Amino acid dipepetide frequency for Peach chlorotic mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.102AlaAla: 5.102 ± 5.022
2.041AlaCys: 2.041 ± 0.95
1.361AlaAsp: 1.361 ± 0.463
2.381AlaGlu: 2.381 ± 0.841
3.061AlaPhe: 3.061 ± 1.583
4.762AlaGly: 4.762 ± 1.407
1.361AlaHis: 1.361 ± 0.664
4.082AlaIle: 4.082 ± 0.677
4.762AlaLys: 4.762 ± 1.368
7.143AlaLeu: 7.143 ± 2.589
0.68AlaMet: 0.68 ± 0.428
2.721AlaAsn: 2.721 ± 1.074
1.361AlaPro: 1.361 ± 0.723
1.361AlaGln: 1.361 ± 0.944
2.721AlaArg: 2.721 ± 1.222
3.741AlaSer: 3.741 ± 1.314
4.422AlaThr: 4.422 ± 3.213
4.762AlaVal: 4.762 ± 1.981
0.0AlaTrp: 0.0 ± 0.0
1.361AlaTyr: 1.361 ± 1.041
0.0AlaXaa: 0.0 ± 0.0
Cys
2.381CysAla: 2.381 ± 0.804
1.361CysCys: 1.361 ± 0.944
0.68CysAsp: 0.68 ± 1.279
1.02CysGlu: 1.02 ± 0.69
2.041CysPhe: 2.041 ± 0.746
3.061CysGly: 3.061 ± 1.177
0.34CysHis: 0.34 ± 0.176
2.721CysIle: 2.721 ± 2.086
0.34CysLys: 0.34 ± 0.176
2.041CysLeu: 2.041 ± 0.95
0.34CysMet: 0.34 ± 0.176
1.02CysAsn: 1.02 ± 1.204
1.02CysPro: 1.02 ± 0.989
1.361CysGln: 1.361 ± 1.505
0.68CysArg: 0.68 ± 0.352
1.701CysSer: 1.701 ± 0.881
3.061CysThr: 3.061 ± 1.173
2.041CysVal: 2.041 ± 1.127
0.0CysTrp: 0.0 ± 0.0
1.02CysTyr: 1.02 ± 0.528
0.0CysXaa: 0.0 ± 0.0
Asp
2.381AspAla: 2.381 ± 1.233
1.361AspCys: 1.361 ± 1.515
2.381AspAsp: 2.381 ± 0.841
4.422AspGlu: 4.422 ± 1.184
3.401AspPhe: 3.401 ± 0.747
4.082AspGly: 4.082 ± 1.145
1.361AspHis: 1.361 ± 0.705
2.381AspIle: 2.381 ± 1.233
1.701AspLys: 1.701 ± 0.684
8.844AspLeu: 8.844 ± 2.888
0.68AspMet: 0.68 ± 0.352
2.721AspAsn: 2.721 ± 1.078
2.041AspPro: 2.041 ± 1.452
1.02AspGln: 1.02 ± 0.853
1.701AspArg: 1.701 ± 0.568
3.741AspSer: 3.741 ± 1.509
1.02AspThr: 1.02 ± 0.69
2.381AspVal: 2.381 ± 0.856
0.68AspTrp: 0.68 ± 0.352
1.701AspTyr: 1.701 ± 0.568
0.0AspXaa: 0.0 ± 0.0
Glu
4.762GluAla: 4.762 ± 1.251
1.02GluCys: 1.02 ± 0.528
2.721GluAsp: 2.721 ± 1.328
5.782GluGlu: 5.782 ± 2.182
3.401GluPhe: 3.401 ± 1.016
2.721GluGly: 2.721 ± 0.959
1.02GluHis: 1.02 ± 0.528
4.422GluIle: 4.422 ± 1.85
2.381GluLys: 2.381 ± 0.525
4.762GluLeu: 4.762 ± 1.942
2.041GluMet: 2.041 ± 1.057
2.381GluAsn: 2.381 ± 0.525
1.701GluPro: 1.701 ± 0.615
1.02GluGln: 1.02 ± 0.528
3.741GluArg: 3.741 ± 0.903
4.082GluSer: 4.082 ± 1.496
2.721GluThr: 2.721 ± 1.222
5.102GluVal: 5.102 ± 2.135
0.68GluTrp: 0.68 ± 0.428
2.041GluTyr: 2.041 ± 2.273
0.0GluXaa: 0.0 ± 0.0
Phe
3.741PheAla: 3.741 ± 1.429
2.041PheCys: 2.041 ± 1.218
3.061PheAsp: 3.061 ± 0.671
5.102PheGlu: 5.102 ± 2.666
3.401PhePhe: 3.401 ± 0.767
3.741PheGly: 3.741 ± 2.392
1.02PheHis: 1.02 ± 0.528
4.762PheIle: 4.762 ± 1.368
3.061PheLys: 3.061 ± 1.585
6.122PheLeu: 6.122 ± 1.871
1.361PheMet: 1.361 ± 0.463
2.381PheAsn: 2.381 ± 1.095
4.082PhePro: 4.082 ± 1.736
2.381PheGln: 2.381 ± 1.233
3.061PheArg: 3.061 ± 0.834
6.122PheSer: 6.122 ± 1.662
3.061PheThr: 3.061 ± 1.021
1.701PheVal: 1.701 ± 0.615
0.68PheTrp: 0.68 ± 0.352
2.721PheTyr: 2.721 ± 0.82
0.0PheXaa: 0.0 ± 0.0
Gly
3.741GlyAla: 3.741 ± 1.13
2.041GlyCys: 2.041 ± 0.702
3.401GlyAsp: 3.401 ± 0.747
3.741GlyGlu: 3.741 ± 1.538
3.741GlyPhe: 3.741 ± 1.42
3.061GlyGly: 3.061 ± 1.344
1.02GlyHis: 1.02 ± 0.528
4.082GlyIle: 4.082 ± 0.683
7.483GlyLys: 7.483 ± 2.724
6.803GlyLeu: 6.803 ± 2.308
0.68GlyMet: 0.68 ± 0.428
2.381GlyAsn: 2.381 ± 0.826
2.721GlyPro: 2.721 ± 1.254
1.02GlyGln: 1.02 ± 0.69
3.061GlyArg: 3.061 ± 2.06
7.143GlySer: 7.143 ± 2.582
3.401GlyThr: 3.401 ± 2.094
3.741GlyVal: 3.741 ± 2.241
1.701GlyTrp: 1.701 ± 0.881
2.041GlyTyr: 2.041 ± 0.915
0.0GlyXaa: 0.0 ± 0.0
His
1.361HisAla: 1.361 ± 2.512
2.041HisCys: 2.041 ± 1.218
1.361HisAsp: 1.361 ± 0.705
1.361HisGlu: 1.361 ± 0.664
2.041HisPhe: 2.041 ± 0.746
1.361HisGly: 1.361 ± 0.944
1.02HisHis: 1.02 ± 2.017
1.361HisIle: 1.361 ± 0.705
2.041HisLys: 2.041 ± 1.057
2.721HisLeu: 2.721 ± 1.078
0.0HisMet: 0.0 ± 0.0
0.34HisAsn: 0.34 ± 0.176
1.02HisPro: 1.02 ± 1.204
1.361HisGln: 1.361 ± 0.664
0.68HisArg: 0.68 ± 0.352
4.082HisSer: 4.082 ± 1.546
0.68HisThr: 0.68 ± 0.352
0.68HisVal: 0.68 ± 0.352
0.0HisTrp: 0.0 ± 0.0
0.68HisTyr: 0.68 ± 0.352
0.0HisXaa: 0.0 ± 0.0
Ile
2.721IleAla: 2.721 ± 1.203
1.361IleCys: 1.361 ± 0.664
2.381IleAsp: 2.381 ± 0.852
4.082IleGlu: 4.082 ± 1.492
4.082IlePhe: 4.082 ± 0.683
4.762IleGly: 4.762 ± 1.477
3.061IleHis: 3.061 ± 0.997
4.082IleIle: 4.082 ± 5.104
3.401IleLys: 3.401 ± 0.668
6.803IleLeu: 6.803 ± 1.667
1.701IleMet: 1.701 ± 0.856
4.422IleAsn: 4.422 ± 1.705
1.701IlePro: 1.701 ± 0.881
1.701IleGln: 1.701 ± 0.684
2.721IleArg: 2.721 ± 0.719
6.803IleSer: 6.803 ± 2.379
3.401IleThr: 3.401 ± 1.188
1.361IleVal: 1.361 ± 2.347
0.68IleTrp: 0.68 ± 0.998
1.361IleTyr: 1.361 ± 0.705
0.0IleXaa: 0.0 ± 0.0
Lys
3.741LysAla: 3.741 ± 0.903
2.041LysCys: 2.041 ± 1.057
2.041LysAsp: 2.041 ± 0.746
3.401LysGlu: 3.401 ± 0.915
5.442LysPhe: 5.442 ± 1.681
4.762LysGly: 4.762 ± 0.976
1.361LysHis: 1.361 ± 0.705
3.741LysIle: 3.741 ± 0.803
5.102LysLys: 5.102 ± 1.457
5.442LysLeu: 5.442 ± 2.203
1.361LysMet: 1.361 ± 0.463
2.381LysAsn: 2.381 ± 0.841
4.762LysPro: 4.762 ± 1.739
1.361LysGln: 1.361 ± 0.463
1.701LysArg: 1.701 ± 0.568
6.122LysSer: 6.122 ± 1.996
1.701LysThr: 1.701 ± 0.684
3.401LysVal: 3.401 ± 1.371
0.0LysTrp: 0.0 ± 0.0
1.361LysTyr: 1.361 ± 0.463
0.0LysXaa: 0.0 ± 0.0
Leu
6.803LeuAla: 6.803 ± 5.301
2.381LeuCys: 2.381 ± 1.233
4.762LeuAsp: 4.762 ± 1.681
6.463LeuGlu: 6.463 ± 2.323
5.442LeuPhe: 5.442 ± 2.203
6.463LeuGly: 6.463 ± 1.706
2.041LeuHis: 2.041 ± 0.95
7.823LeuIle: 7.823 ± 1.474
6.463LeuLys: 6.463 ± 2.375
7.143LeuLeu: 7.143 ± 1.064
2.721LeuMet: 2.721 ± 0.893
4.762LeuAsn: 4.762 ± 0.976
6.463LeuPro: 6.463 ± 2.244
2.721LeuGln: 2.721 ± 0.564
5.102LeuArg: 5.102 ± 1.533
9.524LeuSer: 9.524 ± 2.048
5.102LeuThr: 5.102 ± 1.285
4.422LeuVal: 4.422 ± 1.707
1.02LeuTrp: 1.02 ± 0.528
1.361LeuTyr: 1.361 ± 0.723
0.0LeuXaa: 0.0 ± 0.0
Met
2.381MetAla: 2.381 ± 0.852
0.68MetCys: 0.68 ± 0.352
1.701MetAsp: 1.701 ± 0.684
0.68MetGlu: 0.68 ± 0.428
0.34MetPhe: 0.34 ± 0.176
1.701MetGly: 1.701 ± 0.568
0.0MetHis: 0.0 ± 0.0
0.68MetIle: 0.68 ± 0.352
1.361MetLys: 1.361 ± 0.463
1.361MetLeu: 1.361 ± 0.856
0.34MetMet: 0.34 ± 0.176
0.0MetAsn: 0.0 ± 0.0
1.361MetPro: 1.361 ± 0.944
1.02MetGln: 1.02 ± 1.204
1.701MetArg: 1.701 ± 0.881
2.721MetSer: 2.721 ± 0.926
0.0MetThr: 0.0 ± 0.0
0.68MetVal: 0.68 ± 0.428
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.02AsnAla: 1.02 ± 0.528
2.381AsnCys: 2.381 ± 1.15
1.02AsnAsp: 1.02 ± 0.528
1.701AsnGlu: 1.701 ± 0.568
4.082AsnPhe: 4.082 ± 2.114
3.061AsnGly: 3.061 ± 1.585
1.361AsnHis: 1.361 ± 0.664
3.061AsnIle: 3.061 ± 1.845
1.361AsnLys: 1.361 ± 0.463
4.422AsnLeu: 4.422 ± 1.826
1.02AsnMet: 1.02 ± 0.599
2.041AsnAsn: 2.041 ± 2.059
2.721AsnPro: 2.721 ± 0.82
1.02AsnGln: 1.02 ± 0.41
2.721AsnArg: 2.721 ± 0.719
3.741AsnSer: 3.741 ± 2.465
1.361AsnThr: 1.361 ± 0.664
3.061AsnVal: 3.061 ± 1.173
0.34AsnTrp: 0.34 ± 0.176
1.02AsnTyr: 1.02 ± 0.989
0.0AsnXaa: 0.0 ± 0.0
Pro
2.041ProAla: 2.041 ± 2.079
2.721ProCys: 2.721 ± 1.174
5.102ProAsp: 5.102 ± 1.457
3.061ProGlu: 3.061 ± 1.081
1.701ProPhe: 1.701 ± 0.819
3.401ProGly: 3.401 ± 0.944
1.701ProHis: 1.701 ± 2.393
2.721ProIle: 2.721 ± 0.719
2.041ProLys: 2.041 ± 0.868
4.082ProLeu: 4.082 ± 2.514
0.34ProMet: 0.34 ± 0.511
1.361ProAsn: 1.361 ± 0.664
2.041ProPro: 2.041 ± 0.868
1.02ProGln: 1.02 ± 1.158
1.701ProArg: 1.701 ± 0.819
2.381ProSer: 2.381 ± 1.233
4.082ProThr: 4.082 ± 3.664
3.741ProVal: 3.741 ± 1.629
1.02ProTrp: 1.02 ± 0.528
1.361ProTyr: 1.361 ± 1.151
0.0ProXaa: 0.0 ± 0.0
Gln
0.34GlnAla: 0.34 ± 0.511
0.34GlnCys: 0.34 ± 0.176
0.68GlnAsp: 0.68 ± 0.352
1.02GlnGlu: 1.02 ± 0.41
1.701GlnPhe: 1.701 ± 0.568
1.361GlnGly: 1.361 ± 0.705
0.68GlnHis: 0.68 ± 1.062
2.721GlnIle: 2.721 ± 1.203
2.041GlnLys: 2.041 ± 0.544
3.061GlnLeu: 3.061 ± 0.671
0.68GlnMet: 0.68 ± 0.37
1.361GlnAsn: 1.361 ± 0.664
3.061GlnPro: 3.061 ± 1.802
1.02GlnGln: 1.02 ± 0.41
1.02GlnArg: 1.02 ± 0.69
2.721GlnSer: 2.721 ± 1.232
1.701GlnThr: 1.701 ± 0.568
2.381GlnVal: 2.381 ± 0.841
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
3.401ArgAla: 3.401 ± 0.767
1.02ArgCys: 1.02 ± 0.989
2.381ArgAsp: 2.381 ± 1.241
2.721ArgGlu: 2.721 ± 0.959
3.401ArgPhe: 3.401 ± 1.237
1.701ArgGly: 1.701 ± 1.219
2.381ArgHis: 2.381 ± 0.525
0.68ArgIle: 0.68 ± 0.352
2.381ArgLys: 2.381 ± 0.852
5.442ArgLeu: 5.442 ± 1.164
0.0ArgMet: 0.0 ± 0.0
2.381ArgAsn: 2.381 ± 1.318
1.701ArgPro: 1.701 ± 1.349
1.02ArgGln: 1.02 ± 0.926
3.061ArgArg: 3.061 ± 1.173
4.762ArgSer: 4.762 ± 1.613
2.041ArgThr: 2.041 ± 0.915
3.061ArgVal: 3.061 ± 1.021
1.02ArgTrp: 1.02 ± 0.69
2.721ArgTyr: 2.721 ± 0.959
0.0ArgXaa: 0.0 ± 0.0
Ser
3.741SerAla: 3.741 ± 1.511
1.361SerCys: 1.361 ± 1.151
7.143SerAsp: 7.143 ± 1.809
4.422SerGlu: 4.422 ± 1.551
5.442SerPhe: 5.442 ± 1.07
6.463SerGly: 6.463 ± 2.303
3.401SerHis: 3.401 ± 1.761
5.442SerIle: 5.442 ± 2.369
7.483SerLys: 7.483 ± 1.421
8.163SerLeu: 8.163 ± 2.103
2.041SerMet: 2.041 ± 0.732
2.381SerAsn: 2.381 ± 0.856
3.061SerPro: 3.061 ± 1.278
3.061SerGln: 3.061 ± 0.649
4.422SerArg: 4.422 ± 1.85
8.163SerSer: 8.163 ± 2.751
6.122SerThr: 6.122 ± 1.537
6.803SerVal: 6.803 ± 2.389
1.02SerTrp: 1.02 ± 0.528
3.401SerTyr: 3.401 ± 1.292
0.0SerXaa: 0.0 ± 0.0
Thr
4.082ThrAla: 4.082 ± 2.589
0.34ThrCys: 0.34 ± 1.157
1.02ThrAsp: 1.02 ± 0.528
2.041ThrGlu: 2.041 ± 0.819
5.782ThrPhe: 5.782 ± 0.83
4.082ThrGly: 4.082 ± 1.991
1.02ThrHis: 1.02 ± 0.528
2.721ThrIle: 2.721 ± 0.926
1.701ThrLys: 1.701 ± 0.942
5.782ThrLeu: 5.782 ± 1.054
1.02ThrMet: 1.02 ± 0.41
2.721ThrAsn: 2.721 ± 1.232
2.721ThrPro: 2.721 ± 2.003
1.701ThrGln: 1.701 ± 1.942
1.701ThrArg: 1.701 ± 1.749
4.762ThrSer: 4.762 ± 1.023
3.061ThrThr: 3.061 ± 2.929
3.741ThrVal: 3.741 ± 1.511
0.68ThrTrp: 0.68 ± 0.352
1.02ThrTyr: 1.02 ± 0.41
0.0ThrXaa: 0.0 ± 0.0
Val
2.721ValAla: 2.721 ± 1.713
0.34ValCys: 0.34 ± 0.176
4.422ValAsp: 4.422 ± 1.005
2.721ValGlu: 2.721 ± 1.445
3.741ValPhe: 3.741 ± 4.441
4.422ValGly: 4.422 ± 2.633
1.02ValHis: 1.02 ± 0.69
2.041ValIle: 2.041 ± 2.081
4.082ValLys: 4.082 ± 1.601
5.102ValLeu: 5.102 ± 1.737
0.68ValMet: 0.68 ± 0.352
2.381ValAsn: 2.381 ± 0.841
2.721ValPro: 2.721 ± 1.858
2.381ValGln: 2.381 ± 0.856
4.422ValArg: 4.422 ± 1.672
5.442ValSer: 5.442 ± 2.203
4.082ValThr: 4.082 ± 1.995
3.401ValVal: 3.401 ± 1.136
0.68ValTrp: 0.68 ± 0.428
1.02ValTyr: 1.02 ± 0.41
0.0ValXaa: 0.0 ± 0.0
Trp
0.68TrpAla: 0.68 ± 0.352
0.68TrpCys: 0.68 ± 0.352
0.68TrpAsp: 0.68 ± 0.352
0.34TrpGlu: 0.34 ± 0.176
1.02TrpPhe: 1.02 ± 0.41
1.02TrpGly: 1.02 ± 0.69
0.68TrpHis: 0.68 ± 0.352
0.34TrpIle: 0.34 ± 0.176
0.34TrpLys: 0.34 ± 0.176
1.02TrpLeu: 1.02 ± 0.528
0.0TrpMet: 0.0 ± 0.0
0.68TrpAsn: 0.68 ± 0.998
0.68TrpPro: 0.68 ± 0.352
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.361TrpSer: 1.361 ± 0.463
0.0TrpThr: 0.0 ± 0.0
0.68TrpVal: 0.68 ± 0.352
0.0TrpTrp: 0.0 ± 0.0
0.34TrpTyr: 0.34 ± 0.176
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.041TyrAla: 2.041 ± 1.186
0.68TyrCys: 0.68 ± 1.062
1.701TyrAsp: 1.701 ± 0.881
2.041TyrGlu: 2.041 ± 0.702
0.34TyrPhe: 0.34 ± 0.176
1.02TyrGly: 1.02 ± 0.853
0.34TyrHis: 0.34 ± 1.372
2.721TyrIle: 2.721 ± 1.328
1.701TyrLys: 1.701 ± 0.568
2.721TyrLeu: 2.721 ± 1.012
0.68TyrMet: 0.68 ± 0.352
1.701TyrAsn: 1.701 ± 0.568
0.68TyrPro: 0.68 ± 0.352
0.68TyrGln: 0.68 ± 0.352
1.361TyrArg: 1.361 ± 0.723
4.422TyrSer: 4.422 ± 0.897
0.68TyrThr: 0.68 ± 0.352
0.68TyrVal: 0.68 ± 1.062
0.34TyrTrp: 0.34 ± 0.176
0.34TyrTyr: 0.34 ± 0.511
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2941 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski