Amino acid dipepetide frequency for Entomoplasma luminosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.593AlaAla: 3.593 ± 0.167
0.32AlaCys: 0.32 ± 0.031
2.741AlaAsp: 2.741 ± 0.123
3.472AlaGlu: 3.472 ± 0.11
3.08AlaPhe: 3.08 ± 0.112
3.629AlaGly: 3.629 ± 0.154
1.051AlaHis: 1.051 ± 0.059
6.653AlaIle: 6.653 ± 0.167
6.131AlaLys: 6.131 ± 0.182
5.544AlaLeu: 5.544 ± 0.165
1.612AlaMet: 1.612 ± 0.08
3.713AlaAsn: 3.713 ± 0.133
1.54AlaPro: 1.54 ± 0.073
2.062AlaGln: 2.062 ± 0.083
1.716AlaArg: 1.716 ± 0.075
3.25AlaSer: 3.25 ± 0.12
3.521AlaThr: 3.521 ± 0.14
3.244AlaVal: 3.244 ± 0.114
0.754AlaTrp: 0.754 ± 0.07
1.997AlaTyr: 1.997 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.245CysAla: 0.245 ± 0.026
0.029CysCys: 0.029 ± 0.01
0.251CysAsp: 0.251 ± 0.035
0.349CysGlu: 0.349 ± 0.04
0.336CysPhe: 0.336 ± 0.032
0.427CysGly: 0.427 ± 0.035
0.134CysHis: 0.134 ± 0.022
0.336CysIle: 0.336 ± 0.036
0.362CysLys: 0.362 ± 0.043
0.499CysLeu: 0.499 ± 0.045
0.091CysMet: 0.091 ± 0.016
0.277CysAsn: 0.277 ± 0.036
0.127CysPro: 0.127 ± 0.02
0.176CysGln: 0.176 ± 0.026
0.078CysArg: 0.078 ± 0.016
0.333CysSer: 0.333 ± 0.044
0.189CysThr: 0.189 ± 0.025
0.294CysVal: 0.294 ± 0.036
0.088CysTrp: 0.088 ± 0.017
0.179CysTyr: 0.179 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.296AspAla: 3.296 ± 0.139
0.29AspCys: 0.29 ± 0.039
2.653AspAsp: 2.653 ± 0.093
4.049AspGlu: 4.049 ± 0.131
3.279AspPhe: 3.279 ± 0.115
3.097AspGly: 3.097 ± 0.111
1.025AspHis: 1.025 ± 0.066
4.676AspIle: 4.676 ± 0.148
4.882AspLys: 4.882 ± 0.142
5.916AspLeu: 5.916 ± 0.164
1.217AspMet: 1.217 ± 0.069
2.796AspAsn: 2.796 ± 0.096
1.847AspPro: 1.847 ± 0.089
2.79AspGln: 2.79 ± 0.096
1.364AspArg: 1.364 ± 0.06
2.578AspSer: 2.578 ± 0.103
2.255AspThr: 2.255 ± 0.112
3.498AspVal: 3.498 ± 0.11
0.757AspTrp: 0.757 ± 0.047
2.565AspTyr: 2.565 ± 0.114
0.0AspXaa: 0.0 ± 0.0
Glu
3.792GluAla: 3.792 ± 0.14
0.206GluCys: 0.206 ± 0.028
2.996GluAsp: 2.996 ± 0.116
4.046GluGlu: 4.046 ± 0.159
3.257GluPhe: 3.257 ± 0.11
2.715GluGly: 2.715 ± 0.108
1.067GluHis: 1.067 ± 0.052
7.251GluIle: 7.251 ± 0.173
6.875GluLys: 6.875 ± 0.17
6.353GluLeu: 6.353 ± 0.158
1.997GluMet: 1.997 ± 0.106
4.859GluAsn: 4.859 ± 0.143
1.455GluPro: 1.455 ± 0.074
2.907GluGln: 2.907 ± 0.1
1.896GluArg: 1.896 ± 0.076
2.885GluSer: 2.885 ± 0.103
3.602GluThr: 3.602 ± 0.125
3.987GluVal: 3.987 ± 0.111
0.786GluTrp: 0.786 ± 0.061
2.336GluTyr: 2.336 ± 0.098
0.0GluXaa: 0.0 ± 0.0
Phe
3.077PheAla: 3.077 ± 0.125
0.255PheCys: 0.255 ± 0.036
3.345PheAsp: 3.345 ± 0.113
3.527PheGlu: 3.527 ± 0.117
2.666PhePhe: 2.666 ± 0.128
3.283PheGly: 3.283 ± 0.119
0.542PheHis: 0.542 ± 0.044
4.585PheIle: 4.585 ± 0.153
4.64PheLys: 4.64 ± 0.142
4.581PheLeu: 4.581 ± 0.161
1.041PheMet: 1.041 ± 0.061
3.746PheAsn: 3.746 ± 0.164
1.178PhePro: 1.178 ± 0.063
1.716PheGln: 1.716 ± 0.09
1.198PheArg: 1.198 ± 0.067
3.407PheSer: 3.407 ± 0.118
2.721PheThr: 2.721 ± 0.091
3.449PheVal: 3.449 ± 0.117
0.734PheTrp: 0.734 ± 0.061
1.853PheTyr: 1.853 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
3.527GlyAla: 3.527 ± 0.108
0.313GlyCys: 0.313 ± 0.042
2.77GlyAsp: 2.77 ± 0.101
3.244GlyGlu: 3.244 ± 0.096
3.224GlyPhe: 3.224 ± 0.115
3.165GlyGly: 3.165 ± 0.128
0.95GlyHis: 0.95 ± 0.058
5.629GlyIle: 5.629 ± 0.177
4.242GlyLys: 4.242 ± 0.134
5.303GlyLeu: 5.303 ± 0.189
1.645GlyMet: 1.645 ± 0.078
2.845GlyAsn: 2.845 ± 0.112
1.25GlyPro: 1.25 ± 0.071
2.017GlyGln: 2.017 ± 0.076
1.703GlyArg: 1.703 ± 0.088
3.495GlySer: 3.495 ± 0.133
3.312GlyThr: 3.312 ± 0.135
4.226GlyVal: 4.226 ± 0.111
0.76GlyTrp: 0.76 ± 0.056
1.948GlyTyr: 1.948 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
0.976HisAla: 0.976 ± 0.057
0.095HisCys: 0.095 ± 0.016
0.956HisAsp: 0.956 ± 0.061
0.95HisGlu: 0.95 ± 0.065
0.904HisPhe: 0.904 ± 0.057
1.028HisGly: 1.028 ± 0.062
0.349HisHis: 0.349 ± 0.038
1.26HisIle: 1.26 ± 0.062
1.446HisLys: 1.446 ± 0.093
1.586HisLeu: 1.586 ± 0.081
0.323HisMet: 0.323 ± 0.035
1.047HisAsn: 1.047 ± 0.067
0.666HisPro: 0.666 ± 0.05
0.852HisGln: 0.852 ± 0.057
0.467HisArg: 0.467 ± 0.036
0.737HisSer: 0.737 ± 0.051
0.689HisThr: 0.689 ± 0.054
0.813HisVal: 0.813 ± 0.058
0.215HisTrp: 0.215 ± 0.029
0.565HisTyr: 0.565 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.295IleAla: 6.295 ± 0.165
0.64IleCys: 0.64 ± 0.051
5.998IleAsp: 5.998 ± 0.156
6.458IleGlu: 6.458 ± 0.156
4.66IlePhe: 4.66 ± 0.169
5.714IleGly: 5.714 ± 0.142
1.344IleHis: 1.344 ± 0.069
8.412IleIle: 8.412 ± 0.234
9.0IleLys: 9.0 ± 0.223
8.801IleLeu: 8.801 ± 0.19
1.945IleMet: 1.945 ± 0.093
6.598IleAsn: 6.598 ± 0.168
2.881IlePro: 2.881 ± 0.115
3.544IleGln: 3.544 ± 0.134
2.49IleArg: 2.49 ± 0.084
6.569IleSer: 6.569 ± 0.177
5.208IleThr: 5.208 ± 0.174
5.661IleVal: 5.661 ± 0.149
0.865IleTrp: 0.865 ± 0.06
3.185IleTyr: 3.185 ± 0.11
0.0IleXaa: 0.0 ± 0.0
Lys
5.319LysAla: 5.319 ± 0.156
0.264LysCys: 0.264 ± 0.037
5.329LysAsp: 5.329 ± 0.163
6.911LysGlu: 6.911 ± 0.185
4.076LysPhe: 4.076 ± 0.127
3.818LysGly: 3.818 ± 0.117
1.687LysHis: 1.687 ± 0.07
9.659LysIle: 9.659 ± 0.219
9.235LysLys: 9.235 ± 0.19
7.512LysLeu: 7.512 ± 0.182
2.969LysMet: 2.969 ± 0.102
7.355LysAsn: 7.355 ± 0.175
3.028LysPro: 3.028 ± 0.1
3.919LysGln: 3.919 ± 0.114
2.686LysArg: 2.686 ± 0.096
4.497LysSer: 4.497 ± 0.108
6.751LysThr: 6.751 ± 0.162
5.162LysVal: 5.162 ± 0.145
1.08LysTrp: 1.08 ± 0.089
3.753LysTyr: 3.753 ± 0.15
0.0LysXaa: 0.0 ± 0.0
Leu
5.573LeuAla: 5.573 ± 0.146
0.483LeuCys: 0.483 ± 0.044
5.316LeuAsp: 5.316 ± 0.135
6.216LeuGlu: 6.216 ± 0.193
4.539LeuPhe: 4.539 ± 0.162
5.152LeuGly: 5.152 ± 0.155
1.211LeuHis: 1.211 ± 0.065
8.996LeuIle: 8.996 ± 0.203
9.254LeuLys: 9.254 ± 0.183
7.59LeuLeu: 7.59 ± 0.174
2.199LeuMet: 2.199 ± 0.095
6.794LeuAsn: 6.794 ± 0.166
2.594LeuPro: 2.594 ± 0.099
3.234LeuGln: 3.234 ± 0.155
2.366LeuArg: 2.366 ± 0.093
5.433LeuSer: 5.433 ± 0.152
5.57LeuThr: 5.57 ± 0.146
5.622LeuVal: 5.622 ± 0.154
0.897LeuTrp: 0.897 ± 0.056
2.366LeuTyr: 2.366 ± 0.094
0.0LeuXaa: 0.0 ± 0.0
Met
1.459MetAla: 1.459 ± 0.078
0.111MetCys: 0.111 ± 0.019
1.168MetAsp: 1.168 ± 0.066
1.315MetGlu: 1.315 ± 0.068
1.56MetPhe: 1.56 ± 0.097
1.677MetGly: 1.677 ± 0.081
0.437MetHis: 0.437 ± 0.034
2.317MetIle: 2.317 ± 0.096
2.418MetLys: 2.418 ± 0.098
2.163MetLeu: 2.163 ± 0.093
0.685MetMet: 0.685 ± 0.05
1.759MetAsn: 1.759 ± 0.076
0.751MetPro: 0.751 ± 0.052
0.992MetGln: 0.992 ± 0.057
0.607MetArg: 0.607 ± 0.043
1.602MetSer: 1.602 ± 0.07
1.361MetThr: 1.361 ± 0.066
1.615MetVal: 1.615 ± 0.081
0.238MetTrp: 0.238 ± 0.032
0.646MetTyr: 0.646 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
3.798AsnAla: 3.798 ± 0.154
0.277AsnCys: 0.277 ± 0.033
3.837AsnAsp: 3.837 ± 0.103
4.673AsnGlu: 4.673 ± 0.14
3.655AsnPhe: 3.655 ± 0.12
3.58AsnGly: 3.58 ± 0.119
1.273AsnHis: 1.273 ± 0.086
5.808AsnIle: 5.808 ± 0.15
6.644AsnLys: 6.644 ± 0.173
6.699AsnLeu: 6.699 ± 0.182
1.547AsnMet: 1.547 ± 0.085
4.793AsnAsn: 4.793 ± 0.166
2.741AsnPro: 2.741 ± 0.107
3.521AsnGln: 3.521 ± 0.154
1.762AsnArg: 1.762 ± 0.081
3.886AsnSer: 3.886 ± 0.119
2.868AsnThr: 2.868 ± 0.117
3.733AsnVal: 3.733 ± 0.123
1.015AsnTrp: 1.015 ± 0.071
2.464AsnTyr: 2.464 ± 0.095
0.0AsnXaa: 0.0 ± 0.0
Pro
1.387ProAla: 1.387 ± 0.072
0.104ProCys: 0.104 ± 0.018
1.517ProAsp: 1.517 ± 0.08
2.141ProGlu: 2.141 ± 0.095
1.481ProPhe: 1.481 ± 0.072
1.804ProGly: 1.804 ± 0.085
0.414ProHis: 0.414 ± 0.036
3.071ProIle: 3.071 ± 0.13
2.78ProLys: 2.78 ± 0.098
2.493ProLeu: 2.493 ± 0.099
0.666ProMet: 0.666 ± 0.049
2.454ProAsn: 2.454 ± 0.104
0.679ProPro: 0.679 ± 0.054
0.953ProGln: 0.953 ± 0.054
0.721ProArg: 0.721 ± 0.047
1.739ProSer: 1.739 ± 0.088
2.154ProThr: 2.154 ± 0.079
1.671ProVal: 1.671 ± 0.076
0.392ProTrp: 0.392 ± 0.038
0.845ProTyr: 0.845 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
2.875GlnAla: 2.875 ± 0.126
0.088GlnCys: 0.088 ± 0.017
1.935GlnAsp: 1.935 ± 0.091
2.94GlnGlu: 2.94 ± 0.104
1.56GlnPhe: 1.56 ± 0.074
1.795GlnGly: 1.795 ± 0.077
0.558GlnHis: 0.558 ± 0.047
3.929GlnIle: 3.929 ± 0.114
4.281GlnLys: 4.281 ± 0.116
3.446GlnLeu: 3.446 ± 0.104
0.985GlnMet: 0.985 ± 0.061
3.08GlnAsn: 3.08 ± 0.109
1.149GlnPro: 1.149 ± 0.069
1.788GlnGln: 1.788 ± 0.09
1.07GlnArg: 1.07 ± 0.055
1.788GlnSer: 1.788 ± 0.082
2.496GlnThr: 2.496 ± 0.099
1.925GlnVal: 1.925 ± 0.088
0.424GlnTrp: 0.424 ± 0.044
1.322GlnTyr: 1.322 ± 0.067
0.0GlnXaa: 0.0 ± 0.0
Arg
1.635ArgAla: 1.635 ± 0.089
0.14ArgCys: 0.14 ± 0.022
1.514ArgAsp: 1.514 ± 0.079
1.824ArgGlu: 1.824 ± 0.084
1.39ArgPhe: 1.39 ± 0.072
1.354ArgGly: 1.354 ± 0.085
0.424ArgHis: 0.424 ± 0.041
2.594ArgIle: 2.594 ± 0.096
2.682ArgLys: 2.682 ± 0.102
2.304ArgLeu: 2.304 ± 0.089
0.747ArgMet: 0.747 ± 0.049
1.713ArgAsn: 1.713 ± 0.076
0.927ArgPro: 0.927 ± 0.063
0.985ArgGln: 0.985 ± 0.056
0.985ArgArg: 0.985 ± 0.066
1.55ArgSer: 1.55 ± 0.073
1.462ArgThr: 1.462 ± 0.077
1.586ArgVal: 1.586 ± 0.075
0.326ArgTrp: 0.326 ± 0.033
1.103ArgTyr: 1.103 ± 0.076
0.0ArgXaa: 0.0 ± 0.0
Ser
3.162SerAla: 3.162 ± 0.105
0.307SerCys: 0.307 ± 0.026
2.849SerAsp: 2.849 ± 0.109
3.257SerGlu: 3.257 ± 0.118
3.403SerPhe: 3.403 ± 0.111
3.423SerGly: 3.423 ± 0.099
0.881SerHis: 0.881 ± 0.055
5.648SerIle: 5.648 ± 0.141
5.508SerLys: 5.508 ± 0.143
5.378SerLeu: 5.378 ± 0.14
1.436SerMet: 1.436 ± 0.077
3.707SerAsn: 3.707 ± 0.125
1.534SerPro: 1.534 ± 0.083
1.981SerGln: 1.981 ± 0.092
1.664SerArg: 1.664 ± 0.091
3.72SerSer: 3.72 ± 0.136
3.616SerThr: 3.616 ± 0.118
3.012SerVal: 3.012 ± 0.095
0.816SerTrp: 0.816 ± 0.063
1.925SerTyr: 1.925 ± 0.093
0.0SerXaa: 0.0 ± 0.0
Thr
3.182ThrAla: 3.182 ± 0.152
0.209ThrCys: 0.209 ± 0.024
2.686ThrAsp: 2.686 ± 0.107
2.872ThrGlu: 2.872 ± 0.102
2.947ThrPhe: 2.947 ± 0.111
3.56ThrGly: 3.56 ± 0.132
1.057ThrHis: 1.057 ± 0.067
6.164ThrIle: 6.164 ± 0.222
5.345ThrLys: 5.345 ± 0.147
5.332ThrLeu: 5.332 ± 0.14
1.185ThrMet: 1.185 ± 0.058
4.209ThrAsn: 4.209 ± 0.14
2.17ThrPro: 2.17 ± 0.081
2.033ThrGln: 2.033 ± 0.083
1.547ThrArg: 1.547 ± 0.087
3.704ThrSer: 3.704 ± 0.137
3.726ThrThr: 3.726 ± 0.136
3.061ThrVal: 3.061 ± 0.157
0.542ThrTrp: 0.542 ± 0.042
1.739ThrTyr: 1.739 ± 0.081
0.0ThrXaa: 0.0 ± 0.0
Val
3.87ValAla: 3.87 ± 0.131
0.418ValCys: 0.418 ± 0.035
4.03ValAsp: 4.03 ± 0.124
4.089ValGlu: 4.089 ± 0.138
2.829ValPhe: 2.829 ± 0.105
3.828ValGly: 3.828 ± 0.145
0.842ValHis: 0.842 ± 0.049
5.394ValIle: 5.394 ± 0.14
4.931ValLys: 4.931 ± 0.134
5.531ValLeu: 5.531 ± 0.16
1.429ValMet: 1.429 ± 0.072
3.482ValAsn: 3.482 ± 0.111
1.69ValPro: 1.69 ± 0.078
2.033ValGln: 2.033 ± 0.09
1.612ValArg: 1.612 ± 0.077
3.41ValSer: 3.41 ± 0.105
3.162ValThr: 3.162 ± 0.135
4.291ValVal: 4.291 ± 0.131
0.685ValTrp: 0.685 ± 0.05
1.837ValTyr: 1.837 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.581TrpAla: 0.581 ± 0.041
0.052TrpCys: 0.052 ± 0.013
0.835TrpAsp: 0.835 ± 0.067
0.721TrpGlu: 0.721 ± 0.048
0.708TrpPhe: 0.708 ± 0.047
0.62TrpGly: 0.62 ± 0.054
0.134TrpHis: 0.134 ± 0.023
1.136TrpIle: 1.136 ± 0.07
1.129TrpLys: 1.129 ± 0.075
0.953TrpLeu: 0.953 ± 0.053
0.362TrpMet: 0.362 ± 0.034
1.123TrpAsn: 1.123 ± 0.099
0.277TrpPro: 0.277 ± 0.031
0.287TrpGln: 0.287 ± 0.033
0.241TrpArg: 0.241 ± 0.033
0.773TrpSer: 0.773 ± 0.067
0.855TrpThr: 0.855 ± 0.081
0.63TrpVal: 0.63 ± 0.054
0.189TrpTrp: 0.189 ± 0.022
0.427TrpTyr: 0.427 ± 0.042
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.984TyrAla: 1.984 ± 0.093
0.202TyrCys: 0.202 ± 0.027
2.105TyrAsp: 2.105 ± 0.097
2.216TyrGlu: 2.216 ± 0.089
1.99TyrPhe: 1.99 ± 0.084
1.899TyrGly: 1.899 ± 0.093
0.542TyrHis: 0.542 ± 0.045
2.748TyrIle: 2.748 ± 0.106
3.224TyrLys: 3.224 ± 0.103
3.426TyrLeu: 3.426 ± 0.14
0.796TyrMet: 0.796 ± 0.047
2.222TyrAsn: 2.222 ± 0.094
0.982TyrPro: 0.982 ± 0.066
1.645TyrGln: 1.645 ± 0.076
1.074TyrArg: 1.074 ± 0.068
1.87TyrSer: 1.87 ± 0.083
1.749TyrThr: 1.749 ± 0.081
1.912TyrVal: 1.912 ± 0.075
0.47TyrTrp: 0.47 ± 0.043
1.191TyrTyr: 1.191 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 866 proteins (306459 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski