Amino acid dipepetide frequency for Trametes coccinea BRFM310

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.737AlaAla: 10.737 ± 0.068	1.216AlaCys: 1.216 ± 0.017	4.707AlaAsp: 4.707 ± 0.032	5.471AlaGlu: 5.471 ± 0.034	3.443AlaPhe: 3.443 ± 0.026	6.007AlaGly: 6.007 ± 0.041	2.454AlaHis: 2.454 ± 0.021	4.145AlaIle: 4.145 ± 0.027	3.89AlaLys: 3.89 ± 0.034	9.143AlaLeu: 9.143 ± 0.052	2.049AlaMet: 2.049 ± 0.019	2.783AlaAsn: 2.783 ± 0.024	6.35AlaPro: 6.35 ± 0.054	3.824AlaGln: 3.824 ± 0.032	6.512AlaArg: 6.512 ± 0.045	8.578AlaSer: 8.578 ± 0.059	5.593AlaThr: 5.593 ± 0.043	5.959AlaVal: 5.959 ± 0.036	1.236AlaTrp: 1.236 ± 0.016	2.337AlaTyr: 2.337 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.173CysAla: 1.173 ± 0.014	0.29CysCys: 0.29 ± 0.009	0.629CysAsp: 0.629 ± 0.013	0.608CysGlu: 0.608 ± 0.011	0.477CysPhe: 0.477 ± 0.01	0.956CysGly: 0.956 ± 0.016	0.352CysHis: 0.352 ± 0.007	0.674CysIle: 0.674 ± 0.012	0.461CysLys: 0.461 ± 0.01	1.249CysLeu: 1.249 ± 0.017	0.306CysMet: 0.306 ± 0.008	0.385CysAsn: 0.385 ± 0.009	0.826CysPro: 0.826 ± 0.014	0.418CysGln: 0.418 ± 0.009	0.87CysArg: 0.87 ± 0.014	1.01CysSer: 1.01 ± 0.014	0.764CysThr: 0.764 ± 0.012	0.851CysVal: 0.851 ± 0.015	0.207CysTrp: 0.207 ± 0.006	0.332CysTyr: 0.332 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.469AspAla: 5.469 ± 0.033	0.622AspCys: 0.622 ± 0.011	4.138AspAsp: 4.138 ± 0.039	4.281AspGlu: 4.281 ± 0.037	1.969AspPhe: 1.969 ± 0.021	4.026AspGly: 4.026 ± 0.033	1.202AspHis: 1.202 ± 0.015	2.695AspIle: 2.695 ± 0.023	1.944AspLys: 1.944 ± 0.022	4.734AspLeu: 4.734 ± 0.034	1.153AspMet: 1.153 ± 0.015	1.416AspAsn: 1.416 ± 0.02	3.705AspPro: 3.705 ± 0.027	1.526AspGln: 1.526 ± 0.019	3.014AspArg: 3.014 ± 0.029	3.843AspSer: 3.843 ± 0.03	2.749AspThr: 2.749 ± 0.025	4.141AspVal: 4.141 ± 0.027	0.874AspTrp: 0.874 ± 0.014	1.448AspTyr: 1.448 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.357GluAla: 5.357 ± 0.039	0.632GluCys: 0.632 ± 0.012	4.202GluAsp: 4.202 ± 0.039	5.407GluGlu: 5.407 ± 0.056	1.759GluPhe: 1.759 ± 0.018	3.73GluGly: 3.73 ± 0.029	1.558GluHis: 1.558 ± 0.021	2.51GluIle: 2.51 ± 0.026	2.968GluLys: 2.968 ± 0.027	5.335GluLeu: 5.335 ± 0.041	1.271GluMet: 1.271 ± 0.016	1.716GluAsn: 1.716 ± 0.018	2.974GluPro: 2.974 ± 0.027	2.273GluGln: 2.273 ± 0.024	4.452GluArg: 4.452 ± 0.039	3.789GluSer: 3.789 ± 0.03	2.932GluThr: 2.932 ± 0.029	3.605GluVal: 3.605 ± 0.027	0.886GluTrp: 0.886 ± 0.014	1.507GluTyr: 1.507 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.307PheAla: 3.307 ± 0.027	0.522PheCys: 0.522 ± 0.01	2.127PheAsp: 2.127 ± 0.02	1.884PheGlu: 1.884 ± 0.02	1.426PhePhe: 1.426 ± 0.021	2.578PheGly: 2.578 ± 0.033	0.845PheHis: 0.845 ± 0.011	1.559PheIle: 1.559 ± 0.018	1.311PheLys: 1.311 ± 0.018	3.324PheLeu: 3.324 ± 0.029	0.715PheMet: 0.715 ± 0.011	1.182PheAsn: 1.182 ± 0.016	2.045PhePro: 2.045 ± 0.02	1.142PheGln: 1.142 ± 0.015	1.959PheArg: 1.959 ± 0.021	2.849PheSer: 2.849 ± 0.024	1.984PheThr: 1.984 ± 0.022	2.495PheVal: 2.495 ± 0.023	0.559PheTrp: 0.559 ± 0.011	0.977PheTyr: 0.977 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.679GlyAla: 5.679 ± 0.038	0.869GlyCys: 0.869 ± 0.015	3.396GlyAsp: 3.396 ± 0.027	3.594GlyGlu: 3.594 ± 0.03	2.388GlyPhe: 2.388 ± 0.023	5.478GlyGly: 5.478 ± 0.059	1.719GlyHis: 1.719 ± 0.02	2.941GlyIle: 2.941 ± 0.028	3.139GlyLys: 3.139 ± 0.027	5.519GlyLeu: 5.519 ± 0.039	1.51GlyMet: 1.51 ± 0.02	1.987GlyAsn: 1.987 ± 0.021	3.661GlyPro: 3.661 ± 0.028	2.372GlyGln: 2.372 ± 0.024	4.437GlyArg: 4.437 ± 0.034	5.702GlySer: 5.702 ± 0.047	4.026GlyThr: 4.026 ± 0.032	4.272GlyVal: 4.272 ± 0.034	1.112GlyTrp: 1.112 ± 0.017	1.838GlyTyr: 1.838 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.48HisAla: 2.48 ± 0.024	0.369HisCys: 0.369 ± 0.009	1.352HisAsp: 1.352 ± 0.016	1.28HisGlu: 1.28 ± 0.016	0.909HisPhe: 0.909 ± 0.012	1.787HisGly: 1.787 ± 0.021	0.939HisHis: 0.939 ± 0.019	1.251HisIle: 1.251 ± 0.014	0.837HisLys: 0.837 ± 0.012	2.479HisLeu: 2.479 ± 0.023	0.484HisMet: 0.484 ± 0.009	0.753HisAsn: 0.753 ± 0.012	2.141HisPro: 2.141 ± 0.024	0.858HisGln: 0.858 ± 0.012	1.815HisArg: 1.815 ± 0.022	2.094HisSer: 2.094 ± 0.02	1.485HisThr: 1.485 ± 0.017	1.71HisVal: 1.71 ± 0.02	0.36HisTrp: 0.36 ± 0.009	0.683HisTyr: 0.683 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.186IleAla: 4.186 ± 0.029	0.673IleCys: 0.673 ± 0.013	2.482IleAsp: 2.482 ± 0.024	2.392IleGlu: 2.392 ± 0.024	1.638IlePhe: 1.638 ± 0.019	2.705IleGly: 2.705 ± 0.027	1.129IleHis: 1.129 ± 0.015	2.057IleIle: 2.057 ± 0.024	1.701IleLys: 1.701 ± 0.021	4.161IleLeu: 4.161 ± 0.031	0.86IleMet: 0.86 ± 0.015	1.32IleAsn: 1.32 ± 0.017	3.171IlePro: 3.171 ± 0.024	1.533IleGln: 1.533 ± 0.019	2.755IleArg: 2.755 ± 0.024	3.236IleSer: 3.236 ± 0.029	2.437IleThr: 2.437 ± 0.026	3.151IleVal: 3.151 ± 0.03	0.669IleTrp: 0.669 ± 0.011	1.183IleTyr: 1.183 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.159LysAla: 4.159 ± 0.033	0.425LysCys: 0.425 ± 0.01	2.217LysAsp: 2.217 ± 0.023	2.857LysGlu: 2.857 ± 0.031	1.168LysPhe: 1.168 ± 0.015	2.606LysGly: 2.606 ± 0.03	1.028LysHis: 1.028 ± 0.013	1.671LysIle: 1.671 ± 0.019	2.64LysLys: 2.64 ± 0.038	3.582LysLeu: 3.582 ± 0.031	0.81LysMet: 0.81 ± 0.013	1.203LysAsn: 1.203 ± 0.015	2.59LysPro: 2.59 ± 0.028	1.537LysGln: 1.537 ± 0.017	3.328LysArg: 3.328 ± 0.028	2.762LysSer: 2.762 ± 0.027	2.277LysThr: 2.277 ± 0.02	2.467LysVal: 2.467 ± 0.028	0.594LysTrp: 0.594 ± 0.011	1.116LysTyr: 1.116 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.761LeuAla: 8.761 ± 0.05	1.297LeuCys: 1.297 ± 0.018	5.012LeuAsp: 5.012 ± 0.035	5.242LeuGlu: 5.242 ± 0.036	3.245LeuPhe: 3.245 ± 0.029	5.544LeuGly: 5.544 ± 0.036	2.528LeuHis: 2.528 ± 0.024	3.519LeuIle: 3.519 ± 0.033	3.683LeuLys: 3.683 ± 0.028	8.657LeuLeu: 8.657 ± 0.057	1.681LeuMet: 1.681 ± 0.021	2.783LeuAsn: 2.783 ± 0.021	6.526LeuPro: 6.526 ± 0.04	3.691LeuGln: 3.691 ± 0.032	6.638LeuArg: 6.638 ± 0.045	7.774LeuSer: 7.774 ± 0.044	5.049LeuThr: 5.049 ± 0.036	5.769LeuVal: 5.769 ± 0.035	1.244LeuTrp: 1.244 ± 0.015	2.384LeuTyr: 2.384 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	1.923MetAla: 1.923 ± 0.018	0.258MetCys: 0.258 ± 0.007	1.148MetAsp: 1.148 ± 0.015	1.097MetGlu: 1.097 ± 0.015	0.707MetPhe: 0.707 ± 0.012	1.223MetGly: 1.223 ± 0.018	0.575MetHis: 0.575 ± 0.011	0.821MetIle: 0.821 ± 0.014	0.807MetLys: 0.807 ± 0.013	1.851MetLeu: 1.851 ± 0.02	0.47MetMet: 0.47 ± 0.009	0.661MetAsn: 0.661 ± 0.012	1.406MetPro: 1.406 ± 0.017	0.856MetGln: 0.856 ± 0.013	1.446MetArg: 1.446 ± 0.017	1.98MetSer: 1.98 ± 0.021	1.133MetThr: 1.133 ± 0.016	1.163MetVal: 1.163 ± 0.015	0.271MetTrp: 0.271 ± 0.007	0.54MetTyr: 0.54 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.177AsnAla: 3.177 ± 0.028	0.341AsnCys: 0.341 ± 0.007	1.532AsnAsp: 1.532 ± 0.018	1.532AsnGlu: 1.532 ± 0.017	1.056AsnPhe: 1.056 ± 0.016	2.461AsnGly: 2.461 ± 0.028	0.708AsnHis: 0.708 ± 0.013	1.53AsnIle: 1.53 ± 0.018	1.102AsnLys: 1.102 ± 0.015	2.746AsnLeu: 2.746 ± 0.023	0.648AsnMet: 0.648 ± 0.01	0.994AsnAsn: 0.994 ± 0.013	2.175AsnPro: 2.175 ± 0.022	0.936AsnGln: 0.936 ± 0.014	1.57AsnArg: 1.57 ± 0.018	2.087AsnSer: 2.087 ± 0.02	1.764AsnThr: 1.764 ± 0.018	2.235AsnVal: 2.235 ± 0.022	0.432AsnTrp: 0.432 ± 0.01	0.79AsnTyr: 0.79 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.955ProAla: 6.955 ± 0.054	0.644ProCys: 0.644 ± 0.013	3.49ProAsp: 3.49 ± 0.027	4.003ProGlu: 4.003 ± 0.027	2.215ProPhe: 2.215 ± 0.022	4.292ProGly: 4.292 ± 0.032	1.782ProHis: 1.782 ± 0.021	2.601ProIle: 2.601 ± 0.019	2.361ProLys: 2.361 ± 0.021	5.693ProLeu: 5.693 ± 0.041	1.168ProMet: 1.168 ± 0.016	2.017ProAsn: 2.017 ± 0.023	7.674ProPro: 7.674 ± 0.102	2.602ProGln: 2.602 ± 0.029	4.401ProArg: 4.401 ± 0.037	7.798ProSer: 7.798 ± 0.065	4.577ProThr: 4.577 ± 0.037	4.179ProVal: 4.179 ± 0.034	0.764ProTrp: 0.764 ± 0.01	1.674ProTyr: 1.674 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.523GlnAla: 3.523 ± 0.029	0.478GlnCys: 0.478 ± 0.01	1.867GlnAsp: 1.867 ± 0.02	2.189GlnGlu: 2.189 ± 0.022	1.138GlnPhe: 1.138 ± 0.015	2.187GlnGly: 2.187 ± 0.02	1.108GlnHis: 1.108 ± 0.017	1.514GlnIle: 1.514 ± 0.02	1.512GlnLys: 1.512 ± 0.017	3.36GlnLeu: 3.36 ± 0.025	0.78GlnMet: 0.78 ± 0.012	1.173GlnAsn: 1.173 ± 0.014	2.638GlnPro: 2.638 ± 0.033	2.16GlnGln: 2.16 ± 0.045	2.731GlnArg: 2.731 ± 0.026	2.935GlnSer: 2.935 ± 0.028	2.12GlnThr: 2.12 ± 0.019	2.1GlnVal: 2.1 ± 0.021	0.569GlnTrp: 0.569 ± 0.011	1.069GlnTyr: 1.069 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	6.383ArgAla: 6.383 ± 0.041	0.927ArgCys: 0.927 ± 0.015	3.462ArgAsp: 3.462 ± 0.026	4.181ArgGlu: 4.181 ± 0.034	2.2ArgPhe: 2.2 ± 0.021	4.013ArgGly: 4.013 ± 0.03	1.76ArgHis: 1.76 ± 0.021	2.977ArgIle: 2.977 ± 0.023	3.221ArgLys: 3.221 ± 0.029	6.109ArgLeu: 6.109 ± 0.038	1.482ArgMet: 1.482 ± 0.017	1.955ArgAsn: 1.955 ± 0.02	4.455ArgPro: 4.455 ± 0.039	2.447ArgGln: 2.447 ± 0.022	6.271ArgArg: 6.271 ± 0.053	5.523ArgSer: 5.523 ± 0.046	4.005ArgThr: 4.005 ± 0.028	4.033ArgVal: 4.033 ± 0.031	1.078ArgTrp: 1.078 ± 0.016	1.764ArgTyr: 1.764 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	8.172SerAla: 8.172 ± 0.054	0.973SerCys: 0.973 ± 0.016	4.174SerAsp: 4.174 ± 0.026	4.017SerGlu: 4.017 ± 0.032	2.817SerPhe: 2.817 ± 0.023	5.613SerGly: 5.613 ± 0.039	2.07SerHis: 2.07 ± 0.02	3.414SerIle: 3.414 ± 0.028	3.044SerLys: 3.044 ± 0.029	7.456SerLeu: 7.456 ± 0.046	1.695SerMet: 1.695 ± 0.021	2.35SerAsn: 2.35 ± 0.023	6.859SerPro: 6.859 ± 0.071	3.094SerGln: 3.094 ± 0.033	5.58SerArg: 5.58 ± 0.043	10.01SerSer: 10.01 ± 0.087	5.774SerThr: 5.774 ± 0.049	5.047SerVal: 5.047 ± 0.034	1.032SerTrp: 1.032 ± 0.013	1.894SerTyr: 1.894 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.536ThrAla: 5.536 ± 0.037	0.781ThrCys: 0.781 ± 0.013	2.695ThrAsp: 2.695 ± 0.024	2.7ThrGlu: 2.7 ± 0.023	2.29ThrPhe: 2.29 ± 0.021	3.792ThrGly: 3.792 ± 0.03	1.495ThrHis: 1.495 ± 0.016	2.785ThrIle: 2.785 ± 0.025	2.06ThrLys: 2.06 ± 0.018	5.625ThrLeu: 5.625 ± 0.033	1.103ThrMet: 1.103 ± 0.015	1.702ThrAsn: 1.702 ± 0.018	4.856ThrPro: 4.856 ± 0.039	1.937ThrGln: 1.937 ± 0.018	3.541ThrArg: 3.541 ± 0.025	5.408ThrSer: 5.408 ± 0.043	3.931ThrThr: 3.931 ± 0.037	3.919ThrVal: 3.919 ± 0.036	0.797ThrTrp: 0.797 ± 0.013	1.58ThrTyr: 1.58 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.863ValAla: 5.863 ± 0.04	0.91ValCys: 0.91 ± 0.012	3.812ValAsp: 3.812 ± 0.026	3.851ValGlu: 3.851 ± 0.031	2.398ValPhe: 2.398 ± 0.026	3.945ValGly: 3.945 ± 0.035	1.721ValHis: 1.721 ± 0.019	2.823ValIle: 2.823 ± 0.025	2.684ValLys: 2.684 ± 0.026	6.187ValLeu: 6.187 ± 0.038	1.249ValMet: 1.249 ± 0.017	2.008ValAsn: 2.008 ± 0.023	4.549ValPro: 4.549 ± 0.031	2.474ValGln: 2.474 ± 0.024	4.198ValArg: 4.198 ± 0.031	4.798ValSer: 4.798 ± 0.038	3.495ValThr: 3.495 ± 0.032	4.64ValVal: 4.64 ± 0.04	0.963ValTrp: 0.963 ± 0.014	1.795ValTyr: 1.795 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.154TrpAla: 1.154 ± 0.017	0.208TrpCys: 0.208 ± 0.006	0.87TrpAsp: 0.87 ± 0.014	0.842TrpGlu: 0.842 ± 0.011	0.531TrpPhe: 0.531 ± 0.01	0.837TrpGly: 0.837 ± 0.013	0.371TrpHis: 0.371 ± 0.009	0.687TrpIle: 0.687 ± 0.011	0.695TrpLys: 0.695 ± 0.013	1.363TrpLeu: 1.363 ± 0.017	0.362TrpMet: 0.362 ± 0.008	0.522TrpAsn: 0.522 ± 0.011	0.703TrpPro: 0.703 ± 0.011	0.542TrpGln: 0.542 ± 0.01	1.095TrpArg: 1.095 ± 0.015	1.053TrpSer: 1.053 ± 0.014	0.906TrpThr: 0.906 ± 0.013	0.868TrpVal: 0.868 ± 0.014	0.275TrpTrp: 0.275 ± 0.008	0.424TrpTyr: 0.424 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.443TyrAla: 2.443 ± 0.023	0.402TyrCys: 0.402 ± 0.008	1.635TyrAsp: 1.635 ± 0.019	1.435TyrGlu: 1.435 ± 0.015	1.016TyrPhe: 1.016 ± 0.016	1.86TyrGly: 1.86 ± 0.023	0.723TyrHis: 0.723 ± 0.012	1.267TyrIle: 1.267 ± 0.016	0.973TyrLys: 0.973 ± 0.013	2.454TyrLeu: 2.454 ± 0.026	0.542TyrMet: 0.542 ± 0.009	0.906TyrAsn: 0.906 ± 0.013	1.584TyrPro: 1.584 ± 0.02	0.934TyrGln: 0.934 ± 0.014	1.635TyrArg: 1.635 ± 0.016	1.853TyrSer: 1.853 ± 0.02	1.53TyrThr: 1.53 ± 0.018	1.76TyrVal: 1.76 ± 0.018	0.385TyrTrp: 0.385 ± 0.009	0.856TyrTyr: 0.856 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12648 proteins (5438953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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