Amino acid dipepetide frequency for Coriobacteriaceae bacterium CHKCI002

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.981AlaAla: 17.981 ± 0.212	2.461AlaCys: 2.461 ± 0.063	7.41AlaAsp: 7.41 ± 0.115	7.766AlaGlu: 7.766 ± 0.11	4.998AlaPhe: 4.998 ± 0.085	10.665AlaGly: 10.665 ± 0.141	2.235AlaHis: 2.235 ± 0.057	5.022AlaIle: 5.022 ± 0.087	4.141AlaLys: 4.141 ± 0.073	13.582AlaLeu: 13.582 ± 0.198	3.016AlaMet: 3.016 ± 0.057	2.825AlaAsn: 2.825 ± 0.059	5.054AlaPro: 5.054 ± 0.097	3.725AlaGln: 3.725 ± 0.068	9.079AlaArg: 9.079 ± 0.137	7.992AlaSer: 7.992 ± 0.106	5.613AlaThr: 5.613 ± 0.08	9.987AlaVal: 9.987 ± 0.142	1.421AlaTrp: 1.421 ± 0.042	3.097AlaTyr: 3.097 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	2.273CysAla: 2.273 ± 0.064	0.303CysCys: 0.303 ± 0.02	1.012CysAsp: 1.012 ± 0.033	1.053CysGlu: 1.053 ± 0.032	0.604CysPhe: 0.604 ± 0.026	1.8CysGly: 1.8 ± 0.049	0.312CysHis: 0.312 ± 0.022	0.723CysIle: 0.723 ± 0.028	0.453CysLys: 0.453 ± 0.026	1.364CysLeu: 1.364 ± 0.043	0.416CysMet: 0.416 ± 0.024	0.368CysAsn: 0.368 ± 0.02	0.898CysPro: 0.898 ± 0.037	0.352CysGln: 0.352 ± 0.018	0.917CysArg: 0.917 ± 0.032	0.897CysSer: 0.897 ± 0.035	0.785CysThr: 0.785 ± 0.031	1.414CysVal: 1.414 ± 0.05	0.166CysTrp: 0.166 ± 0.013	0.423CysTyr: 0.423 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	8.749AspAla: 8.749 ± 0.144	0.697AspCys: 0.697 ± 0.032	3.68AspAsp: 3.68 ± 0.091	5.43AspGlu: 5.43 ± 0.09	2.323AspPhe: 2.323 ± 0.053	5.842AspGly: 5.842 ± 0.155	0.839AspHis: 0.839 ± 0.037	2.67AspIle: 2.67 ± 0.064	1.732AspLys: 1.732 ± 0.042	5.129AspLeu: 5.129 ± 0.074	1.423AspMet: 1.423 ± 0.042	1.287AspAsn: 1.287 ± 0.044	3.122AspPro: 3.122 ± 0.083	1.207AspGln: 1.207 ± 0.035	3.179AspArg: 3.179 ± 0.065	2.496AspSer: 2.496 ± 0.065	2.406AspThr: 2.406 ± 0.055	4.882AspVal: 4.882 ± 0.075	0.687AspTrp: 0.687 ± 0.03	1.767AspTyr: 1.767 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	8.6GluAla: 8.6 ± 0.109	0.802GluCys: 0.802 ± 0.033	3.447GluAsp: 3.447 ± 0.071	4.845GluGlu: 4.845 ± 0.077	2.033GluPhe: 2.033 ± 0.053	6.225GluGly: 6.225 ± 0.109	1.351GluHis: 1.351 ± 0.043	2.665GluIle: 2.665 ± 0.062	2.72GluLys: 2.72 ± 0.063	6.09GluLeu: 6.09 ± 0.086	1.547GluMet: 1.547 ± 0.046	1.92GluAsn: 1.92 ± 0.05	2.729GluPro: 2.729 ± 0.062	2.116GluGln: 2.116 ± 0.052	6.271GluArg: 6.271 ± 0.109	3.107GluSer: 3.107 ± 0.066	3.131GluThr: 3.131 ± 0.063	4.747GluVal: 4.747 ± 0.064	0.705GluTrp: 0.705 ± 