Amino acid dipepetide frequency for Terriglobus roseus (strain DSM 18391 / NRRL B-41598 / KBS 63)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.079AlaAla: 15.079 ± 0.133	0.982AlaCys: 0.982 ± 0.031	5.681AlaAsp: 5.681 ± 0.072	6.161AlaGlu: 6.161 ± 0.084	3.654AlaPhe: 3.654 ± 0.054	9.296AlaGly: 9.296 ± 0.107	2.22AlaHis: 2.22 ± 0.043	5.534AlaIle: 5.534 ± 0.066	4.425AlaLys: 4.425 ± 0.079	11.348AlaLeu: 11.348 ± 0.118	3.189AlaMet: 3.189 ± 0.049	3.635AlaAsn: 3.635 ± 0.054	5.599AlaPro: 5.599 ± 0.082	4.549AlaGln: 4.549 ± 0.069	6.043AlaArg: 6.043 ± 0.076	6.935AlaSer: 6.935 ± 0.074	7.18AlaThr: 7.18 ± 0.096	8.429AlaVal: 8.429 ± 0.085	1.352AlaTrp: 1.352 ± 0.035	2.618AlaTyr: 2.618 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.925CysAla: 0.925 ± 0.029	0.156CysCys: 0.156 ± 0.011	0.453CysAsp: 0.453 ± 0.017	0.383CysGlu: 0.383 ± 0.018	0.363CysPhe: 0.363 ± 0.016	0.953CysGly: 0.953 ± 0.027	0.207CysHis: 0.207 ± 0.014	0.445CysIle: 0.445 ± 0.02	0.23CysLys: 0.23 ± 0.012	0.729CysLeu: 0.729 ± 0.023	0.195CysMet: 0.195 ± 0.012	0.231CysAsn: 0.231 ± 0.013	0.407CysPro: 0.407 ± 0.021	0.207CysGln: 0.207 ± 0.012	0.466CysArg: 0.466 ± 0.019	0.584CysSer: 0.584 ± 0.022	0.566CysThr: 0.566 ± 0.024	0.618CysVal: 0.618 ± 0.02	0.105CysTrp: 0.105 ± 0.009	0.217CysTyr: 0.217 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.216AspAla: 6.216 ± 0.068	0.379AspCys: 0.379 ± 0.017	2.607AspAsp: 2.607 ± 0.04	2.954AspGlu: 2.954 ± 0.06	2.105AspPhe: 2.105 ± 0.036	4.68AspGly: 4.68 ± 0.062	1.178AspHis: 1.178 ± 0.031	2.28AspIle: 2.28 ± 0.038	1.813AspLys: 1.813 ± 0.043	5.27AspLeu: 5.27 ± 0.069	1.0AspMet: 1.0 ± 0.027	1.443AspAsn: 1.443 ± 0.035	3.119AspPro: 3.119 ± 0.052	1.62AspGln: 1.62 ± 0.038	3.456AspArg: 3.456 ± 0.053	2.582AspSer: 2.582 ± 0.054	2.752AspThr: 2.752 ± 0.044	3.838AspVal: 3.838 ± 0.057	0.816AspTrp: 0.816 ± 0.024	1.484AspTyr: 1.484 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.826GluAla: 5.826 ± 0.093	0.354GluCys: 0.354 ± 0.016	2.579GluAsp: 2.579 ± 0.048	2.972GluGlu: 2.972 ± 0.065	1.797GluPhe: 1.797 ± 0.04	3.516GluGly: 3.516 ± 0.052	1.304GluHis: 1.304 ± 0.031	2.87GluIle: 2.87 ± 0.055	2.041GluLys: 2.041 ± 0.042	5.06GluLeu: 5.06 ± 0.074	1.37GluMet: 1.37 ± 0.033	1.525GluAsn: 1.525 ± 0.035	2.267GluPro: 2.267 ± 0.038	2.295GluGln: 2.295 ± 0.044	3.924GluArg: 3.924 ± 0.057	2.816GluSer: 2.816 ± 0.041	3.025GluThr: 3.025 ± 0.048	3.543GluVal: 3.543 ± 0.053	0.637GluTrp: 0.637 ± 0.023	1.297GluTyr: 1.297 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.448PheAla: 4.448 ± 0.067	0.402PheCys: 0.402 ± 0.018	2.311PheAsp: 2.311 ± 0.042	1.813PheGlu: 1.813 ± 0.036	1.673PhePhe: 1.673 ± 0.039	3.587PheGly: 3.587 ± 0.065	0.979PheHis: 0.979 ± 0.027	1.351PheIle: 1.351 ± 0.031	0.955PheLys: 0.955 ± 0.03	3.776PheLeu: 3.776 ± 0.071	0.67PheMet: 0.67 ± 0.022	1.409PheAsn: 1.409 ± 0.041	1.719PhePro: 1.719 ± 0.034	1.285PheGln: 1.285 ± 0.036	2.291PheArg: 2.291 ± 0.043	2.486PheSer: 2.486 ± 0.046	2.503PheThr: 2.503 ± 0.046	2.646PheVal: 2.646 ± 0.043	0.475PheTrp: 0.475 ± 0.018	1.107PheTyr: 1.107 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.119GlyAla: 8.119 ± 0.077	0.824GlyCys: 0.824 ± 0.027	4.058GlyAsp: 4.058 ± 0.059	3.86GlyGlu: 3.86 ± 0.059	3.337GlyPhe: 3.337 ± 0.051	7.167GlyGly: 7.167 ± 0.113	1.745GlyHis: 1.745 ± 0.036	4.322GlyIle: 4.322 ± 0.064	3.656GlyLys: 3.656 ± 0.063	7.354GlyLeu: 7.354 ± 0.085	2.13GlyMet: 2.13 ± 0.044	2.837GlyAsn: 2.837 ± 0.056	3.241GlyPro: 3.241 ± 0.073	2.725GlyGln: 2.725 ± 0.052	4.723GlyArg: 4.723 ± 0.06	5.624GlySer: 5.624 ± 0.082	5.921GlyThr: 5.921 ± 0.115	6.008GlyVal: 6.008 ± 0.073	1.259GlyTrp: 1.259 ± 0.032	2.526GlyTyr: 2.526 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.468HisAla: 2.468 ± 0.038	0.193HisCys: 0.193 ± 0.012	1.26HisAsp: 1.26 ± 0.035	1.1HisGlu: 1.1 ± 0.031	0.993HisPhe: 0.993 ± 0.028	1.965HisGly: 1.965 ± 0.036	0.591HisHis: 0.591 ± 0.021	1.013HisIle: 1.013 ± 0.028	0.626HisLys: 0.626 ± 0.022	2.238HisLeu: 2.238 ± 0.04	0.516HisMet: 0.516 ± 0.018	0.663HisAsn: 0.663 ± 0.02	1.41HisPro: 1.41 ± 0.038	0.647HisGln: 0.647 ± 0.02	1.412HisArg: 1.412 ± 0.03	1.238HisSer: 1.238 ± 0.028	1.29HisThr: 1.29 ± 0.029	1.589HisVal: 1.589 ± 0.033	0.35HisTrp: 0.35 ± 0.017	0.637HisTyr: 0.637 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.467IleAla: 6.467 ± 0.075	0.42IleCys: 0.42 ± 0.016	3.013IleAsp: 3.013 ± 0.049	2.682IleGlu: 2.682 ± 0.046	1.823IlePhe: 1.823 ± 0.041	4.035IleGly: 4.035 ± 0.062	0.98IleHis: 0.98 ± 0.027	1.709IleIle: 1.709 ± 0.047	1.348IleLys: 1.348 ± 0.033	4.159IleLeu: 4.159 ± 0.067	0.694IleMet: 0.694 ± 0.023	1.554IleAsn: 1.554 ± 0.038	2.564IlePro: 2.564 ± 0.046	1.479IleGln: 1.479 ± 0.032	2.841IleArg: 2.841 ± 0.052	2.972IleSer: 2.972 ± 0.047	3.319IleThr: 3.319 ± 0.06	3.814IleVal: 3.814 ± 0.06	0.483IleTrp: 0.483 ± 0.02	1.289IleTyr: 1.289 