Amino acid dipepetide frequency for Propioniciclava sp. HDW11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.25AlaAla: 22.25 ± 0.286
1.041AlaCys: 1.041 ± 0.036
9.183AlaAsp: 9.183 ± 0.108
7.861AlaGlu: 7.861 ± 0.111
4.04AlaPhe: 4.04 ± 0.067
13.085AlaGly: 13.085 ± 0.147
2.732AlaHis: 2.732 ± 0.053
5.055AlaIle: 5.055 ± 0.079
2.726AlaLys: 2.726 ± 0.068
15.34AlaLeu: 15.34 ± 0.171
2.966AlaMet: 2.966 ± 0.052
2.162AlaAsn: 2.162 ± 0.047
7.241AlaPro: 7.241 ± 0.107
3.953AlaGln: 3.953 ± 0.06
9.943AlaArg: 9.943 ± 0.132
7.673AlaSer: 7.673 ± 0.095
7.959AlaThr: 7.959 ± 0.098
11.269AlaVal: 11.269 ± 0.121
2.423AlaTrp: 2.423 ± 0.06
2.356AlaTyr: 2.356 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.88CysAla: 0.88 ± 0.033
0.098CysCys: 0.098 ± 0.013
0.367CysAsp: 0.367 ± 0.021
0.32CysGlu: 0.32 ± 0.02
0.198CysPhe: 0.198 ± 0.014
0.755CysGly: 0.755 ± 0.031
0.171CysHis: 0.171 ± 0.014
0.218CysIle: 0.218 ± 0.016
0.085CysLys: 0.085 ± 0.011
0.598CysLeu: 0.598 ± 0.027
0.102CysMet: 0.102 ± 0.01
0.109CysAsn: 0.109 ± 0.011
0.461CysPro: 0.461 ± 0.028
0.134CysGln: 0.134 ± 0.013
0.495CysArg: 0.495 ± 0.022
0.447CysSer: 0.447 ± 0.023
0.427CysThr: 0.427 ± 0.024
0.546CysVal: 0.546 ± 0.027
0.14CysTrp: 0.14 ± 0.012
0.127CysTyr: 0.127 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
10.665AspAla: 10.665 ± 0.119
0.299AspCys: 0.299 ± 0.019
3.74AspAsp: 3.74 ± 0.084
3.773AspGlu: 3.773 ± 0.077
1.622AspPhe: 1.622 ± 0.045
5.808AspGly: 5.808 ± 0.099
1.366AspHis: 1.366 ± 0.036
1.873AspIle: 1.873 ± 0.045
1.169AspLys: 1.169 ± 0.04
6.946AspLeu: 6.946 ± 0.089
0.843AspMet: 0.843 ± 0.03
0.895AspAsn: 0.895 ± 0.031
4.682AspPro: 4.682 ± 0.081
1.674AspGln: 1.674 ± 0.045
4.295AspArg: 4.295 ± 0.07
2.035AspSer: 2.035 ± 0.051
2.704AspThr: 2.704 ± 0.05
5.254AspVal: 5.254 ± 0.069
0.936AspTrp: 0.936 ± 0.038
1.144AspTyr: 1.144 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.43GluAla: 7.43 ± 0.105
0.246GluCys: 0.246 ± 0.015
2.811GluAsp: 2.811 ± 0.064
2.848GluGlu: 2.848 ± 0.067
1.478GluPhe: 1.478 ± 0.041
4.08GluGly: 4.08 ± 0.063
1.417GluHis: 1.417 ± 0.039
2.134GluIle: 2.134 ± 0.056
1.208GluLys: 1.208 ± 0.04
5.671GluLeu: 5.671 ± 0.089
0.942GluMet: 0.942 ± 0.034
0.917GluAsn: 0.917 ± 0.036
3.209GluPro: 3.209 ± 0.064
2.0GluGln: 2.0 ± 0.045
4.915GluArg: 4.915 ± 0.076
2.204GluSer: 2.204 ± 0.057
2.479GluThr: 2.479 ± 0.055
4.661GluVal: 4.661 ± 0.083
0.728GluTrp: 0.728 ± 0.033
0.948GluTyr: 0.948 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.227PheAla: 4.227 ± 0.082
0.247PheCys: 0.247 ± 0.016
2.148PheAsp: 2.148 ± 0.052
1.496PheGlu: 1.496 ± 0.042
1.034PhePhe: 1.034 ± 0.035
3.334PheGly: 3.334 ± 0.064
0.588PheHis: 0.588 ± 0.024
1.073PheIle: 1.073 ± 0.038
0.521PheLys: 0.521 ± 0.023
2.89PheLeu: 2.89 ± 0.061
0.506PheMet: 0.506 ± 0.023
0.674PheAsn: 0.674 ± 0.028
1.458PhePro: 1.458 ± 0.038
0.652PheGln: 0.652 ± 0.024
1.657PheArg: 1.657 ± 0.04
1.62PheSer: 1.62 ± 0.046
2.064PheThr: 2.064 ± 0.049
2.816PheVal: 2.816 ± 0.051
0.508PheTrp: 0.508 ± 0.026
0.638PheTyr: 0.638 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.845GlyAla: 10.845 ± 0.132
0.728GlyCys: 0.728 ± 0.029
5.061GlyAsp: 5.061 ± 0.078
4.85GlyGlu: 4.85 ± 0.065
3.259GlyPhe: 3.259 ± 0.06
7.847GlyGly: 7.847 ± 0.116
2.036GlyHis: 2.036 ± 0.051
3.887GlyIle: 3.887 ± 0.061
2.006GlyLys: 2.006 ± 0.055
9.805GlyLeu: 9.805 ± 0.129
2.118GlyMet: 2.118 ± 0.052
1.654GlyAsn: 1.654 ± 0.048
4.351GlyPro: 4.351 ± 0.072
2.561GlyGln: 2.561 ± 0.051
7.391GlyArg: 7.391 ± 0.111
4.855GlySer: 4.855 ± 0.078
5.652GlyThr: 5.652 ± 0.078
8.602GlyVal: 8.602 ± 0.117
1.972GlyTrp: 1.972 ± 0.05
2.242GlyTyr: 2.242 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.687HisAla: 2.687 ± 0.053
0.143HisCys: 0.143 ± 0.013
1.402HisAsp: 1.402 ± 0.038
1.062HisGlu: 1.062 ± 0.039
0.558HisPhe: 0.558 ± 0.023
1.988HisGly: 1.988 ± 0.05
0.612HisHis: 0.612 ± 0.028
0.578HisIle: 0.578 ± 0.025
0.286HisLys: 0.286 ± 0.018
2.317HisLeu: 2.317 ± 0.051
0.315HisMet: 0.315 ± 0.017
0.39HisAsn: 0.39 ± 0.022
1.746HisPro: 1.746 ± 0.042
0.563HisGln: 0.563 ± 0.023
1.729HisArg: 1.729 ± 0.048
0.779HisSer: 0.779 ± 0.028
1.07HisThr: 1.07 ± 0.038
1.727HisVal: 1.727 ± 0.04
0.324HisTrp: 0.324 ± 0.02
0.413HisTyr: 0.413 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.815IleAla: 5.815 ± 0.087
0.306IleCys: 0.306 ± 0.018
2.689IleAsp: 2.689 ± 0.06
2.358IleGlu: 2.358 ± 0.051
1.067IlePhe: 1.067 ± 0.039
3.941IleGly: 3.941 ± 0.069
0.666IleHis: 0.666 ± 0.028
1.567IleIle: 1.567 ± 0.049
0.81IleLys: 0.81 ± 0.031
3.296IleLeu: 3.296 ± 0.065
0.71IleMet: 0.71 ± 0.026
0.886IleAsn: 0.886 ± 0.034
2.068IlePro: 2.068 ± 0.051
0.869IleGln: 0.869 ± 0.03
2.193IleArg: 2.193 ± 0.042
1.912IleSer: 1.912 ± 0.044
2.533IleThr: 2.533 ± 0.05
3.698IleVal: 3.698 ± 0.07
0.472IleTrp: 0.472 ± 0.024
0.647IleTyr: 0.647 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
