.428 ± 0.028	1.269TyrGlu: 1.269 ± 0.028	0.993TyrPhe: 0.993 ± 0.023	2.135TyrGly: 2.135 ± 0.033	0.505TyrHis: 0.505 ± 0.016	0.962TyrIle: 0.962 ± 0.022	0.623TyrLys: 0.623 ± 0.02	2.33TyrLeu: 2.33 ± 0.036	0.448TyrMet: 0.448 ± 0.017	0.577TyrAsn: 0.577 ± 0.019	1.124TyrPro: 1.124 ± 0.023	0.724TyrGln: 0.724 ± 0.02	1.915TyrArg: 1.915 ± 0.032	1.26TyrSer: 1.26 ± 0.026	1.02TyrThr: 1.02 ± 0.025	1.67TyrVal: 1.67 ± 0.031	0.337TyrTrp: 0.337 ± 0.013	0.63TyrTyr: 0.63 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6273 proteins (1950178 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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