0.026	1.696GluTyr: 1.696 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	4.928PheAla: 4.928 ± 0.08	0.713PheCys: 0.713 ± 0.025	2.833PheAsp: 2.833 ± 0.057	2.579PheGlu: 2.579 ± 0.057	1.567PhePhe: 1.567 ± 0.051	3.677PheGly: 3.677 ± 0.063	0.615PheHis: 0.615 ± 0.023	1.432PheIle: 1.432 ± 0.043	1.211PheLys: 1.211 ± 0.042	3.466PheLeu: 3.466 ± 0.078	0.906PheMet: 0.906 ± 0.033	0.99PheAsn: 0.99 ± 0.032	1.496PhePro: 1.496 ± 0.046	0.831PheGln: 0.831 ± 0.028	1.632PheArg: 1.632 ± 0.044	2.649PheSer: 2.649 ± 0.061	1.882PheThr: 1.882 ± 0.065	3.239PheVal: 3.239 ± 0.068	0.505PheTrp: 0.505 ± 0.022	1.13PheTyr: 1.13 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.584GlyAla: 10.584 ± 0.142	1.749GlyCys: 1.749 ± 0.046	4.569GlyAsp: 4.569 ± 0.102	5.502GlyGlu: 5.502 ± 0.099	3.661GlyPhe: 3.661 ± 0.077	7.426GlyGly: 7.426 ± 0.113	1.376GlyHis: 1.376 ± 0.037	4.487GlyIle: 4.487 ± 0.09	3.403GlyLys: 3.403 ± 0.065	7.639GlyLeu: 7.639 ± 0.106	2.502GlyMet: 2.502 ± 0.059	2.243GlyAsn: 2.243 ± 0.061	2.437GlyPro: 2.437 ± 0.066	2.195GlyGln: 2.195 ± 0.051	5.552GlyArg: 5.552 ± 0.095	5.311GlySer: 5.311 ± 0.086	4.541GlyThr: 4.541 ± 0.083	7.176GlyVal: 7.176 ± 0.101	1.06GlyTrp: 1.06 ± 0.039	2.555GlyTyr: 2.555 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.097HisAla: 2.097 ± 0.05	0.308HisCys: 0.308 ± 0.019	1.1HisAsp: 1.1 ± 0.038	1.078HisGlu: 1.078 ± 0.035	0.572HisPhe: 0.572 ± 0.024	1.59HisGly: 1.59 ± 0.045	0.349HisHis: 0.349 ± 0.019	0.795HisIle: 0.795 ± 0.03	0.439HisLys: 0.439 ± 0.023	1.6HisLeu: 1.6 ± 0.051	0.396HisMet: 0.396 ± 0.021	0.415HisAsn: 0.415 ± 0.022	1.107HisPro: 1.107 ± 0.037	0.382HisGln: 0.382 ± 0.022	1.144HisArg: 1.144 ± 0.039	0.853HisSer: 0.853 ± 0.032	0.789HisThr: 0.789 ± 0.027	1.509HisVal: 1.509 ± 0.046	0.187HisTrp: 0.187 ± 0.013	0.503HisTyr: 0.503 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.941IleAla: 5.941 ± 0.109	0.738IleCys: 0.738 ± 0.03	3.302IleAsp: 3.302 ± 0.065	3.418IleGlu: 3.418 ± 0.061	1.174IlePhe: 1.174 ± 0.046	3.754IleGly: 3.754 ± 0.09	0.657IleHis: 0.657 ± 0.026	1.782IleIle: 1.782 ± 0.054	1.398IleLys: 1.398 ± 0.048	3.235IleLeu: 3.235 ± 0.065	1.131IleMet: 1.131 ± 0.038	1.171IleAsn: 1.171 ± 0.038	2.019IlePro: 2.019 ± 0.047	0.947IleGln: 0.947 ± 0.034	2.105IleArg: 2.105 ± 0.055	2.296IleSer: 2.296 ± 0.054	2.188IleThr: 2.188 ± 0.052	4.381IleVal: 4.381 ± 0.09	0.424IleTrp: 0.424 ± 0.023	0.952IleTyr: 0.952 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.839LysAla: 3.839 ± 0.067	0.435LysCys: 0.435 ± 0.025	1.945LysAsp: 1.945 ± 0.046	2.193LysGlu: 2.193 ± 0.057	0.811LysPhe: 0.811 ± 0.031	2.87LysGly: 2.87 ± 0.066	0.61LysHis: 0.61 ± 0.025	1.438LysIle: 1.438 ± 0.038	1.777LysLys: 1.777 ± 0.052	3.026LysLeu: 3.026 ± 0.06	0.86LysMet: 0.86 ± 0.032	1.14LysAsn: 1.14 ± 0.032	1.758LysPro: 1.758 ± 0.048	1.049LysGln: 1.049 ± 0.036	2.989LysArg: 2.989 ± 0.062	1.907LysSer: 1.907 ± 0.052	2.028LysThr: 2.028 ± 0.05	2.381LysVal: 2.381 ± 0.057	0.356LysTrp: 0.356 ± 0.016	0.889LysTyr: 0.889 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	12.842LeuAla: 12.842 ± 0.175	1.451LeuCys: 1.451 ± 0.039	5.819LeuAsp: 5.819 ± 0.079	5.536LeuGlu: 5.536 ± 0.079	3.824LeuPhe: 3.824 ± 0.088	7.518LeuGly: 7.518 ± 0.102	1.521LeuHis: 1.521 ± 0.045	3.552LeuIle: 3.552 ± 0.078	2.893LeuLys: 2.893 ± 0.064	8.328LeuLeu: 8.328 ± 0.145	2.458LeuMet: 2.458 ± 0.055	2.022LeuAsn: 2.022 ± 0.048	4.587LeuPro: 4.587 ± 0.077	1.974LeuGln: 1.974 ± 0.05	5.814LeuArg: 5.814 ± 0.091	6.505LeuSer: 6.505 ± 0.097	4.189LeuThr: 4.189 ± 0.065	8.433LeuVal: 8.433 ± 0.136	0.966LeuTrp: 0.966 ± 0.029	2.371LeuTyr: 2.371 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.144MetAla: 3.144 ± 0.077	0.335MetCys: 0.335 ± 0.019	1.348MetAsp: 1.348 ± 0.04	1.549MetGlu: 1.549 ± 0.041	0.798MetPhe: 0.798 ± 0.028	2.219MetGly: 2.219 ± 0.051	0.428MetHis: 0.428 ± 0.02	1.045MetIle: 1.045 ± 0.039	0.985MetLys: 0.985 ± 0.032	2.448MetLeu: 2.448 ± 0.058	0.707MetMet: 0.707 ± 0.031	0.887MetAsn: 0.887 ± 0.031	1.331MetPro: 1.331 ± 0.035	0.716MetGln: 0.716 ± 0.028	1.901MetArg: 1.901 ± 0.05	1.557MetSer: 1.557 ± 0.045	1.455MetThr: 1.455 ± 0.04	1.743MetVal: 1.743 ± 0.051	0.254MetTrp: 0.254 ± 0.014	0.503MetTyr: 0.503 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.245AsnAla: 3.245 ± 0.064	0.34AsnCys: 0.34 ± 0.021	1.502AsnAsp: 1.502 ± 0.051	1.7AsnGlu: 1.7 ± 0.045	0.855AsnPhe: 0.855 ± 0.03	2.281AsnGly: 2.281 ± 0.063	0.45AsnHis: 0.45 ± 0.023	1.164AsnIle: 1.164 ± 0.036	0.81AsnLys: 0.81 ± 0.035	2.319AsnLeu: 2.319 ± 0.05	0.625AsnMet: 0.625 ± 0.025	0.687AsnAsn: 0.687 ± 0.035	1.785AsnPro: 1.785 ± 0.053	0.657AsnGln: 0.657 ± 0.028	1.607AsnArg: 1.607 ± 0.048	1.241AsnSer: 1.241 ± 0.036	1.332AsnThr: 1.332 ± 0.043	2.156AsnVal: 2.156 ± 0.052	0.319AsnTrp: 0.319 ± 0.02	0.753AsnTyr: 0.753 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.453ProAla: 5.453 ± 0.093	0.668ProCys: 