Amino acid dipepetide frequency for Mesorhizobium metallidurans STM 2683

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.882AlaAla: 16.882 ± 0.142	1.073AlaCys: 1.073 ± 0.026	6.897AlaAsp: 6.897 ± 0.057	7.419AlaGlu: 7.419 ± 0.068	4.645AlaPhe: 4.645 ± 0.054	11.047AlaGly: 11.047 ± 0.085	2.109AlaHis: 2.109 ± 0.038	6.8AlaIle: 6.8 ± 0.067	4.617AlaLys: 4.617 ± 0.059	12.699AlaLeu: 12.699 ± 0.1	3.548AlaMet: 3.548 ± 0.044	3.037AlaAsn: 3.037 ± 0.038	5.047AlaPro: 5.047 ± 0.059	3.383AlaGln: 3.383 ± 0.045	8.473AlaArg: 8.473 ± 0.073	6.729AlaSer: 6.729 ± 0.065	5.862AlaThr: 5.862 ± 0.07	8.773AlaVal: 8.773 ± 0.074	1.464AlaTrp: 1.464 ± 0.032	2.58AlaTyr: 2.58 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.973CysAla: 0.973 ± 0.022	0.153CysCys: 0.153 ± 0.01	0.525CysAsp: 0.525 ± 0.018	0.433CysGlu: 0.433 ± 0.016	0.369CysPhe: 0.369 ± 0.015	0.944CysGly: 0.944 ± 0.021	0.256CysHis: 0.256 ± 0.013	0.402CysIle: 0.402 ± 0.015	0.205CysLys: 0.205 ± 0.01	0.821CysLeu: 0.821 ± 0.022	0.179CysMet: 0.179 ± 0.011	0.24CysAsn: 0.24 ± 0.012	0.459CysPro: 0.459 ± 0.015	0.25CysGln: 0.25 ± 0.013	0.753CysArg: 0.753 ± 0.02	0.511CysSer: 0.511 ± 0.017	0.426CysThr: 0.426 ± 0.018	0.624CysVal: 0.624 ± 0.02	0.136CysTrp: 0.136 ± 0.008	0.211CysTyr: 0.211 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.583AspAla: 6.583 ± 0.064	0.512AspCys: 0.512 ± 0.018	3.146AspAsp: 3.146 ± 0.052	3.378AspGlu: 3.378 ± 0.047	2.35AspPhe: 2.35 ± 0.035	5.154AspGly: 5.154 ± 0.059	1.307AspHis: 1.307 ± 0.034	3.314AspIle: 3.314 ± 0.042	1.999AspLys: 1.999 ± 0.034	5.588AspLeu: 5.588 ± 0.055	1.396AspMet: 1.396 ± 0.03	1.439AspAsn: 1.439 ± 0.031	3.281AspPro: 3.281 ± 0.041	1.773AspGln: 1.773 ± 0.029	4.493AspArg: 4.493 ± 0.057	2.099AspSer: 2.099 ± 0.034	2.564AspThr: 2.564 ± 0.037	4.025AspVal: 4.025 ± 0.045	0.965AspTrp: 0.965 ± 0.023	1.449AspTyr: 1.449 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.364GluAla: 7.364 ± 0.075	0.378GluCys: 0.378 ± 0.017	2.546GluAsp: 2.546 ± 0.042	2.922GluGlu: 2.922 ± 0.047	1.879GluPhe: 1.879 ± 0.038	3.948GluGly: 3.948 ± 0.048	1.159GluHis: 1.159 ± 0.029	3.597GluIle: 3.597 ± 0.057	2.667GluLys: 2.667 ± 0.046	5.214GluLeu: 5.214 ± 0.063	1.527GluMet: 1.527 ± 0.031	1.663GluAsn: 1.663 ± 0.028	2.742GluPro: 2.742 ± 0.039	2.002GluGln: 2.002 ± 0.033	4.711GluArg: 4.711 ± 0.062	2.219GluSer: 2.219 ± 0.034	3.418GluThr: 3.418 ± 0.045	3.577GluVal: 3.577 ± 0.043	0.704GluTrp: 0.704 ± 0.019	0.973GluTyr: 0.973 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.772PheAla: 4.772 ± 0.052	0.442PheCys: 0.442 ± 0.015	2.716PheAsp: 2.716 ± 0.032	2.208PheGlu: 2.208 ± 0.038	1.53PhePhe: 1.53 ± 0.032	3.787PheGly: 3.787 ± 0.046	0.798PheHis: 0.798 ± 0.022	1.839PheIle: 1.839 ± 0.034	1.098PheLys: 1.098 ± 0.027	3.47PheLeu: 3.47 ± 0.046	0.866PheMet: 0.866 ± 0.022	1.069PheAsn: 1.069 ± 0.025	1.657PhePro: 1.657 ± 0.026	1.07PheGln: 1.07 ± 0.023	2.383PheArg: 2.383 ± 0.043	2.458PheSer: 2.458 ± 0.037	1.873PheThr: 1.873 ± 0.031	2.996PheVal: 2.996 ± 0.044	0.578PheTrp: 0.578 ± 0.02	0.902PheTyr: 0.902 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.988GlyAla: 8.988 ± 0.082	0.897GlyCys: 0.897 ± 0.025	4.472GlyAsp: 4.472 ± 0.054	4.715GlyGlu: 4.715 ± 0.049	3.686GlyPhe: 3.686 ± 0.047	7.251GlyGly: 7.251 ± 0.147	1.929GlyHis: 1.929 ± 0.037	5.003GlyIle: 5.003 ± 0.055	3.967GlyLys: 3.967 ± 0.055	8.752GlyLeu: 8.752 ± 0.061	2.406GlyMet: 2.406 ± 0.04	2.348GlyAsn: 2.348 ± 0.047	3.45GlyPro: 3.45 ± 0.049	2.794GlyGln: 2.794 ± 0.039	6.043GlyArg: 6.043 ± 0.065	4.811GlySer: 4.811 ± 0.058	4.441GlyThr: 4.441 ± 0.048	6.007GlyVal: 6.007 ± 0.058	1.328GlyTrp: 1.328 ± 0.026	2.308GlyTyr: 2.308 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.303HisAla: 2.303 ± 0.036	0.254HisCys: 0.254 ± 0.011	1.257HisAsp: 1.257 ± 0.028	1.068HisGlu: 1.068 ± 0.024	0.87HisPhe: 0.87 ± 0.023	2.003HisGly: 2.003 ± 0.037	0.571HisHis: 0.571 ± 0.021	0.986HisIle: 0.986 ± 0.025	0.555HisLys: 0.555 ± 0.018	1.976HisLeu: 1.976 ± 0.036	0.513HisMet: 0.513 ± 0.016	0.484HisAsn: 0.484 ± 0.016	1.3HisPro: 1.3 ± 0.026	0.611HisGln: 0.611 ± 0.02	1.539HisArg: 1.539 ± 0.032	1.013HisSer: 1.013 ± 0.026	0.775HisThr: 0.775 ± 0.02	1.508HisVal: 1.508 ± 0.026	0.312HisTrp: 0.312 ± 0.013	0.553HisTyr: 0.553 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.67IleAla: 7.67 ± 0.058	0.507IleCys: 0.507 ± 0.016	3.7IleAsp: 3.7 ± 0.048	3.709IleGlu: 3.709 ± 0.049	1.849IlePhe: 1.849 ± 0.032	5.322IleGly: 5.322 ± 0.061	1.013IleHis: 1.013 ± 0.025	2.489IleIle: 2.489 ± 0.043	1.626IleLys: 1.626 ± 0.034	4.584IleLeu: 4.584 ± 0.054	1.116IleMet: 1.116 ± 0.027	1.448IleAsn: 1.448 ± 0.027	2.408IlePro: 2.408 ± 0.036	1.184IleGln: 1.184 ± 0.024	3.422IleArg: 3.422 ± 0.042	3.278IleSer: 3.278 ± 0.045	2.539IleThr: 2.539 ± 0.039	4.719IleVal: 4.719 ± 0.06	0.619IleTrp: 0.619 ± 0.019	1.159IleTyr: 1.159 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.852LysAla: 4.852 ± 0.064	0.2LysCys: 0.2 ± 0.011	1.903LysAsp: 1.903 ± 0.038	1.711LysGlu: 1.711 ± 0.036	1.037LysPhe: 1.037 ± 0.024	2.916LysGly: 2.916 ± 0.046	0.684LysHis: 0.684 ± 0.021	2.045LysIle: 2.045 ± 0.033	1.663LysLys: 1.663 ± 0.036	3.656LysLeu: 3.656 ± 0.056	0.922LysMet: 0.922 ± 0.022	1.002LysAsn: 1.002 ± 0.027	2.389LysPro: 2.389 ± 0.044	1.156LysGln: 1.156 ± 0.028	2.667LysArg: 2.667 ± 0.042	2.181LysSer: 2.181 ± 0.034	2.271LysThr: 2.271 ± 0.041	2.772LysVal: 2.772 ± 0.041	0.442LysTrp: 0.442 ± 0.016	0.704LysTyr: 0.704 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.184LeuAla: 13.184 ± 0.105	0.907LeuCys: 0.907 ± 0.022	5.947LeuAsp: 5.947 ± 0.057	4.959LeuGlu: 4.959 ± 0.055	3.662LeuPhe: 3.662 ± 0.05	8.184LeuGly: 8.184 ± 0.073	1.835LeuHis: 1.835 ± 0.032	5.101LeuIle: 5.101 ± 0.057	3.91LeuLys: 3.91 ± 0.054	9.093LeuLeu: 9.093 ± 0.092	2.258LeuMet: 2.258 ± 0.036	2.546LeuAsn: 2.546 ± 0.035	5.362LeuPro: 5.362 ± 0.054	2.661LeuGln: 2.661 ± 0.038	6.527LeuArg: 6.527 ± 0.069	6.597LeuSer: 6.597 ± 0.052	5.217LeuThr: 5.217 ± 0.052	7.515LeuVal: 7.515 ± 0.06	1.105LeuTrp: 1.105 ± 0.022	2.068LeuTyr: 2.068 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.292MetAla: 3.292 ± 0.04	0.158MetCys: 0.158 ± 0.008	1.091MetAsp: 1.091 ± 0.023	1.09MetGlu: 1.09 ± 0.027	0.759MetPhe: 0.759 ± 0.021	1.721MetGly: 1.721 ± 0.035	0.471MetHis: 0.471 ± 0.017	1.412MetIle: 1.412 ± 0.032	1.097MetLys: 1.097 ± 0.025	2.562MetLeu: 2.562 ± 0.04	0.689MetMet: 0.689 ± 0.021	0.831MetAsn: 0.831 ± 0.024	1.568MetPro: 1.568 ± 0.031	0.839MetGln: 0.839 ± 0.021	1.883MetArg: 1.883 ± 0.031	1.667MetSer: 1.667 ± 0.029	1.832MetThr: 1.832 ± 0.034	1.797MetVal: 1.797 ± 0.035	0.23MetTrp: 0.23 ± 0.012	0.299MetTyr: 0.299 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.269AsnAla: 3.269 ± 0.045	0.267AsnCys: 0.267 ± 0.013	1.489AsnAsp: 1.489 ± 0.029	1.342AsnGlu: 1.342 ± 0.027	1.083AsnPhe: 1.083 ± 0.024	2.501AsnGly: 2.501 ± 0.046	0.519AsnHis: 0.519 ± 0.017	1.448AsnIle: 1.448 ± 0.027	0.762AsnLys: 0.762 ± 0.022	2.546AsnLeu: 2.546 ± 0.037	0.66AsnMet: 0.66 ± 0.021	0.763AsnAsn: 0.763 ± 0.025	1.866AsnPro: 1.866 ± 0.036	0.785AsnGln: 0.785 ± 0.022	1.891AsnArg: 1.891 ± 0.031	1.355AsnSer: 1.355 ± 0.029	1.234AsnThr: 1.234 ± 0.026	1.965AsnVal: 1.965 ± 0.04	0.474AsnTrp: 0.474 ± 0.016	0.726AsnTyr: 0.726 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.202ProAla: 6.202 ± 0.069	0.357ProCys: 0.357 ± 0.015	3.577ProAsp: 3.577 ± 0.039	3.32ProGlu: 3.32 ± 0.044	2.014ProPhe: 2.014 ± 0.034	4.376ProGly: 4.376 ± 0.049	1.024ProHis: 1.024 ± 0.023	2.343ProIle: 2.343 ± 0.035	1.927ProLys: 1.927 ± 0.035	4.753ProLeu: 4.753 ± 0.056	1.18ProMet: 1.18 ± 0.025	1.362ProAsn: 1.362 ± 0.03	2.404ProPro: 2.404 ± 0.044	1.568ProGln: 1.568 ± 0.025	2.876ProArg: 2.876 ± 0.044	2.828ProSer: 2.828 ± 0.046	2.444ProThr: 2.444 ± 0.04	4.169ProVal: 4.169 ± 0.049	0.732ProTrp: 0.732 ± 0.021	1.228ProTyr: 1.228 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.897GlnAla: 3.897 ± 0.053	0.236GlnCys: 0.236 ± 0.011	1.413GlnAsp: 1.413 ± 0.031	1.448GlnGlu: 1.448 ± 0.03	1.045GlnPhe: 1.045 ± 0.025	2.253GlnGly: 2.253 ± 0.037	0.617GlnHis: 0.617 ± 0.017	1.758GlnIle: 1.758 ± 0.03	1.231GlnLys: 1.231 ± 0.028	2.713GlnLeu: 2.713 ± 0.039	0.883GlnMet: 0.883 ± 0.022	0.895GlnAsn: 0.895 ± 0.023	1.717GlnPro: 1.717 ± 0.036	1.123GlnGln: 1.123 ± 0.029	2.423GlnArg: 2.423 ± 0.043	1.815GlnSer: 1.815 ± 0.037	1.681GlnThr: 1.681 ± 0.032	2.0GlnVal: 2.0 ± 0.035	0.392GlnTrp: 0.392 ± 0.015	0.596GlnTyr: 0.596 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.492ArgAla: 7.492 ± 0.07	0.611ArgCys: 0.611 ± 0.018	4.07ArgAsp: 4.07 ± 0.053	3.896ArgGlu: 3.896 ± 0.051	2.975ArgPhe: 2.975 ± 0.039	4.731ArgGly: 4.731 ± 0.051	1.859ArgHis: 1.859 ± 0.037	4.091ArgIle: 4.091 ± 0.049	2.657ArgLys: 2.657 ± 0.042	7.896ArgLeu: 7.896 ± 0.086	1.856ArgMet: 1.856 ± 0.031	2.042ArgAsn: 2.042 ± 0.034	3.586ArgPro: 3.586 ± 0.053	2.749ArgGln: 2.749 ± 0.045	5.89ArgArg: 5.89 ± 0.085	4.005ArgSer: 4.005 ± 0.045	3.497ArgThr: 3.497 ± 0.039	4.342ArgVal: 4.342 ± 0.054	0.998ArgTrp: 0.998 ± 0.025	1.687ArgTyr: 1.687 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.44SerAla: 6.44 ± 0.067	0.472SerCys: 0.472 ± 0.017	3.105SerAsp: 3.105 ± 0.034	2.815SerGlu: 2.815 ± 0.039	2.398SerPhe: 2.398 ± 0.039	5.901SerGly: 5.901 ± 0.063	1.177SerHis: 1.177 ± 0.027	3.048SerIle: 3.048 ± 0.046	1.803SerLys: 1.803 ± 0.032	5.598SerLeu: 5.598 ± 0.064	1.41SerMet: 1.41 ± 0.029	1.445SerAsn: 1.445 ± 0.03	2.901SerPro: 2.901 ± 0.043	1.686SerGln: 1.686 ± 0.034	3.863SerArg: 3.863 ± 0.044	3.291SerSer: 3.291 ± 0.045	2.751SerThr: 2.751 ± 0.04	4.281SerVal: 4.281 ± 0.052	0.781SerTrp: 0.781 ± 0.021	1.246SerTyr: 1.246 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.07ThrAla: 6.07 ± 0.062	0.407ThrCys: 0.407 ± 0.015	2.656ThrAsp: 2.656 ± 0.038	2.615ThrGlu: 2.615 ± 0.043	1.987ThrPhe: 1.987 ± 0.035	5.021ThrGly: 5.021 ± 0.051	0.925ThrHis: 0.925 ± 0.024	3.117ThrIle: 3.117 ± 0.049	1.648ThrLys: 1.648 ± 0.026	5.508ThrLeu: 5.508 ± 0.054	1.289ThrMet: 1.289 ± 0.028	1.293ThrAsn: 1.293 ± 0.027	2.973ThrPro: 2.973 ± 0.04	1.28ThrGln: 1.28 ± 0.031	3.201ThrArg: 3.201 ± 0.041	2.934ThrSer: 2.934 ± 0.039	2.742ThrThr: 2.742 ± 0.048	4.298ThrVal: 4.298 ± 0.056	0.641ThrTrp: 0.641 ± 0.019	1.141ThrTyr: 1.141 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.18ValAla: 9.18 ± 0.071	0.626ValCys: 0.626 ± 0.02	4.264ValAsp: 4.264 ± 0.047	4.426ValGlu: 4.426 ± 0.05	2.912ValPhe: 2.912 ± 0.04	5.654ValGly: 5.654 ± 0.064	1.368ValHis: 1.368 ± 0.03	3.952ValIle: 3.952 ± 0.052	2.549ValLys: 2.549 ± 0.044	7.354ValLeu: 7.354 ± 0.069	1.806ValMet: 1.806 ± 0.03	1.933ValAsn: 1.933 ± 0.034	3.71ValPro: 3.71 ± 0.041	1.893ValGln: 1.893 ± 0.036	4.94ValArg: 4.94 ± 0.062	4.549ValSer: 4.549 ± 0.06	4.324ValThr: 4.324 ± 0.048	5.868ValVal: 5.868 ± 0.065	0.912ValTrp: 0.912 ± 0.023	1.438ValTyr: 1.438 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.216TrpAla: 1.216 ± 0.025	0.148TrpCys: 0.148 ± 0.009	0.636TrpAsp: 0.636 ± 0.018	0.517TrpGlu: 0.517 ± 0.017	0.553TrpPhe: 0.553 ± 0.02	0.858TrpGly: 0.858 ± 0.022	0.336TrpHis: 0.336 ± 0.013	0.667TrpIle: 0.667 ± 0.019	0.527TrpLys: 0.527 ± 0.016	1.667TrpLeu: 1.667 ± 0.033	0.35TrpMet: 0.35 ± 0.015	0.49TrpAsn: 0.49 ± 0.017	0.719TrpPro: 0.719 ± 0.019	0.617TrpGln: 0.617 ± 0.022	1.166TrpArg: 1.166 ± 0.029	0.864TrpSer: 0.864 ± 0.023	0.783TrpThr: 0.783 ± 0.021	0.784TrpVal: 0.784 ± 0.023	0.227TrpTrp: 0.227 ± 0.011	0.269TrpTyr: 0.269 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.455TyrAla: 2.455 ± 0.038	0.266TyrCys: 0.266 ± 0.013	1.406TyrAsp: 1.406 ± 0.029	1.218TyrGlu: 1.218 ± 0.025	0.91TyrPhe: 0.91 ± 0.023	2.025TyrGly: 2.025 ± 0.03	0.495TyrHis: 0.495 ± 0.016	0.949TyrIle: 0.949 ± 0.026	0.668TyrLys: 0.668 ± 0.022	2.188TyrLeu: 2.188 ± 0.035	0.434TyrMet: 0.434 ± 0.016	0.612TyrAsn: 0.612 ± 0.018	1.144TyrPro: 1.144 ± 0.026	0.71TyrGln: 0.71 ± 0.02	1.784TyrArg: 1.784 ± 0.034	1.209TyrSer: 1.209 ± 0.028	1.07TyrThr: 1.07 ± 0.027	1.637TyrVal: 1.637 ± 0.031	0.355TyrTrp: 0.355 ± 0.016	0.566TyrTyr: 0.566 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6696 proteins (1837213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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