Amino acid dipepetide frequency for Bacillus lacisalsi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.209AlaAla: 8.209 ± 0.109	0.71AlaCys: 0.71 ± 0.026	4.504AlaAsp: 4.504 ± 0.076	6.019AlaGlu: 6.019 ± 0.086	3.768AlaPhe: 3.768 ± 0.07	7.693AlaGly: 7.693 ± 0.098	1.493AlaHis: 1.493 ± 0.035	5.028AlaIle: 5.028 ± 0.077	3.49AlaLys: 3.49 ± 0.069	7.829AlaLeu: 7.829 ± 0.098	2.293AlaMet: 2.293 ± 0.054	2.257AlaAsn: 2.257 ± 0.049	2.465AlaPro: 2.465 ± 0.051	2.172AlaGln: 2.172 ± 0.047	3.653AlaArg: 3.653 ± 0.064	4.535AlaSer: 4.535 ± 0.068	3.176AlaThr: 3.176 ± 0.157	7.239AlaVal: 7.239 ± 0.089	0.753AlaTrp: 0.753 ± 0.027	2.392AlaTyr: 2.392 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.513CysAla: 0.513 ± 0.022	0.103CysCys: 0.103 ± 0.01	0.368CysAsp: 0.368 ± 0.018	0.458CysGlu: 0.458 ± 0.022	0.316CysPhe: 0.316 ± 0.019	0.737CysGly: 0.737 ± 0.027	0.191CysHis: 0.191 ± 0.014	0.375CysIle: 0.375 ± 0.021	0.262CysLys: 0.262 ± 0.016	0.656CysLeu: 0.656 ± 0.026	0.173CysMet: 0.173 ± 0.012	0.205CysAsn: 0.205 ± 0.013	0.389CysPro: 0.389 ± 0.019	0.173CysGln: 0.173 ± 0.012	0.494CysArg: 0.494 ± 0.025	0.482CysSer: 0.482 ± 0.022	0.415CysThr: 0.415 ± 0.017	0.397CysVal: 0.397 ± 0.018	0.068CysTrp: 0.068 ± 0.008	0.224CysTyr: 0.224 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.963AspAla: 3.963 ± 0.073	0.373AspCys: 0.373 ± 0.02	3.329AspAsp: 3.329 ± 0.08	5.262AspGlu: 5.262 ± 0.08	2.39AspPhe: 2.39 ± 0.045	4.275AspGly: 4.275 ± 0.082	1.463AspHis: 1.463 ± 0.044	3.44AspIle: 3.44 ± 0.056	2.395AspLys: 2.395 ± 0.045	5.439AspLeu: 5.439 ± 0.067	1.54AspMet: 1.54 ± 0.042	1.702AspAsn: 1.702 ± 0.04	2.566AspPro: 2.566 ± 0.045	2.134AspGln: 2.134 ± 0.041	3.332AspArg: 3.332 ± 0.052	2.692AspSer: 2.692 ± 0.045	2.837AspThr: 2.837 ± 0.055	4.218AspVal: 4.218 ± 0.064	0.766AspTrp: 0.766 ± 0.03	2.159AspTyr: 2.159 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	7.033GluAla: 7.033 ± 0.095	0.361GluCys: 0.361 ± 0.019	4.822GluAsp: 4.822 ± 0.086	8.67GluGlu: 8.67 ± 0.131	2.318GluPhe: 2.318 ± 0.052	5.364GluGly: 5.364 ± 0.067	1.578GluHis: 1.578 ± 0.036	4.491GluIle: 4.491 ± 0.068	5.82GluLys: 5.82 ± 0.087	7.072GluLeu: 7.072 ± 0.088	2.432GluMet: 2.432 ± 0.047	3.401GluAsn: 3.401 ± 0.065	2.567GluPro: 2.567 ± 0.051	3.395GluGln: 3.395 ± 0.059	4.388GluArg: 4.388 ± 0.061	3.781GluSer: 3.781 ± 0.062	4.594GluThr: 4.594 ± 0.074	5.229GluVal: 5.229 ± 0.078	1.005GluTrp: 1.005 ± 0.032	2.18GluTyr: 2.18 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.417PheAla: 3.417 ± 0.063	0.338PheCys: 0.338 ± 0.017	2.565PheAsp: 2.565 ± 0.046	2.941PheGlu: 2.941 ± 0.053	2.383PhePhe: 2.383 ± 0.062	3.39PheGly: 3.39 ± 0.058	1.064PheHis: 1.064 ± 0.03	3.153PheIle: 3.153 ± 0.067	1.805PheLys: 1.805 ± 0.039	4.45PheLeu: 4.45 ± 0.068	1.182PheMet: 1.182 ± 0.035	1.592PheAsn: 1.592 ± 0.039	1.711PhePro: 1.711 ± 0.036	1.393PheGln: 1.393 ± 0.034	1.987PheArg: 1.987 ± 0.045	3.179PheSer: 3.179 ± 0.053	2.928PheThr: 2.928 ± 0.052	3.14PheVal: 3.14 ± 0.061	0.514PheTrp: 0.514 ± 0.023	1.634PheTyr: 1.634 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	6.041GlyAla: 6.041 ± 0.164	0.672GlyCys: 0.672 ± 0.025	3.931GlyAsp: 3.931 ± 0.073	5.648GlyGlu: 5.648 ± 0.094	3.567GlyPhe: 3.567 ± 0.062	5.802GlyGly: 5.802 ± 0.093	1.575GlyHis: 1.575 ± 0.039	5.583GlyIle: 5.583 ± 0.073	4.389GlyLys: 4.389 ± 0.071	7.197GlyLeu: 7.197 ± 0.078	2.346GlyMet: 2.346 ± 0.046	2.67GlyAsn: 2.67 ± 0.073	2.3GlyPro: 2.3 ± 0.118	2.296GlyGln: 2.296 ± 0.048	3.731GlyArg: 3.731 ± 0.06	4.654GlySer: 4.654 ± 0.083	4.649GlyThr: 4.649 ± 0.077	5.514GlyVal: 5.514 ± 0.064	0.946GlyTrp: 0.946 ± 0.031	2.691GlyTyr: 2.691 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.53HisAla: 1.53 ± 0.04	0.189HisCys: 0.189 ± 0.014	1.167HisAsp: 1.167 ± 0.037	1.629HisGlu: 1.629 ± 0.038	1.053HisPhe: 1.053 ± 0.031	1.562HisGly: 1.562 ± 0.041	0.685HisHis: 0.685 ± 0.024	1.297HisIle: 1.297 ± 0.034	0.921HisLys: 0.921 ± 0.03	2.245HisLeu: 2.245 ± 0.048	0.566HisMet: 0.566 ± 0.021	0.731HisAsn: 0.731 ± 0.024	1.158HisPro: 1.158 ± 0.03	0.78HisGln: 0.78 ± 0.026	1.158HisArg: 1.158 ± 0.033	1.236HisSer: 1.236 ± 0.036	1.251HisThr: 1.251 ± 0.033	1.569HisVal: 1.569 ± 0.038	0.27HisTrp: 0.27 ± 0.019	0.867HisTyr: 0.867 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.331IleAla: 5.331 ± 0.074	0.496IleCys: 0.496 ± 0.02	3.761IleAsp: 3.761 ± 0.053	4.761IleGlu: 4.761 ± 0.074	2.722IlePhe: 2.722 ± 0.059	5.304IleGly: 5.304 ± 0.085	1.455IleHis: 1.455 ± 0.035	4.183IleIle: 4.183 ± 0.08	2.729IleLys: 2.729 ± 0.054	5.936IleLeu: 5.936 ± 0.095	1.51IleMet: 1.51 ± 0.039	2.269IleAsn: 2.269 ± 0.054	2.952IlePro: 2.952 ± 0.053	2.105IleGln: 2.105 ± 0.044	3.554IleArg: 3.554 ± 0.06	3.972IleSer: 3.972 ± 0.061	3.892IleThr: 3.892 ± 0.057	4.744IleVal: 4.744 ± 0.064	0.585IleTrp: 0.585 ± 0.024	1.995IleTyr: 1.995 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.22LysAla: 4.22 ± 0.076	0.239LysCys: 0.239 ± 0.016	3.108LysAsp: 3.108 ± 0.061	5.646LysGlu: 5.646 ± 0.077	1.292LysPhe: 1.292 ± 0.032	3.895LysGly: 3.895 ± 0.055	1.116LysHis: 1.116 ± 0.031	2.854LysIle: 2.854 ± 0.054	4.669LysLys: 4.669 ± 0.079	4.306LysLeu: 4.306 ± 0.066	1.741LysMet: 1.741 ± 0.041	2.285LysAsn: 2.285 ± 0.049	1.986LysPro: 1.986 ± 0.036	2.352LysGln: 2.352 ± 0.047	3.259LysArg: 3.259 ± 0.054	2.671LysSer: 2.671 ± 0.052	3.138LysThr: 3.138 ± 0.061	3.635LysVal: 3.635 ± 0.068	0.657LysTrp: 0.657 ± 0.023	1.432LysTyr: 1.432 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	8.004LeuAla: 8.004 ± 0.116	0.615LeuCys: 0.615 ± 0.022	5.022LeuAsp: 5.022 ± 0.065	6.758LeuGlu: 6.758 ± 0.082	4.731LeuPhe: 4.731 ± 0.085	6.533LeuGly: 6.533 ± 0.09	1.98LeuHis: 1.98 ± 0.045	6.224LeuIle: 6.224 ± 0.094	5.425LeuLys: 5.425 ± 0.071	9.368LeuLeu: 9.368 ± 0.135	2.578LeuMet: 2.578 ± 0.049	3.621LeuAsn: 3.621 ± 0.056	4.206LeuPro: 4.206 ± 0.063	2.962LeuGln: 2.962 ± 0.057	4.294LeuArg: 4.294 ± 0.066	6.341LeuSer: 6.341 ± 0.072	5.948LeuThr: 5.948 ± 0.072	6.328LeuVal: 6.328 ± 0.077	0.853LeuTrp: 0.853 ± 0.033	3.06LeuTyr: 3.06 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.321MetAla: 2.321 ± 0.051	0.157MetCys: 0.157 ± 0.012	1.637MetAsp: 1.637 ± 0.04	2.031MetGlu: 2.031 ± 0.045	1.176MetPhe: 1.176 ± 0.036	1.828MetGly: 1.828 ± 0.051	0.487MetHis: 0.487 ± 0.022	2.133MetIle: 2.133 ± 0.046	2.344MetLys: 2.344 ± 0.041	2.536MetLeu: 2.536 ± 0.052	0.994MetMet: 0.994 ± 0.041	1.512MetAsn: 1.512 ± 0.038	1.106MetPro: 1.106 ± 0.038	0.843MetGln: 0.843 ± 0.032	1.271MetArg: 1.271 ± 0.036	1.761MetSer: 1.761 ± 0.047	1.938MetThr: 1.938 ± 0.043	1.778MetVal: 1.778 ± 0.039	0.228MetTrp: 0.228 ± 0.014	0.749MetTyr: 0.749 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.393AsnAla: 2.393 ± 0.05	0.234AsnCys: 0.234 ± 0.014	1.979AsnAsp: 1.979 ± 0.045	3.014AsnGlu: 3.014 ± 0.046	1.329AsnPhe: 1.329 ± 0.035	3.226AsnGly: 3.226 ± 0.085	0.887AsnHis: 0.887 ± 0.025	2.275AsnIle: 2.275 ± 0.049	1.724AsnLys: 1.724 ± 0.042	3.113AsnLeu: 3.113 ± 0.048	1.046AsnMet: 1.046 ± 0.033	1.343AsnAsn: 1.343 ± 0.041	1.938AsnPro: 1.938 ± 0.044	1.397AsnGln: 1.397 ± 0.039	2.347AsnArg: 2.347 ± 0.049	1.839AsnSer: 1.839 ± 0.043	1.85AsnThr: 1.85 ± 0.04	2.814AsnVal: 2.814 ± 0.05	0.419AsnTrp: 0.419 ± 0.02	1.184AsnTyr: 1.184 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.249ProAla: 3.249 ± 0.056	0.229ProCys: 0.229 ± 0.015	2.861ProAsp: 2.861 ± 0.054	3.855ProGlu: 3.855 ± 0.067	2.152ProPhe: 2.152 ± 0.046	3.179ProGly: 3.179 ± 0.06	0.901ProHis: 0.901 ± 0.028	1.999ProIle: 1.999 ± 0.05	1.585ProLys: 1.585 ± 0.046	3.639ProLeu: 3.639 ± 0.053	0.92ProMet: 0.92 ± 0.031	1.22ProAsn: 1.22 ± 0.037	1.227ProPro: 1.227 ± 0.041	1.046ProGln: 1.046 ± 0.032	1.35ProArg: 1.35 ± 0.038	2.288ProSer: 2.288 ± 0.049	1.558ProThr: 1.558 ± 0.115	3.891ProVal: 3.891 ± 0.069	0.419ProTrp: 0.419 ± 0.019	1.451ProTyr: 1.451 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.857GlnAla: 2.857 ± 0.051	0.177GlnCys: 0.177 ± 0.013	1.609GlnAsp: 1.609 ± 0.041	2.713GlnGlu: 2.713 ± 0.051	1.428GlnPhe: 1.428 ± 0.036	2.185GlnGly: 2.185 ± 0.043	0.672GlnHis: 0.672 ± 0.025	2.072GlnIle: 2.072 ± 0.046	2.047GlnLys: 2.047 ± 0.044	3.239GlnLeu: 3.239 ± 0.057	1.215GlnMet: 1.215 ± 0.038	1.325GlnAsn: 1.325 ± 0.037	1.176GlnPro: 1.176 ± 0.032	1.509GlnGln: 1.509 ± 0.052	1.645GlnArg: 1.645 ± 0.042	1.91GlnSer: 1.91 ± 0.04	1.929GlnThr: 1.929 ± 0.044	2.424GlnVal: 2.424 ± 0.053	0.407GlnTrp: 0.407 ± 0.019	1.039GlnTyr: 1.039 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.148ArgAla: 3.148 ± 0.056	0.339ArgCys: 0.339 ± 0.019	2.656ArgAsp: 2.656 ± 0.043	4.43ArgGlu: 4.43 ± 0.075	2.428ArgPhe: 2.428 ± 0.051	3.007ArgGly: 3.007 ± 0.059	1.197ArgHis: 1.197 ± 0.033	3.471ArgIle: 3.471 ± 0.057	3.515ArgLys: 3.515 ± 0.062	4.939ArgLeu: 4.939 ± 0.074	1.706ArgMet: 1.706 ± 0.042	1.997ArgAsn: 1.997 ± 0.039	1.761ArgPro: 1.761 ± 0.044	1.982ArgGln: 1.982 ± 0.044	2.728ArgArg: 2.728 ± 0.057	2.923ArgSer: 2.923 ± 0.054	2.782ArgThr: 2.782 ± 0.047	3.277ArgVal: 3.277 ± 0.056	0.62ArgTrp: 0.62 ± 0.028	1.815ArgTyr: 1.815 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.275SerAla: 4.275 ± 0.065	0.415SerCys: 0.415 ± 0.021	3.226SerAsp: 3.226 ± 0.065	4.336SerGlu: 4.336 ± 0.07	3.175SerPhe: 3.175 ± 0.055	5.202SerGly: 5.202 ± 0.075	1.243SerHis: 1.243 ± 0.035	3.672SerIle: 3.672 ± 0.057	2.607SerLys: 2.607 ± 0.049	5.91SerLeu: 5.91 ± 0.079	1.682SerMet: 1.682 ± 0.038	1.746SerAsn: 1.746 ± 0.041	2.333SerPro: 2.333 ± 0.043	1.792SerGln: 1.792 ± 0.047	3.246SerArg: 3.246 ± 0.055	3.727SerSer: 3.727 ± 0.067	2.797SerThr: 2.797 ± 0.046	4.465SerVal: 4.465 ± 0.074	0.668SerTrp: 0.668 ± 0.027	1.949SerTyr: 1.949 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.058ThrAla: 5.058 ± 0.071	0.371ThrCys: 0.371 ± 0.018	3.259ThrAsp: 3.259 ± 0.056	3.994ThrGlu: 3.994 ± 0.056	2.686ThrPhe: 2.686 ± 0.052	5.654ThrGly: 5.654 ± 0.28	1.113ThrHis: 1.113 ± 0.035	3.875ThrIle: 3.875 ± 0.059	2.519ThrLys: 2.519 ± 0.051	5.145ThrLeu: 5.145 ± 0.072	1.379ThrMet: 1.379 ± 0.037	1.81ThrAsn: 1.81 ± 0.042	2.289ThrPro: 2.289 ± 0.048	1.329ThrGln: 1.329 ± 0.035	2.337ThrArg: 2.337 ± 0.047	3.075ThrSer: 3.075 ± 0.054	2.578ThrThr: 2.578 ± 0.051	4.83ThrVal: 4.83 ± 0.061	0.571ThrTrp: 0.571 ± 0.023	1.824ThrTyr: 1.824 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.186ValAla: 5.186 ± 0.084	0.629ValCys: 0.629 ± 0.024	3.807ValAsp: 3.807 ± 0.06	5.021ValGlu: 5.021 ± 0.074	3.58ValPhe: 3.58 ± 0.063	4.07ValGly: 4.07 ± 0.073	1.642ValHis: 1.642 ± 0.038	5.453ValIle: 5.453 ± 0.08	4.186ValLys: 4.186 ± 0.072	7.436ValLeu: 7.436 ± 0.083	2.249ValMet: 2.249 ± 0.044	2.996ValAsn: 2.996 ± 0.051	3.189ValPro: 3.189 ± 0.058	2.329ValGln: 2.329 ± 0.039	3.568ValArg: 3.568 ± 0.057	4.859ValSer: 4.859 ± 0.075	4.974ValThr: 4.974 ± 0.071	5.171ValVal: 5.171 ± 0.076	0.774ValTrp: 0.774 ± 0.027	2.482ValTyr: 2.482 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.703TrpAla: 0.703 ± 0.029	0.087TrpCys: 0.087 ± 0.008	0.638TrpAsp: 0.638 ± 0.027	0.77TrpGlu: 0.77 ± 0.028	0.576TrpPhe: 0.576 ± 0.021	0.748TrpGly: 0.748 ± 0.029	0.279TrpHis: 0.279 ± 0.015	0.784TrpIle: 0.784 ± 0.024	0.635TrpLys: 0.635 ± 0.025	1.262TrpLeu: 1.262 ± 0.037	0.414TrpMet: 0.414 ± 0.021	0.478TrpAsn: 0.478 ± 0.019	0.344TrpPro: 0.344 ± 0.018	0.439TrpGln: 0.439 ± 0.021	0.475TrpArg: 0.475 ± 0.022	0.595TrpSer: 0.595 ± 0.022	0.612TrpThr: 0.612 ± 0.025	0.671TrpVal: 0.671 ± 0.026	0.148TrpTrp: 0.148 ± 0.011	0.387TrpTyr: 0.387 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.229TyrAla: 2.229 ± 0.042	0.263TyrCys: 0.263 ± 0.014	2.026TyrAsp: 2.026 ± 0.046	2.546TyrGlu: 2.546 ± 0.051	1.698TyrPhe: 1.698 ± 0.037	2.546TyrGly: 2.546 ± 0.055	0.842TyrHis: 0.842 ± 0.029	1.894TyrIle: 1.894 ± 0.04	1.434TyrLys: 1.434 ± 0.04	3.134TyrLeu: 3.134 ± 0.054	0.86TyrMet: 0.86 ± 0.025	1.191TyrAsn: 1.191 ± 0.03	1.357TyrPro: 1.357 ± 0.04	1.148TyrGln: 1.148 ± 0.032	1.904TyrArg: 1.904 ± 0.042	1.947TyrSer: 1.947 ± 0.04	1.852TyrThr: 1.852 ± 0.036	2.27TyrVal: 2.27 ± 0.051	0.374TyrTrp: 0.374 ± 0.019	1.277TyrTyr: 1.277 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3874 proteins (1131585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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