2.711LysAla: 2.711 ± 0.068
0.074LysCys: 0.074 ± 0.009
1.069LysAsp: 1.069 ± 0.039
0.947LysGlu: 0.947 ± 0.037
0.51LysPhe: 0.51 ± 0.025
1.581LysGly: 1.581 ± 0.051
0.374LysHis: 0.374 ± 0.02
0.815LysIle: 0.815 ± 0.033
0.779LysLys: 0.779 ± 0.036
1.941LysLeu: 1.941 ± 0.053
0.439LysMet: 0.439 ± 0.023
0.468LysAsn: 0.468 ± 0.025
1.15LysPro: 1.15 ± 0.039
0.69LysGln: 0.69 ± 0.029
1.385LysArg: 1.385 ± 0.041
0.984LysSer: 0.984 ± 0.035
1.176LysThr: 1.176 ± 0.035
1.869LysVal: 1.869 ± 0.047
0.22LysTrp: 0.22 ± 0.016
0.448LysTyr: 0.448 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
16.209LeuAla: 16.209 ± 0.17
0.645LeuCys: 0.645 ± 0.031
6.985LeuAsp: 6.985 ± 0.092
4.681LeuGlu: 4.681 ± 0.076
2.806LeuPhe: 2.806 ± 0.06
9.985LeuGly: 9.985 ± 0.133
1.956LeuHis: 1.956 ± 0.042
4.232LeuIle: 4.232 ± 0.076
1.809LeuLys: 1.809 ± 0.048
10.846LeuLeu: 10.846 ± 0.152
1.929LeuMet: 1.929 ± 0.052
1.955LeuAsn: 1.955 ± 0.044
6.057LeuPro: 6.057 ± 0.084
2.391LeuGln: 2.391 ± 0.054
7.593LeuArg: 7.593 ± 0.102
5.161LeuSer: 5.161 ± 0.077
6.848LeuThr: 6.848 ± 0.088
9.423LeuVal: 9.423 ± 0.107
1.373LeuTrp: 1.373 ± 0.047
1.633LeuTyr: 1.633 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.57MetAla: 2.57 ± 0.053
0.126MetCys: 0.126 ± 0.012
1.003MetAsp: 1.003 ± 0.036
0.766MetGlu: 0.766 ± 0.032
0.638MetPhe: 0.638 ± 0.031
1.498MetGly: 1.498 ± 0.043
0.318MetHis: 0.318 ± 0.018
0.912MetIle: 0.912 ± 0.033
0.48MetLys: 0.48 ± 0.022
2.065MetLeu: 2.065 ± 0.043
0.421MetMet: 0.421 ± 0.021
0.544MetAsn: 0.544 ± 0.024
1.136MetPro: 1.136 ± 0.034
0.505MetGln: 0.505 ± 0.025
1.343MetArg: 1.343 ± 0.036
1.353MetSer: 1.353 ± 0.04
1.663MetThr: 1.663 ± 0.04
1.605MetVal: 1.605 ± 0.037
0.221MetTrp: 0.221 ± 0.014
0.285MetTyr: 0.285 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.468AsnAla: 2.468 ± 0.05
0.135AsnCys: 0.135 ± 0.013
1.032AsnAsp: 1.032 ± 0.038
0.883AsnGlu: 0.883 ± 0.032
0.534AsnPhe: 0.534 ± 0.03
1.673AsnGly: 1.673 ± 0.049
0.436AsnHis: 0.436 ± 0.022
0.71AsnIle: 0.71 ± 0.028
0.431AsnLys: 0.431 ± 0.024
1.873AsnLeu: 1.873 ± 0.043
0.348AsnMet: 0.348 ± 0.02
0.466AsnAsn: 0.466 ± 0.027
1.565AsnPro: 1.565 ± 0.041
0.574AsnGln: 0.574 ± 0.024
1.294AsnArg: 1.294 ± 0.039
0.813AsnSer: 0.813 ± 0.029
1.138AsnThr: 1.138 ± 0.039
1.518AsnVal: 1.518 ± 0.041
0.309AsnTrp: 0.309 ± 0.021
0.504AsnTyr: 0.504 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
8.348ProAla: 8.348 ± 0.117
0.3ProCys: 0.3 ± 0.019
4.73ProAsp: 4.73 ± 0.076
3.794ProGlu: 3.794 ± 0.064
1.616ProPhe: 1.616 ± 0.04
6.101ProGly: 6.101 ± 0.095
1.238ProHis: 1.238 ± 0.036
1.898ProIle: 1.898 ± 0.048
1.019ProLys: 1.019 ± 0.041
5.312ProLeu: 5.312 ± 0.073
1.056ProMet: 1.056 ± 0.029
1.112ProAsn: 1.112 ± 0.04
2.928ProPro: 2.928 ± 0.066
1.665ProGln: 1.665 ± 0.042
4.106ProArg: 4.106 ± 0.081
2.981ProSer: 2.981 ± 0.061
4.04ProThr: 4.04 ± 0.078
4.728ProVal: 4.728 ± 0.078
1.065ProTrp: 1.065 ± 0.036
1.127ProTyr: 1.127 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.902GlnAla: 3.902 ± 0.075
0.144GlnCys: 0.144 ± 0.011
1.244GlnAsp: 1.244 ± 0.039
1.217GlnGlu: 1.217 ± 0.04
0.854GlnPhe: 0.854 ± 0.028
2.263GlnGly: 2.263 ± 0.047
0.617GlnHis: 0.617 ± 0.025
1.181GlnIle: 1.181 ± 0.039
0.557GlnLys: 0.557 ± 0.03
2.928GlnLeu: 2.928 ± 0.079
0.578GlnMet: 0.578 ± 0.023
0.536GlnAsn: 0.536 ± 0.023
1.63GlnPro: 1.63 ± 0.044
1.18GlnGln: 1.18 ± 0.04
2.464GlnArg: 2.464 ± 0.059
1.191GlnSer: 1.191 ± 0.037
1.4GlnThr: 1.4 ± 0.037
2.661GlnVal: 2.661 ± 0.047
0.471GlnTrp: 0.471 ± 0.025
0.547GlnTyr: 0.547 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
9.699ArgAla: 9.699 ± 0.131
0.499ArgCys: 0.499 ± 0.025
4.359ArgAsp: 4.359 ± 0.064
3.95ArgGlu: 3.95 ± 0.074
2.271ArgPhe: 2.271 ± 0.053
5.818ArgGly: 5.818 ± 0.099
1.719ArgHis: 1.719 ± 0.046
3.127ArgIle: 3.127 ± 0.057
1.287ArgLys: 1.287 ± 0.043
7.781ArgLeu: 7.781 ± 0.117
1.646ArgMet: 1.646 ± 0.044
1.326ArgAsn: 1.326 ± 0.041
4.811ArgPro: 4.811 ± 0.08
2.074ArgGln: 2.074 ± 0.044
7.17ArgArg: 7.17 ± 0.117
3.808ArgSer: 3.808 ± 0.065
4.361ArgThr: 4.361 ± 0.074
6.0ArgVal: 6.0 ± 0.08
1.398ArgTrp: 1.398 ± 0.038
1.499ArgTyr: 1.499 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.173SerAla: 6.173 ± 0.084
0.332SerCys: 0.332 ± 0.022
2.821SerAsp: 2.821 ± 0.052
2.391SerGlu: 2.391 ± 0.049
1.728SerPhe: 1.728 ± 0.042
5.541SerGly: 5.541 ± 0.079
0.933SerHis: 0.933 ± 0.033
1.968SerIle: 1.968 ± 0.051
0.999SerLys: 0.999 ± 0.031
4.852SerLeu: 4.852 ± 0.074
1.167SerMet: 1.167 ± 0.035
0.955SerAsn: 0.955 ± 0.031
3.119SerPro: 3.119 ± 0.065
1.293SerGln: 1.293 ± 0.044
3.592SerArg: 3.592 ± 0.064
2.71SerSer: 2.71 ± 0.061
3.029SerThr: 3.029 ± 0.06
4.108SerVal: 4.108 ± 0.066
0.969SerTrp: 0.969 ± 0.035
1.133SerTyr: 1.133 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
7.466ThrAla: 7.466 ± 0.089
0.39ThrCys: 0.39 ± 0.023
3.553ThrAsp: 3.553 ± 0.062
2.696ThrGlu: 2.696 ± 0.056
1.979ThrPhe: 1.979 ± 0.047
5.691ThrGly: 5.691 ± 0.083
1.218ThrHis: 1.218 ± 0.033
2.483ThrIle: 2.483 ± 0.048
1.162ThrLys: 1.162 ± 0.037
6.409ThrLeu: 6.409 ± 0.084
1.126ThrMet: 1.126 ± 0.037
1.156ThrAsn: 1.156 ± 0.034
4.603ThrPro: 4.603 ± 0.087
1.591ThrGln: 1.591 ± 0.045
4.041ThrArg: 4.041 ± 0.065
3.111ThrSer: 3.111 ± 0.057
3.764ThrThr: 3.764 ± 0.077
5.44ThrVal: 5.44 ± 0.089
1.138ThrTrp: 1.138 ± 0.036
1.172ThrTyr: 1.172 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
12.515ValAla: 12.515 ± 0.143
0.619ValCys: 0.619 ± 0.025
5.388ValAsp: 5.388 ± 0.081
4.746ValGlu: 4.746 ± 0.071
2.624ValPhe: 2.624 ± 0.06
7.652ValGly: 7.652 ± 0.099
1.612ValHis: 1.612 ± 0.041
3.639ValIle: 3.639 ± 0.073
1.641ValLys: 1.641 ± 0.046
9.365ValLeu: 9.365 ± 0.113
1.675ValMet: 1.675 ± 0.048
1.685ValAsn: 1.685 ± 0.049
5.014ValPro: 5.014 ± 0.084
2.088ValGln: 2.088 ± 0.045
6.071ValArg: 6.071 ± 0.09
4.274ValSer: 4.274 ± 0.065
5.765ValThr: 5.765 ± 0.08
8.477ValVal: 8.477 ± 0.112
1.24ValTrp: 1.24 ± 0.038
1.429ValTyr: 1.429 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.904TrpAla: 1.904 ± 0.049
0.144TrpCys: 0.144 ± 0.012
0.896TrpAsp: 0.896 ± 0.036
0.692TrpGlu: 0.692 ± 0.03
0.645TrpPhe: 0.645 ± 0.023
1.228TrpGly: 1.228 ± 0.047
0.324TrpHis: 0.324 ± 0.018
0.63TrpIle: 0.63 ± 0.032
0.305TrpLys: 0.305 ± 0.017
2.067TrpLeu: 2.067 ± 0.062
0.329TrpMet: 0.329 ± 0.019
0.412TrpAsn: 0.412 ± 0.019
0.896TrpPro: 0.896 ± 0.034
0.547TrpGln: 0.547 ± 0.024
1.43TrpArg: 1.43 ± 0.042
0.988TrpSer: 0.988 ± 0.038
1.037TrpThr: 1.037 ± 0.039
1.415TrpVal: 1.415 ± 0.044
0.493TrpTrp: 0.493 ± 0.025
0.34TrpTyr: 0.34 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.492TyrAla: 2.492 ± 0.05
0.161TyrCys: 0.161 ± 0.012
1.24TyrAsp: 1.24 ± 0.033
0.997TyrGlu: 0.997 ± 0.033
0.69TyrPhe: 0.69 ± 0.027
1.851TyrGly: 1.851 ± 0.049
0.357TyrHis: 0.357 ± 0.018
0.526TyrIle: 0.526 ± 0.025
0.349TyrLys: 0.349 ± 0.022
2.214TyrLeu: 2.214 ± 0.047
0.237TyrMet: 0.237 ± 0.017
0.401TyrAsn: 0.401 ± 0.023
1.041TyrPro: 1.041 ± 0.035
0.563TyrGln: 0.563 ± 0.028
1.497TyrArg: 1.497 ± 0.036
0.914TyrSer: 0.914 ± 0.028
1.081TyrThr: 1.081 ± 0.033
1.702TyrVal: 1.702 ± 0.042
0.323TyrTrp: 0.323 ± 0.021
0.434TyrTyr: 0.434 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3100 proteins (963778 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski