Amino acid dipepetide frequency for Mycobacterium sp. 1164966.3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.773AlaAla: 19.773 ± 0.18
1.061AlaCys: 1.061 ± 0.024
8.014AlaAsp: 8.014 ± 0.069
7.881AlaGlu: 7.881 ± 0.097
3.393AlaPhe: 3.393 ± 0.049
11.582AlaGly: 11.582 ± 0.106
2.675AlaHis: 2.675 ± 0.038
5.247AlaIle: 5.247 ± 0.059
3.248AlaLys: 3.248 ± 0.053
12.494AlaLeu: 12.494 ± 0.106
2.874AlaMet: 2.874 ± 0.04
2.713AlaAsn: 2.713 ± 0.043
6.119AlaPro: 6.119 ± 0.086
4.12AlaGln: 4.12 ± 0.053
8.815AlaArg: 8.815 ± 0.083
6.037AlaSer: 6.037 ± 0.065
6.9AlaThr: 6.9 ± 0.074
11.254AlaVal: 11.254 ± 0.097
1.633AlaTrp: 1.633 ± 0.032
2.384AlaTyr: 2.384 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.103CysAla: 1.103 ± 0.028
0.099CysCys: 0.099 ± 0.008
0.57CysAsp: 0.57 ± 0.016
0.461CysGlu: 0.461 ± 0.018
0.255CysPhe: 0.255 ± 0.012
0.997CysGly: 0.997 ± 0.027
0.202CysHis: 0.202 ± 0.011
0.285CysIle: 0.285 ± 0.015
0.127CysLys: 0.127 ± 0.008
0.717CysLeu: 0.717 ± 0.018
0.138CysMet: 0.138 ± 0.01
0.189CysAsn: 0.189 ± 0.01
0.507CysPro: 0.507 ± 0.017
0.247CysGln: 0.247 ± 0.012
0.661CysArg: 0.661 ± 0.023
0.506CysSer: 0.506 ± 0.016
0.488CysThr: 0.488 ± 0.021
0.711CysVal: 0.711 ± 0.018
0.149CysTrp: 0.149 ± 0.01
0.198CysTyr: 0.198 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.466AspAla: 7.466 ± 0.09
0.474AspCys: 0.474 ± 0.017
4.2AspAsp: 4.2 ± 0.061
4.129AspGlu: 4.129 ± 0.053
1.883AspPhe: 1.883 ± 0.035
5.71AspGly: 5.71 ± 0.059
1.442AspHis: 1.442 ± 0.034
2.715AspIle: 2.715 ± 0.049
1.396AspLys: 1.396 ± 0.033
5.933AspLeu: 5.933 ± 0.068
1.045AspMet: 1.045 ± 0.029
1.245AspAsn: 1.245 ± 0.026
4.332AspPro: 4.332 ± 0.057
1.825AspGln: 1.825 ± 0.035
4.538AspArg: 4.538 ± 0.053
2.791AspSer: 2.791 ± 0.047
2.977AspThr: 2.977 ± 0.041
5.326AspVal: 5.326 ± 0.065
0.993AspTrp: 0.993 ± 0.026
1.486AspTyr: 1.486 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
6.212GluAla: 6.212 ± 0.082
0.401GluCys: 0.401 ± 0.018
2.376GluAsp: 2.376 ± 0.036
2.613GluGlu: 2.613 ± 0.051
1.871GluPhe: 1.871 ± 0.035
3.287GluGly: 3.287 ± 0.048
1.56GluHis: 1.56 ± 0.031
2.696GluIle: 2.696 ± 0.047
1.33GluLys: 1.33 ± 0.032
6.909GluLeu: 6.909 ± 0.085
1.135GluMet: 1.135 ± 0.028
1.152GluAsn: 1.152 ± 0.032
3.081GluPro: 3.081 ± 0.053
2.268GluGln: 2.268 ± 0.043
4.5GluArg: 4.5 ± 0.053
2.762GluSer: 2.762 ± 0.038
2.726GluThr: 2.726 ± 0.041
4.447GluVal: 4.447 ± 0.066
0.804GluTrp: 0.804 ± 0.026
1.14GluTyr: 1.14 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.039PheAla: 4.039 ± 0.053
0.336PheCys: 0.336 ± 0.015
2.497PheAsp: 2.497 ± 0.06
1.68PheGlu: 1.68 ± 0.036
0.997PhePhe: 0.997 ± 0.027
3.484PheGly: 3.484 ± 0.046
0.657PheHis: 0.657 ± 0.017
1.099PheIle: 1.099 ± 0.027
0.588PheLys: 0.588 ± 0.019
2.472PheLeu: 2.472 ± 0.038
0.503PheMet: 0.503 ± 0.016
0.79PheAsn: 0.79 ± 0.025
1.498PhePro: 1.498 ± 0.034
0.741PheGln: 0.741 ± 0.019
1.793PheArg: 1.793 ± 0.034
1.761PheSer: 1.761 ± 0.035
2.037PheThr: 2.037 ± 0.038
2.571PheVal: 2.571 ± 0.038
0.435PheTrp: 0.435 ± 0.016
0.717PheTyr: 0.717 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
9.545GlyAla: 9.545 ± 0.094
0.844GlyCys: 0.844 ± 0.024
4.832GlyAsp: 4.832 ± 0.053
4.381GlyGlu: 4.381 ± 0.062
3.026GlyPhe: 3.026 ± 0.05
7.425GlyGly: 7.425 ± 0.099
2.007GlyHis: 2.007 ± 0.035
4.129GlyIle: 4.129 ± 0.052
2.474GlyLys: 2.474 ± 0.045
8.383GlyLeu: 8.383 ± 0.081
2.255GlyMet: 2.255 ± 0.043
1.946GlyAsn: 1.946 ± 0.048
4.698GlyPro: 4.698 ± 0.069
2.908GlyGln: 2.908 ± 0.055
6.367GlyArg: 6.367 ± 0.061
5.244GlySer: 5.244 ± 0.057
4.964GlyThr: 4.964 ± 0.064
7.193GlyVal: 7.193 ± 0.068
1.644GlyTrp: 1.644 ± 0.032
2.429GlyTyr: 2.429 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.525HisAla: 2.525 ± 0.039
0.242HisCys: 0.242 ± 0.014
1.398HisAsp: 1.398 ± 0.028
1.087HisGlu: 1.087 ± 0.026
0.691HisPhe: 0.691 ± 0.022
2.162HisGly: 2.162 ± 0.035
0.691HisHis: 0.691 ± 0.02
0.915HisIle: 0.915 ± 0.026
0.377HisLys: 0.377 ± 0.017
2.18HisLeu: 2.18 ± 0.041
0.383HisMet: 0.383 ± 0.013
0.518HisAsn: 0.518 ± 0.019
1.709HisPro: 1.709 ± 0.037
0.742HisGln: 0.742 ± 0.023
1.961HisArg: 1.961 ± 0.047
1.139HisSer: 1.139 ± 0.026
1.243HisThr: 1.243 ± 0.029
1.742HisVal: 1.742 ± 0.032
0.391HisTrp: 0.391 ± 0.015
0.593HisTyr: 0.593 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.294IleAla: 6.294 ± 0.065
0.435IleCys: 0.435 ± 0.017
3.441IleAsp: 3.441 ± 0.052
2.715IleGlu: 2.715 ± 0.05
1.082IlePhe: 1.082 ± 0.026
4.389IleGly: 4.389 ± 0.058
0.855IleHis: 0.855 ± 0.02
1.437IleIle: 1.437 ± 0.034
0.956IleLys: 0.956 ± 0.028
3.025IleLeu: 3.025 ± 0.042
0.644IleMet: 0.644 ± 0.021
1.178IleAsn: 1.178 ± 0.03
2.426IlePro: 2.426 ± 0.039
1.004IleGln: 1.004 ± 0.026
2.691IleArg: 2.691 ± 0.046
2.458IleSer: 2.458 ± 0.039
2.807IleThr: 2.807 ± 0.041
3.647IleVal: 3.647 ± 0.053
0.489IleTrp: 0.489 ± 0.019
