Amino acid dipepetide frequency for Nitrosomonas cryotolerans ATCC 49181

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.447AlaAla: 8.447 ± 0.167	1.073AlaCys: 1.073 ± 0.042	4.452AlaAsp: 4.452 ± 0.081	5.132AlaGlu: 5.132 ± 0.093	3.382AlaPhe: 3.382 ± 0.065	6.197AlaGly: 6.197 ± 0.112	2.031AlaHis: 2.031 ± 0.053	6.434AlaIle: 6.434 ± 0.104	3.969AlaLys: 3.969 ± 0.084	9.571AlaLeu: 9.571 ± 0.138	2.47AlaMet: 2.47 ± 0.061	3.411AlaAsn: 3.411 ± 0.067	2.784AlaPro: 2.784 ± 0.055	3.604AlaGln: 3.604 ± 0.082	5.054AlaArg: 5.054 ± 0.08	4.894AlaSer: 4.894 ± 0.084	4.512AlaThr: 4.512 ± 0.08	5.705AlaVal: 5.705 ± 0.099	1.053AlaTrp: 1.053 ± 0.034	2.399AlaTyr: 2.399 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.874CysAla: 0.874 ± 0.031	0.134CysCys: 0.134 ± 0.014	0.521CysAsp: 0.521 ± 0.027	0.495CysGlu: 0.495 ± 0.025	0.43CysPhe: 0.43 ± 0.024	1.02CysGly: 1.02 ± 0.037	0.467CysHis: 0.467 ± 0.032	0.692CysIle: 0.692 ± 0.034	0.334CysLys: 0.334 ± 0.022	1.025CysLeu: 1.025 ± 0.038	0.238CysMet: 0.238 ± 0.019	0.429CysAsn: 0.429 ± 0.03	0.526CysPro: 0.526 ± 0.027	0.412CysGln: 0.412 ± 0.024	0.525CysArg: 0.525 ± 0.028	0.666CysSer: 0.666 ± 0.031	0.554CysThr: 0.554 ± 0.03	0.654CysVal: 0.654 ± 0.034	0.125CysTrp: 0.125 ± 0.012	0.324CysTyr: 0.324 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.212AspAla: 4.212 ± 0.088	0.506AspCys: 0.506 ± 0.026	2.493AspAsp: 2.493 ± 0.072	3.206AspGlu: 3.206 ± 0.063	2.427AspPhe: 2.427 ± 0.062	3.301AspGly: 3.301 ± 0.077	1.294AspHis: 1.294 ± 0.048	4.006AspIle: 4.006 ± 0.071	2.733AspLys: 2.733 ± 0.068	5.118AspLeu: 5.118 ± 0.083	1.38AspMet: 1.38 ± 0.04	2.168AspAsn: 2.168 ± 0.054	2.189AspPro: 2.189 ± 0.059	2.095AspGln: 2.095 ± 0.055	2.557AspArg: 2.557 ± 0.062	3.136AspSer: 3.136 ± 0.064	2.758AspThr: 2.758 ± 0.072	3.168AspVal: 3.168 ± 0.065	0.804AspTrp: 0.804 ± 0.039	1.86AspTyr: 1.86 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.058GluAla: 5.058 ± 0.087	0.529GluCys: 0.529 ± 0.03	2.409GluAsp: 2.409 ± 0.058	3.126GluGlu: 3.126 ± 0.072	2.239GluPhe: 2.239 ± 0.054	2.985GluGly: 2.985 ± 0.065	1.336GluHis: 1.336 ± 0.045	4.935GluIle: 4.935 ± 0.09	3.719GluLys: 3.719 ± 0.076	5.906GluLeu: 5.906 ± 0.088	1.62GluMet: 1.62 ± 0.044	2.633GluAsn: 2.633 ± 0.053	1.983GluPro: 1.983 ± 0.047	3.129GluGln: 3.129 ± 0.063	3.574GluArg: 3.574 ± 0.069	3.542GluSer: 3.542 ± 0.07	3.353GluThr: 3.353 ± 0.063	3.38GluVal: 3.38 ± 0.063	0.759GluTrp: 0.759 ± 0.036	1.66GluTyr: 1.66 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.269PheAla: 3.269 ± 0.069	0.504PheCys: 0.504 ± 0.025	2.456PheAsp: 2.456 ± 0.05	2.287PheGlu: 2.287 ± 0.044	1.873PhePhe: 1.873 ± 0.057	2.949PheGly: 2.949 ± 0.067	0.865PheHis: 0.865 ± 0.03	2.917PheIle: 2.917 ± 0.06	1.901PheLys: 1.901 ± 0.053	3.932PheLeu: 3.932 ± 0.076	0.984PheMet: 0.984 ± 0.039	1.91PheAsn: 1.91 ± 0.049	1.602PhePro: 1.602 ± 0.051	1.302PheGln: 1.302 ± 0.041	1.97PheArg: 1.97 ± 0.046	3.264PheSer: 3.264 ± 0.065	2.132PheThr: 2.132 ± 0.058	2.582PheVal: 2.582 ± 0.062	0.554PheTrp: 0.554 ± 0.028	1.33PheTyr: 1.33 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.202GlyAla: 5.202 ± 0.094	0.943GlyCys: 0.943 ± 0.04	3.241GlyAsp: 3.241 ± 0.06	3.876GlyGlu: 3.876 ± 0.073	3.16GlyPhe: 3.16 ± 0.071	4.975GlyGly: 4.975 ± 0.103	1.826GlyHis: 1.826 ± 0.054	5.278GlyIle: 5.278 ± 0.097	3.803GlyLys: 3.803 ± 0.07	7.098GlyLeu: 7.098 ± 0.123	1.99GlyMet: 1.99 ± 0.058	2.628GlyAsn: 2.628 ± 0.065	1.738GlyPro: 1.738 ± 0.053	2.472GlyGln: 2.472 ± 0.063	3.68GlyArg: 3.68 ± 0.074	4.111GlySer: 4.111 ± 0.067	3.478GlyThr: 3.478 ± 0.07	4.838GlyVal: 4.838 ± 0.101	1.085GlyTrp: 1.085 ± 0.032	2.492GlyTyr: 2.492 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.262HisAla: 2.262 ± 0.057	0.344HisCys: 0.344 ± 0.024	1.4HisAsp: 1.4 ± 0.044	1.363HisGlu: 1.363 ± 0.041	1.152HisPhe: 1.152 ± 0.041	1.766HisGly: 1.766 ± 0.05	0.929HisHis: 0.929 ± 0.045	1.692HisIle: 1.692 ± 0.046	1.069HisLys: 1.069 ± 0.038	2.701HisLeu: 2.701 ± 0.067	0.604HisMet: 0.604 ± 0.027	0.959HisAsn: 0.959 ± 0.037	1.317HisPro: 1.317 ± 0.045	1.076HisGln: 1.076 ± 0.037	1.318HisArg: 1.318 ± 0.045	1.613HisSer: 1.613 ± 0.047	1.35HisThr: 1.35 ± 0.044	1.527HisVal: 1.527 ± 0.045	0.342HisTrp: 0.342 ± 0.023	0.982HisTyr: 0.982 ± 0.046	0.0HisXaa: 0.0 ± 0.0
Ile	6.845IleAla: 6.845 ± 0.106	0.707IleCys: 0.707 ± 0.029	4.199IleAsp: 4.199 ± 0.077	4.61IleGlu: 4.61 ± 0.08	2.717IlePhe: 2.717 ± 0.066	5.088IleGly: 5.088 ± 0.092	1.76IleHis: 1.76 ± 0.045	4.88IleIle: 4.88 ± 0.1	3.639IleLys: 3.639 ± 0.081	7.002IleLeu: 7.002 ± 0.106	1.617IleMet: 1.617 ± 0.047	3.22IleAsn: 3.22 ± 0.07	3.352IlePro: 3.352 ± 0.07	2.743IleGln: 2.743 ± 0.07	3.751IleArg: 3.751 ± 0.072	4.883IleSer: 4.883 ± 0.076	4.294IleThr: 4.294 ± 0.079	4.365IleVal: 4.365 ± 0.084	0.741IleTrp: 0.741 ± 0.031	1.899IleTyr: 1.899 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.047LysAla: 4.047 ± 0.087	0.323LysCys: 0.323 ± 0.023	2.265LysAsp: 2.265 ± 0.058	2.753LysGlu: 2.753 ± 0.064	1.483LysPhe: 1.483 ± 0.05	2.83LysGly: 2.83 ± 0.062	1.167LysHis: 1.167 ± 0.043	3.877LysIle: 3.877 ± 0.074	3.196LysLys: 3.196 ± 0.09	5.222LysLeu: 5.222 ± 0.098	1.378LysMet: 1.378 ± 0.042	2.6LysAsn: 2.6 ± 0.07	2.161LysPro: 2.161 ± 0.055	2.962LysGln: 2.962 ± 0.082	2.966LysArg: 2.966 ± 0.067	3.085LysSer: 3.085 ± 0.077	2.825LysThr: 2.825 ± 0.061	2.734LysVal: 2.734 ± 0.066	0.532LysTrp: 0.532 ± 0.032	1.272LysTyr: 1.272 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	10.07LeuAla: 10.07 ± 0.133	1.024LeuCys: 1.024 ± 0.036	5.717LeuAsp: 5.717 ± 0.109	6.058LeuGlu: 6.058 ± 0.097	4.289LeuPhe: 4.289 ± 0.088	6.816LeuGly: 6.816 ± 0.11	2.619LeuHis: 2.619 ± 0.061	7.171LeuIle: 7.171 ± 0.122	5.317LeuLys: 5.317 ± 0.098	11.957LeuLeu: 11.957 ± 0.213	2.527LeuMet: 2.527 ± 0.055	4.449LeuAsn: 4.449 ± 0.088	5.189LeuPro: 5.189 ± 0.08	4.215LeuGln: 4.215 ± 0.084	5.822LeuArg: 5.822 ± 0.089	7.628LeuSer: 7.628 ± 0.125	5.863LeuThr: 5.863 ± 0.1	6.511LeuVal: 6.511 ± 0.097	1.344LeuTrp: 1.344 ± 0.047	2.578LeuTyr: 2.578 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.239MetAla: 2.239 ± 0.059	0.166MetCys: 0.166 ± 0.015	1.14MetAsp: 1.14 ± 0.039	1.327MetGlu: 1.327 ± 0.041	0.813MetPhe: 0.813 ± 0.03	1.777MetGly: 1.777 ± 0.051	0.7MetHis: 0.7 ± 0.026	1.743MetIle: 1.743 ± 0.048	1.358MetLys: 1.358 ± 0.044	2.857MetLeu: 2.857 ± 0.06	0.68MetMet: 0.68 ± 0.036	1.229MetAsn: 1.229 ± 0.041	1.277MetPro: 1.277 ± 0.044	1.261MetGln: 1.261 ± 0.043	1.519MetArg: 1.519 ± 0.049	1.654MetSer: 1.654 ± 0.051	1.569MetThr: 1.569 ± 0.044	1.678MetVal: 1.678 ± 0.05	0.173MetTrp: 0.173 ± 0.015	0.412MetTyr: 0.412 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.33AsnAla: 3.33 ± 0.061	0.388AsnCys: 0.388 ± 0.023	1.988AsnAsp: 1.988 ± 0.05	2.328AsnGlu: 2.328 ± 0.06	1.634AsnPhe: 1.634 ± 0.049	2.728AsnGly: 2.728 ± 0.071	1.122AsnHis: 1.122 ± 0.04	2.998AsnIle: 2.998 ± 0.063	2.317AsnLys: 2.317 ± 0.055	4.537AsnLeu: 4.537 ± 0.087	1.115AsnMet: 1.115 ± 0.037	1.94AsnAsn: 1.94 ± 0.063	2.158AsnPro: 2.158 ± 0.055	2.089AsnGln: 2.089 ± 0.061	2.368AsnArg: 2.368 ± 0.057	2.425AsnSer: 2.425 ± 0.064	2.331AsnThr: 2.331 ± 0.056	2.379AsnVal: 2.379 ± 0.057	0.639AsnTrp: 0.639 ± 0.031	1.221AsnTyr: 1.221 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	3.498ProAla: 3.498 ± 0.076	0.381ProCys: 0.381 ± 0.032	2.788ProAsp: 2.788 ± 0.061	3.124ProGlu: 3.124 ± 0.07	1.681ProPhe: 1.681 ± 0.045	2.983ProGly: 2.983 ± 0.068	0.997ProHis: 0.997 ± 0.037	2.653ProIle: 2.653 ± 0.061	1.793ProLys: 1.793 ± 0.062	4.439ProLeu: 4.439 ± 0.086	1.009ProMet: 1.009 ± 0.038	1.593ProAsn: 1.593 ± 0.042	1.783ProPro: 1.783 ± 0.053	1.675ProGln: 1.675 ± 0.049	1.821ProArg: 1.821 ± 0.049	2.308ProSer: 2.308 ± 0.052	2.071ProThr: 2.071 ± 0.057	3.373ProVal: 3.373 ± 0.072	0.554ProTrp: 0.554 ± 0.031	1.24ProTyr: 1.24 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.183GlnAla: 4.183 ± 0.086	0.367GlnCys: 0.367 ± 0.023	1.884GlnAsp: 1.884 ± 0.056	2.359GlnGlu: 2.359 ± 0.065	1.583GlnPhe: 1.583 ± 0.048	2.816GlnGly: 2.816 ± 0.064	1.268GlnHis: 1.268 ± 0.045	3.042GlnIle: 3.042 ± 0.07	2.09GlnLys: 2.09 ± 0.062	4.635GlnLeu: 4.635 ± 0.088	1.026GlnMet: 1.026 ± 0.039	1.572GlnAsn: 1.572 ± 0.054	1.857GlnPro: 1.857 ± 0.054	2.41GlnGln: 2.41 ± 0.071	2.612GlnArg: 2.612 ± 0.06	2.643GlnSer: 2.643 ± 0.059	2.244GlnThr: 2.244 ± 0.059	2.74GlnVal: 2.74 ± 0.058	0.575GlnTrp: 0.575 ± 0.029	1.304GlnTyr: 1.304 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	4.144ArgAla: 4.144 ± 0.08	0.541ArgCys: 0.541 ± 0.027	2.809ArgAsp: 2.809 ± 0.06	3.353ArgGlu: 3.353 ± 0.07	2.587ArgPhe: 2.587 ± 0.057	3.16ArgGly: 3.16 ± 0.065	1.622ArgHis: 1.622 ± 0.05	4.37ArgIle: 4.37 ± 0.075	2.88ArgLys: 2.88 ± 0.064	6.514ArgLeu: 6.514 ± 0.108	1.517ArgMet: 1.517 ± 0.045	2.433ArgAsn: 2.433 ± 0.058	1.951ArgPro: 1.951 ± 0.051	2.48ArgGln: 2.48 ± 0.051	3.1ArgArg: 3.1 ± 0.076	2.93ArgSer: 2.93 ± 0.061	2.55ArgThr: 2.55 ± 0.057	3.467ArgVal: 3.467 ± 0.069	0.731ArgTrp: 0.731 ± 0.03	2.129ArgTyr: 2.129 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.129SerAla: 5.129 ± 0.099	0.681SerCys: 0.681 ± 0.033	3.286SerAsp: 3.286 ± 0.063	3.572SerGlu: 3.572 ± 0.071	2.612SerPhe: 2.612 ± 0.059	5.255SerGly: 5.255 ± 0.093	1.535SerHis: 1.535 ± 0.042	4.462SerIle: 4.462 ± 0.071	2.854SerLys: 2.854 ± 0.072	6.373SerLeu: 6.373 ± 0.1	1.604SerMet: 1.604 ± 0.048	2.67SerAsn: 2.67 ± 0.062	2.628SerPro: 2.628 ± 0.06	2.693SerGln: 2.693 ± 0.064	3.606SerArg: 3.606 ± 0.073	4.105SerSer: 4.105 ± 0.091	3.143SerThr: 3.143 ± 0.067	3.947SerVal: 3.947 ± 0.078	0.809SerTrp: 0.809 ± 0.036	1.759SerTyr: 1.759 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.829ThrAla: 4.829 ± 0.087	0.617ThrCys: 0.617 ± 0.028	2.836ThrAsp: 2.836 ± 0.058	3.118ThrGlu: 3.118 ± 0.064	1.967ThrPhe: 1.967 ± 0.054	4.303ThrGly: 4.303 ± 0.079	1.445ThrHis: 1.445 ± 0.043	3.672ThrIle: 3.672 ± 0.073	1.893ThrLys: 1.893 ± 0.055	6.48ThrLeu: 6.48 ± 0.106	1.157ThrMet: 1.157 ± 0.044	1.86ThrAsn: 1.86 ± 0.051	2.785ThrPro: 2.785 ± 0.065	2.317ThrGln: 2.317 ± 0.059	2.989ThrArg: 2.989 ± 0.058	3.085ThrSer: 3.085 ± 0.066	2.948ThrThr: 2.948 ± 0.066	3.662ThrVal: 3.662 ± 0.075	0.582ThrTrp: 0.582 ± 0.028	1.371ThrTyr: 1.371 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.634ValAla: 5.634 ± 0.098	0.719ValCys: 0.719 ± 0.032	3.472ValAsp: 3.472 ± 0.066	3.768ValGlu: 3.768 ± 0.081	2.639ValPhe: 2.639 ± 0.068	4.124ValGly: 4.124 ± 0.077	1.432ValHis: 1.432 ± 0.043	4.859ValIle: 4.859 ± 0.092	2.941ValLys: 2.941 ± 0.064	6.83ValLeu: 6.83 ± 0.101	1.793ValMet: 1.793 ± 0.049	2.772ValAsn: 2.772 ± 0.062	2.486ValPro: 2.486 ± 0.059	2.091ValGln: 2.091 ± 0.054	3.242ValArg: 3.242 ± 0.068	4.248ValSer: 4.248 ± 0.081	3.84ValThr: 3.84 ± 0.069	4.335ValVal: 4.335 ± 0.078	0.721ValTrp: 0.721 ± 0.031	1.643ValTyr: 1.643 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.803TrpAla: 0.803 ± 0.033	0.146TrpCys: 0.146 ± 0.015	0.557TrpAsp: 0.557 ± 0.027	0.609TrpGlu: 0.609 ± 0.025	0.552TrpPhe: 0.552 ± 0.028	0.792TrpGly: 0.792 ± 0.032	0.452TrpHis: 0.452 ± 0.026	0.904TrpIle: 0.904 ± 0.038	0.644TrpLys: 0.644 ± 0.03	1.782TrpLeu: 1.782 ± 0.056	0.302TrpMet: 0.302 ± 0.023	0.472TrpAsn: 0.472 ± 0.029	0.476TrpPro: 0.476 ± 0.026	0.718TrpGln: 0.718 ± 0.03	0.872TrpArg: 0.872 ± 0.037	0.724TrpSer: 0.724 ± 0.033	0.481TrpThr: 0.481 ± 0.026	0.849TrpVal: 0.849 ± 0.035	0.187TrpTrp: 0.187 ± 0.018	0.485TrpTyr: 0.485 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.501TyrAla: 2.501 ± 0.06	0.353TyrCys: 0.353 ± 0.023	1.496TyrAsp: 1.496 ± 0.046	1.408TyrGlu: 1.408 ± 0.042	1.363TyrPhe: 1.363 ± 0.045	2.049TyrGly: 2.049 ± 0.049	0.897TyrHis: 0.897 ± 0.034	1.727TyrIle: 1.727 ± 0.041	1.229TyrLys: 1.229 ± 0.049	3.186TyrLeu: 3.186 ± 0.074	0.559TyrMet: 0.559 ± 0.028	1.088TyrAsn: 1.088 ± 0.036	1.524TyrPro: 1.524 ± 0.051	1.467TyrGln: 1.467 ± 0.042	1.921TyrArg: 1.921 ± 0.049	1.779TyrSer: 1.779 ± 0.056	1.619TyrThr: 1.619 ± 0.048	1.697TyrVal: 1.697 ± 0.041	0.495TyrTrp: 0.495 ± 0.025	1.037TyrTyr: 1.037 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2414 proteins (781301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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