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.831LysAla: 3.831 ± 0.067	0.192LysCys: 0.192 ± 0.013	1.895LysAsp: 1.895 ± 0.04	1.73LysGlu: 1.73 ± 0.04	1.078LysPhe: 1.078 ± 0.031	2.517LysGly: 2.517 ± 0.048	0.85LysHis: 0.85 ± 0.026	1.777LysIle: 1.777 ± 0.034	1.615LysLys: 1.615 ± 0.046	3.733LysLeu: 3.733 ± 0.064	1.017LysMet: 1.017 ± 0.029	1.213LysAsn: 1.213 ± 0.032	2.327LysPro: 2.327 ± 0.047	1.565LysGln: 1.565 ± 0.036	2.28LysArg: 2.28 ± 0.045	2.165LysSer: 2.165 ± 0.047	2.416LysThr: 2.416 ± 0.046	2.487LysVal: 2.487 ± 0.045	0.432LysTrp: 0.432 ± 0.018	0.966LysTyr: 0.966 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	10.976LeuAla: 10.976 ± 0.11	0.956LeuCys: 0.956 ± 0.027	4.973LeuAsp: 4.973 ± 0.065	4.675LeuGlu: 4.675 ± 0.065	3.522LeuPhe: 3.522 ± 0.057	7.239LeuGly: 7.239 ± 0.081	2.421LeuHis: 2.421 ± 0.044	4.343LeuIle: 4.343 ± 0.063	3.683LeuLys: 3.683 ± 0.059	10.645LeuLeu: 10.645 ± 0.139	2.088LeuMet: 2.088 ± 0.046	3.182LeuAsn: 3.182 ± 0.051	5.938LeuPro: 5.938 ± 0.067	4.069LeuGln: 4.069 ± 0.057	7.231LeuArg: 7.231 ± 0.084	6.566LeuSer: 6.566 ± 0.083	6.31LeuThr: 6.31 ± 0.084	6.347LeuVal: 6.347 ± 0.083	1.206LeuTrp: 1.206 ± 0.033	2.362LeuTyr: 2.362 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.553MetAla: 2.553 ± 0.046	0.171MetCys: 0.171 ± 0.013	1.141MetAsp: 1.141 ± 0.027	1.106MetGlu: 1.106 ± 0.031	0.678MetPhe: 0.678 ± 0.023	1.662MetGly: 1.662 ± 0.036	0.617MetHis: 0.617 ± 0.025	1.064MetIle: 1.064 ± 0.032	1.109MetLys: 1.109 ± 0.024	2.568MetLeu: 2.568 ± 0.051	0.618MetMet: 0.618 ± 0.021	0.814MetAsn: 0.814 ± 0.025	1.592MetPro: 1.592 ± 0.042	1.118MetGln: 1.118 ± 0.029	1.697MetArg: 1.697 ± 0.036	1.569MetSer: 1.569 ± 0.034	1.566MetThr: 1.566 ± 0.037	1.534MetVal: 1.534 ± 0.033	0.209MetTrp: 0.209 ± 0.011	0.479MetTyr: 0.479 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.707AsnAla: 3.707 ± 0.061	0.279AsnCys: 0.279 ± 0.015	1.649AsnAsp: 1.649 ± 0.034	1.421AsnGlu: 1.421 ± 0.03	1.468AsnPhe: 1.468 ± 0.039	3.309AsnGly: 3.309 ± 0.067	0.654AsnHis: 0.654 ± 0.022	1.632AsnIle: 1.632 ± 0.037	0.94AsnLys: 0.94 ± 0.03	3.164AsnLeu: 3.164 ± 0.053	0.664AsnMet: 0.664 ± 0.02	1.302AsnAsn: 1.302 ± 0.046	2.094AsnPro: 2.094 ± 0.045	1.135AsnGln: 1.135 ± 0.038	1.854AsnArg: 1.854 ± 0.04	2.051AsnSer: 2.051 ± 0.05	2.142AsnThr: 2.142 ± 0.05	2.502AsnVal: 2.502 ± 0.051	0.416AsnTrp: 0.416 ± 0.02	1.097AsnTyr: 1.097 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	6.629ProAla: 6.629 ± 0.091	0.302ProCys: 0.302 ± 0.015	2.989ProAsp: 2.989 ± 0.046	3.273ProGlu: 3.273 ± 0.048	1.903ProPhe: 1.903 ± 0.039	4.551ProGly: 4.551 ± 0.062	1.129ProHis: 1.129 ± 0.029	2.396ProIle: 2.396 ± 0.038	1.976ProLys: 1.976 ± 0.041	4.826ProLeu: 4.826 ± 0.064	1.276ProMet: 1.276 ± 0.029	1.905ProAsn: 1.905 ± 0.046	2.573ProPro: 2.573 ± 0.064	2.147ProGln: 2.147 ± 0.046	2.671ProArg: 2.671 ± 0.049	3.261ProSer: 3.261 ± 0.051	3.363ProThr: 3.363 ± 0.062	4.23ProVal: 4.23 ± 0.058	0.637ProTrp: 0.637 ± 0.025	1.329ProTyr: 1.329 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.02GlnAla: 4.02 ± 0.063	0.252GlnCys: 0.252 ± 0.015	1.65GlnAsp: 1.65 ± 0.037	1.67GlnGlu: 1.67 ± 0.037	1.395GlnPhe: 1.395 ± 0.032	2.513GlnGly: 2.513 ± 0.049	0.93GlnHis: 0.93 ± 0.027	2.003GlnIle: 2.003 ± 0.045	1.341GlnLys: 1.341 ± 0.03	3.463GlnLeu: 3.463 ± 0.052	1.124GlnMet: 1.124 ± 0.027	1.242GlnAsn: 1.242 ± 0.032	2.224GlnPro: 2.224 ± 0.045	2.319GlnGln: 2.319 ± 0.084	2.743GlnArg: 2.743 ± 0.055	2.331GlnSer: 2.331 ± 0.046	2.451GlnThr: 2.451 ± 0.039	2.705GlnVal: 2.705 ± 0.051	0.557GlnTrp: 0.557 ± 0.021	1.045GlnTyr: 1.045 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.054ArgAla: 6.054 ± 0.077	0.48ArgCys: 0.48 ± 0.018	3.205ArgAsp: 3.205 ± 0.048	3.779ArgGlu: 3.779 ± 0.071	2.64ArgPhe: 2.64 ± 0.045	4.22ArgGly: 4.22 ± 0.065	1.307ArgHis: 1.307 ± 0.035	3.434ArgIle: 3.434 ± 0.049	2.305ArgLys: 2.305 ± 0.043	5.976ArgLeu: 5.976 ± 0.081	1.916ArgMet: 1.916 ± 0.041	2.23ArgAsn: 2.23 ± 0.048	2.904ArgPro: 2.904 ± 0.053	2.248ArgGln: 2.248 ± 0.046	4.288ArgArg: 4.288 ± 0.071	3.95ArgSer: 3.95 ± 0.053	3.735ArgThr: 3.735 ± 0.051	4.552ArgVal: 4.552 ± 0.062	0.971ArgTrp: 0.971 ± 0.027	1.939ArgTyr: 1.939 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.994SerAla: 6.994 ± 0.081	0.516SerCys: 0.516 ± 0.022	2.971SerAsp: 2.971 ± 0.047	2.832SerGlu: 2.832 ± 0.051	2.603SerPhe: 2.603 ± 0.045	5.745SerGly: 5.745 ± 0.08	1.258SerHis: 1.258 ± 0.03	3.182SerIle: 3.182 ± 0.047	2.055SerLys: 2.055 ± 0.039	6.322SerLeu: 6.322 ± 0.083	1.534SerMet: 1.534 ± 0.036	2.155SerAsn: 2.155 ± 0.046	3.312SerPro: 3.312 ± 0.06	2.144SerGln: 2.144 ± 0.039	3.503SerArg: 3.503 ± 0.056	4.328SerSer: 4.328 ± 0.078	4.129SerThr: 4.129 ± 0.066	4.715SerVal: 4.715 ± 0.065	0.724SerTrp: 0.724 ± 0.022	1.712SerTyr: 1.712 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.492ThrAla: 7.492 ± 0.093	0.56ThrCys: 0.56 ± 0.027	3.099ThrAsp: 3.099 ± 0.051	2.876ThrGlu: 2.876 ± 0.046	2.484ThrPhe: 2.484 ± 0.046	6.041ThrGly: 6.041 ± 0.097	1.339ThrHis: 1.339 ± 0.032	3.198ThrIle: 3.198 ± 0.066	1.994ThrLys: 1.994 ± 0.038	6.596ThrLeu: 6.596 ± 0.082	1.322ThrMet: 1.322 ± 0.032	2.08ThrAsn: 2.08 ± 0.054	4.217ThrPro: 4.217 ± 0.077	2.182ThrGln: 2.182 ± 0.042	3.341ThrArg: 3.341 ± 0.05	3.901ThrSer: 3.901 ± 0.062	4.193ThrThr: 4.193 ± 0.081	5.333ThrVal: 5.333 ± 0.086	0.795ThrTrp: 0.795 ± 0.026	1.673ThrTyr: 1.673 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	8.271ValAla: 8.271 ± 0.079	0.7ValCys: 0.7 ± 0.021	3.886ValAsp: 3.886 ± 0.057	3.835ValGlu: 3.835 ± 0.061	2.651ValPhe: 2.651 ± 0.044	5.253ValGly: 5.253 ± 0.062	1.571ValHis: 1.571 ± 0.032	3.371ValIle: 3.371 ± 0.057	2.517ValLys: 2.517 ± 0.046	7.52ValLeu: 7.52 ± 0.081	1.632ValMet: 1.632 ± 0.039	2.516ValAsn: 2.516 ± 0.05	4.01ValPro: 4.01 ± 0.05	2.628ValGln: 2.628 ± 0.045	4.623ValArg: 4.623 ± 0.061	4.764ValSer: 4.764 ± 0.072	5.207ValThr: 5.207 ± 0.08	5.698ValVal: 5.698 ± 0.076	0.887ValTrp: 0.887 ± 0.028	1.743ValTyr: 1.743 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.01TrpAla: 1.01 ± 0.03	0.115TrpCys: 0.115 ± 0.01	0.64TrpAsp: 0.64 ± 0.021	0.561TrpGlu: 0.561 ± 0.024	0.555TrpPhe: 0.555 ± 0.023	0.812TrpGly: 0.812 ± 0.026	0.368TrpHis: 0.368 ± 0.016	0.698TrpIle: 0.698 ± 0.025	0.618TrpLys: 0.618 ± 0.021	1.397TrpLeu: 1.397 ± 0.037	0.405TrpMet: 0.405 ± 0.016	0.536TrpAsn: 0.536 ± 0.02	0.543TrpPro: 0.543 ± 0.024	0.674TrpGln: 0.674 ± 0.025	0.85TrpArg: 0.85 ± 0.026	0.923TrpSer: 0.923 ± 0.025	0.85TrpThr: 0.85 ± 0.024	0.798TrpVal: 0.798 ± 0.029	0.236TrpTrp: 0.236 ± 0.013	0.319TrpTyr: 0.319 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.824TyrAla: 2.824 ± 0.044	0.206TyrCys: 0.206 ± 0.011	1.535TyrAsp: 1.535 ± 0.038	1.332TyrGlu: 1.332 ± 0.032	1.165TyrPhe: 1.165 ± 0.032	2.376TyrGly: 2.376 ± 0.045	0.555TyrHis: 0.555 ± 0.019	1.025TyrIle: 1.025 ± 0.027	0.84TyrLys: 0.84 ± 0.025	2.588TyrLeu: 2.588 ± 0.041	0.502TyrMet: 0.502 ± 0.018	1.007TyrAsn: 1.007 ± 0.036	1.308TyrPro: 1.308 ± 0.035	0.942TyrGln: 0.942 ± 0.03	1.893TyrArg: 1.893 ± 0.035	1.685TyrSer: 1.685 ± 0.036	1.796TyrThr: 1.796 ± 0.045	1.899TyrVal: 1.899 ± 0.036	0.36TyrTrp: 0.36 ± 0.018	0.768TyrTyr: 0.768 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3936 proteins (1413377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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