Amino acid dipepetide frequency for Geoalkalibacter ferrihydriticus DSM 17813

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.366AlaAla: 12.366 ± 0.172	1.317AlaCys: 1.317 ± 0.046	5.405AlaAsp: 5.405 ± 0.077	7.027AlaGlu: 7.027 ± 0.106	3.784AlaPhe: 3.784 ± 0.066	8.72AlaGly: 8.72 ± 0.121	1.948AlaHis: 1.948 ± 0.046	4.861AlaIle: 4.861 ± 0.087	2.996AlaLys: 2.996 ± 0.07	11.987AlaLeu: 11.987 ± 0.137	2.428AlaMet: 2.428 ± 0.056	2.34AlaAsn: 2.34 ± 0.053	4.378AlaPro: 4.378 ± 0.084	4.278AlaGln: 4.278 ± 0.078	7.544AlaArg: 7.544 ± 0.112	4.35AlaSer: 4.35 ± 0.079	4.496AlaThr: 4.496 ± 0.066	7.556AlaVal: 7.556 ± 0.089	1.056AlaTrp: 1.056 ± 0.04	2.308AlaTyr: 2.308 ± 0.059	0.003AlaXaa: 0.003 ± 0.003
Cys	1.233CysAla: 1.233 ± 0.038	0.185CysCys: 0.185 ± 0.016	0.64CysAsp: 0.64 ± 0.027	0.634CysGlu: 0.634 ± 0.025	0.43CysPhe: 0.43 ± 0.02	1.278CysGly: 1.278 ± 0.045	0.659CysHis: 0.659 ± 0.076	0.549CysIle: 0.549 ± 0.028	0.328CysLys: 0.328 ± 0.018	1.191CysLeu: 1.191 ± 0.038	0.209CysMet: 0.209 ± 0.016	0.331CysAsn: 0.331 ± 0.017	0.703CysPro: 0.703 ± 0.036	0.354CysGln: 0.354 ± 0.02	0.996CysArg: 0.996 ± 0.036	0.662CysSer: 0.662 ± 0.027	0.553CysThr: 0.553 ± 0.027	0.709CysVal: 0.709 ± 0.029	0.137CysTrp: 0.137 ± 0.012	0.286CysTyr: 0.286 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.084AspAla: 5.084 ± 0.072	0.7AspCys: 0.7 ± 0.033	2.668AspAsp: 2.668 ± 0.06	3.839AspGlu: 3.839 ± 0.069	2.688AspPhe: 2.688 ± 0.063	4.232AspGly: 4.232 ± 0.093	1.168AspHis: 1.168 ± 0.036	3.277AspIle: 3.277 ± 0.059	1.975AspLys: 1.975 ± 0.053	7.038AspLeu: 7.038 ± 0.093	1.115AspMet: 1.115 ± 0.034	1.542AspAsn: 1.542 ± 0.045	3.154AspPro: 3.154 ± 0.063	1.948AspGln: 1.948 ± 0.046	3.284AspArg: 3.284 ± 0.065	2.489AspSer: 2.489 ± 0.057	2.156AspThr: 2.156 ± 0.049	3.599AspVal: 3.599 ± 0.067	0.715AspTrp: 0.715 ± 0.032	1.713AspTyr: 1.713 ± 0.049	0.005AspXaa: 0.005 ± 0.003
Glu	6.452GluAla: 6.452 ± 0.103	0.538GluCys: 0.538 ± 0.022	3.423GluAsp: 3.423 ± 0.071	5.175GluGlu: 5.175 ± 0.096	2.387GluPhe: 2.387 ± 0.057	4.892GluGly: 4.892 ± 0.074	1.363GluHis: 1.363 ± 0.038	4.522GluIle: 4.522 ± 0.069	3.728GluLys: 3.728 ± 0.075	6.912GluLeu: 6.912 ± 0.107	1.837GluMet: 1.837 ± 0.043	2.187GluAsn: 2.187 ± 0.046	2.37GluPro: 2.37 ± 0.059	3.019GluGln: 3.019 ± 0.07	5.241GluArg: 5.241 ± 0.086	3.036GluSer: 3.036 ± 0.057	3.313GluThr: 3.313 ± 0.063	5.145GluVal: 5.145 ± 0.089	0.545GluTrp: 0.545 ± 0.025	1.395GluTyr: 1.395 ± 0.037	0.003GluXaa: 0.003 ± 0.002
Phe	4.052PheAla: 4.052 ± 0.065	0.625PheCys: 0.625 ± 0.026	2.575PheAsp: 2.575 ± 0.055	2.321PheGlu: 2.321 ± 0.055	2.161PhePhe: 2.161 ± 0.053	3.497PheGly: 3.497 ± 0.062	0.922PheHis: 0.922 ± 0.03	2.158PheIle: 2.158 ± 0.044	1.342PheLys: 1.342 ± 0.04	4.305PheLeu: 4.305 ± 0.072	0.889PheMet: 0.889 ± 0.034	1.364PheAsn: 1.364 ± 0.042	1.784PhePro: 1.784 ± 0.045	1.201PheGln: 1.201 ± 0.038	2.466PheArg: 2.466 ± 0.05	2.953PheSer: 2.953 ± 0.06	2.181PheThr: 2.181 ± 0.052	2.74PheVal: 2.74 ± 0.057	0.55PheTrp: 0.55 ± 0.03	1.227PheTyr: 1.227 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	7.471GlyAla: 7.471 ± 0.095	1.217GlyCys: 1.217 ± 0.042	4.212GlyAsp: 4.212 ± 0.08	5.657GlyGlu: 5.657 ± 0.087	3.483GlyPhe: 3.483 ± 0.067	6.546GlyGly: 6.546 ± 0.089	1.823GlyHis: 1.823 ± 0.046	4.694GlyIle: 4.694 ± 0.074	3.42GlyLys: 3.42 ± 0.07	8.632GlyLeu: 8.632 ± 0.125	2.162GlyMet: 2.162 ± 0.048	2.43GlyAsn: 2.43 ± 0.065	2.683GlyPro: 2.683 ± 0.061	2.87GlyGln: 2.87 ± 0.061	5.99GlyArg: 5.99 ± 0.088	4.134GlySer: 4.134 ± 0.078	3.976GlyThr: 3.976 ± 0.07	6.015GlyVal: 6.015 ± 0.084	1.013GlyTrp: 1.013 ± 0.04	2.423GlyTyr: 2.423 ± 0.053	0.005GlyXaa: 0.005 ± 0.003
His	1.919HisAla: 1.919 ± 0.046	0.308HisCys: 0.308 ± 0.018	1.091HisAsp: 1.091 ± 0.032	1.217HisGlu: 1.217 ± 0.037	1.016HisPhe: 1.016 ± 0.03	1.847HisGly: 1.847 ± 0.053	0.606HisHis: 0.606 ± 0.034	1.142HisIle: 1.142 ± 0.037	0.686HisLys: 0.686 ± 0.027	2.749HisLeu: 2.749 ± 0.056	0.451HisMet: 0.451 ± 0.02	0.702HisAsn: 0.702 ± 0.03	1.451HisPro: 1.451 ± 0.042	0.923HisGln: 0.923 ± 0.033	1.511HisArg: 1.511 ± 0.044	1.119HisSer: 1.119 ± 0.037	0.974HisThr: 0.974 ± 0.037	1.24HisVal: 1.24 ± 0.03	0.285HisTrp: 0.285 ± 0.019	0.662HisTyr: 0.662 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.499IleAla: 5.499 ± 0.093	0.669IleCys: 0.669 ± 0.026	3.445IleAsp: 3.445 ± 0.074	3.767IleGlu: 3.767 ± 0.083	2.32IlePhe: 2.32 ± 0.061	4.41IleGly: 4.41 ± 0.071	1.242IleHis: 1.242 ± 0.033	2.714IleIle: 2.714 ± 0.072	1.963IleLys: 1.963 ± 0.054	5.913IleLeu: 5.913 ± 0.097	1.07IleMet: 1.07 ± 0.034	1.94IleAsn: 1.94 ± 0.041	2.612IlePro: 2.612 ± 0.052	1.52IleGln: 1.52 ± 0.043	3.439IleArg: 3.439 ± 0.063	3.273IleSer: 3.273 ± 0.065	2.753IleThr: 2.753 ± 0.059	3.632IleVal: 3.632 ± 0.073	0.496IleTrp: 0.496 ± 0.025	1.372IleTyr: 1.372 ± 0.039	0.001IleXaa: 0.001 ± 0.001
Lys	3.48LysAla: 3.48 ± 0.07	0.328LysCys: 0.328 ± 0.021	2.072LysAsp: 2.072 ± 0.049	2.581LysGlu: 2.581 ± 0.064	1.186LysPhe: 1.186 ± 0.041	2.864LysGly: 2.864 ± 0.064	0.686LysHis: 0.686 ± 0.028	2.558LysIle: 2.558 ± 0.063	2.444LysLys: 2.444 ± 0.072	3.461LysLeu: 3.461 ± 0.066	1.017LysMet: 1.017 ± 0.036	1.406LysAsn: 1.406 ± 0.047	1.662LysPro: 1.662 ± 0.045	1.25LysGln: 1.25 ± 0.04	2.302LysArg: 2.302 ± 0.051	2.102LysSer: 2.102 ± 0.047	2.012LysThr: 2.012 ± 0.044	2.76LysVal: 2.76 ± 0.059	0.284LysTrp: 0.284 ± 0.017	0.846LysTyr: 0.846 ± 0.033	0.001LysXaa: 0.001 ± 0.001
Leu	12.658LeuAla: 12.658 ± 0.148	1.361LeuCys: 1.361 ± 0.042	6.188LeuAsp: 6.188 ± 0.088	7.448LeuGlu: 7.448 ± 0.111	4.415LeuPhe: 4.415 ± 0.075	8.765LeuGly: 8.765 ± 0.111	2.378LeuHis: 2.378 ± 0.057	5.528LeuIle: 5.528 ± 0.093	4.326LeuLys: 4.326 ± 0.078	12.475LeuLeu: 12.475 ± 0.174	2.377LeuMet: 2.377 ± 0.057	3.064LeuAsn: 3.064 ± 0.054	5.766LeuPro: 5.766 ± 0.09	3.857LeuGln: 3.857 ± 0.065	8.295LeuArg: 8.295 ± 0.121	6.648LeuSer: 6.648 ± 0.097	5.486LeuThr: 5.486 ± 0.076	8.365LeuVal: 8.365 ± 0.109	1.126LeuTrp: 1.126 ± 0.041	2.465LeuTyr: 2.465 ± 0.055	0.001LeuXaa: 0.001 ± 0.001
Met	2.455MetAla: 2.455 ± 0.06	0.167MetCys: 0.167 ± 0.014	1.182MetAsp: 1.182 ± 0.034	1.468MetGlu: 1.468 ± 0.039	0.682MetPhe: 0.682 ± 0.03	1.795MetGly: 1.795 ± 0.047	0.441MetHis: 0.441 ± 0.022	1.191MetIle: 1.191 ± 0.04	1.171MetLys: 1.171 ± 0.037	2.301MetLeu: 2.301 ± 0.049	0.517MetMet: 0.517 ± 0.027	0.832MetAsn: 0.832 ± 0.03	1.196MetPro: 1.196 ± 0.036	0.865MetGln: 0.865 ± 0.028	1.469MetArg: 1.469 ± 0.036	1.327MetSer: 1.327 ± 0.036	1.312MetThr: 1.312 ± 0.037	1.762MetVal: 1.762 ± 0.053	0.151MetTrp: 0.151 ± 0.014	0.357MetTyr: 0.357 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.629AsnAla: 2.629 ± 0.057	0.408AsnCys: 0.408 ± 0.024	1.426AsnAsp: 1.426 ± 0.046	1.528AsnGlu: 1.528 ± 0.038	1.304AsnPhe: 1.304 ± 0.035	1.995AsnGly: 1.995 ± 0.054	0.659AsnHis: 0.659 ± 0.024	1.83AsnIle: 1.83 ± 0.05	0.946AsnLys: 0.946 ± 0.039	3.984AsnLeu: 3.984 ± 0.072	0.607AsnMet: 0.607 ± 0.028	0.965AsnAsn: 0.965 ± 0.043	2.113AsnPro: 2.113 ± 0.049	1.092AsnGln: 1.092 ± 0.032	2.032AsnArg: 2.032 ± 0.054	1.391AsnSer: 1.391 ± 0.04	1.32AsnThr: 1.32 ± 0.045	2.036AsnVal: 2.036 ± 0.054	0.373AsnTrp: 0.373 ± 0.019	0.872AsnTyr: 0.872 ± 0.03	0.002AsnXaa: 0.002 ± 0.002
