Amino acid dipepetide frequency for Acidovorax sp. SLBN-42

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.264AlaAla: 22.264 ± 0.204
0.668AlaCys: 0.668 ± 0.022
8.514AlaAsp: 8.514 ± 0.085
8.75AlaGlu: 8.75 ± 0.093
4.145AlaPhe: 4.145 ± 0.055
12.576AlaGly: 12.576 ± 0.102
2.517AlaHis: 2.517 ± 0.043
6.257AlaIle: 6.257 ± 0.075
2.635AlaLys: 2.635 ± 0.055
13.878AlaLeu: 13.878 ± 0.129
2.848AlaMet: 2.848 ± 0.044
2.32AlaAsn: 2.32 ± 0.043
6.641AlaPro: 6.641 ± 0.092
3.284AlaGln: 3.284 ± 0.05
9.752AlaArg: 9.752 ± 0.098
7.964AlaSer: 7.964 ± 0.083
7.666AlaThr: 7.666 ± 0.082
11.892AlaVal: 11.892 ± 0.111
2.05AlaTrp: 2.05 ± 0.039
2.463AlaTyr: 2.463 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.602CysAla: 0.602 ± 0.02
0.048CysCys: 0.048 ± 0.006
0.337CysAsp: 0.337 ± 0.015
0.263CysGlu: 0.263 ± 0.016
0.173CysPhe: 0.173 ± 0.011
0.535CysGly: 0.535 ± 0.023
0.131CysHis: 0.131 ± 0.011
0.179CysIle: 0.179 ± 0.011
0.062CysLys: 0.062 ± 0.007
0.393CysLeu: 0.393 ± 0.017
0.081CysMet: 0.081 ± 0.007
0.09CysAsn: 0.09 ± 0.008
0.267CysPro: 0.267 ± 0.015
0.101CysGln: 0.101 ± 0.008
0.363CysArg: 0.363 ± 0.017
0.332CysSer: 0.332 ± 0.014
0.309CysThr: 0.309 ± 0.015
0.396CysVal: 0.396 ± 0.017
0.068CysTrp: 0.068 ± 0.007
0.098CysTyr: 0.098 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
9.596AspAla: 9.596 ± 0.091
0.246AspCys: 0.246 ± 0.014
4.374AspAsp: 4.374 ± 0.066
4.69AspGlu: 4.69 ± 0.056
1.715AspPhe: 1.715 ± 0.039
6.08AspGly: 6.08 ± 0.083
1.236AspHis: 1.236 ± 0.027
2.117AspIle: 2.117 ± 0.048
0.703AspLys: 0.703 ± 0.025
6.183AspLeu: 6.183 ± 0.073
0.743AspMet: 0.743 ± 0.024
0.832AspAsn: 0.832 ± 0.027
4.31AspPro: 4.31 ± 0.064
1.411AspGln: 1.411 ± 0.036
4.831AspArg: 4.831 ± 0.064
2.274AspSer: 2.274 ± 0.039
2.746AspThr: 2.746 ± 0.044
5.661AspVal: 5.661 ± 0.071
1.026AspTrp: 1.026 ± 0.026
1.223AspTyr: 1.223 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
7.799GluAla: 7.799 ± 0.082
0.249GluCys: 0.249 ± 0.014
2.35GluAsp: 2.35 ± 0.046
3.142GluGlu: 3.142 ± 0.055
1.941GluPhe: 1.941 ± 0.038
4.171GluGly: 4.171 ± 0.052
1.778GluHis: 1.778 ± 0.037
2.559GluIle: 2.559 ± 0.05
1.049GluLys: 1.049 ± 0.035
7.58GluLeu: 7.58 ± 0.088
0.834GluMet: 0.834 ± 0.022
1.052GluAsn: 1.052 ± 0.028
3.503GluPro: 3.503 ± 0.052
2.316GluGln: 2.316 ± 0.047
6.133GluArg: 6.133 ± 0.072
2.964GluSer: 2.964 ± 0.05
2.932GluThr: 2.932 ± 0.043
4.878GluVal: 4.878 ± 0.067
1.003GluTrp: 1.003 ± 0.027
1.23GluTyr: 1.23 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.413PheAla: 4.413 ± 0.055
0.155PheCys: 0.155 ± 0.01
2.452PheAsp: 2.452 ± 0.046
1.979PheGlu: 1.979 ± 0.035
0.981PhePhe: 0.981 ± 0.03
3.507PheGly: 3.507 ± 0.049
0.607PheHis: 0.607 ± 0.02
1.272PheIle: 1.272 ± 0.036
0.393PheLys: 0.393 ± 0.017
2.896PheLeu: 2.896 ± 0.055
0.467PheMet: 0.467 ± 0.018
0.654PheAsn: 0.654 ± 0.022
1.451PhePro: 1.451 ± 0.031
0.762PheGln: 0.762 ± 0.027
1.936PheArg: 1.936 ± 0.04
1.616PheSer: 1.616 ± 0.036
2.093PheThr: 2.093 ± 0.041
2.817PheVal: 2.817 ± 0.045
0.549PheTrp: 0.549 ± 0.023
0.633PheTyr: 0.633 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
11.204GlyAla: 11.204 ± 0.103
0.593GlyCys: 0.593 ± 0.021
5.233GlyAsp: 5.233 ± 0.065
5.194GlyGlu: 5.194 ± 0.064
3.385GlyPhe: 3.385 ± 0.057
8.048GlyGly: 8.048 ± 0.103
1.868GlyHis: 1.868 ± 0.039
4.745GlyIle: 4.745 ± 0.065
1.726GlyLys: 1.726 ± 0.04
9.084GlyLeu: 9.084 ± 0.086
2.017GlyMet: 2.017 ± 0.037
1.625GlyAsn: 1.625 ± 0.035
4.065GlyPro: 4.065 ± 0.055
2.189GlyGln: 2.189 ± 0.04
6.907GlyArg: 6.907 ± 0.076
5.111GlySer: 5.111 ± 0.065
5.476GlyThr: 5.476 ± 0.081
8.065GlyVal: 8.065 ± 0.077
1.706GlyTrp: 1.706 ± 0.037
2.32GlyTyr: 2.32 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.58HisAla: 2.58 ± 0.048
0.111HisCys: 0.111 ± 0.008
1.453HisAsp: 1.453 ± 0.036
1.313HisGlu: 1.313 ± 0.033
0.577HisPhe: 0.577 ± 0.02
2.141HisGly: 2.141 ± 0.038
0.588HisHis: 0.588 ± 0.022
0.65HisIle: 0.65 ± 0.022
0.24HisLys: 0.24 ± 0.012
2.1HisLeu: 2.1 ± 0.04
0.292HisMet: 0.292 ± 0.015
0.319HisAsn: 0.319 ± 0.016
1.609HisPro: 1.609 ± 0.034
0.44HisGln: 0.44 ± 0.016
1.682HisArg: 1.682 ± 0.033
0.92HisSer: 0.92 ± 0.025
0.95HisThr: 0.95 ± 0.025
1.836HisVal: 1.836 ± 0.035
0.313HisTrp: 0.313 ± 0.014
0.438HisTyr: 0.438 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
7.1IleAla: 7.1 ± 0.072
0.227IleCys: 0.227 ± 0.011
3.385IleAsp: 3.385 ± 0.051
3.006IleGlu: 3.006 ± 0.043
1.083IlePhe: 1.083 ± 0.031
4.63IleGly: 4.63 ± 0.067
0.668IleHis: 0.668 ± 0.023
1.683IleIle: 1.683 ± 0.037
0.626IleLys: 0.626 ± 0.027
3.327IleLeu: 3.327 ± 0.059
0.626IleMet: 0.626 ± 0.02
0.726IleAsn: 0.726 ± 0.025
2.289IlePro: 2.289 ± 0.04
0.871IleGln: 0.871 ± 0.027
2.858IleArg: 2.858 ± 0.045
2.139IleSer: 2.139 ± 0.039
2.61IleThr: 2.61 ± 0.046
4.745IleVal: 4.745 ± 0.062
0.499IleTrp: 0.499 ± 0.021
0.672IleTyr: 0.672 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
2.02LysAla: 2.02 ± 0.047
0.061LysCys: 0.061 ± 0.007
0.825LysAsp: 0.825 ± 0.029
0.823LysGlu: 0.823 ± 0.028
0.425LysPhe: 0.425 ± 0.019
1.336LysGly: 1.336 ± 0.042
0.43LysHis: 0.43 ± 0.017
0.698LysIle: 0.698 ± 0.024
0.502LysLys: 0.502 ± 0.025
1.776LysLeu: 1.776 ± 0.04
0.301LysMet: 0.301 ± 0.015
0.404LysAsn: 0.404 ± 0.021
1.092LysPro: 1.092 ± 0.031
0.613LysGln: 0.613 ± 0.021
1.361LysArg: 1.361 ± 0.036
0.94LysSer: 0.94 ± 0.032
1.045LysThr: 1.045 ± 0.032
1.448LysVal: 1.448 ± 0.038
0.23LysTrp: 0.23 ± 0.011
0.369LysTyr: 0.369 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
15.528LeuAla: 15.528 ± 0.139
0.455LeuCys: 0.455 ± 0.02
6.985LeuAsp: 6.985 ± 0.08
5.91LeuGlu: 5.91 ± 0.069
2.835LeuPhe: 2.835 ± 0.051
9.589LeuGly: 9.589 ± 0.094
1.927LeuHis: 1.927 ± 0.036
4.243LeuIle: 4.243 ± 0.061
1.543LeuLys: 1.543 ± 0.038
9.937LeuLeu: 9.937 ± 0.108
1.567LeuMet: 1.567 ± 0.037
1.668LeuAsn: 1.668 ± 0.035
5.523LeuPro: 5.523 ± 0.072
2.323LeuGln: 2.323 ± 0.039
7.407LeuArg: 7.407 ± 0.078
5.179LeuSer: 5.179 ± 0.065
5.74LeuThr: 5.74 ± 0.072
10.018LeuVal: 10.018 ± 0.106
1.216LeuTrp: 1.216 ± 0.033
1.591LeuTyr: 1.591 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.105MetAla: 2.105 ± 0.031
0.086MetCys: 0.086 ± 0.007
0.773MetAsp: 0.773 ± 0.025
0.627MetGlu: 0.627 ± 0.021
0.498MetPhe: 0.498 ± 0.018
1.285MetGly: 1.285 ± 0.029
0.406MetHis: 0.406 ± 0.018
0.778MetIle: 0.778 ± 0.024
0.371MetLys: 0.371 ± 0.017
1.943MetLeu: 1.943 ± 0.038
0.299MetMet: 0.299 ± 0.016
0.476MetAsn: 0.476 ± 0.02
1.228MetPro: 1.228 ± 0.032
0.542MetGln: 0.542 ± 0.019
1.446MetArg: 1.446 ± 0.03
1.41MetSer: 1.41 ± 0.033
1.725MetThr: 1.725 ± 0.034
1.313MetVal: 1.313 ± 0.031
0.2MetTrp: 0.2 ± 0.012
0.284MetTyr: 0.284 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.392AsnAla: 2.392 ± 0.042
0.108AsnCys: 0.108 ± 0.008
1.054AsnAsp: 1.054 ± 0.026
0.976AsnGlu: 0.976 ± 0.028
0.588AsnPhe: 0.588 ± 0.02
1.824AsnGly: 1.824 ± 0.041
0.373AsnHis: 0.373 ± 0.017
0.723AsnIle: 0.723 ± 0.023
0.267AsnLys: 0.267 ± 0.015
1.809AsnLeu: 1.809 ± 0.036
0.303AsnMet: 0.303 ± 0.015
0.388AsnAsn: 0.388 ± 0.018
1.521AsnPro: 1.521 ± 0.036
0.469AsnGln: 0.469 ± 0.021
1.308AsnArg: 1.308 ± 0.033
0.904AsnSer: 0.904 ± 0.029
1.06AsnThr: 1.06 ± 0.031
1.583AsnVal: 1.583 ± 0.04
0.31AsnTrp: 0.31 ± 0.016
0.431AsnTyr: 0.431 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
7.592ProAla: 7.592 ± 0.096
0.174ProCys: 0.174 ± 0.011
4.023ProAsp: 4.023 ± 0.059
4.128ProGlu: 4.128 ± 0.061
1.795ProPhe: 1.795 ± 0.033
5.344ProGly: 5.344 ± 0.062
1.08ProHis: 1.08 ± 0.026
2.211ProIle: 2.211 ± 0.037
0.98ProLys: 0.98 ± 0.029
4.869ProLeu: 4.869 ± 0.06
0.954ProMet: 0.954 ± 0.025
1.098ProAsn: 1.098 ± 0.026
2.588ProPro: 2.588 ± 0.07
1.321ProGln: 1.321 ± 0.03
3.529ProArg: 3.529 ± 0.058
3.065ProSer: 3.065 ± 0.053
3.32ProThr: 3.32 ± 0.056
5.158ProVal: 5.158 ± 0.062
0.935ProTrp: 0.935 ± 0.026
1.1ProTyr: 1.1 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.339GlnAla: 3.339 ± 0.053
0.106GlnCys: 0.106 ± 0.01
1.098GlnAsp: 1.098 ± 0.029
1.167GlnGlu: 1.167 ± 0.031
0.879GlnPhe: 0.879 ± 0.025
1.899GlnGly: 1.899 ± 0.039
0.581GlnHis: 0.581 ± 0.021
1.048GlnIle: 1.048 ± 0.029
0.515GlnLys: 0.515 ± 0.022
2.987GlnLeu: 2.987 ± 0.045
0.434GlnMet: 0.434 ± 0.019
0.51GlnAsn: 0.51 ± 0.021
1.504GlnPro: 1.504 ± 0.04
1.022GlnGln: 1.022 ± 0.032
2.285GlnArg: 2.285 ± 0.039
1.312GlnSer: 1.312 ± 0.03
1.296GlnThr: 1.296 ± 0.029
2.307GlnVal: 2.307 ± 0.046
0.434GlnTrp: 0.434 ± 0.017
0.596GlnTyr: 0.596 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
9.61ArgAla: 9.61 ± 0.097
0.328ArgCys: 0.328 ± 0.016
4.388ArgAsp: 4.388 ± 0.055
4.597ArgGlu: 4.597 ± 0.073
2.593ArgPhe: 2.593 ± 0.045
5.65ArgGly: 5.65 ± 0.071
1.759ArgHis: 1.759 ± 0.04
3.703ArgIle: 3.703 ± 0.055
1.16ArgLys: 1.16 ± 0.031
8.047ArgLeu: 8.047 ± 0.095
1.881ArgMet: 1.881 ± 0.033
1.42ArgAsn: 1.42 ± 0.035
4.083ArgPro: 4.083 ± 0.059
1.924ArgGln: 1.924 ± 0.043
7.334ArgArg: 7.334 ± 0.094
4.238ArgSer: 4.238 ± 0.05
4.144ArgThr: 4.144 ± 0.055
6.381ArgVal: 6.381 ± 0.076
1.236ArgTrp: 1.236 ± 0.034
1.687ArgTyr: 1.687 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.763SerAla: 6.763 ± 0.078
0.243SerCys: 0.243 ± 0.013
3.069SerAsp: 3.069 ± 0.054
2.63SerGlu: 2.63 ± 0.045
1.867SerPhe: 1.867 ± 0.036
5.765SerGly: 5.765 ± 0.069
0.965SerHis: 0.965 ± 0.027
2.488SerIle: 2.488 ± 0.04
0.937SerLys: 0.937 ± 0.027
5.148SerLeu: 5.148 ± 0.059
1.161SerMet: 1.161 ± 0.027
1.034SerAsn: 1.034 ± 0.029
3.056SerPro: 3.056 ± 0.045
1.257SerGln: 1.257 ± 0.032
3.754SerArg: 3.754 ± 0.055
3.113SerSer: 3.113 ± 0.044
3.359SerThr: 3.359 ± 0.051
4.722SerVal: 4.722 ± 0.053
0.879SerTrp: 0.879 ± 0.025
1.102SerTyr: 1.102 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
7.44ThrAla: 7.44 ± 0.076
0.262ThrCys: 0.262 ± 0.014
3.5ThrAsp: 3.5 ± 0.058
3.078ThrGlu: 3.078 ± 0.052
1.84ThrPhe: 1.84 ± 0.038
5.712ThrGly: 5.712 ± 0.072
1.1ThrHis: 1.1 ± 0.029
2.785ThrIle: 2.785 ± 0.048
1.01ThrLys: 1.01 ± 0.03
5.647ThrLeu: 5.647 ± 0.07
0.969ThrMet: 0.969 ± 0.024
1.129ThrAsn: 1.129 ± 0.032
3.739ThrPro: 3.739 ± 0.052
1.279ThrGln: 1.279 ± 0.03
3.786ThrArg: 3.786 ± 0.052
3.211ThrSer: 3.211 ± 0.048
3.694ThrThr: 3.694 ± 0.062
5.612ThrVal: 5.612 ± 0.071
0.892ThrTrp: 0.892 ± 0.026
1.066ThrTyr: 1.066 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
12.619ValAla: 12.619 ± 0.104
0.479ValCys: 0.479 ± 0.02
6.015ValAsp: 6.015 ± 0.073
5.378ValGlu: 5.378 ± 0.06
3.005ValPhe: 3.005 ± 0.051
7.377ValGly: 7.377 ± 0.079
1.876ValHis: 1.876 ± 0.038
4.279ValIle: 4.279 ± 0.067
1.411ValLys: 1.411 ± 0.035
9.585ValLeu: 9.585 ± 0.09
1.429ValMet: 1.429 ± 0.033
1.811ValAsn: 1.811 ± 0.039
5.009ValPro: 5.009 ± 0.061
2.132ValGln: 2.132 ± 0.039
6.405ValArg: 6.405 ± 0.08
4.614ValSer: 4.614 ± 0.058
5.529ValThr: 5.529 ± 0.061
9.289ValVal: 9.289 ± 0.101
1.209ValTrp: 1.209 ± 0.031
1.603ValTyr: 1.603 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.692TrpAla: 1.692 ± 0.039
0.106TrpCys: 0.106 ± 0.008
0.781TrpAsp: 0.781 ± 0.028
0.679TrpGlu: 0.679 ± 0.023
0.6TrpPhe: 0.6 ± 0.02
1.11TrpGly: 1.11 ± 0.03
0.324TrpHis: 0.324 ± 0.015
0.775TrpIle: 0.775 ± 0.023
0.287TrpLys: 0.287 ± 0.015
1.822TrpLeu: 1.822 ± 0.038
0.355TrpMet: 0.355 ± 0.016
0.454TrpAsn: 0.454 ± 0.019
0.766TrpPro: 0.766 ± 0.025
0.561TrpGln: 0.561 ± 0.022
1.331TrpArg: 1.331 ± 0.035
0.995TrpSer: 0.995 ± 0.03
0.923TrpThr: 0.923 ± 0.027
1.212TrpVal: 1.212 ± 0.029
0.399TrpTrp: 0.399 ± 0.017
0.314TrpTyr: 0.314 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.428TyrAla: 2.428 ± 0.037
0.123TyrCys: 0.123 ± 0.009
1.384TyrAsp: 1.384 ± 0.035
1.137TyrGlu: 1.137 ± 0.028
0.709TyrPhe: 0.709 ± 0.021
1.982TyrGly: 1.982 ± 0.042
0.34TyrHis: 0.34 ± 0.015
0.577TyrIle: 0.577 ± 0.021
0.281TyrLys: 0.281 ± 0.014
2.176TyrLeu: 2.176 ± 0.045
0.237TyrMet: 0.237 ± 0.013
0.381TyrAsn: 0.381 ± 0.017
1.018TyrPro: 1.018 ± 0.027
0.503TyrGln: 0.503 ± 0.02
1.754TyrArg: 1.754 ± 0.034
1.009TyrSer: 1.009 ± 0.025
1.135TyrThr: 1.135 ± 0.027
1.718TyrVal: 1.718 ± 0.037
0.333TyrTrp: 0.333 ± 0.017
0.473TyrTyr: 0.473 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4383 proteins (1418679 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski