Amino acid dipepetide frequency for Monilinia fructigena

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.599AlaAla: 7.599 ± 0.064	0.904AlaCys: 0.904 ± 0.018	3.941AlaAsp: 3.941 ± 0.032	5.192AlaGlu: 5.192 ± 0.042	2.897AlaPhe: 2.897 ± 0.028	5.259AlaGly: 5.259 ± 0.038	1.632AlaHis: 1.632 ± 0.02	4.494AlaIle: 4.494 ± 0.037	4.37AlaLys: 4.37 ± 0.034	6.945AlaLeu: 6.945 ± 0.052	1.771AlaMet: 1.771 ± 0.018	3.143AlaAsn: 3.143 ± 0.032	4.618AlaPro: 4.618 ± 0.044	3.177AlaGln: 3.177 ± 0.031	4.314AlaArg: 4.314 ± 0.033	6.886AlaSer: 6.886 ± 0.05	5.017AlaThr: 5.017 ± 0.031	4.416AlaVal: 4.416 ± 0.039	1.069AlaTrp: 1.069 ± 0.016	2.024AlaTyr: 2.024 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.828CysAla: 0.828 ± 0.013	0.219CysCys: 0.219 ± 0.007	0.544CysAsp: 0.544 ± 0.012	0.624CysGlu: 0.624 ± 0.012	0.464CysPhe: 0.464 ± 0.011	0.93CysGly: 0.93 ± 0.016	0.341CysHis: 0.341 ± 0.009	0.712CysIle: 0.712 ± 0.013	0.603CysLys: 0.603 ± 0.014	1.103CysLeu: 1.103 ± 0.019	0.275CysMet: 0.275 ± 0.008	0.452CysAsn: 0.452 ± 0.012	0.573CysPro: 0.573 ± 0.013	0.41CysGln: 0.41 ± 0.011	0.654CysArg: 0.654 ± 0.013	0.847CysSer: 0.847 ± 0.018	0.653CysThr: 0.653 ± 0.013	0.684CysVal: 0.684 ± 0.013	0.21CysTrp: 0.21 ± 0.007	0.384CysTyr: 0.384 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.359AspAla: 4.359 ± 0.031	0.594AspCys: 0.594 ± 0.013	4.448AspAsp: 4.448 ± 0.06	4.677AspGlu: 4.677 ± 0.045	2.201AspPhe: 2.201 ± 0.023	3.818AspGly: 3.818 ± 0.033	1.177AspHis: 1.177 ± 0.017	3.373AspIle: 3.373 ± 0.032	2.515AspLys: 2.515 ± 0.03	4.866AspLeu: 4.866 ± 0.04	1.221AspMet: 1.221 ± 0.016	2.117AspAsn: 2.117 ± 0.025	2.973AspPro: 2.973 ± 0.028	1.769AspGln: 1.769 ± 0.021	2.894AspArg: 2.894 ± 0.032	4.183AspSer: 4.183 ± 0.033	2.949AspThr: 2.949 ± 0.028	3.321AspVal: 3.321 ± 0.03	0.835AspTrp: 0.835 ± 0.015	1.59AspTyr: 1.59 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	5.24GluAla: 5.24 ± 0.044	0.67GluCys: 0.67 ± 0.014	4.535GluAsp: 4.535 ± 0.046	6.411GluGlu: 6.411 ± 0.079	2.017GluPhe: 2.017 ± 0.023	4.01GluGly: 4.01 ± 0.035	1.343GluHis: 1.343 ± 0.018	3.691GluIle: 3.691 ± 0.037	4.453GluLys: 4.453 ± 0.043	5.322GluLeu: 5.322 ± 0.041	1.593GluMet: 1.593 ± 0.021	2.831GluAsn: 2.831 ± 0.029	2.814GluPro: 2.814 ± 0.037	2.431GluGln: 2.431 ± 0.026	4.096GluArg: 4.096 ± 0.037	4.648GluSer: 4.648 ± 0.04	3.479GluThr: 3.479 ± 0.034	3.741GluVal: 3.741 ± 0.033	0.908GluTrp: 0.908 ± 0.014	1.72GluTyr: 1.72 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.803PheAla: 2.803 ± 0.028	0.534PheCys: 0.534 ± 0.011	2.231PheAsp: 2.231 ± 0.024	2.276PheGlu: 2.276 ± 0.023	1.411PhePhe: 1.411 ± 0.021	2.77PheGly: 2.77 ± 0.032	0.904PheHis: 0.904 ± 0.015	1.82PheIle: 1.82 ± 0.024	1.786PheLys: 1.786 ± 0.024	3.152PheLeu: 3.152 ± 0.03	0.77PheMet: 0.77 ± 0.013	1.588PheAsn: 1.588 ± 0.02	1.787PhePro: 1.787 ± 0.023	1.374PheGln: 1.374 ± 0.02	1.743PheArg: 1.743 ± 0.019	2.94PheSer: 2.94 ± 0.03	2.163PheThr: 2.163 ± 0.027	2.066PheVal: 2.066 ± 0.023	0.531PheTrp: 0.531 ± 0.012	1.032PheTyr: 1.032 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	4.944GlyAla: 4.944 ± 0.034	0.835GlyCys: 0.835 ± 0.015	3.449GlyAsp: 3.449 ± 0.034	3.711GlyGlu: 3.711 ± 0.033	2.628GlyPhe: 2.628 ± 0.028	5.672GlyGly: 5.672 ± 0.064	1.678GlyHis: 1.678 ± 0.019	3.788GlyIle: 3.788 ± 0.034	3.845GlyLys: 3.845 ± 0.041	5.6GlyLeu: 5.6 ± 0.045	1.555GlyMet: 1.555 ± 0.022	2.855GlyAsn: 2.855 ± 0.032	3.014GlyPro: 3.014 ± 0.029	2.369GlyGln: 2.369 ± 0.026	3.908GlyArg: 3.908 ± 0.035	5.82GlySer: 5.82 ± 0.046	4.008GlyThr: 4.008 ± 0.034	4.074GlyVal: 4.074 ± 0.033	1.1GlyTrp: 1.1 ± 0.017	2.299GlyTyr: 2.299 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	1.64HisAla: 1.64 ± 0.017	0.329HisCys: 0.329 ± 0.009	1.205HisAsp: 1.205 ± 0.017	1.275HisGlu: 1.275 ± 0.018	0.903HisPhe: 0.903 ± 0.014	1.603HisGly: 1.603 ± 0.022	0.78HisHis: 0.78 ± 0.017	1.308HisIle: 1.308 ± 0.019	1.058HisLys: 1.058 ± 0.017	2.089HisLeu: 2.089 ± 0.025	0.489HisMet: 0.489 ± 0.01	0.941HisAsn: 0.941 ± 0.015	1.564HisPro: 1.564 ± 0.02	1.017HisGln: 1.017 ± 0.017	1.518HisArg: 1.518 ± 0.022	1.824HisSer: 1.824 ± 0.022	1.323HisThr: 1.323 ± 0.018	1.245HisVal: 1.245 ± 0.016	0.296HisTrp: 0.296 ± 0.008	0.674HisTyr: 0.674 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.282IleAla: 4.282 ± 0.03	0.758IleCys: 0.758 ± 0.014	3.241IleAsp: 3.241 ± 0.032	3.464IleGlu: 3.464 ± 0.029	2.056IlePhe: 2.056 ± 0.024	3.451IleGly: 3.451 ± 0.031	1.269IleHis: 1.269 ± 0.016	2.968IleIle: 2.968 ± 0.031	2.818IleLys: 2.818 ± 0.027	4.783IleLeu: 4.783 ± 0.038	1.152IleMet: 1.152 ± 0.016	2.3IleAsn: 2.3 ± 0.025	3.421IlePro: 3.421 ± 0.031	2.101IleGln: 2.101 ± 0.024	3.004IleArg: 3.004 ± 0.028	4.625IleSer: 4.625 ± 0.036	3.322IleThr: 3.322 ± 0.029	3.178IleVal: 3.178 ± 0.03	0.791IleTrp: 0.791 ± 0.014	1.592IleTyr: 1.592 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.699LysAla: 4.699 ± 0.045	0.565LysCys: 0.565 ± 0.014	3.171LysAsp: 3.171 ± 0.031	4.324LysGlu: 4.324 ± 0.045	1.68LysPhe: 1.68 ± 0.019	3.356LysGly: 3.356 ± 0.032	1.222LysHis: 1.222 ± 0.018	2.849LysIle: 2.849 ± 0.031	4.181LysLys: 4.181 ± 0.053	4.538LysLeu: 4.538 ± 0.035	1.142LysMet: 1.142 ± 0.016	2.239LysAsn: 2.239 ± 0.025	2.841LysPro: 2.841 ± 0.029	1.975LysGln: 1.975 ± 0.024	3.937LysArg: 3.937 ± 0.038	4.254LysSer: 4.254 ± 0.036	3.239LysThr: 3.239 ± 0.03	3.227LysVal: 3.227 ± 0.03	0.811LysTrp: 0.811 ± 0.014	1.481LysTyr: 1.481 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	7.031LeuAla: 7.031 ± 0.053	1.083LeuCys: 1.083 ± 0.019	4.78LeuAsp: 4.78 ± 0.033	5.717LeuGlu: 5.717 ± 0.042	2.866LeuPhe: 2.866 ± 0.032	5.226LeuGly: 5.226 ± 0.043	2.011LeuHis: 2.011 ± 0.024	4.102LeuIle: 4.102 ± 0.038	4.804LeuLys: 4.804 ± 0.039	7.561LeuLeu: 7.561 ± 0.062	1.692LeuMet: 1.692 ± 0.021	3.365LeuAsn: 3.365 ± 0.031	5.417LeuPro: 5.417 ± 0.044	3.69LeuGln: 3.69 ± 0.033	5.386LeuArg: 5.386 ± 0.041	7.068LeuSer: 7.068 ± 0.051	4.774LeuThr: 4.774 ± 0.036	4.789LeuVal: 4.789 ± 0.036	1.013LeuTrp: 1.013 ± 0.018	2.292LeuTyr: 2.292 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.981MetAla: 1.981 ± 0.024	0.229MetCys: 0.229 ± 0.007	1.371MetAsp: 1.371 ± 0.018	1.419MetGlu: 1.419 ± 0.018	0.692MetPhe: 0.692 ± 0.013	1.529MetGly: 1.529 ± 0.021	0.479MetHis: 0.479 ± 0.01	1.153MetIle: 1.153 ± 0.016	1.186MetLys: 1.186 ± 0.018	1.742MetLeu: 1.742 ± 0.023	0.602MetMet: 0.602 ± 0.014	0.913MetAsn: 0.913 ± 0.014	1.127MetPro: 1.127 ± 0.017	0.856MetGln: 0.856 ± 0.016	1.282MetArg: 1.282 ± 0.021	1.837MetSer: 1.837 ± 0.021	1.258MetThr: 1.258 ± 0.018	1.262MetVal: 1.262 ± 0.017	0.222MetTrp: 0.222 ± 0.008	0.481MetTyr: 0.481 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.402AsnAla: 3.402 ± 0.029	0.481AsnCys: 0.481 ± 0.01	2.199AsnAsp: 2.199 ± 0.024	2.53AsnGlu: 2.53 ± 0.025	1.599AsnPhe: 1.599 ± 0.021	3.292AsnGly: 3.292 ± 0.037	1.009AsnHis: 1.009 ± 0.018	2.437AsnIle: 2.437 ± 0.025	1.98AsnLys: 1.98 ± 0.024	3.494AsnLeu: 3.494 ± 0.03	0.918AsnMet: 0.918 ± 0.015	1.999AsnAsn: 1.999 ± 0.032	2.555AsnPro: 2.555 ± 0.027	1.615AsnGln: 1.615 ± 0.023	2.136AsnArg: 2.136 ± 0.023	3.498AsnSer: 3.498 ± 0.033	2.77AsnThr: 2.77 ± 0.029	2.35AsnVal: 2.35 ± 0.025	0.549AsnTrp: 0.549 ± 0.014	1.183AsnTyr: 1.183 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	4.556ProAla: 4.556 ± 0.036	0.436ProCys: 0.436 ± 0.01	2.702ProAsp: 2.702 ± 0.025	3.723ProGlu: 3.723 ± 0.031	1.91ProPhe: 1.91 ± 0.02	3.695ProGly: 3.695 ± 0.031	1.257ProHis: 1.257 ± 0.016	3.004ProIle: 3.004 ± 0.024	2.992ProLys: 2.992 ± 0.028	4.525ProLeu: 4.525 ± 0.035	1.082ProMet: 1.082 ± 0.016	2.414ProAsn: 2.414 ± 0.028	4.926ProPro: 4.926 ± 0.064	2.552ProGln: 2.552 ± 0.032	3.271ProArg: 3.271 ± 0.032	5.94ProSer: 5.94 ± 0.051	4.353ProThr: 4.353 ± 0.042	3.161ProVal: 3.161 ± 0.033	0.68ProTrp: 0.68 ± 0.014	1.423ProTyr: 1.423 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.117GlnAla: 3.117 ± 0.03	0.459GlnCys: 0.459 ± 0.009	1.96GlnAsp: 1.96 ± 0.021	2.537GlnGlu: 2.537 ± 0.026	1.248GlnPhe: 1.248 ± 0.016	2.459GlnGly: 2.459 ± 0.027	1.029GlnHis: 1.029 ± 0.019	2.095GlnIle: 2.095 ± 0.024	2.275GlnLys: 2.275 ± 0.025	3.249GlnLeu: 3.249 ± 0.032	0.854GlnMet: 0.854 ± 0.014	1.816GlnAsn: 1.816 ± 0.024	2.331GlnPro: 2.331 ± 0.032	2.374GlnGln: 2.374 ± 0.054	2.543GlnArg: 2.543 ± 0.029	3.213GlnSer: 3.213 ± 0.03	2.355GlnThr: 2.355 ± 0.024	2.045GlnVal: 2.045 ± 0.021	0.543GlnTrp: 0.543 ± 0.013	1.267GlnTyr: 1.267 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	4.272ArgAla: 4.272 ± 0.03	0.665ArgCys: 0.665 ± 0.013	3.064ArgAsp: 3.064 ± 0.032	3.834ArgGlu: 3.834 ± 0.036	2.042ArgPhe: 2.042 ± 0.022	3.649ArgGly: 3.649 ± 0.039	1.423ArgHis: 1.423 ± 0.019	3.075ArgIle: 3.075 ± 0.027	4.1ArgLys: 4.1 ± 0.038	5.06ArgLeu: 5.06 ± 0.043	1.341ArgMet: 1.341 ± 0.016	2.584ArgAsn: 2.584 ± 0.024	3.236ArgPro: 3.236 ± 0.031	2.442ArgGln: 2.442 ± 0.028	4.883ArgArg: 4.883 ± 0.048	4.799ArgSer: 4.799 ± 0.047	3.285ArgThr: 3.285 ± 0.033	2.996ArgVal: 2.996 ± 0.029	0.875ArgTrp: 0.875 ± 0.016	1.582ArgTyr: 1.582 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.342SerAla: 6.342 ± 0.052	0.81SerCys: 0.81 ± 0.017	4.289SerAsp: 4.289 ± 0.031	4.436SerGlu: 4.436 ± 0.045	3.004SerPhe: 3.004 ± 0.027	5.566SerGly: 5.566 ± 0.046	2.002SerHis: 2.002 ± 0.025	4.718SerIle: 4.718 ± 0.034	4.374SerLys: 4.374 ± 0.034	6.874SerLeu: 6.874 ± 0.048	1.697SerMet: 1.697 ± 0.022	3.817SerAsn: 3.817 ± 0.038	5.751SerPro: 5.751 ± 0.063	3.493SerGln: 3.493 ± 0.034	4.81SerArg: 4.81 ± 0.038	9.471SerSer: 9.471 ± 0.116	6.339SerThr: 6.339 ± 0.059	4.269SerVal: 4.269 ± 0.037	1.015SerTrp: 1.015 ± 0.016	2.251SerTyr: 2.251 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	4.997ThrAla: 4.997 ± 0.036	0.718ThrCys: 0.718 ± 0.012	2.791ThrAsp: 2.791 ± 0.026	3.314ThrGlu: 3.314 ± 0.036	2.248ThrPhe: 2.248 ± 0.025	4.147ThrGly: 4.147 ± 0.037	1.282ThrHis: 1.282 ± 0.015	3.724ThrIle: 3.724 ± 0.035	3.166ThrLys: 3.166 ± 0.03	5.273ThrLeu: 5.273 ± 0.04	1.213ThrMet: 1.213 ± 0.016	2.512ThrAsn: 2.512 ± 0.026	4.562ThrPro: 4.562 ± 0.043	2.291ThrGln: 2.291 ± 0.026	3.19ThrArg: 3.19 ± 0.025	6.063ThrSer: 6.063 ± 0.063	4.674ThrThr: 4.674 ± 0.056	3.353ThrVal: 3.353 ± 0.032	0.773ThrTrp: 0.773 ± 0.014	1.627ThrTyr: 1.627 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.449ValAla: 4.449 ± 0.04	0.613ValCys: 0.613 ± 0.011	3.406ValAsp: 3.406 ± 0.029	4.026ValGlu: 4.026 ± 0.038	2.205ValPhe: 2.205 ± 0.025	3.735ValGly: 3.735 ± 0.031	1.136ValHis: 1.136 ± 0.017	2.955ValIle: 2.955 ± 0.026	3.052ValLys: 3.052 ± 0.028	4.849ValLeu: 4.849 ± 0.041	1.28ValMet: 1.28 ± 0.017	2.216ValAsn: 2.216 ± 0.023	3.137ValPro: 3.137 ± 0.025	2.162ValGln: 2.162 ± 0.024	3.049ValArg: 3.049 ± 0.025	4.252ValSer: 4.252 ± 0.033	3.413ValThr: 3.413 ± 0.03	3.718ValVal: 3.718 ± 0.032	0.805ValTrp: 0.805 ± 0.015	1.581ValTyr: 1.581 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.02TrpAla: 1.02 ± 0.014	0.207TrpCys: 0.207 ± 0.007	0.807TrpAsp: 0.807 ± 0.014	0.832TrpGlu: 0.832 ± 0.014	0.467TrpPhe: 0.467 ± 0.012	0.883TrpGly: 0.883 ± 0.017	0.323TrpHis: 0.323 ± 0.009	0.838TrpIle: 0.838 ± 0.015	0.86TrpLys: 0.86 ± 0.013	1.18TrpLeu: 1.18 ± 0.016	0.388TrpMet: 0.388 ± 0.01	0.615TrpAsn: 0.615 ± 0.012	0.538TrpPro: 0.538 ± 0.01	0.525TrpGln: 0.525 ± 0.012	0.921TrpArg: 0.921 ± 0.016	1.068TrpSer: 1.068 ± 0.015	0.847TrpThr: 0.847 ± 0.015	0.713TrpVal: 0.713 ± 0.011	0.384TrpTrp: 0.384 ± 0.01	0.41TrpTyr: 0.41 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.107TyrAla: 2.107 ± 0.022	0.403TyrCys: 0.403 ± 0.011	1.744TyrAsp: 1.744 ± 0.025	1.628TyrGlu: 1.628 ± 0.018	1.144TyrPhe: 1.144 ± 0.018	2.102TyrGly: 2.102 ± 0.026	0.785TyrHis: 0.785 ± 0.012	1.471TyrIle: 1.471 ± 0.018	1.312TyrLys: 1.312 ± 0.018	2.462TyrLeu: 2.462 ± 0.027	0.588TyrMet: 0.588 ± 0.011	1.28TyrAsn: 1.28 ± 0.021	1.417TyrPro: 1.417 ± 0.021	1.146TyrGln: 1.146 ± 0.016	1.671TyrArg: 1.671 ± 0.023	2.091TyrSer: 2.091 ± 0.023	1.697TyrThr: 1.697 ± 0.022	1.431TyrVal: 1.431 ± 0.02	0.416TyrTrp: 0.416 ± 0.01	0.897TyrTyr: 0.897 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10740 proteins (4314917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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