0.668 ± 0.025	3.071ProAsp: 3.071 ± 0.069	3.494ProGlu: 3.494 ± 0.059	1.909ProPhe: 1.909 ± 0.045	3.308ProGly: 3.308 ± 0.06	0.907ProHis: 0.907 ± 0.034	1.803ProIle: 1.803 ± 0.047	1.491ProLys: 1.491 ± 0.036	4.122ProLeu: 4.122 ± 0.067	0.886ProMet: 0.886 ± 0.037	1.189ProAsn: 1.189 ± 0.044	1.542ProPro: 1.542 ± 0.051	1.35ProGln: 1.35 ± 0.045	2.671ProArg: 2.671 ± 0.061	2.985ProSer: 2.985 ± 0.062	2.23ProThr: 2.23 ± 0.052	3.691ProVal: 3.691 ± 0.065	0.527ProTrp: 0.527 ± 0.023	1.339ProTyr: 1.339 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.002GlnAla: 3.002 ± 0.066	0.342GlnCys: 0.342 ± 0.019	1.239GlnAsp: 1.239 ± 0.039	1.669GlnGlu: 1.669 ± 0.044	0.856GlnPhe: 0.856 ± 0.028	2.344GlnGly: 2.344 ± 0.062	0.465GlnHis: 0.465 ± 0.021	1.247GlnIle: 1.247 ± 0.036	1.105GlnLys: 1.105 ± 0.037	2.385GlnLeu: 2.385 ± 0.052	0.771GlnMet: 0.771 ± 0.027	0.836GlnAsn: 0.836 ± 0.034	1.229GlnPro: 1.229 ± 0.045	0.982GlnGln: 0.982 ± 0.046	1.98GlnArg: 1.98 ± 0.057	1.344GlnSer: 1.344 ± 0.036	1.559GlnThr: 1.559 ± 0.035	1.958GlnVal: 1.958 ± 0.048	0.333GlnTrp: 0.333 ± 0.021	0.714GlnTyr: 0.714 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.51ArgAla: 8.51 ± 0.14	1.109ArgCys: 1.109 ± 0.052	3.681ArgAsp: 3.681 ± 0.074	4.927ArgGlu: 4.927 ± 0.079	2.828ArgPhe: 2.828 ± 0.055	4.696ArgGly: 4.696 ± 0.078	1.225ArgHis: 1.225 ± 0.039	3.418ArgIle: 3.418 ± 0.069	2.497ArgLys: 2.497 ± 0.057	5.857ArgLeu: 5.857 ± 0.09	2.167ArgMet: 2.167 ± 0.053	1.657ArgAsn: 1.657 ± 0.044	2.805ArgPro: 2.805 ± 0.065	1.855ArgGln: 1.855 ± 0.051	5.442ArgArg: 5.442 ± 0.124	3.655ArgSer: 3.655 ± 0.07	3.502ArgThr: 3.502 ± 0.069	4.754ArgVal: 4.754 ± 0.085	0.738ArgTrp: 0.738 ± 0.027	1.925ArgTyr: 1.925 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.988SerAla: 6.988 ± 0.109	1.007SerCys: 1.007 ± 0.042	3.366SerAsp: 3.366 ± 0.078	3.53SerGlu: 3.53 ± 0.072	2.691SerPhe: 2.691 ± 0.059	5.368SerGly: 5.368 ± 0.088	0.975SerHis: 0.975 ± 0.034	2.623SerIle: 2.623 ± 0.065	1.917SerLys: 1.917 ± 0.049	5.323SerLeu: 5.323 ± 0.089	1.542SerMet: 1.542 ± 0.036	1.45SerAsn: 1.45 ± 0.042	2.554SerPro: 2.554 ± 0.057	1.595SerGln: 1.595 ± 0.04	3.609SerArg: 3.609 ± 0.071	3.75SerSer: 3.75 ± 0.08	3.033SerThr: 3.033 ± 0.061	4.554SerVal: 4.554 ± 0.072	0.797SerTrp: 0.797 ± 0.034	1.707SerTyr: 1.707 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.419ThrAla: 5.419 ± 0.09	0.811ThrCys: 0.811 ± 0.031	2.731ThrAsp: 2.731 ± 0.063	2.569ThrGlu: 2.569 ± 0.054	2.038ThrPhe: 2.038 ± 0.051	4.66ThrGly: 4.66 ± 0.099	0.901ThrHis: 0.901 ± 0.031	2.235ThrIle: 2.235 ± 0.056	1.54ThrLys: 1.54 ± 0.041	4.742ThrLeu: 4.742 ± 0.075	1.154ThrMet: 1.154 ± 0.037	1.338ThrAsn: 1.338 ± 0.046	2.652ThrPro: 2.652 ± 0.055	1.225ThrGln: 1.225 ± 0.042	2.703ThrArg: 2.703 ± 0.057	2.909ThrSer: 2.909 ± 0.059	2.563ThrThr: 2.563 ± 0.058	4.627ThrVal: 4.627 ± 0.086	0.653ThrTrp: 0.653 ± 0.029	1.544ThrTyr: 1.544 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	10.18ValAla: 10.18 ± 0.135	1.558ValCys: 1.558 ± 0.049	4.837ValAsp: 4.837 ± 0.093	5.377ValGlu: 5.377 ± 0.086	3.195ValPhe: 3.195 ± 0.064	6.392ValGly: 6.392 ± 0.107	1.309ValHis: 1.309 ± 0.043	3.451ValIle: 3.451 ± 0.081	2.635ValLys: 2.635 ± 0.056	8.038ValLeu: 8.038 ± 0.121	1.945ValMet: 1.945 ± 0.055	2.197ValAsn: 2.197 ± 0.046	3.868ValPro: 3.868 ± 0.072	1.997ValGln: 1.997 ± 0.047	5.827ValArg: 5.827 ± 0.097	5.018ValSer: 5.018 ± 0.078	3.839ValThr: 3.839 ± 0.069	7.607ValVal: 7.607 ± 0.125	0.876ValTrp: 0.876 ± 0.036	2.091ValTyr: 2.091 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	1.152TrpAla: 1.152 ± 0.034	0.242TrpCys: 0.242 ± 0.015	0.718TrpAsp: 0.718 ± 0.032	0.699TrpGlu: 0.699 ± 0.03	0.484TrpPhe: 0.484 ± 0.027	0.98TrpGly: 0.98 ± 0.039	0.239TrpHis: 0.239 ± 0.016	0.54TrpIle: 0.54 ± 0.029	0.381TrpLys: 0.381 ± 0.021	1.127TrpLeu: 1.127 ± 0.039	0.416TrpMet: 0.416 ± 0.02	0.387TrpAsn: 0.387 ± 0.022	0.456TrpPro: 0.456 ± 0.023	0.427TrpGln: 0.427 ± 0.021	0.809TrpArg: 0.809 ± 0.031	0.598TrpSer: 0.598 ± 0.027	0.573TrpThr: 0.573 ± 0.029	0.797TrpVal: 0.797 ± 0.031	0.177TrpTrp: 0.177 ± 0.015	0.313TrpTyr: 0.313 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.143TyrAla: 3.143 ± 0.064	0.462TyrCys: 0.462 ± 0.025	1.937TyrAsp: 1.937 ± 0.055	1.834TyrGlu: 1.834 ± 0.048	1.057TyrPhe: 1.057 ± 0.035	2.356TyrGly: 2.356 ± 0.057	0.446TyrHis: 0.446 ± 0.022	0.921TyrIle: 0.921 ± 0.033	0.773TyrLys: 0.773 ± 0.032	2.785TyrLeu: 2.785 ± 0.049	0.485TyrMet: 0.485 ± 0.023	0.818TyrAsn: 0.818 ± 0.036	1.209TyrPro: 1.209 ± 0.036	0.776TyrGln: 0.776 ± 0.034	2.02TyrArg: 2.02 ± 0.049	1.309TyrSer: 1.309 ± 0.047	1.376TyrThr: 1.376 ± 0.044	2.202TyrVal: 2.202 ± 0.05	0.365TyrTrp: 0.365 ± 0.02	0.874TyrTyr: 0.874 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2836 proteins (947897 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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