0.846IleTyr: 0.846 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.768LysAla: 2.768 ± 0.047
0.135LysCys: 0.135 ± 0.009
1.135LysAsp: 1.135 ± 0.026
1.031LysGlu: 1.031 ± 0.03
0.688LysPhe: 0.688 ± 0.019
1.62LysGly: 1.62 ± 0.04
0.547LysHis: 0.547 ± 0.021
1.078LysIle: 1.078 ± 0.028
0.699LysLys: 0.699 ± 0.028
2.416LysLeu: 2.416 ± 0.046
0.496LysMet: 0.496 ± 0.019
0.559LysAsn: 0.559 ± 0.019
1.619LysPro: 1.619 ± 0.037
0.788LysGln: 0.788 ± 0.022
1.778LysArg: 1.778 ± 0.031
1.362LysSer: 1.362 ± 0.032
1.4LysThr: 1.4 ± 0.032
2.019LysVal: 2.019 ± 0.036
0.351LysTrp: 0.351 ± 0.014
0.525LysTyr: 0.525 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.012LeuAla: 14.012 ± 0.108
0.886LeuCys: 0.886 ± 0.023
6.561LeuAsp: 6.561 ± 0.075
4.426LeuGlu: 4.426 ± 0.061
2.714LeuPhe: 2.714 ± 0.044
8.401LeuGly: 8.401 ± 0.071
2.096LeuHis: 2.096 ± 0.037
4.113LeuIle: 4.113 ± 0.055
1.943LeuLys: 1.943 ± 0.034
9.606LeuLeu: 9.606 ± 0.094
1.795LeuMet: 1.795 ± 0.031
2.214LeuAsn: 2.214 ± 0.038
5.91LeuPro: 5.91 ± 0.067
2.724LeuGln: 2.724 ± 0.047
7.733LeuArg: 7.733 ± 0.081
5.8LeuSer: 5.8 ± 0.062
6.238LeuThr: 6.238 ± 0.061
8.391LeuVal: 8.391 ± 0.078
1.22LeuTrp: 1.22 ± 0.031
1.69LeuTyr: 1.69 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
2.691MetAla: 2.691 ± 0.047
0.191MetCys: 0.191 ± 0.011
0.937MetAsp: 0.937 ± 0.027
0.753MetGlu: 0.753 ± 0.021
0.684MetPhe: 0.684 ± 0.022
1.471MetGly: 1.471 ± 0.033
0.443MetHis: 0.443 ± 0.016
0.916MetIle: 0.916 ± 0.023
0.485MetLys: 0.485 ± 0.017
2.188MetLeu: 2.188 ± 0.038
0.44MetMet: 0.44 ± 0.018
0.538MetAsn: 0.538 ± 0.019
1.32MetPro: 1.32 ± 0.028
0.581MetGln: 0.581 ± 0.017
1.625MetArg: 1.625 ± 0.031
1.536MetSer: 1.536 ± 0.031
1.76MetThr: 1.76 ± 0.03
1.657MetVal: 1.657 ± 0.034
0.297MetTrp: 0.297 ± 0.013
0.371MetTyr: 0.371 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.798AsnAla: 2.798 ± 0.046
0.216AsnCys: 0.216 ± 0.011
1.283AsnAsp: 1.283 ± 0.026
1.044AsnGlu: 1.044 ± 0.029
0.735AsnPhe: 0.735 ± 0.023
2.117AsnGly: 2.117 ± 0.037
0.501AsnHis: 0.501 ± 0.018
1.003AsnIle: 1.003 ± 0.026
0.483AsnLys: 0.483 ± 0.019
2.179AsnLeu: 2.179 ± 0.039
0.457AsnMet: 0.457 ± 0.017
0.624AsnAsn: 0.624 ± 0.023
1.791AsnPro: 1.791 ± 0.033
0.713AsnGln: 0.713 ± 0.024
1.681AsnArg: 1.681 ± 0.04
1.215AsnSer: 1.215 ± 0.032
1.305AsnThr: 1.305 ± 0.032
1.841AsnVal: 1.841 ± 0.036
0.402AsnTrp: 0.402 ± 0.016
0.609AsnTyr: 0.609 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.151ProAla: 7.151 ± 0.103
0.305ProCys: 0.305 ± 0.015
4.399ProAsp: 4.399 ± 0.054
3.747ProGlu: 3.747 ± 0.053
1.681ProPhe: 1.681 ± 0.031
5.635ProGly: 5.635 ± 0.067
1.223ProHis: 1.223 ± 0.029
2.277ProIle: 2.277 ± 0.039
1.401ProLys: 1.401 ± 0.037
4.958ProLeu: 4.958 ± 0.064
1.251ProMet: 1.251 ± 0.027
1.398ProAsn: 1.398 ± 0.03
4.0ProPro: 4.0 ± 0.095
1.963ProGln: 1.963 ± 0.035
3.594ProArg: 3.594 ± 0.053
3.229ProSer: 3.229 ± 0.057
3.402ProThr: 3.402 ± 0.048
4.988ProVal: 4.988 ± 0.063
0.85ProTrp: 0.85 ± 0.027
1.237ProTyr: 1.237 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.809GlnAla: 3.809 ± 0.05
0.228GlnCys: 0.228 ± 0.012
1.259GlnAsp: 1.259 ± 0.035
1.244GlnGlu: 1.244 ± 0.031
1.026GlnPhe: 1.026 ± 0.026
2.028GlnGly: 2.028 ± 0.04
0.85GlnHis: 0.85 ± 0.021
1.551GlnIle: 1.551 ± 0.035
0.642GlnLys: 0.642 ± 0.022
3.829GlnLeu: 3.829 ± 0.053
0.691GlnMet: 0.691 ± 0.023
0.629GlnAsn: 0.629 ± 0.021
2.069GlnPro: 2.069 ± 0.036
1.352GlnGln: 1.352 ± 0.033
3.023GlnArg: 3.023 ± 0.046
1.58GlnSer: 1.58 ± 0.032
1.663GlnThr: 1.663 ± 0.029
2.664GlnVal: 2.664 ± 0.043
0.615GlnTrp: 0.615 ± 0.019
0.684GlnTyr: 0.684 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
8.414ArgAla: 8.414 ± 0.094
0.648ArgCys: 0.648 ± 0.023
4.326ArgAsp: 4.326 ± 0.057
3.932ArgGlu: 3.932 ± 0.055
2.554ArgPhe: 2.554 ± 0.038
5.232ArgGly: 5.232 ± 0.058
1.86ArgHis: 1.86 ± 0.034
3.503ArgIle: 3.503 ± 0.052
1.757ArgLys: 1.757 ± 0.036
7.906ArgLeu: 7.906 ± 0.079
1.872ArgMet: 1.872 ± 0.028
1.709ArgAsn: 1.709 ± 0.03
4.126ArgPro: 4.126 ± 0.059
2.505ArgGln: 2.505 ± 0.04
6.73ArgArg: 6.73 ± 0.086
4.074ArgSer: 4.074 ± 0.052
3.91ArgThr: 3.91 ± 0.049
5.713ArgVal: 5.713 ± 0.07
1.421ArgTrp: 1.421 ± 0.036
2.016ArgTyr: 2.016 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
7.012SerAla: 7.012 ± 0.084
0.441SerCys: 0.441 ± 0.017
3.345SerAsp: 3.345 ± 0.047
2.628SerGlu: 2.628 ± 0.045
1.681SerPhe: 1.681 ± 0.032
5.757SerGly: 5.757 ± 0.072
1.112SerHis: 1.112 ± 0.027
2.145SerIle: 2.145 ± 0.036
1.263SerLys: 1.263 ± 0.031
4.849SerLeu: 4.849 ± 0.057
1.396SerMet: 1.396 ± 0.03
1.194SerAsn: 1.194 ± 0.03
3.164SerPro: 3.164 ± 0.046
1.629SerGln: 1.629 ± 0.036
3.911SerArg: 3.911 ± 0.049
3.253SerSer: 3.253 ± 0.052
3.237SerThr: 3.237 ± 0.047
4.464SerVal: 4.464 ± 0.057
0.964SerTrp: 0.964 ± 0.024
1.318SerTyr: 1.318 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
7.45ThrAla: 7.45 ± 0.073
0.44ThrCys: 0.44 ± 0.016
3.474ThrAsp: 3.474 ± 0.045
3.097ThrGlu: 3.097 ± 0.04
1.764ThrPhe: 1.764 ± 0.035
5.562ThrGly: 5.562 ± 0.06
1.196ThrHis: 1.196 ± 0.026
2.44ThrIle: 2.44 ± 0.041
1.349ThrLys: 1.349 ± 0.032
5.453ThrLeu: 5.453 ± 0.059
1.227ThrMet: 1.227 ± 0.029
1.291ThrAsn: 1.291 ± 0.029
3.629ThrPro: 3.629 ± 0.044
1.573ThrGln: 1.573 ± 0.03
3.605ThrArg: 3.605 ± 0.047
3.198ThrSer: 3.198 ± 0.047
3.642ThrThr: 3.642 ± 0.047
5.447ThrVal: 5.447 ± 0.066
0.874ThrTrp: 0.874 ± 0.027
1.253ThrTyr: 1.253 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
11.065ValAla: 11.065 ± 0.106
0.814ValCys: 0.814 ± 0.023
5.587ValAsp: 5.587 ± 0.069
4.564ValGlu: 4.564 ± 0.055
2.61ValPhe: 2.61 ± 0.044
6.745ValGly: 6.745 ± 0.066
1.857ValHis: 1.857 ± 0.033
3.923ValIle: 3.923 ± 0.052
1.767ValLys: 1.767 ± 0.033
8.804ValLeu: 8.804 ± 0.09
1.625ValMet: 1.625 ± 0.033
2.183ValAsn: 2.183 ± 0.037
4.568ValPro: 4.568 ± 0.054
2.264ValGln: 2.264 ± 0.04
5.91ValArg: 5.91 ± 0.057
4.692ValSer: 4.692 ± 0.055
5.201ValThr: 5.201 ± 0.06
8.425ValVal: 8.425 ± 0.085
1.08ValTrp: 1.08 ± 0.029
1.643ValTyr: 1.643 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.554TrpAla: 1.554 ± 0.034
0.178TrpCys: 0.178 ± 0.01
0.857TrpAsp: 0.857 ± 0.024
0.728TrpGlu: 0.728 ± 0.019
0.523TrpPhe: 0.523 ± 0.017
1.006TrpGly: 1.006 ± 0.026
0.381TrpHis: 0.381 ± 0.016
0.649TrpIle: 0.649 ± 0.019
0.348TrpLys: 0.348 ± 0.016
1.774TrpLeu: 1.774 ± 0.033
0.345TrpMet: 0.345 ± 0.015
0.442TrpAsn: 0.442 ± 0.015
0.832TrpPro: 0.832 ± 0.026
0.671TrpGln: 0.671 ± 0.018
1.34TrpArg: 1.34 ± 0.029
0.973TrpSer: 0.973 ± 0.028
0.907TrpThr: 0.907 ± 0.023
1.141TrpVal: 1.141 ± 0.029
0.344TrpTrp: 0.344 ± 0.016
0.337TrpTyr: 0.337 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.538TyrAla: 2.538 ± 0.04
0.235TyrCys: 0.235 ± 0.011
1.416TyrAsp: 1.416 ± 0.031
1.129TyrGlu: 1.129 ± 0.028
0.84TyrPhe: 0.84 ± 0.021
2.084TyrGly: 2.084 ± 0.049
0.537TyrHis: 0.537 ± 0.018
0.699TyrIle: 0.699 ± 0.021
0.381TyrLys: 0.381 ± 0.015
2.397TyrLeu: 2.397 ± 0.039
0.308TyrMet: 0.308 ± 0.013
0.485TyrAsn: 0.485 ± 0.019
1.288TyrPro: 1.288 ± 0.034
0.817TyrGln: 0.817 ± 0.021
1.953TyrArg: 1.953 ± 0.035
1.155TyrSer: 1.155 ± 0.029
1.154TyrThr: 1.154 ± 0.028
1.686TyrVal: 1.686 ± 0.032
0.375TyrTrp: 0.375 ± 0.016
0.533TyrTyr: 0.533 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4963 proteins (1635646 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski