Amino acid dipepetide frequency for Capnocytophaga cynodegmi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.859AlaAla: 2.859 ± 0.07
0.515AlaCys: 0.515 ± 0.029
2.898AlaAsp: 2.898 ± 0.067
4.159AlaGlu: 4.159 ± 0.084
3.156AlaPhe: 3.156 ± 0.075
3.57AlaGly: 3.57 ± 0.071
0.925AlaHis: 0.925 ± 0.034
4.797AlaIle: 4.797 ± 0.094
4.679AlaLys: 4.679 ± 0.086
5.621AlaLeu: 5.621 ± 0.084
1.434AlaMet: 1.434 ± 0.049
3.242AlaAsn: 3.242 ± 0.082
1.712AlaPro: 1.712 ± 0.063
2.449AlaGln: 2.449 ± 0.069
2.027AlaArg: 2.027 ± 0.051
3.88AlaSer: 3.88 ± 0.082
3.417AlaThr: 3.417 ± 0.111
3.76AlaVal: 3.76 ± 0.088
0.545AlaTrp: 0.545 ± 0.026
2.315AlaTyr: 2.315 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.372CysAla: 0.372 ± 0.021
0.105CysCys: 0.105 ± 0.012
0.418CysAsp: 0.418 ± 0.027
0.518CysGlu: 0.518 ± 0.03
0.486CysPhe: 0.486 ± 0.022
0.589CysGly: 0.589 ± 0.031
0.17CysHis: 0.17 ± 0.021
0.586CysIle: 0.586 ± 0.027
0.582CysLys: 0.582 ± 0.03
0.642CysLeu: 0.642 ± 0.027
0.164CysMet: 0.164 ± 0.014
0.452CysAsn: 0.452 ± 0.032
0.311CysPro: 0.311 ± 0.026
0.27CysGln: 0.27 ± 0.018
0.218CysArg: 0.218 ± 0.017
0.569CysSer: 0.569 ± 0.036
0.409CysThr: 0.409 ± 0.027
0.49CysVal: 0.49 ± 0.033
0.095CysTrp: 0.095 ± 0.01
0.326CysTyr: 0.326 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
2.979AspAla: 2.979 ± 0.075
0.409AspCys: 0.409 ± 0.027
2.432AspAsp: 2.432 ± 0.065
3.698AspGlu: 3.698 ± 0.078
3.916AspPhe: 3.916 ± 0.071
3.052AspGly: 3.052 ± 0.086
0.534AspHis: 0.534 ± 0.029
4.361AspIle: 4.361 ± 0.072
4.473AspLys: 4.473 ± 0.085
4.635AspLeu: 4.635 ± 0.087
1.081AspMet: 1.081 ± 0.04
3.033AspAsn: 3.033 ± 0.071
1.288AspPro: 1.288 ± 0.054
0.992AspGln: 0.992 ± 0.037
1.678AspArg: 1.678 ± 0.048
2.802AspSer: 2.802 ± 0.06
2.536AspThr: 2.536 ± 0.056
3.265AspVal: 3.265 ± 0.073
0.664AspTrp: 0.664 ± 0.03
2.628AspTyr: 2.628 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
4.351GluAla: 4.351 ± 0.091
0.388GluCys: 0.388 ± 0.024
3.233GluAsp: 3.233 ± 0.079
5.445GluGlu: 5.445 ± 0.119
3.086GluPhe: 3.086 ± 0.063
3.89GluGly: 3.89 ± 0.071
1.078GluHis: 1.078 ± 0.038
6.52GluIle: 6.52 ± 0.11
7.896GluLys: 7.896 ± 0.13
6.303GluLeu: 6.303 ± 0.1
1.69GluMet: 1.69 ± 0.051
5.679GluAsn: 5.679 ± 0.095
1.568GluPro: 1.568 ± 0.045
2.661GluGln: 2.661 ± 0.065
2.94GluArg: 2.94 ± 0.074
3.398GluSer: 3.398 ± 0.076
3.502GluThr: 3.502 ± 0.077
4.587GluVal: 4.587 ± 0.085
0.661GluTrp: 0.661 ± 0.032
2.665GluTyr: 2.665 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.047PheAla: 3.047 ± 0.061
0.497PheCys: 0.497 ± 0.026
3.195PheAsp: 3.195 ± 0.06
3.696PheGlu: 3.696 ± 0.08
3.231PhePhe: 3.231 ± 0.08
3.406PheGly: 3.406 ± 0.086
0.897PheHis: 0.897 ± 0.038
3.951PheIle: 3.951 ± 0.084
3.438PheLys: 3.438 ± 0.073
5.35PheLeu: 5.35 ± 0.121
1.203PheMet: 1.203 ± 0.037
2.863PheAsn: 2.863 ± 0.064
1.936PhePro: 1.936 ± 0.048
1.861PheGln: 1.861 ± 0.056
1.926PheArg: 1.926 ± 0.05
4.519PheSer: 4.519 ± 0.094
2.891PheThr: 2.891 ± 0.07
3.579PheVal: 3.579 ± 0.063
0.665PheTrp: 0.665 ± 0.028
2.363PheTyr: 2.363 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
3.717GlyAla: 3.717 ± 0.083
0.595GlyCys: 0.595 ± 0.051
2.838GlyAsp: 2.838 ± 0.066
3.759GlyGlu: 3.759 ± 0.065
3.394GlyPhe: 3.394 ± 0.073
4.237GlyGly: 4.237 ± 0.098
0.982GlyHis: 0.982 ± 0.033
5.129GlyIle: 5.129 ± 0.098
5.698GlyLys: 5.698 ± 0.099
5.083GlyLeu: 5.083 ± 0.096
1.458GlyMet: 1.458 ± 0.047
3.787GlyAsn: 3.787 ± 0.094
0.749GlyPro: 0.749 ± 0.032
1.819GlyGln: 1.819 ± 0.051
2.088GlyArg: 2.088 ± 0.059
3.644GlySer: 3.644 ± 0.082
3.56GlyThr: 3.56 ± 0.112
4.285GlyVal: 4.285 ± 0.086
0.687GlyTrp: 0.687 ± 0.027
2.883GlyTyr: 2.883 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
0.69HisAla: 0.69 ± 0.032
0.202HisCys: 0.202 ± 0.017
0.66HisAsp: 0.66 ± 0.032
0.755HisGlu: 0.755 ± 0.033
1.275HisPhe: 1.275 ± 0.04
0.872HisGly: 0.872 ± 0.032
0.444HisHis: 0.444 ± 0.026
1.566HisIle: 1.566 ± 0.042
1.401HisLys: 1.401 ± 0.045
1.931HisLeu: 1.931 ± 0.048
0.207HisMet: 0.207 ± 0.017
1.088HisAsn: 1.088 ± 0.038
0.75HisPro: 0.75 ± 0.035
0.733HisGln: 0.733 ± 0.031
0.687HisArg: 0.687 ± 0.032
1.241HisSer: 1.241 ± 0.041
0.99HisThr: 0.99 ± 0.037
0.641HisVal: 0.641 ± 0.027
0.231HisTrp: 0.231 ± 0.016
0.873HisTyr: 0.873 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.117IleAla: 5.117 ± 0.091
0.697IleCys: 0.697 ± 0.034
4.519IleAsp: 4.519 ± 0.077
5.957IleGlu: 5.957 ± 0.095
4.354IlePhe: 4.354 ± 0.096
4.758IleGly: 4.758 ± 0.088
1.418IleHis: 1.418 ± 0.043
6.074IleIle: 6.074 ± 0.122
5.885IleLys: 5.885 ± 0.1
7.304IleLeu: 7.304 ± 0.13
1.29IleMet: 1.29 ± 0.044
4.479IleAsn: 4.479 ± 0.074
3.301IlePro: 3.301 ± 0.059
2.82IleGln: 2.82 ± 0.06
3.013IleArg: 3.013 ± 0.06
6.266IleSer: 6.266 ± 0.09
4.918IleThr: 4.918 ± 0.106
4.829IleVal: 4.829 ± 0.076
0.713IleTrp: 0.713 ± 0.03
3.142IleTyr: 3.142 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
4.933LysAla: 4.933 ± 0.093
0.405LysCys: 0.405 ± 0.023
4.395LysAsp: 4.395 ± 0.085
7.245LysGlu: 7.245 ± 0.122
3.024LysPhe: 3.024 ± 0.061
4.978LysGly: 4.978 ± 0.089
1.481LysHis: 1.481 ± 0.043
7.213LysIle: 7.213 ± 0.12
7.712LysLys: 7.712 ± 0.144
6.292LysLeu: 6.292 ± 0.103
2.362LysMet: 2.362 ± 0.057
6.16LysAsn: 6.16 ± 0.105
2.427LysPro: 2.427 ± 0.055
3.315LysGln: 3.315 ± 0.066
3.134LysArg: 3.134 ± 0.071
4.915LysSer: 4.915 ± 0.088
4.802LysThr: 4.802 ± 0.089
4.909LysVal: 4.909 ± 0.085
0.858LysTrp: 0.858 ± 0.03
3.653LysTyr: 3.653 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
5.39LeuAla: 5.39 ± 0.111
0.754LeuCys: 0.754 ± 0.037
4.285LeuAsp: 4.285 ± 0.077
5.986LeuGlu: 5.986 ± 0.115
5.02LeuPhe: 5.02 ± 0.109
5.586LeuGly: 5.586 ± 0.105
1.661LeuHis: 1.661 ± 0.053
6.402LeuIle: 6.402 ± 0.112
7.967LeuLys: 7.967 ± 0.119
8.783LeuLeu: 8.783 ± 0.162
1.967LeuMet: 1.967 ± 0.056
5.17LeuAsn: 5.17 ± 0.087
3.701LeuPro: 3.701 ± 0.073
3.854LeuGln: 3.854 ± 0.083
3.398LeuArg: 3.398 ± 0.06
6.884LeuSer: 6.884 ± 0.109
4.856LeuThr: 4.856 ± 0.082
5.026LeuVal: 5.026 ± 0.098
0.903LeuTrp: 0.903 ± 0.035
3.295LeuTyr: 3.295 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.527MetAla: 1.527 ± 0.054
0.133MetCys: 0.133 ± 0.012
0.952MetAsp: 0.952 ± 0.038
1.52MetGlu: 1.52 ± 0.052
0.942MetPhe: 0.942 ± 0.034
1.463MetGly: 1.463 ± 0.042
0.358MetHis: 0.358 ± 0.023
1.614MetIle: 1.614 ± 0.055
2.242MetLys: 2.242 ± 0.056
1.943MetLeu: 1.943 ± 0.056
0.579MetMet: 0.579 ± 0.028
1.349MetAsn: 1.349 ± 0.04
0.794MetPro: 0.794 ± 0.031
0.885MetGln: 0.885 ± 0.034
0.93MetArg: 0.93 ± 0.041
1.289MetSer: 1.289 ± 0.05
1.007MetThr: 1.007 ± 0.034
1.258MetVal: 1.258 ± 0.039
0.179MetTrp: 0.179 ± 0.015
0.784MetTyr: 0.784 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.421AsnAla: 3.421 ± 0.071
0.466AsnCys: 0.466 ± 0.034
2.978AsnAsp: 2.978 ± 0.063
4.035AsnGlu: 4.035 ± 0.074
3.311AsnPhe: 3.311 ± 0.065
3.575AsnGly: 3.575 ± 0.1
1.188AsnHis: 1.188 ± 0.043
5.227AsnIle: 5.227 ± 0.08
4.606AsnLys: 4.606 ± 0.084
5.545AsnLeu: 5.545 ± 0.087
1.111AsnMet: 1.111 ± 0.037
3.548AsnAsn: 3.548 ± 0.09
2.904AsnPro: 2.904 ± 0.072
2.56AsnGln: 2.56 ± 0.065
2.402AsnArg: 2.402 ± 0.059
3.635AsnSer: 3.635 ± 0.078
3.47AsnThr: 3.47 ± 0.071
3.808AsnVal: 3.808 ± 0.086
0.788AsnTrp: 0.788 ± 0.033
2.917AsnTyr: 2.917 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
1.608ProAla: 1.608 ± 0.068
0.222ProCys: 0.222 ± 0.018
1.821ProAsp: 1.821 ± 0.059
2.862ProGlu: 2.862 ± 0.06
1.931ProPhe: 1.931 ± 0.05
1.282ProGly: 1.282 ± 0.042
0.606ProHis: 0.606 ± 0.03
2.824ProIle: 2.824 ± 0.058
2.78ProLys: 2.78 ± 0.066
2.84ProLeu: 2.84 ± 0.057
0.751ProMet: 0.751 ± 0.032
2.262ProAsn: 2.262 ± 0.06
0.865ProPro: 0.865 ± 0.051
1.385ProGln: 1.385 ± 0.041
0.894ProArg: 0.894 ± 0.034
2.133ProSer: 2.133 ± 0.057
2.026ProThr: 2.026 ± 0.066
2.092ProVal: 2.092 ± 0.063
0.298ProTrp: 0.298 ± 0.02
1.531ProTyr: 1.531 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.044GlnAla: 2.044 ± 0.056
0.189GlnCys: 0.189 ± 0.017
1.467GlnAsp: 1.467 ± 0.042
2.805GlnGlu: 2.805 ± 0.064
1.627GlnPhe: 1.627 ± 0.044
2.039GlnGly: 2.039 ± 0.055
0.678GlnHis: 0.678 ± 0.03
2.997GlnIle: 2.997 ± 0.067
3.786GlnLys: 3.786 ± 0.081
3.335GlnLeu: 3.335 ± 0.075
0.993GlnMet: 0.993 ± 0.039
2.569GlnAsn: 2.569 ± 0.062
1.104GlnPro: 1.104 ± 0.038
1.834GlnGln: 1.834 ± 0.061
1.512GlnArg: 1.512 ± 0.044
2.162GlnSer: 2.162 ± 0.06
2.213GlnThr: 2.213 ± 0.056
2.087GlnVal: 2.087 ± 0.056
0.482GlnTrp: 0.482 ± 0.026
1.401GlnTyr: 1.401 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
1.989ArgAla: 1.989 ± 0.05
0.21ArgCys: 0.21 ± 0.015
1.661ArgAsp: 1.661 ± 0.05
2.618ArgGlu: 2.618 ± 0.068
1.988ArgPhe: 1.988 ± 0.043
2.008ArgGly: 2.008 ± 0.055
0.646ArgHis: 0.646 ± 0.028
3.117ArgIle: 3.117 ± 0.062
3.372ArgLys: 3.372 ± 0.066
3.437ArgLeu: 3.437 ± 0.077
0.998ArgMet: 0.998 ± 0.033
2.475ArgAsn: 2.475 ± 0.052
1.12ArgPro: 1.12 ± 0.039
1.217ArgGln: 1.217 ± 0.036
1.411ArgArg: 1.411 ± 0.047
1.874ArgSer: 1.874 ± 0.051
1.973ArgThr: 1.973 ± 0.044
2.227ArgVal: 2.227 ± 0.051
0.465ArgTrp: 0.465 ± 0.024
1.652ArgTyr: 1.652 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.629SerAla: 3.629 ± 0.062
0.66SerCys: 0.66 ± 0.031
3.693SerAsp: 3.693 ± 0.081
4.92SerGlu: 4.92 ± 0.088
4.013SerPhe: 4.013 ± 0.084
4.284SerGly: 4.284 ± 0.081
1.107SerHis: 1.107 ± 0.04
4.842SerIle: 4.842 ± 0.094
4.879SerLys: 4.879 ± 0.079
6.119SerLeu: 6.119 ± 0.095
1.161SerMet: 1.161 ± 0.041
3.558SerAsn: 3.558 ± 0.072
2.135SerPro: 2.135 ± 0.049
2.421SerGln: 2.421 ± 0.057
2.122SerArg: 2.122 ± 0.05
4.124SerSer: 4.124 ± 0.095
2.959SerThr: 2.959 ± 0.069
4.604SerVal: 4.604 ± 0.079
0.636SerTrp: 0.636 ± 0.029
2.855SerTyr: 2.855 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.292ThrAla: 3.292 ± 0.086
0.342ThrCys: 0.342 ± 0.034
3.093ThrAsp: 3.093 ± 0.062
3.923ThrGlu: 3.923 ± 0.074
3.088ThrPhe: 3.088 ± 0.079
3.454ThrGly: 3.454 ± 0.099
1.05ThrHis: 1.05 ± 0.037
4.836ThrIle: 4.836 ± 0.115
3.922ThrLys: 3.922 ± 0.073
5.214ThrLeu: 5.214 ± 0.084
1.025ThrMet: 1.025 ± 0.039
3.132ThrAsn: 3.132 ± 0.072
2.53ThrPro: 2.53 ± 0.087
2.18ThrGln: 2.18 ± 0.066
1.633ThrArg: 1.633 ± 0.044
3.729ThrSer: 3.729 ± 0.092
3.149ThrThr: 3.149 ± 0.1
2.484ThrVal: 2.484 ± 0.083
0.507ThrTrp: 0.507 ± 0.026
2.429ThrTyr: 2.429 ± 0.089
0.0ThrXaa: 0.0 ± 0.0
Val
4.003ValAla: 4.003 ± 0.088
0.547ValCys: 0.547 ± 0.029
2.959ValAsp: 2.959 ± 0.065
4.023ValGlu: 4.023 ± 0.083
3.334ValPhe: 3.334 ± 0.072
3.937ValGly: 3.937 ± 0.081
0.945ValHis: 0.945 ± 0.036
4.837ValIle: 4.837 ± 0.075
4.747ValLys: 4.747 ± 0.085
5.587ValLeu: 5.587 ± 0.098
1.29ValMet: 1.29 ± 0.044
3.324ValAsn: 3.324 ± 0.073
2.147ValPro: 2.147 ± 0.05
1.856ValGln: 1.856 ± 0.052
2.335ValArg: 2.335 ± 0.056
4.558ValSer: 4.558 ± 0.079
3.513ValThr: 3.513 ± 0.118
4.34ValVal: 4.34 ± 0.104
0.574ValTrp: 0.574 ± 0.025
2.446ValTyr: 2.446 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
0.602TrpAla: 0.602 ± 0.027
0.104TrpCys: 0.104 ± 0.011
0.571TrpAsp: 0.571 ± 0.025
0.774TrpGlu: 0.774 ± 0.034
0.572TrpPhe: 0.572 ± 0.025
0.736TrpGly: 0.736 ± 0.031
0.228TrpHis: 0.228 ± 0.016
0.832TrpIle: 0.832 ± 0.037
0.945TrpLys: 0.945 ± 0.04
1.026TrpLeu: 1.026 ± 0.04
0.258TrpMet: 0.258 ± 0.019
0.702TrpAsn: 0.702 ± 0.031
0.104TrpPro: 0.104 ± 0.013
0.483TrpGln: 0.483 ± 0.025
0.391TrpArg: 0.391 ± 0.023
0.545TrpSer: 0.545 ± 0.028
0.533TrpThr: 0.533 ± 0.025
0.595TrpVal: 0.595 ± 0.026
0.14TrpTrp: 0.14 ± 0.016
0.447TrpTyr: 0.447 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.388TyrAla: 2.388 ± 0.062
0.335TyrCys: 0.335 ± 0.02
2.389TyrAsp: 2.389 ± 0.059
2.841TyrGlu: 2.841 ± 0.057
2.767TyrPhe: 2.767 ± 0.064
2.675TyrGly: 2.675 ± 0.069
0.841TyrHis: 0.841 ± 0.035
3.128TyrIle: 3.128 ± 0.069
3.205TyrLys: 3.205 ± 0.064
3.897TyrLeu: 3.897 ± 0.073
0.726TyrMet: 0.726 ± 0.029
2.624TyrAsn: 2.624 ± 0.074
1.569TyrPro: 1.569 ± 0.05
1.729TyrGln: 1.729 ± 0.051
1.718TyrArg: 1.718 ± 0.052
2.552TyrSer: 2.552 ± 0.065
2.29TyrThr: 2.29 ± 0.083
2.435TyrVal: 2.435 ± 0.054
0.495TyrTrp: 0.495 ± 0.025
1.914TyrTyr: 1.914 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2439 proteins (792223 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski