Amino acid dipepetide frequency for Hyperthermophilic Archaeal Virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.415AlaAla: 2.415 ± 0.691
1.672AlaCys: 1.672 ± 0.635
2.787AlaAsp: 2.787 ± 0.674
5.016AlaGlu: 5.016 ± 1.377
2.043AlaPhe: 2.043 ± 0.815
5.945AlaGly: 5.945 ± 1.086
0.929AlaHis: 0.929 ± 0.487
3.901AlaIle: 3.901 ± 1.14
2.601AlaLys: 2.601 ± 1.021
8.36AlaLeu: 8.36 ± 0.65
1.3AlaMet: 1.3 ± 0.308
2.229AlaAsn: 2.229 ± 0.7
3.344AlaPro: 3.344 ± 0.757
1.115AlaGln: 1.115 ± 0.592
3.715AlaArg: 3.715 ± 0.928
7.059AlaSer: 7.059 ± 1.159
7.059AlaThr: 7.059 ± 1.921
8.545AlaVal: 8.545 ± 1.411
1.115AlaTrp: 1.115 ± 0.497
5.759AlaTyr: 5.759 ± 0.501
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.372CysAsp: 0.372 ± 0.155
0.186CysGlu: 0.186 ± 0.13
0.186CysPhe: 0.186 ± 0.193
1.115CysGly: 1.115 ± 0.334
0.0CysHis: 0.0 ± 0.0
0.557CysIle: 0.557 ± 0.313
0.186CysLys: 0.186 ± 0.224
0.743CysLeu: 0.743 ± 0.506
0.186CysMet: 0.186 ± 0.329
0.186CysAsn: 0.186 ± 0.214
0.743CysPro: 0.743 ± 0.279
0.186CysGln: 0.186 ± 0.191
0.372CysArg: 0.372 ± 0.19
1.3CysSer: 1.3 ± 0.5
0.557CysThr: 0.557 ± 0.372
0.186CysVal: 0.186 ± 0.193
0.186CysTrp: 0.186 ± 0.193
0.186CysTyr: 0.186 ± 0.203
0.0CysXaa: 0.0 ± 0.0
Asp
2.601AspAla: 2.601 ± 0.803
0.186AspCys: 0.186 ± 0.208
1.115AspAsp: 1.115 ± 0.383
3.53AspGlu: 3.53 ± 1.266
1.672AspPhe: 1.672 ± 0.671
2.972AspGly: 2.972 ± 1.547
0.743AspHis: 0.743 ± 0.629
2.972AspIle: 2.972 ± 1.129
2.229AspLys: 2.229 ± 0.703
3.158AspLeu: 3.158 ± 0.729
0.743AspMet: 0.743 ± 0.25
1.3AspAsn: 1.3 ± 0.409
1.486AspPro: 1.486 ± 0.466
0.743AspGln: 0.743 ± 0.406
2.415AspArg: 2.415 ± 0.635
2.787AspSer: 2.787 ± 0.601
2.972AspThr: 2.972 ± 0.873
4.644AspVal: 4.644 ± 1.044
0.372AspTrp: 0.372 ± 0.293
2.601AspTyr: 2.601 ± 0.829
0.0AspXaa: 0.0 ± 0.0
Glu
4.83GluAla: 4.83 ± 1.713
0.929GluCys: 0.929 ± 0.437
2.229GluAsp: 2.229 ± 0.752
4.644GluGlu: 4.644 ± 1.988
2.043GluPhe: 2.043 ± 0.552
3.344GluGly: 3.344 ± 1.194
0.929GluHis: 0.929 ± 0.655
4.83GluIle: 4.83 ± 1.817
4.644GluLys: 4.644 ± 2.079
6.688GluLeu: 6.688 ± 2.657
0.557GluMet: 0.557 ± 0.42
0.743GluAsn: 0.743 ± 0.395
2.972GluPro: 2.972 ± 0.783
2.043GluGln: 2.043 ± 0.703
2.415GluArg: 2.415 ± 0.991
3.715GluSer: 3.715 ± 0.654
0.743GluThr: 0.743 ± 0.417
4.83GluVal: 4.83 ± 1.25
1.3GluTrp: 1.3 ± 0.497
2.229GluTyr: 2.229 ± 0.739
0.0GluXaa: 0.0 ± 0.0
Phe
1.858PheAla: 1.858 ± 0.441
0.186PheCys: 0.186 ± 0.193
1.858PheAsp: 1.858 ± 0.462
2.601PheGlu: 2.601 ± 0.783
1.858PhePhe: 1.858 ± 0.491
1.858PheGly: 1.858 ± 0.66
0.186PheHis: 0.186 ± 0.13
3.715PheIle: 3.715 ± 0.732
2.415PheLys: 2.415 ± 0.98
2.043PheLeu: 2.043 ± 0.773
0.372PheMet: 0.372 ± 0.304
2.229PheAsn: 2.229 ± 0.599
2.229PhePro: 2.229 ± 0.545
0.372PheGln: 0.372 ± 0.232
2.043PheArg: 2.043 ± 0.588
2.415PheSer: 2.415 ± 0.778
3.344PheThr: 3.344 ± 0.916
2.043PheVal: 2.043 ± 1.074
0.186PheTrp: 0.186 ± 0.193
1.486PheTyr: 1.486 ± 0.502
0.0PheXaa: 0.0 ± 0.0
Gly
4.83GlyAla: 4.83 ± 1.131
0.0GlyCys: 0.0 ± 0.0
2.601GlyAsp: 2.601 ± 0.648
2.972GlyGlu: 2.972 ± 0.866
3.158GlyPhe: 3.158 ± 0.959
5.016GlyGly: 5.016 ± 1.061
0.743GlyHis: 0.743 ± 0.429
6.13GlyIle: 6.13 ± 1.219
3.344GlyLys: 3.344 ± 1.47
7.988GlyLeu: 7.988 ± 1.029
0.929GlyMet: 0.929 ± 0.436
3.53GlyAsn: 3.53 ± 1.301
1.486GlyPro: 1.486 ± 0.396
1.3GlyGln: 1.3 ± 0.413
3.53GlyArg: 3.53 ± 0.931
6.688GlySer: 6.688 ± 2.341
4.458GlyThr: 4.458 ± 1.861
8.36GlyVal: 8.36 ± 1.095
1.672GlyTrp: 1.672 ± 0.426
3.344GlyTyr: 3.344 ± 1.071
0.0GlyXaa: 0.0 ± 0.0
His
1.3HisAla: 1.3 ± 0.387
0.0HisCys: 0.0 ± 0.0
0.186HisAsp: 0.186 ± 0.157
0.743HisGlu: 0.743 ± 0.322
0.372HisPhe: 0.372 ± 0.155
1.115HisGly: 1.115 ± 0.551
0.372HisHis: 0.372 ± 0.257
1.115HisIle: 1.115 ± 0.481
0.372HisLys: 0.372 ± 0.244
2.043HisLeu: 2.043 ± 0.758
0.372HisMet: 0.372 ± 0.155
0.557HisAsn: 0.557 ± 0.25
0.743HisPro: 0.743 ± 0.322
0.0HisGln: 0.0 ± 0.0
0.929HisArg: 0.929 ± 0.58
0.743HisSer: 0.743 ± 0.31
0.929HisThr: 0.929 ± 0.361
1.858HisVal: 1.858 ± 0.858
0.0HisTrp: 0.0 ± 0.0
0.743HisTyr: 0.743 ± 0.465
0.0HisXaa: 0.0 ± 0.0
Ile
5.202IleAla: 5.202 ± 0.992
0.372IleCys: 0.372 ± 0.202
3.715IleAsp: 3.715 ± 0.746
2.601IleGlu: 2.601 ± 1.048
1.3IlePhe: 1.3 ± 0.429
4.087IleGly: 4.087 ± 1.007
1.672IleHis: 1.672 ± 0.685
4.273IleIle: 4.273 ± 1.472
1.672IleLys: 1.672 ± 0.801
3.715IleLeu: 3.715 ± 1.421
1.115IleMet: 1.115 ± 0.572
2.972IleAsn: 2.972 ± 1.111
3.53IlePro: 3.53 ± 0.759
1.486IleGln: 1.486 ± 0.764
2.972IleArg: 2.972 ± 1.005
4.087IleSer: 4.087 ± 0.63
3.53IleThr: 3.53 ± 0.901
5.202IleVal: 5.202 ± 1.024
0.372IleTrp: 0.372 ± 0.19
2.229IleTyr: 2.229 ± 0.427
0.0IleXaa: 0.0 ± 0.0
Lys
5.387LysAla: 5.387 ± 1.877
0.557LysCys: 0.557 ± 0.449
0.929LysAsp: 0.929 ± 0.48
2.229LysGlu: 2.229 ± 1.213
0.557LysPhe: 0.557 ± 0.416
2.787LysGly: 2.787 ± 0.839
2.043LysHis: 2.043 ± 0.798
0.929LysIle: 0.929 ± 0.601
2.787LysLys: 2.787 ± 1.253
4.458LysLeu: 4.458 ± 1.094
1.486LysMet: 1.486 ± 0.745
2.043LysAsn: 2.043 ± 0.704
4.458LysPro: 4.458 ± 1.222
1.115LysGln: 1.115 ± 0.652
2.415LysArg: 2.415 ± 1.069
2.043LysSer: 2.043 ± 0.677
4.087LysThr: 4.087 ± 0.979
3.53LysVal: 3.53 ± 1.178
1.486LysTrp: 1.486 ± 0.546
4.087LysTyr: 4.087 ± 1.084
0.0LysXaa: 0.0 ± 0.0
Leu
8.174LeuAla: 8.174 ± 1.191
0.743LeuCys: 0.743 ± 0.525
5.573LeuAsp: 5.573 ± 1.147
6.502LeuGlu: 6.502 ± 2.449
3.158LeuPhe: 3.158 ± 0.519
5.945LeuGly: 5.945 ± 1.003
1.672LeuHis: 1.672 ± 0.588
5.202LeuIle: 5.202 ± 0.989
6.873LeuLys: 6.873 ± 2.19
9.289LeuLeu: 9.289 ± 1.686
0.929LeuMet: 0.929 ± 0.435
4.273LeuAsn: 4.273 ± 1.024
5.202LeuPro: 5.202 ± 1.446
1.858LeuGln: 1.858 ± 0.363
5.387LeuArg: 5.387 ± 0.924
5.945LeuSer: 5.945 ± 1.222
5.945LeuThr: 5.945 ± 1.238
12.632LeuVal: 12.632 ± 1.781
1.486LeuTrp: 1.486 ± 0.469
3.715LeuTyr: 3.715 ± 1.025
0.0LeuXaa: 0.0 ± 0.0
Met
1.486MetAla: 1.486 ± 0.392
0.186MetCys: 0.186 ± 0.329
0.929MetAsp: 0.929 ± 0.476
1.115MetGlu: 1.115 ± 0.449
0.372MetPhe: 0.372 ± 0.278
0.743MetGly: 0.743 ± 0.42
0.557MetHis: 0.557 ± 0.397
0.929MetIle: 0.929 ± 0.347
1.115MetLys: 1.115 ± 0.424
2.415MetLeu: 2.415 ± 0.556
0.372MetMet: 0.372 ± 0.327
0.0MetAsn: 0.0 ± 0.0
1.115MetPro: 1.115 ± 0.368
0.186MetGln: 0.186 ± 0.193
1.3MetArg: 1.3 ± 0.589
1.858MetSer: 1.858 ± 1.052
0.372MetThr: 0.372 ± 0.217
1.3MetVal: 1.3 ± 0.415
0.186MetTrp: 0.186 ± 0.191
0.929MetTyr: 0.929 ± 0.451
0.0MetXaa: 0.0 ± 0.0
Asn
3.53AsnAla: 3.53 ± 1.005
0.557AsnCys: 0.557 ± 0.334
1.858AsnAsp: 1.858 ± 0.496
1.3AsnGlu: 1.3 ± 0.677
0.743AsnPhe: 0.743 ± 0.342
5.202AsnGly: 5.202 ± 1.884
0.372AsnHis: 0.372 ± 0.217
2.415AsnIle: 2.415 ± 0.73
1.858AsnLys: 1.858 ± 0.857
3.158AsnLeu: 3.158 ± 0.735
0.929AsnMet: 0.929 ± 0.552
2.229AsnAsn: 2.229 ± 0.886
2.415AsnPro: 2.415 ± 0.592
0.557AsnGln: 0.557 ± 0.31
1.672AsnArg: 1.672 ± 0.436
2.601AsnSer: 2.601 ± 0.87
2.043AsnThr: 2.043 ± 1.121
2.415AsnVal: 2.415 ± 0.822
0.0AsnTrp: 0.0 ± 0.0
2.601AsnTyr: 2.601 ± 0.726
0.0AsnXaa: 0.0 ± 0.0
Pro
4.644ProAla: 4.644 ± 0.638
0.372ProCys: 0.372 ± 0.376
2.229ProAsp: 2.229 ± 0.549
3.158ProGlu: 3.158 ± 1.011
2.229ProPhe: 2.229 ± 0.402
5.573ProGly: 5.573 ± 0.883
0.929ProHis: 0.929 ± 0.382
1.672ProIle: 1.672 ± 0.555
1.486ProLys: 1.486 ± 0.965
5.945ProLeu: 5.945 ± 1.525
0.186ProMet: 0.186 ± 0.283
1.3ProAsn: 1.3 ± 0.413
3.901ProPro: 3.901 ± 0.654
0.929ProGln: 0.929 ± 0.366
2.601ProArg: 2.601 ± 0.5
4.087ProSer: 4.087 ± 0.874
1.672ProThr: 1.672 ± 0.441
5.945ProVal: 5.945 ± 1.323
0.743ProTrp: 0.743 ± 0.441
1.486ProTyr: 1.486 ± 0.427
0.0ProXaa: 0.0 ± 0.0
Gln
2.415GlnAla: 2.415 ± 0.666
0.0GlnCys: 0.0 ± 0.0
0.557GlnAsp: 0.557 ± 0.41
1.115GlnGlu: 1.115 ± 0.499
0.372GlnPhe: 0.372 ± 0.296
1.115GlnGly: 1.115 ± 0.314
0.0GlnHis: 0.0 ± 0.0
0.557GlnIle: 0.557 ± 0.376
0.186GlnLys: 0.186 ± 0.279
2.601GlnLeu: 2.601 ± 0.663
0.186GlnMet: 0.186 ± 0.13
0.557GlnAsn: 0.557 ± 0.323
1.858GlnPro: 1.858 ± 0.452
0.557GlnGln: 0.557 ± 0.344
0.929GlnArg: 0.929 ± 0.342
1.486GlnSer: 1.486 ± 0.37
0.743GlnThr: 0.743 ± 0.332
2.787GlnVal: 2.787 ± 0.504
0.372GlnTrp: 0.372 ± 0.222
1.858GlnTyr: 1.858 ± 0.546
0.0GlnXaa: 0.0 ± 0.0
Arg
2.601ArgAla: 2.601 ± 1.077
0.929ArgCys: 0.929 ± 0.512
2.972ArgAsp: 2.972 ± 0.73
3.53ArgGlu: 3.53 ± 1.233
3.158ArgPhe: 3.158 ± 0.507
4.087ArgGly: 4.087 ± 1.332
0.557ArgHis: 0.557 ± 0.411
4.087ArgIle: 4.087 ± 0.656
2.972ArgLys: 2.972 ± 1.101
5.945ArgLeu: 5.945 ± 0.831
0.743ArgMet: 0.743 ± 0.371
1.115ArgAsn: 1.115 ± 0.676
1.486ArgPro: 1.486 ± 0.538
1.858ArgGln: 1.858 ± 0.48
3.901ArgArg: 3.901 ± 2.195
2.972ArgSer: 2.972 ± 0.73
3.158ArgThr: 3.158 ± 0.794
4.644ArgVal: 4.644 ± 0.824
0.557ArgTrp: 0.557 ± 0.366
3.344ArgTyr: 3.344 ± 0.716
0.186ArgXaa: 0.186 ± 0.258
Ser
6.13SerAla: 6.13 ± 1.299
0.557SerCys: 0.557 ± 0.261
2.229SerAsp: 2.229 ± 0.674
4.83SerGlu: 4.83 ± 1.012
3.715SerPhe: 3.715 ± 0.962
5.573SerGly: 5.573 ± 1.965
0.557SerHis: 0.557 ± 0.273
3.53SerIle: 3.53 ± 0.813
3.53SerLys: 3.53 ± 1.01
7.617SerLeu: 7.617 ± 1.323
2.601SerMet: 2.601 ± 0.422
2.601SerAsn: 2.601 ± 0.959
4.644SerPro: 4.644 ± 0.729
2.415SerGln: 2.415 ± 0.678
4.644SerArg: 4.644 ± 0.981
6.873SerSer: 6.873 ± 1.179
5.945SerThr: 5.945 ± 1.503
7.059SerVal: 7.059 ± 1.354
1.115SerTrp: 1.115 ± 0.368
4.273SerTyr: 4.273 ± 1.566
0.0SerXaa: 0.0 ± 0.0
Thr
5.945ThrAla: 5.945 ± 1.327
0.0ThrCys: 0.0 ± 0.0
1.672ThrAsp: 1.672 ± 0.678
1.672ThrGlu: 1.672 ± 0.577
0.929ThrPhe: 0.929 ± 0.382
6.502ThrGly: 6.502 ± 1.346
0.186ThrHis: 0.186 ± 0.157
2.229ThrIle: 2.229 ± 0.704
1.672ThrLys: 1.672 ± 0.654
8.174ThrLeu: 8.174 ± 2.3
1.486ThrMet: 1.486 ± 0.64
1.486ThrAsn: 1.486 ± 0.867
3.158ThrPro: 3.158 ± 0.623
0.743ThrGln: 0.743 ± 0.318
4.273ThrArg: 4.273 ± 0.93
6.688ThrSer: 6.688 ± 1.875
2.415ThrThr: 2.415 ± 1.022
7.245ThrVal: 7.245 ± 2.029
1.115ThrTrp: 1.115 ± 0.599
2.229ThrTyr: 2.229 ± 0.791
0.0ThrXaa: 0.0 ± 0.0
Val
8.731ValAla: 8.731 ± 1.672
0.186ValCys: 0.186 ± 0.13
4.087ValAsp: 4.087 ± 0.656
5.387ValGlu: 5.387 ± 1.537
4.83ValPhe: 4.83 ± 0.997
4.644ValGly: 4.644 ± 1.093
1.486ValHis: 1.486 ± 0.495
3.715ValIle: 3.715 ± 0.94
6.316ValLys: 6.316 ± 1.281
9.474ValLeu: 9.474 ± 1.234
0.743ValMet: 0.743 ± 0.512
5.945ValAsn: 5.945 ± 1.066
3.901ValPro: 3.901 ± 0.994
1.3ValGln: 1.3 ± 0.377
5.202ValArg: 5.202 ± 0.967
9.846ValSer: 9.846 ± 2.109
4.458ValThr: 4.458 ± 1.059
7.988ValVal: 7.988 ± 1.838
2.043ValTrp: 2.043 ± 0.684
7.059ValTyr: 7.059 ± 2.253
0.0ValXaa: 0.0 ± 0.0
Trp
0.557TrpAla: 0.557 ± 0.302
0.0TrpCys: 0.0 ± 0.0
0.929TrpAsp: 0.929 ± 0.391
1.3TrpGlu: 1.3 ± 0.509
0.557TrpPhe: 0.557 ± 0.239
0.743TrpGly: 0.743 ± 0.287
0.372TrpHis: 0.372 ± 0.26
0.929TrpIle: 0.929 ± 0.48
0.557TrpLys: 0.557 ± 0.326
2.229TrpLeu: 2.229 ± 0.742
0.186TrpMet: 0.186 ± 0.13
0.557TrpAsn: 0.557 ± 0.283
0.0TrpPro: 0.0 ± 0.0
0.186TrpGln: 0.186 ± 0.13
1.3TrpArg: 1.3 ± 0.651
1.3TrpSer: 1.3 ± 0.348
1.486TrpThr: 1.486 ± 0.73
1.486TrpVal: 1.486 ± 0.618
0.557TrpTrp: 0.557 ± 0.262
0.743TrpTyr: 0.743 ± 0.336
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.273TyrAla: 4.273 ± 0.605
0.0TyrCys: 0.0 ± 0.0
2.415TyrAsp: 2.415 ± 0.73
2.229TyrGlu: 2.229 ± 0.785
2.043TyrPhe: 2.043 ± 0.613
3.715TyrGly: 3.715 ± 1.382
0.186TyrHis: 0.186 ± 0.157
2.415TyrIle: 2.415 ± 0.74
2.601TyrLys: 2.601 ± 0.908
4.273TyrLeu: 4.273 ± 0.831
1.858TyrMet: 1.858 ± 0.386
2.601TyrAsn: 2.601 ± 0.776
2.601TyrPro: 2.601 ± 0.682
1.3TyrGln: 1.3 ± 0.309
2.787TyrArg: 2.787 ± 0.719
5.945TyrSer: 5.945 ± 1.764
3.901TyrThr: 3.901 ± 1.553
4.644TyrVal: 4.644 ± 1.347
1.115TyrTrp: 1.115 ± 0.623
3.158TyrTyr: 3.158 ± 1.259
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.186XaaLeu: 0.186 ± 0.258
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (5384 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski