Amino acid dipepetide frequency for Sporosarcina psychrophila (Bacillus psychrophilus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.102AlaAla: 6.102 ± 0.1	0.572AlaCys: 0.572 ± 0.022	3.987AlaAsp: 3.987 ± 0.115	5.002AlaGlu: 5.002 ± 0.071	3.521AlaPhe: 3.521 ± 0.057	5.685AlaGly: 5.685 ± 0.089	1.308AlaHis: 1.308 ± 0.033	6.651AlaIle: 6.651 ± 0.082	4.514AlaLys: 4.514 ± 0.067	7.586AlaLeu: 7.586 ± 0.085	2.194AlaMet: 2.194 ± 0.038	2.788AlaAsn: 2.788 ± 0.052	2.059AlaPro: 2.059 ± 0.04	2.256AlaGln: 2.256 ± 0.048	2.718AlaArg: 2.718 ± 0.05	4.24AlaSer: 4.24 ± 0.073	4.252AlaThr: 4.252 ± 0.113	5.789AlaVal: 5.789 ± 0.072	0.607AlaTrp: 0.607 ± 0.028	2.297AlaTyr: 2.297 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.43CysAla: 0.43 ± 0.021	0.078CysCys: 0.078 ± 0.008	0.361CysAsp: 0.361 ± 0.017	0.44CysGlu: 0.44 ± 0.022	0.264CysPhe: 0.264 ± 0.014	0.635CysGly: 0.635 ± 0.023	0.172CysHis: 0.172 ± 0.012	0.488CysIle: 0.488 ± 0.018	0.316CysLys: 0.316 ± 0.018	0.537CysLeu: 0.537 ± 0.024	0.16CysMet: 0.16 ± 0.011	0.256CysAsn: 0.256 ± 0.014	0.319CysPro: 0.319 ± 0.016	0.184CysGln: 0.184 ± 0.012	0.24CysArg: 0.24 ± 0.013	0.449CysSer: 0.449 ± 0.018	0.381CysThr: 0.381 ± 0.018	0.373CysVal: 0.373 ± 0.017	0.06CysTrp: 0.06 ± 0.007	0.206CysTyr: 0.206 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.966AspAla: 3.966 ± 0.165	0.341AspCys: 0.341 ± 0.016	2.758AspAsp: 2.758 ± 0.06	4.685AspGlu: 4.685 ± 0.065	2.498AspPhe: 2.498 ± 0.043	3.711AspGly: 3.711 ± 0.068	1.01AspHis: 1.01 ± 0.026	4.212AspIle: 4.212 ± 0.065	3.245AspLys: 3.245 ± 0.057	4.892AspLeu: 4.892 ± 0.067	1.493AspMet: 1.493 ± 0.031	2.031AspAsn: 2.031 ± 0.043	1.971AspPro: 1.971 ± 0.044	1.541AspGln: 1.541 ± 0.036	2.17AspArg: 2.17 ± 0.04	2.887AspSer: 2.887 ± 0.048	2.579AspThr: 2.579 ± 0.045	4.065AspVal: 4.065 ± 0.061	0.666AspTrp: 0.666 ± 0.025	2.16AspTyr: 2.16 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.34GluAla: 5.34 ± 0.076	0.338GluCys: 0.338 ± 0.021	3.847GluAsp: 3.847 ± 0.067	6.335GluGlu: 6.335 ± 0.083	2.662GluPhe: 2.662 ± 0.044	4.453GluGly: 4.453 ± 0.061	1.387GluHis: 1.387 ± 0.035	5.671GluIle: 5.671 ± 0.076	5.904GluLys: 5.904 ± 0.085	7.291GluLeu: 7.291 ± 0.074	2.432GluMet: 2.432 ± 0.044	3.329GluAsn: 3.329 ± 0.056	2.019GluPro: 2.019 ± 0.047	3.277GluGln: 3.277 ± 0.057	3.469GluArg: 3.469 ± 0.068	3.857GluSer: 3.857 ± 0.063	4.024GluThr: 4.024 ± 0.06	5.232GluVal: 5.232 ± 0.065	0.869GluTrp: 0.869 ± 0.027	1.958GluTyr: 1.958 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.227PheAla: 3.227 ± 0.052	0.309PheCys: 0.309 ± 0.017	2.564PheAsp: 2.564 ± 0.046	3.006PheGlu: 3.006 ± 0.045	2.283PhePhe: 2.283 ± 0.048	3.588PheGly: 3.588 ± 0.054	0.946PheHis: 0.946 ± 0.028	4.148PheIle: 4.148 ± 0.072	2.409PheLys: 2.409 ± 0.045	4.393PheLeu: 4.393 ± 0.069	1.291PheMet: 1.291 ± 0.032	1.983PheAsn: 1.983 ± 0.042	1.612PhePro: 1.612 ± 0.038	1.43PheGln: 1.43 ± 0.035	1.598PheArg: 1.598 ± 0.037	3.309PheSer: 3.309 ± 0.064	2.783PheThr: 2.783 ± 0.043	3.218PheVal: 3.218 ± 0.051	0.459PheTrp: 0.459 ± 0.018	1.583PheTyr: 1.583 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.297GlyAla: 5.297 ± 0.11	0.572GlyCys: 0.572 ± 0.02	3.479GlyAsp: 3.479 ± 0.076	4.598GlyGlu: 4.598 ± 0.061	3.526GlyPhe: 3.526 ± 0.067	4.99GlyGly: 4.99 ± 0.081	1.421GlyHis: 1.421 ± 0.035	6.279GlyIle: 6.279 ± 0.083	5.124GlyLys: 5.124 ± 0.071	6.753GlyLeu: 6.753 ± 0.079	2.198GlyMet: 2.198 ± 0.046	2.819GlyAsn: 2.819 ± 0.047	1.829GlyPro: 1.829 ± 0.048	2.257GlyGln: 2.257 ± 0.052	2.749GlyArg: 2.749 ± 0.047	4.136GlySer: 4.136 ± 0.065	4.303GlyThr: 4.303 ± 0.061	5.15GlyVal: 5.15 ± 0.078	0.788GlyTrp: 0.788 ± 0.029	2.655GlyTyr: 2.655 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.391HisAla: 1.391 ± 0.037	0.175HisCys: 0.175 ± 0.013	1.007HisAsp: 1.007 ± 0.03	1.416HisGlu: 1.416 ± 0.036	1.005HisPhe: 1.005 ± 0.03	1.348HisGly: 1.348 ± 0.034	0.531HisHis: 0.531 ± 0.021	1.431HisIle: 1.431 ± 0.034	0.892HisLys: 0.892 ± 0.024	1.974HisLeu: 1.974 ± 0.045	0.491HisMet: 0.491 ± 0.021	0.717HisAsn: 0.717 ± 0.026	1.047HisPro: 1.047 ± 0.033	0.68HisGln: 0.68 ± 0.025	0.797HisArg: 0.797 ± 0.025	1.136HisSer: 1.136 ± 0.033	1.074HisThr: 1.074 ± 0.033	1.389HisVal: 1.389 ± 0.04	0.201HisTrp: 0.201 ± 0.014	0.779HisTyr: 0.779 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.856IleAla: 6.856 ± 0.088	0.599IleCys: 0.599 ± 0.021	4.543IleAsp: 4.543 ± 0.07	5.972IleGlu: 5.972 ± 0.079	3.286IlePhe: 3.286 ± 0.063	6.524IleGly: 6.524 ± 0.091	1.615IleHis: 1.615 ± 0.038	6.466IleIle: 6.466 ± 0.089	4.024IleLys: 4.024 ± 0.069	7.277IleLeu: 7.277 ± 0.102	1.976IleMet: 1.976 ± 0.035	3.032IleAsn: 3.032 ± 0.053	3.405IlePro: 3.405 ± 0.05	2.724IleGln: 2.724 ± 0.047	3.296IleArg: 3.296 ± 0.05	5.02IleSer: 5.02 ± 0.067	4.568IleThr: 4.568 ± 0.062	6.2IleVal: 6.2 ± 0.078	0.679IleTrp: 0.679 ± 0.024	2.423IleTyr: 2.423 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.386LysAla: 4.386 ± 0.068	0.287LysCys: 0.287 ± 0.017	3.698LysAsp: 3.698 ± 0.066	5.995LysGlu: 5.995 ± 0.065	2.088LysPhe: 2.088 ± 0.044	4.155LysGly: 4.155 ± 0.053	1.1LysHis: 1.1 ± 0.028	4.366LysIle: 4.366 ± 0.069	5.315LysLys: 5.315 ± 0.07	5.741LysLeu: 5.741 ± 0.062	2.324LysMet: 2.324 ± 0.044	3.018LysAsn: 3.018 ± 0.051	2.112LysPro: 2.112 ± 0.045	2.441LysGln: 2.441 ± 0.046	3.109LysArg: 3.109 ± 0.053	3.789LysSer: 3.789 ± 0.052	3.629LysThr: 3.629 ± 0.058	4.633LysVal: 4.633 ± 0.065	0.767LysTrp: 0.767 ± 0.028	1.952LysTyr: 1.952 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	7.53LeuAla: 7.53 ± 0.091	0.594LeuCys: 0.594 ± 0.024	4.861LeuAsp: 4.861 ± 0.069	6.455LeuGlu: 6.455 ± 0.075	5.016LeuPhe: 5.016 ± 0.079	6.521LeuGly: 6.521 ± 0.083	1.888LeuHis: 1.888 ± 0.042	7.521LeuIle: 7.521 ± 0.093	6.096LeuLys: 6.096 ± 0.066	10.38LeuLeu: 10.38 ± 0.116	2.511LeuMet: 2.511 ± 0.045	4.045LeuAsn: 4.045 ± 0.055	3.883LeuPro: 3.883 ± 0.061	3.339LeuGln: 3.339 ± 0.047	3.623LeuArg: 3.623 ± 0.062	6.609LeuSer: 6.609 ± 0.084	5.991LeuThr: 5.991 ± 0.074	6.515LeuVal: 6.515 ± 0.083	0.78LeuTrp: 0.78 ± 0.027	3.054LeuTyr: 3.054 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.125MetAla: 2.125 ± 0.045	0.134MetCys: 0.134 ± 0.012	1.622MetAsp: 1.622 ± 0.035	2.039MetGlu: 2.039 ± 0.044	1.068MetPhe: 1.068 ± 0.032	1.904MetGly: 1.904 ± 0.04	0.495MetHis: 0.495 ± 0.02	2.252MetIle: 2.252 ± 0.042	2.682MetLys: 2.682 ± 0.05	2.624MetLeu: 2.624 ± 0.052	0.937MetMet: 0.937 ± 0.036	1.576MetAsn: 1.576 ± 0.034	1.099MetPro: 1.099 ± 0.032	0.958MetGln: 0.958 ± 0.029	1.19MetArg: 1.19 ± 0.038	1.688MetSer: 1.688 ± 0.039	2.108MetThr: 2.108 ± 0.04	1.647MetVal: 1.647 ± 0.037	0.219MetTrp: 0.219 ± 0.015	0.803MetTyr: 0.803 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.903AsnAla: 2.903 ± 0.05	0.269AsnCys: 0.269 ± 0.013	2.257AsnAsp: 2.257 ± 0.045	3.416AsnGlu: 3.416 ± 0.052	1.66AsnPhe: 1.66 ± 0.04	3.291AsnGly: 3.291 ± 0.054	0.893AsnHis: 0.893 ± 0.027	3.002AsnIle: 3.002 ± 0.058	2.621AsnLys: 2.621 ± 0.05	3.691AsnLeu: 3.691 ± 0.056	1.254AsnMet: 1.254 ± 0.029	1.881AsnAsn: 1.881 ± 0.048	2.116AsnPro: 2.116 ± 0.04	1.454AsnGln: 1.454 ± 0.041	2.004AsnArg: 2.004 ± 0.036	2.319AsnSer: 2.319 ± 0.044	2.114AsnThr: 2.114 ± 0.042	3.002AsnVal: 3.002 ± 0.049	0.463AsnTrp: 0.463 ± 0.02	1.512AsnTyr: 1.512 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.375ProAla: 2.375 ± 0.053	0.174ProCys: 0.174 ± 0.013	1.94ProAsp: 1.94 ± 0.044	2.975ProGlu: 2.975 ± 0.051	1.96ProPhe: 1.96 ± 0.041	2.383ProGly: 2.383 ± 0.063	0.789ProHis: 0.789 ± 0.026	2.957ProIle: 2.957 ± 0.056	2.049ProLys: 2.049 ± 0.043	3.479ProLeu: 3.479 ± 0.055	0.87ProMet: 0.87 ± 0.031	1.603ProAsn: 1.603 ± 0.034	0.987ProPro: 0.987 ± 0.034	1.009ProGln: 1.009 ± 0.029	1.028ProArg: 1.028 ± 0.028	2.256ProSer: 2.256 ± 0.044	2.051ProThr: 2.051 ± 0.048	2.959ProVal: 2.959 ± 0.056	0.334ProTrp: 0.334 ± 0.014	1.369ProTyr: 1.369 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.624GlnAla: 2.624 ± 0.046	0.164GlnCys: 0.164 ± 0.012	1.545GlnAsp: 1.545 ± 0.036	2.411GlnGlu: 2.411 ± 0.044	1.566GlnPhe: 1.566 ± 0.029	1.997GlnGly: 1.997 ± 0.044	0.69GlnHis: 0.69 ± 0.027	2.314GlnIle: 2.314 ± 0.048	2.253GlnLys: 2.253 ± 0.044	3.679GlnLeu: 3.679 ± 0.063	1.082GlnMet: 1.082 ± 0.036	1.394GlnAsn: 1.394 ± 0.036	1.109GlnPro: 1.109 ± 0.03	1.71GlnGln: 1.71 ± 0.047	1.398GlnArg: 1.398 ± 0.039	2.114GlnSer: 2.114 ± 0.053	1.827GlnThr: 1.827 ± 0.042	2.231GlnVal: 2.231 ± 0.049	0.377GlnTrp: 0.377 ± 0.017	1.099GlnTyr: 1.099 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.632ArgAla: 2.632 ± 0.049	0.246ArgCys: 0.246 ± 0.015	1.983ArgAsp: 1.983 ± 0.043	3.009ArgGlu: 3.009 ± 0.057	1.911ArgPhe: 1.911 ± 0.037	2.365ArgGly: 2.365 ± 0.049	0.795ArgHis: 0.795 ± 0.022	3.305ArgIle: 3.305 ± 0.057	3.187ArgLys: 3.187 ± 0.048	4.094ArgLeu: 4.094 ± 0.051	1.353ArgMet: 1.353 ± 0.032	1.889ArgAsn: 1.889 ± 0.043	1.292ArgPro: 1.292 ± 0.034	1.453ArgGln: 1.453 ± 0.038	1.831ArgArg: 1.831 ± 0.044	2.166ArgSer: 2.166 ± 0.047	2.241ArgThr: 2.241 ± 0.045	2.67ArgVal: 2.67 ± 0.051	0.39ArgTrp: 0.39 ± 0.018	1.416ArgTyr: 1.416 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.113SerAla: 4.113 ± 0.066	0.354SerCys: 0.354 ± 0.017	3.061SerAsp: 3.061 ± 0.048	3.94SerGlu: 3.94 ± 0.063	3.442SerPhe: 3.442 ± 0.051	4.755SerGly: 4.755 ± 0.064	1.124SerHis: 1.124 ± 0.029	5.32SerIle: 5.32 ± 0.066	3.594SerLys: 3.594 ± 0.057	6.015SerLeu: 6.015 ± 0.077	1.841SerMet: 1.841 ± 0.037	2.424SerAsn: 2.424 ± 0.046	2.15SerPro: 2.15 ± 0.047	1.769SerGln: 1.769 ± 0.043	2.371SerArg: 2.371 ± 0.047	3.896SerSer: 3.896 ± 0.063	3.386SerThr: 3.386 ± 0.058	4.441SerVal: 4.441 ± 0.057	0.567SerTrp: 0.567 ± 0.022	2.086SerTyr: 2.086 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.401ThrAla: 4.401 ± 0.067	0.304ThrCys: 0.304 ± 0.018	3.114ThrAsp: 3.114 ± 0.062	3.955ThrGlu: 3.955 ± 0.051	2.824ThrPhe: 2.824 ± 0.046	4.636ThrGly: 4.636 ± 0.107	1.094ThrHis: 1.094 ± 0.032	4.956ThrIle: 4.956 ± 0.063	3.372ThrLys: 3.372 ± 0.05	5.374ThrLeu: 5.374 ± 0.066	1.462ThrMet: 1.462 ± 0.034	2.382ThrAsn: 2.382 ± 0.046	2.32ThrPro: 2.32 ± 0.046	1.456ThrGln: 1.456 ± 0.039	1.897ThrArg: 1.897 ± 0.037	3.512ThrSer: 3.512 ± 0.047	3.29ThrThr: 3.29 ± 0.065	4.705ThrVal: 4.705 ± 0.069	0.524ThrTrp: 0.524 ± 0.021	1.932ThrTyr: 1.932 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.538ValAla: 5.538 ± 0.074	0.519ValCys: 0.519 ± 0.024	3.87ValAsp: 3.87 ± 0.062	5.009ValGlu: 5.009 ± 0.067	3.321ValPhe: 3.321 ± 0.054	4.863ValGly: 4.863 ± 0.065	1.371ValHis: 1.371 ± 0.031	5.847ValIle: 5.847 ± 0.076	4.688ValLys: 4.688 ± 0.069	7.157ValLeu: 7.157 ± 0.085	2.025ValMet: 2.025 ± 0.04	3.09ValAsn: 3.09 ± 0.05	2.632ValPro: 2.632 ± 0.044	2.241ValGln: 2.241 ± 0.046	2.866ValArg: 2.866 ± 0.055	4.571ValSer: 4.571 ± 0.07	4.49ValThr: 4.49 ± 0.072	5.197ValVal: 5.197 ± 0.082	0.63ValTrp: 0.63 ± 0.021	2.165ValTyr: 2.165 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.618TrpAla: 0.618 ± 0.025	0.075TrpCys: 0.075 ± 0.008	0.477TrpAsp: 0.477 ± 0.021	0.614TrpGlu: 0.614 ± 0.024	0.472TrpPhe: 0.472 ± 0.019	0.662TrpGly: 0.662 ± 0.024	0.206TrpHis: 0.206 ± 0.015	0.863TrpIle: 0.863 ± 0.03	0.689TrpLys: 0.689 ± 0.023	1.131TrpLeu: 1.131 ± 0.034	0.348TrpMet: 0.348 ± 0.017	0.507TrpAsn: 0.507 ± 0.021	0.264TrpPro: 0.264 ± 0.016	0.344TrpGln: 0.344 ± 0.017	0.404TrpArg: 0.404 ± 0.019	0.611TrpSer: 0.611 ± 0.023	0.609TrpThr: 0.609 ± 0.022	0.553TrpVal: 0.553 ± 0.022	0.124TrpTrp: 0.124 ± 0.011	0.296TrpTyr: 0.296 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.274TyrAla: 2.274 ± 0.046	0.246TyrCys: 0.246 ± 0.013	1.908TyrAsp: 1.908 ± 0.041	2.421TyrGlu: 2.421 ± 0.047	1.764TyrPhe: 1.764 ± 0.041	2.455TyrGly: 2.455 ± 0.05	0.646TyrHis: 0.646 ± 0.022	2.436TyrIle: 2.436 ± 0.047	1.929TyrLys: 1.929 ± 0.038	3.144TyrLeu: 3.144 ± 0.046	0.928TyrMet: 0.928 ± 0.024	1.359TyrAsn: 1.359 ± 0.033	1.319TyrPro: 1.319 ± 0.034	1.062TyrGln: 1.062 ± 0.033	1.471TyrArg: 1.471 ± 0.038	2.085TyrSer: 2.085 ± 0.039	1.809TyrThr: 1.809 ± 0.041	2.122TyrVal: 2.122 ± 0.045	0.366TyrTrp: 0.366 ± 0.018	1.292TyrTyr: 1.292 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4219 proteins (1221369 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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