Amino acid dipepetide frequency for Sphingopyxis sp. QXT-31

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.028AlaAla: 22.028 ± 0.223	1.011AlaCys: 1.011 ± 0.03	8.45AlaAsp: 8.45 ± 0.087	8.177AlaGlu: 8.177 ± 0.088	4.466AlaPhe: 4.466 ± 0.059	12.195AlaGly: 12.195 ± 0.115	2.289AlaHis: 2.289 ± 0.052	7.007AlaIle: 7.007 ± 0.088	4.795AlaLys: 4.795 ± 0.079	14.084AlaLeu: 14.084 ± 0.15	4.222AlaMet: 4.222 ± 0.065	3.331AlaAsn: 3.331 ± 0.059	7.023AlaPro: 7.023 ± 0.105	4.14AlaGln: 4.14 ± 0.058	9.356AlaArg: 9.356 ± 0.1	6.694AlaSer: 6.694 ± 0.082	6.892AlaThr: 6.892 ± 0.101	8.861AlaVal: 8.861 ± 0.085	1.768AlaTrp: 1.768 ± 0.045	2.617AlaTyr: 2.617 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.885CysAla: 0.885 ± 0.028	0.086CysCys: 0.086 ± 0.009	0.538CysAsp: 0.538 ± 0.022	0.363CysGlu: 0.363 ± 0.016	0.273CysPhe: 0.273 ± 0.015	0.806CysGly: 0.806 ± 0.023	0.204CysHis: 0.204 ± 0.018	0.35CysIle: 0.35 ± 0.016	0.16CysLys: 0.16 ± 0.012	0.661CysLeu: 0.661 ± 0.024	0.132CysMet: 0.132 ± 0.011	0.207CysAsn: 0.207 ± 0.013	0.426CysPro: 0.426 ± 0.023	0.196CysGln: 0.196 ± 0.014	0.514CysArg: 0.514 ± 0.021	0.437CysSer: 0.437 ± 0.017	0.4CysThr: 0.4 ± 0.02	0.487CysVal: 0.487 ± 0.021	0.109CysTrp: 0.109 ± 0.01	0.169CysTyr: 0.169 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.584AspAla: 8.584 ± 0.075	0.5AspCys: 0.5 ± 0.021	3.558AspAsp: 3.558 ± 0.057	3.48AspGlu: 3.48 ± 0.06	2.337AspPhe: 2.337 ± 0.046	6.047AspGly: 6.047 ± 0.082	1.323AspHis: 1.323 ± 0.037	3.19AspIle: 3.19 ± 0.054	1.905AspLys: 1.905 ± 0.042	5.719AspLeu: 5.719 ± 0.071	1.405AspMet: 1.405 ± 0.037	1.443AspAsn: 1.443 ± 0.04	3.868AspPro: 3.868 ± 0.064	1.596AspGln: 1.596 ± 0.033	4.829AspArg: 4.829 ± 0.075	2.418AspSer: 2.418 ± 0.043	2.672AspThr: 2.672 ± 0.044	4.083AspVal: 4.083 ± 0.065	1.19AspTrp: 1.19 ± 0.031	1.866AspTyr: 1.866 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.127GluAla: 8.127 ± 0.114	0.309GluCys: 0.309 ± 0.017	2.669GluAsp: 2.669 ± 0.05	2.882GluGlu: 2.882 ± 0.062	1.52GluPhe: 1.52 ± 0.037	4.689GluGly: 4.689 ± 0.063	1.031GluHis: 1.031 ± 0.032	2.916GluIle: 2.916 ± 0.048	2.047GluLys: 2.047 ± 0.044	5.076GluLeu: 5.076 ± 0.068	1.398GluMet: 1.398 ± 0.035	1.31GluAsn: 1.31 ± 0.033	2.533GluPro: 2.533 ± 0.049	1.806GluGln: 1.806 ± 0.035	4.639GluArg: 4.639 ± 0.073	2.23GluSer: 2.23 ± 0.044	3.035GluThr: 3.035 ± 0.055	3.558GluVal: 3.558 ± 0.058	0.784GluTrp: 0.784 ± 0.023	1.025GluTyr: 1.025 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	5.173PheAla: 5.173 ± 0.065	0.306PheCys: 0.306 ± 0.016	2.815PheAsp: 2.815 ± 0.046	2.008PheGlu: 2.008 ± 0.046	1.304PhePhe: 1.304 ± 0.035	3.823PheGly: 3.823 ± 0.057	0.671PheHis: 0.671 ± 0.027	1.409PheIle: 1.409 ± 0.036	0.846PheLys: 0.846 ± 0.03	3.132PheLeu: 3.132 ± 0.055	0.698PheMet: 0.698 ± 0.026	1.051PheAsn: 1.051 ± 0.035	1.557PhePro: 1.557 ± 0.037	0.917PheGln: 0.917 ± 0.028	2.189PheArg: 2.189 ± 0.041	1.855PheSer: 1.855 ± 0.04	1.986PheThr: 1.986 ± 0.039	2.638PheVal: 2.638 ± 0.048	0.503PheTrp: 0.503 ± 0.025	0.865PheTyr: 0.865 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.826GlyAla: 10.826 ± 0.121	0.784GlyCys: 0.784 ± 0.028	5.652GlyAsp: 5.652 ± 0.076	5.298GlyGlu: 5.298 ± 0.071	3.63GlyPhe: 3.63 ± 0.056	9.028GlyGly: 9.028 ± 0.15	1.927GlyHis: 1.927 ± 0.043	4.599GlyIle: 4.599 ± 0.062	3.498GlyLys: 3.498 ± 0.057	8.543GlyLeu: 8.543 ± 0.088	2.236GlyMet: 2.236 ± 0.044	2.477GlyAsn: 2.477 ± 0.092	3.798GlyPro: 3.798 ± 0.054	3.053GlyGln: 3.053 ± 0.049	6.262GlyArg: 6.262 ± 0.074	4.896GlySer: 4.896 ± 0.078	4.998GlyThr: 4.998 ± 0.097	6.253GlyVal: 6.253 ± 0.076	1.82GlyTrp: 1.82 ± 0.041	2.405GlyTyr: 2.405 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.334HisAla: 2.334 ± 0.046	0.219HisCys: 0.219 ± 0.013	1.214HisAsp: 1.214 ± 0.032	0.903HisGlu: 0.903 ± 0.027	0.854HisPhe: 0.854 ± 0.03	1.958HisGly: 1.958 ± 0.042	0.527HisHis: 0.527 ± 0.022	0.969HisIle: 0.969 ± 0.03	0.516HisLys: 0.516 ± 0.019	1.794HisLeu: 1.794 ± 0.043	0.457HisMet: 0.457 ± 0.018	0.44HisAsn: 0.44 ± 0.02	1.269HisPro: 1.269 ± 0.033	0.516HisGln: 0.516 ± 0.022	1.462HisArg: 1.462 ± 0.042	0.944HisSer: 0.944 ± 0.029	0.599HisThr: 0.599 ± 0.022	1.416HisVal: 1.416 ± 0.034	0.397HisTrp: 0.397 ± 0.019	0.561HisTyr: 0.561 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	8.088IleAla: 8.088 ± 0.086	0.383IleCys: 0.383 ± 0.018	4.253IleAsp: 4.253 ± 0.064	3.347IleGlu: 3.347 ± 0.058	1.713IlePhe: 1.713 ± 0.045	5.123IleGly: 5.123 ± 0.07	0.87IleHis: 0.87 ± 0.028	1.921IleIle: 1.921 ± 0.045	1.248IleLys: 1.248 ± 0.035	4.111IleLeu: 4.111 ± 0.058	0.854IleMet: 0.854 ± 0.027	1.273IleAsn: 1.273 ± 0.036	2.266IlePro: 2.266 ± 0.045	1.087IleGln: 1.087 ± 0.034	3.159IleArg: 3.159 ± 0.054	2.375IleSer: 2.375 ± 0.04	2.324IleThr: 2.324 ± 0.052	4.216IleVal: 4.216 ± 0.063	0.675IleTrp: 0.675 ± 0.023	0.987IleTyr: 0.987 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.507LysAla: 4.507 ± 0.068	0.158LysCys: 0.158 ± 0.012	1.72LysAsp: 1.72 ± 0.044	1.374LysGlu: 1.374 ± 0.039	0.911LysPhe: 0.911 ± 0.03	2.82LysGly: 2.82 ± 0.047	0.587LysHis: 0.587 ± 0.023	1.482LysIle: 1.482 ± 0.038	1.265LysLys: 1.265 ± 0.035	3.277LysLeu: 3.277 ± 0.062	0.783LysMet: 0.783 ± 0.027	0.701LysAsn: 0.701 ± 0.023	2.058LysPro: 2.058 ± 0.042	0.889LysGln: 0.889 ± 0.028	2.237LysArg: 2.237 ± 0.048	1.631LysSer: 1.631 ± 0.039	1.735LysThr: 1.735 ± 0.04	2.136LysVal: 2.136 ± 0.048	0.449LysTrp: 0.449 ± 0.018	0.654LysTyr: 0.654 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.747LeuAla: 14.747 ± 0.138	0.695LeuCys: 0.695 ± 0.022	5.947LeuAsp: 5.947 ± 0.076	4.219LeuGlu: 4.219 ± 0.053	3.79LeuPhe: 3.79 ± 0.067	8.408LeuGly: 8.408 ± 0.082	1.817LeuHis: 1.817 ± 0.046	4.841LeuIle: 4.841 ± 0.07	2.92LeuLys: 2.92 ± 0.049	9.513LeuLeu: 9.513 ± 0.123	2.067LeuMet: 2.067 ± 0.048	2.221LeuAsn: 2.221 ± 0.047	5.624LeuPro: 5.624 ± 0.07	2.317LeuGln: 2.317 ± 0.043	6.314LeuArg: 6.314 ± 0.085	5.573LeuSer: 5.573 ± 0.073	5.579LeuThr: 5.579 ± 0.077	7.293LeuVal: 7.293 ± 0.079	1.29LeuTrp: 1.29 ± 0.039	1.985LeuTyr: 1.985 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.292MetAla: 3.292 ± 0.056	0.14MetCys: 0.14 ± 0.011	1.054MetAsp: 1.054 ± 0.03	1.065MetGlu: 1.065 ± 0.032	0.68MetPhe: 0.68 ± 0.023	1.89MetGly: 1.89 ± 0.044	0.412MetHis: 0.412 ± 0.02	1.34MetIle: 1.34 ± 0.036	0.908MetLys: 0.908 ± 0.026	2.699MetLeu: 2.699 ± 0.048	0.632MetMet: 0.632 ± 0.025	0.652MetAsn: 0.652 ± 0.021	1.451MetPro: 1.451 ± 0.035	0.698MetGln: 0.698 ± 0.027	1.76MetArg: 1.76 ± 0.042	1.385MetSer: 1.385 ± 0.029	1.845MetThr: 1.845 ± 0.04	1.534MetVal: 1.534 ± 0.038	0.227MetTrp: 0.227 ± 0.014	0.245MetTyr: 0.245 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.268AsnAla: 3.268 ± 0.061	0.238AsnCys: 0.238 ± 0.014	1.511AsnAsp: 1.511 ± 0.05	1.09AsnGlu: 1.09 ± 0.03	1.04AsnPhe: 1.04 ± 0.032	2.462AsnGly: 2.462 ± 0.059	0.452AsnHis: 0.452 ± 0.022	1.407AsnIle: 1.407 ± 0.034	0.667AsnLys: 0.667 ± 0.025	2.421AsnLeu: 2.421 ± 0.052	0.549AsnMet: 0.549 ± 0.022	0.735AsnAsn: 0.735 ± 0.032	1.77AsnPro: 1.77 ± 0.038	0.682AsnGln: 0.682 ± 0.028	1.79AsnArg: 1.79 ± 0.041	1.226AsnSer: 1.226 ± 0.038	1.01AsnThr: 1.01 ± 0.035	1.795AsnVal: 1.795 ± 0.048	0.437AsnTrp: 0.437 ± 0.019	0.733AsnTyr: 0.733 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.715ProAla: 7.715 ± 0.1	0.316ProCys: 0.316 ± 0.016	3.811ProAsp: 3.811 ± 0.061	3.392ProGlu: 3.392 ± 0.06	1.855ProPhe: 1.855 ± 0.037	5.098ProGly: 5.098 ± 0.065	1.022ProHis: 1.022 ± 0.03	2.387ProIle: 2.387 ± 0.046	1.694ProLys: 1.694 ± 0.039	4.977ProLeu: 4.977 ± 0.067	1.232ProMet: 1.232 ± 0.031	1.245ProAsn: 1.245 ± 0.035	3.019ProPro: 3.019 ± 0.073	1.538ProGln: 1.538 ± 0.038	2.999ProArg: 2.999 ± 0.052	2.511ProSer: 2.511 ± 0.043	2.603ProThr: 2.603 ± 0.043	4.435ProVal: 4.435 ± 0.069	0.694ProTrp: 0.694 ± 0.025	1.143ProTyr: 1.143 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.845GlnAla: 3.845 ± 0.056	0.201GlnCys: 0.201 ± 0.013	1.336GlnAsp: 1.336 ± 0.034	1.15GlnGlu: 1.15 ± 0.034	1.03GlnPhe: 1.03 ± 0.03	2.349GlnGly: 2.349 ± 0.046	0.591GlnHis: 0.591 ± 0.019	1.654GlnIle: 1.654 ± 0.035	0.875GlnLys: 0.875 ± 0.027	3.059GlnLeu: 3.059 ± 0.05	0.755GlnMet: 0.755 ± 0.025	0.73GlnAsn: 0.73 ± 0.027	1.727GlnPro: 1.727 ± 0.038	1.09GlnGln: 1.09 ± 0.035	2.36GlnArg: 2.36 ± 0.046	1.596GlnSer: 1.596 ± 0.041	1.433GlnThr: 1.433 ± 0.034	2.049GlnVal: 2.049 ± 0.039	0.43GlnTrp: 0.43 ± 0.02	0.654GlnTyr: 0.654 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.723ArgAla: 8.723 ± 0.083	0.478ArgCys: 0.478 ± 0.021	4.273ArgAsp: 4.273 ± 0.07	3.854ArgGlu: 3.854 ± 0.063	2.953ArgPhe: 2.953 ± 0.054	5.208ArgGly: 5.208 ± 0.074	1.584ArgHis: 1.584 ± 0.038	4.042ArgIle: 4.042 ± 0.064	2.008ArgLys: 2.008 ± 0.041	7.79ArgLeu: 7.79 ± 0.096	1.824ArgMet: 1.824 ± 0.04	1.694ArgAsn: 1.694 ± 0.037	3.51ArgPro: 3.51 ± 0.05	2.248ArgGln: 2.248 ± 0.048	5.378ArgArg: 5.378 ± 0.089	3.449ArgSer: 3.449 ± 0.061	3.32ArgThr: 3.32 ± 0.049	4.577ArgVal: 4.577 ± 0.066	1.262ArgTrp: 1.262 ± 0.037	1.813ArgTyr: 1.813 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.29SerAla: 6.29 ± 0.079	0.376SerCys: 0.376 ± 0.019	3.161SerAsp: 3.161 ± 0.05	2.565SerGlu: 2.565 ± 0.05	2.223SerPhe: 2.223 ± 0.04	5.319SerGly: 5.319 ± 0.083	0.917SerHis: 0.917 ± 0.028	2.64SerIle: 2.64 ± 0.044	1.394SerLys: 1.394 ± 0.035	4.958SerLeu: 4.958 ± 0.068	1.134SerMet: 1.134 ± 0.031	1.383SerAsn: 1.383 ± 0.035	2.705SerPro: 2.705 ± 0.044	1.392SerGln: 1.392 ± 0.039	3.139SerArg: 3.139 ± 0.057	2.527SerSer: 2.527 ± 0.051	2.335SerThr: 2.335 ± 0.057	3.608SerVal: 3.608 ± 0.058	0.833SerTrp: 0.833 ± 0.028	1.338SerTyr: 1.338 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.509ThrAla: 6.509 ± 0.093	0.354ThrCys: 0.354 ± 0.018	3.023ThrAsp: 3.023 ± 0.053	2.312ThrGlu: 2.312 ± 0.043	1.614ThrPhe: 1.614 ± 0.037	5.497ThrGly: 5.497 ± 0.111	0.991ThrHis: 0.991 ± 0.031	3.045ThrIle: 3.045 ± 0.055	1.392ThrLys: 1.392 ± 0.032	5.627ThrLeu: 5.627 ± 0.069	1.185ThrMet: 1.185 ± 0.037	1.36ThrAsn: 1.36 ± 0.036	3.324ThrPro: 3.324 ± 0.058	1.293ThrGln: 1.293 ± 0.034	3.356ThrArg: 3.356 ± 0.057	2.658ThrSer: 2.658 ± 0.056	2.738ThrThr: 2.738 ± 0.059	3.883ThrVal: 3.883 ± 0.062	0.592ThrTrp: 0.592 ± 0.023	1.063ThrTyr: 1.063 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.188ValAla: 10.188 ± 0.098	0.502ValCys: 0.502 ± 0.02	4.55ValAsp: 4.55 ± 0.067	4.379ValGlu: 4.379 ± 0.056	2.082ValPhe: 2.082 ± 0.038	5.908ValGly: 5.908 ± 0.065	1.306ValHis: 1.306 ± 0.034	3.534ValIle: 3.534 ± 0.053	2.129ValLys: 2.129 ± 0.044	5.794ValLeu: 5.794 ± 0.071	1.572ValMet: 1.572 ± 0.04	1.924ValAsn: 1.924 ± 0.043	3.933ValPro: 3.933 ± 0.059	2.081ValGln: 2.081 ± 0.042	4.947ValArg: 4.947 ± 0.067	3.691ValSer: 3.691 ± 0.063	4.467ValThr: 4.467 ± 0.078	5.099ValVal: 5.099 ± 0.082	0.854ValTrp: 0.854 ± 0.027	1.431ValTyr: 1.431 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.493TrpAla: 1.493 ± 0.039	0.125TrpCys: 0.125 ± 0.01	0.824TrpAsp: 0.824 ± 0.028	0.598TrpGlu: 0.598 ± 0.023	0.61TrpPhe: 0.61 ± 0.023	1.056TrpGly: 1.056 ± 0.03	0.358TrpHis: 0.358 ± 0.015	0.706TrpIle: 0.706 ± 0.026	0.476TrpLys: 0.476 ± 0.02	1.83TrpLeu: 1.83 ± 0.05	0.354TrpMet: 0.354 ± 0.018	0.465TrpAsn: 0.465 ± 0.023	0.787TrpPro: 0.787 ± 0.031	0.685TrpGln: 0.685 ± 0.026	1.335TrpArg: 1.335 ± 0.036	0.911TrpSer: 0.911 ± 0.029	0.879TrpThr: 0.879 ± 0.026	0.908TrpVal: 0.908 ± 0.029	0.288TrpTrp: 0.288 ± 0.017	0.305TrpTyr: 0.305 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.787TyrAla: 2.787 ± 0.047	0.218TyrCys: 0.218 ± 0.014	1.652TyrAsp: 1.652 ± 0.044	1.132TyrGlu: 1.132 ± 0.034	0.86TyrPhe: 0.86 ± 0.025	2.3TyrGly: 2.3 ± 0.047	0.469TyrHis: 0.469 ± 0.018	0.835TyrIle: 0.835 ± 0.025	0.632TyrLys: 0.632 ± 0.023	2.096TyrLeu: 2.096 ± 0.043	0.418TyrMet: 0.418 ± 0.02	0.639TyrAsn: 0.639 ± 0.024	1.038TyrPro: 1.038 ± 0.032	0.692TyrGln: 0.692 ± 0.023	1.962TyrArg: 1.962 ± 0.049	1.232TyrSer: 1.232 ± 0.03	0.964TyrThr: 0.964 ± 0.028	1.544TyrVal: 1.544 ± 0.034	0.389TyrTrp: 0.389 ± 0.019	0.655TyrTyr: 0.655 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4007 proteins (1276034 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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