Pro	4.906ProAla: 4.906 ± 0.082	0.465ProCys: 0.465 ± 0.022	2.924ProAsp: 2.924 ± 0.055	3.942ProGlu: 3.942 ± 0.063	1.982ProPhe: 1.982 ± 0.05	4.228ProGly: 4.228 ± 0.082	1.044ProHis: 1.044 ± 0.032	1.928ProIle: 1.928 ± 0.053	1.314ProLys: 1.314 ± 0.04	5.229ProLeu: 5.229 ± 0.093	0.959ProMet: 0.959 ± 0.028	1.111ProAsn: 1.111 ± 0.034	2.315ProPro: 2.315 ± 0.056	2.139ProGln: 2.139 ± 0.046	2.895ProArg: 2.895 ± 0.061	2.244ProSer: 2.244 ± 0.051	2.123ProThr: 2.123 ± 0.046	3.74ProVal: 3.74 ± 0.074	0.638ProTrp: 0.638 ± 0.029	1.147ProTyr: 1.147 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.207GlnAla: 4.207 ± 0.074	0.316GlnCys: 0.316 ± 0.019	1.763GlnAsp: 1.763 ± 0.042	2.606GlnGlu: 2.606 ± 0.06	1.129GlnPhe: 1.129 ± 0.035	3.371GlnGly: 3.371 ± 0.064	0.654GlnHis: 0.654 ± 0.024	2.162GlnIle: 2.162 ± 0.048	1.539GlnLys: 1.539 ± 0.047	3.398GlnLeu: 3.398 ± 0.065	0.937GlnMet: 0.937 ± 0.033	1.08GlnAsn: 1.08 ± 0.034	1.617GlnPro: 1.617 ± 0.049	1.56GlnGln: 1.56 ± 0.048	2.825GlnArg: 2.825 ± 0.058	1.869GlnSer: 1.869 ± 0.04	1.79GlnThr: 1.79 ± 0.043	3.334GlnVal: 3.334 ± 0.058	0.428GlnTrp: 0.428 ± 0.021	0.73GlnTyr: 0.73 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.077ArgAla: 6.077 ± 0.091	0.815ArgCys: 0.815 ± 0.032	3.887ArgAsp: 3.887 ± 0.062	5.479ArgGlu: 5.479 ± 0.085	3.136ArgPhe: 3.136 ± 0.062	4.758ArgGly: 4.758 ± 0.067	1.73ArgHis: 1.73 ± 0.049	4.419ArgIle: 4.419 ± 0.074	2.747ArgLys: 2.747 ± 0.06	8.41ArgLeu: 8.41 ± 0.106	1.784ArgMet: 1.784 ± 0.047	2.155ArgAsn: 2.155 ± 0.052	3.045ArgPro: 3.045 ± 0.052	2.966ArgGln: 2.966 ± 0.056	5.859ArgArg: 5.859 ± 0.099	3.443ArgSer: 3.443 ± 0.067	3.082ArgThr: 3.082 ± 0.059	4.788ArgVal: 4.788 ± 0.07	0.794ArgTrp: 0.794 ± 0.031	1.91ArgTyr: 1.91 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.205SerAla: 5.205 ± 0.065	0.697SerCys: 0.697 ± 0.035	2.802SerAsp: 2.802 ± 0.057	3.147SerGlu: 3.147 ± 0.053	2.405SerPhe: 2.405 ± 0.056	5.117SerGly: 5.117 ± 0.076	1.129SerHis: 1.129 ± 0.031	2.516SerIle: 2.516 ± 0.057	1.524SerLys: 1.524 ± 0.049	6.392SerLeu: 6.392 ± 0.084	1.178SerMet: 1.178 ± 0.038	1.403SerAsn: 1.403 ± 0.042	2.598SerPro: 2.598 ± 0.051	1.745SerGln: 1.745 ± 0.04	3.721SerArg: 3.721 ± 0.063	2.994SerSer: 2.994 ± 0.062	2.322SerThr: 2.322 ± 0.052	3.464SerVal: 3.464 ± 0.065	0.683SerTrp: 0.683 ± 0.031	1.375SerTyr: 1.375 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.691ThrAla: 4.691 ± 0.068	0.599ThrCys: 0.599 ± 0.025	2.448ThrAsp: 2.448 ± 0.063	2.528ThrGlu: 2.528 ± 0.055	1.948ThrPhe: 1.948 ± 0.043	4.299ThrGly: 4.299 ± 0.078	1.009ThrHis: 1.009 ± 0.035	2.448ThrIle: 2.448 ± 0.051	1.249ThrLys: 1.249 ± 0.041	6.34ThrLeu: 6.34 ± 0.084	0.855ThrMet: 0.855 ± 0.033	1.4ThrAsn: 1.4 ± 0.037	2.772ThrPro: 2.772 ± 0.057	1.599ThrGln: 1.599 ± 0.048	3.14ThrArg: 3.14 ± 0.054	2.505ThrSer: 2.505 ± 0.055	2.528ThrThr: 2.528 ± 0.063	3.248ThrVal: 3.248 ± 0.069	0.554ThrTrp: 0.554 ± 0.026	1.28ThrTyr: 1.28 ± 0.041	0.002ThrXaa: 0.002 ± 0.002
Val	7.564ValAla: 7.564 ± 0.088	0.897ValCys: 0.897 ± 0.028	4.243ValAsp: 4.243 ± 0.081	5.03ValGlu: 5.03 ± 0.076	3.068ValPhe: 3.068 ± 0.062	5.426ValGly: 5.426 ± 0.078	1.524ValHis: 1.524 ± 0.041	3.984ValIle: 3.984 ± 0.074	2.562ValLys: 2.562 ± 0.064	7.808ValLeu: 7.808 ± 0.1	1.586ValMet: 1.586 ± 0.044	2.125ValAsn: 2.125 ± 0.05	3.28ValPro: 3.28 ± 0.058	2.388ValGln: 2.388 ± 0.05	5.156ValArg: 5.156 ± 0.08	3.945ValSer: 3.945 ± 0.065	3.542ValThr: 3.542 ± 0.061	5.983ValVal: 5.983 ± 0.115	0.689ValTrp: 0.689 ± 0.028	1.672ValTyr: 1.672 ± 0.047	0.004ValXaa: 0.004 ± 0.002
Trp	0.898TrpAla: 0.898 ± 0.033	0.112TrpCys: 0.112 ± 0.01	0.598TrpAsp: 0.598 ± 0.026	0.688TrpGlu: 0.688 ± 0.027	0.45TrpPhe: 0.45 ± 0.023	0.801TrpGly: 0.801 ± 0.032	0.292TrpHis: 0.292 ± 0.019	0.52TrpIle: 0.52 ± 0.022	0.374TrpLys: 0.374 ± 0.023	1.278TrpLeu: 1.278 ± 0.041	0.259TrpMet: 0.259 ± 0.018	0.375TrpAsn: 0.375 ± 0.022	0.501TrpPro: 0.501 ± 0.025	0.633TrpGln: 0.633 ± 0.028	0.924TrpArg: 0.924 ± 0.038	0.637TrpSer: 0.637 ± 0.032	0.459TrpThr: 0.459 ± 0.023	0.738TrpVal: 0.738 ± 0.03	0.169TrpTrp: 0.169 ± 0.014	0.289TrpTyr: 0.289 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.298TyrAla: 2.298 ± 0.056	0.341TyrCys: 0.341 ± 0.017	1.397TyrAsp: 1.397 ± 0.052	1.398TyrGlu: 1.398 ± 0.035	1.335TyrPhe: 1.335 ± 0.039	2.012TyrGly: 2.012 ± 0.049	0.618TyrHis: 0.618 ± 0.026	1.046TyrIle: 1.046 ± 0.038	0.665TyrLys: 0.665 ± 0.027	3.189TyrLeu: 3.189 ± 0.064	0.404TyrMet: 0.404 ± 0.021	0.759TyrAsn: 0.759 ± 0.026	1.272TyrPro: 1.272 ± 0.035	1.107TyrGln: 1.107 ± 0.038	2.194TyrArg: 2.194 ± 0.053	1.293TyrSer: 1.293 ± 0.038	1.069TyrThr: 1.069 ± 0.034	1.621TyrVal: 1.621 ± 0.041	0.309TyrTrp: 0.309 ± 0.02	0.786TyrTyr: 0.786 ± 0.033	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.002	0.001XaaCys: 0.001 ± 0.001	0.003XaaAsp: 0.003 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.003XaaPhe: 0.003 ± 0.002	0.004XaaGly: 0.004 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.002	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.002XaaVal: 0.002 ± 0.003	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2928 proteins (946041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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