Amino acid dipepetide frequency for Marinobacterium aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.222AlaAla: 12.222 ± 0.106	1.264AlaCys: 1.264 ± 0.034	5.992AlaAsp: 5.992 ± 0.098	6.285AlaGlu: 6.285 ± 0.07	3.758AlaPhe: 3.758 ± 0.05	8.829AlaGly: 8.829 ± 0.092	1.93AlaHis: 1.93 ± 0.036	5.488AlaIle: 5.488 ± 0.071	3.037AlaLys: 3.037 ± 0.047	13.438AlaLeu: 13.438 ± 0.123	2.847AlaMet: 2.847 ± 0.046	2.671AlaAsn: 2.671 ± 0.051	4.345AlaPro: 4.345 ± 0.062	5.105AlaGln: 5.105 ± 0.064	6.85AlaArg: 6.85 ± 0.08	6.007AlaSer: 6.007 ± 0.067	4.87AlaThr: 4.87 ± 0.077	7.32AlaVal: 7.32 ± 0.082	1.328AlaTrp: 1.328 ± 0.037	2.334AlaTyr: 2.334 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.128CysAla: 1.128 ± 0.033	0.2CysCys: 0.2 ± 0.013	0.674CysAsp: 0.674 ± 0.023	0.652CysGlu: 0.652 ± 0.023	0.399CysPhe: 0.399 ± 0.017	1.084CysGly: 1.084 ± 0.031	0.331CysHis: 0.331 ± 0.015	0.57CysIle: 0.57 ± 0.022	0.295CysLys: 0.295 ± 0.014	1.118CysLeu: 1.118 ± 0.026	0.244CysMet: 0.244 ± 0.014	0.332CysAsn: 0.332 ± 0.016	0.516CysPro: 0.516 ± 0.023	0.439CysGln: 0.439 ± 0.017	0.69CysArg: 0.69 ± 0.022	0.708CysSer: 0.708 ± 0.019	0.547CysThr: 0.547 ± 0.021	0.735CysVal: 0.735 ± 0.026	0.174CysTrp: 0.174 ± 0.011	0.328CysTyr: 0.328 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.025AspAla: 6.025 ± 0.071	0.587AspCys: 0.587 ± 0.017	3.089AspAsp: 3.089 ± 0.082	3.466AspGlu: 3.466 ± 0.06	2.237AspPhe: 2.237 ± 0.04	4.236AspGly: 4.236 ± 0.096	1.137AspHis: 1.137 ± 0.028	3.414AspIle: 3.414 ± 0.057	1.893AspLys: 1.893 ± 0.04	5.83AspLeu: 5.83 ± 0.084	1.436AspMet: 1.436 ± 0.033	1.79AspAsn: 1.79 ± 0.041	2.746AspPro: 2.746 ± 0.044	2.308AspGln: 2.308 ± 0.042	3.233AspArg: 3.233 ± 0.05	3.409AspSer: 3.409 ± 0.065	2.821AspThr: 2.821 ± 0.068	3.508AspVal: 3.508 ± 0.058	0.972AspTrp: 0.972 ± 0.027	1.87AspTyr: 1.87 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.209GluAla: 6.209 ± 0.073	0.47GluCys: 0.47 ± 0.018	2.638GluAsp: 2.638 ± 0.045	2.807GluGlu: 2.807 ± 0.045	1.936GluPhe: 1.936 ± 0.034	3.799GluGly: 3.799 ± 0.049	1.433GluHis: 1.433 ± 0.032	3.05GluIle: 3.05 ± 0.039	2.104GluLys: 2.104 ± 0.047	7.221GluLeu: 7.221 ± 0.075	1.428GluMet: 1.428 ± 0.034	1.708GluAsn: 1.708 ± 0.037	2.44GluPro: 2.44 ± 0.05	3.782GluGln: 3.782 ± 0.057	4.358GluArg: 4.358 ± 0.061	3.08GluSer: 3.08 ± 0.055	2.79GluThr: 2.79 ± 0.046	4.111GluVal: 4.111 ± 0.064	0.613GluTrp: 0.613 ± 0.022	1.374GluTyr: 1.374 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.636PheAla: 3.636 ± 0.052	0.541PheCys: 0.541 ± 0.017	2.618PheAsp: 2.618 ± 0.041	2.332PheGlu: 2.332 ± 0.041	1.508PhePhe: 1.508 ± 0.038	3.498PheGly: 3.498 ± 0.052	0.79PheHis: 0.79 ± 0.024	1.98PheIle: 1.98 ± 0.038	1.239PheLys: 1.239 ± 0.03	3.167PheLeu: 3.167 ± 0.057	0.966PheMet: 0.966 ± 0.031	1.375PheAsn: 1.375 ± 0.029	1.403PhePro: 1.403 ± 0.032	1.105PheGln: 1.105 ± 0.028	1.949PheArg: 1.949 ± 0.034	2.789PheSer: 2.789 ± 0.041	1.835PheThr: 1.835 ± 0.038	2.806PheVal: 2.806 ± 0.048	0.533PheTrp: 0.533 ± 0.019	1.133PheTyr: 1.133 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.475GlyAla: 7.475 ± 0.081	1.066GlyCys: 1.066 ± 0.028	4.2GlyAsp: 4.2 ± 0.075	4.481GlyGlu: 4.481 ± 0.067	3.421GlyPhe: 3.421 ± 0.053	6.062GlyGly: 6.062 ± 0.092	1.818GlyHis: 1.818 ± 0.039	4.858GlyIle: 4.858 ± 0.067	2.9GlyLys: 2.9 ± 0.047	9.202GlyLeu: 9.202 ± 0.096	2.247GlyMet: 2.247 ± 0.043	2.333GlyAsn: 2.333 ± 0.062	2.602GlyPro: 2.602 ± 0.05	3.331GlyGln: 3.331 ± 0.05	4.619GlyArg: 4.619 ± 0.064	4.665GlySer: 4.665 ± 0.091	3.925GlyThr: 3.925 ± 0.061	5.825GlyVal: 5.825 ± 0.071	1.248GlyTrp: 1.248 ± 0.03	2.561GlyTyr: 2.561 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.954HisAla: 1.954 ± 0.04	0.359HisCys: 0.359 ± 0.016	1.09HisAsp: 1.09 ± 0.027	1.151HisGlu: 1.151 ± 0.03	1.004HisPhe: 1.004 ± 0.025	1.663HisGly: 1.663 ± 0.034	0.589HisHis: 0.589 ± 0.019	1.192HisIle: 1.192 ± 0.026	0.672HisLys: 0.672 ± 0.023	2.36HisLeu: 2.36 ± 0.043	0.541HisMet: 0.541 ± 0.018	0.692HisAsn: 0.692 ± 0.023	1.363HisPro: 1.363 ± 0.03	1.024HisGln: 1.024 ± 0.027	1.503HisArg: 1.503 ± 0.034	1.398HisSer: 1.398 ± 0.035	0.9HisThr: 0.9 ± 0.025	1.195HisVal: 1.195 ± 0.035	0.428HisTrp: 0.428 ± 0.017	0.78HisTyr: 0.78 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.019IleAla: 6.019 ± 0.07	0.669IleCys: 0.669 ± 0.021	3.66IleAsp: 3.66 ± 0.046	3.812IleGlu: 3.812 ± 0.056	1.715IlePhe: 1.715 ± 0.043	4.588IleGly: 4.588 ± 0.066	1.011IleHis: 1.011 ± 0.027	2.563IleIle: 2.563 ± 0.051	1.842IleLys: 1.842 ± 0.038	4.922IleLeu: 4.922 ± 0.068	1.122IleMet: 1.122 ± 0.031	1.965IleAsn: 1.965 ± 0.038	2.48IlePro: 2.48 ± 0.047	1.794IleGln: 1.794 ± 0.035	3.359IleArg: 3.359 ± 0.054	3.62IleSer: 3.62 ± 0.052	2.757IleThr: 2.757 ± 0.047	3.308IleVal: 3.308 ± 0.052	0.606IleTrp: 0.606 ± 0.018	1.333IleTyr: 1.333 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.586LysAla: 3.586 ± 0.054	0.217LysCys: 0.217 ± 0.012	1.683LysAsp: 1.683 ± 0.039	1.505LysGlu: 1.505 ± 0.037	0.859LysPhe: 0.859 ± 0.025	2.437LysGly: 2.437 ± 0.047	0.667LysHis: 0.667 ± 0.02	1.62LysIle: 1.62 ± 0.038	1.366LysLys: 1.366 ± 0.035	3.497LysLeu: 3.497 ± 0.045	0.851LysMet: 0.851 ± 0.028	1.002LysAsn: 1.002 ± 0.027	1.766LysPro: 1.766 ± 0.037	1.534LysGln: 1.534 ± 0.035	2.184LysArg: 2.184 ± 0.047	1.909LysSer: 1.909 ± 0.035	1.881LysThr: 1.881 ± 0.04	2.454LysVal: 2.454 ± 0.045	0.324LysTrp: 0.324 ± 0.017	0.751LysTyr: 0.751 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.84LeuAla: 12.84 ± 0.108	1.392LeuCys: 1.392 ± 0.033	6.739LeuAsp: 6.739 ± 0.076	6.843LeuGlu: 6.843 ± 0.081	4.33LeuPhe: 4.33 ± 0.062	9.025LeuGly: 9.025 ± 0.103	2.419LeuHis: 2.419 ± 0.044	6.015LeuIle: 6.015 ± 0.076	4.068LeuLys: 4.068 ± 0.062	13.789LeuLeu: 13.789 ± 0.163	3.068LeuMet: 3.068 ± 0.051	3.713LeuAsn: 3.713 ± 0.058	5.686LeuPro: 5.686 ± 0.074	5.478LeuGln: 5.478 ± 0.079	6.925LeuArg: 6.925 ± 0.073	7.86LeuSer: 7.86 ± 0.088	5.303LeuThr: 5.303 ± 0.076	7.982LeuVal: 7.982 ± 0.086	1.377LeuTrp: 1.377 ± 0.034	2.724LeuTyr: 2.724 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.885MetAla: 2.885 ± 0.045	0.188MetCys: 0.188 ± 0.011	1.199MetAsp: 1.199 ± 0.032	1.172MetGlu: 1.172 ± 0.031	0.776MetPhe: 0.776 ± 0.025	1.858MetGly: 1.858 ± 0.033	0.523MetHis: 0.523 ± 0.02	1.321MetIle: 1.321 ± 0.035	1.007MetLys: 1.007 ± 0.027	3.007MetLeu: 3.007 ± 0.049	0.691MetMet: 0.691 ± 0.025	0.855MetAsn: 0.855 ± 0.023	1.355MetPro: 1.355 ± 0.029	1.259MetGln: 1.259 ± 0.031	1.418MetArg: 1.418 ± 0.03	1.766MetSer: 1.766 ± 0.036	1.572MetThr: 1.572 ± 0.035	1.732MetVal: 1.732 ± 0.037	0.162MetTrp: 0.162 ± 0.01	0.373MetTyr: 0.373 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.035AsnAla: 3.035 ± 0.05	0.366AsnCys: 0.366 ± 0.017	1.642AsnAsp: 1.642 ± 0.042	1.472AsnGlu: 1.472 ± 0.029	1.089AsnPhe: 1.089 ± 0.028	2.526AsnGly: 2.526 ± 0.062	0.63AsnHis: 0.63 ± 0.022	1.768AsnIle: 1.768 ± 0.038	0.933AsnLys: 0.933 ± 0.031	3.396AsnLeu: 3.396 ± 0.051	0.71AsnMet: 0.71 ± 0.023	1.009AsnAsn: 1.009 ± 0.029	1.967AsnPro: 1.967 ± 0.038	1.188AsnGln: 1.188 ± 0.031	2.005AsnArg: 2.005 ± 0.042	1.777AsnSer: 1.777 ± 0.035	1.555AsnThr: 1.555 ± 0.033	1.799AsnVal: 1.799 ± 0.038	0.467AsnTrp: 0.467 ± 0.019	0.836AsnTyr: 0.836 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.332ProAla: 5.332 ± 0.064	0.421ProCys: 0.421 ± 0.023	3.011ProAsp: 3.011 ± 0.047	3.343ProGlu: 3.343 ± 0.049	1.763ProPhe: 1.763 ± 0.034	4.047ProGly: 4.047 ± 0.063	0.963ProHis: 0.963 ± 0.027	1.989ProIle: 1.989 ± 0.041	1.249ProLys: 1.249 ± 0.034	5.287ProLeu: 5.287 ± 0.068	1.146ProMet: 1.146 ± 0.028	1.25ProAsn: 1.25 ± 0.034	1.697ProPro: 1.697 ± 0.041	2.093ProGln: 2.093 ± 0.04	2.349ProArg: 2.349 ± 0.045	2.381ProSer: 2.381 ± 0.043	1.943ProThr: 1.943 ± 0.041	3.866ProVal: 3.866 ± 0.054	0.663ProTrp: 0.663 ± 0.023	1.162ProTyr: 1.162 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	5.603GlnAla: 5.603 ± 0.072	0.388GlnCys: 0.388 ± 0.015	2.185GlnAsp: 2.185 ± 0.035	2.133GlnGlu: 2.133 ± 0.045	1.402GlnPhe: 1.402 ± 0.031	3.506GlnGly: 3.506 ± 0.049	1.258GlnHis: 1.258 ± 0.033	2.22GlnIle: 2.22 ± 0.039	1.21GlnLys: 1.21 ± 0.03	5.896GlnLeu: 5.896 ± 0.081	1.057GlnMet: 1.057 ± 0.03	1.128GlnAsn: 1.128 ± 0.031	2.136GlnPro: 2.136 ± 0.05	3.377GlnGln: 3.377 ± 0.072	3.416GlnArg: 3.416 ± 0.059	2.512GlnSer: 2.512 ± 0.042	2.01GlnThr: 2.01 ± 0.04	3.314GlnVal: 3.314 ± 0.048	0.639GlnTrp: 0.639 ± 0.023	1.076GlnTyr: 1.076 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.921ArgAla: 5.921 ± 0.073	0.63ArgCys: 0.63 ± 0.024	3.428ArgAsp: 3.428 ± 0.055	3.858ArgGlu: 3.858 ± 0.056	2.714ArgPhe: 2.714 ± 0.048	3.918ArgGly: 3.918 ± 0.056	1.618ArgHis: 1.618 ± 0.034	3.736ArgIle: 3.736 ± 0.046	2.084ArgLys: 2.084 ± 0.038	7.982ArgLeu: 7.982 ± 0.102	1.666ArgMet: 1.666 ± 0.03	1.958ArgAsn: 1.958 ± 0.041	2.653ArgPro: 2.653 ± 0.046	3.286ArgGln: 3.286 ± 0.056	4.167ArgArg: 4.167 ± 0.06	3.52ArgSer: 3.52 ± 0.05	2.719ArgThr: 2.719 ± 0.041	4.352ArgVal: 4.352 ± 0.057	0.958ArgTrp: 0.958 ± 0.025	2.032ArgTyr: 2.032 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.327SerAla: 6.327 ± 0.08	0.661SerCys: 0.661 ± 0.024	3.333SerAsp: 3.333 ± 0.06	3.195SerGlu: 3.195 ± 0.049	2.381SerPhe: 2.381 ± 0.044	5.486SerGly: 5.486 ± 0.077	1.438SerHis: 1.438 ± 0.036	3.259SerIle: 3.259 ± 0.05	1.755SerLys: 1.755 ± 0.035	7.216SerLeu: 7.216 ± 0.077	1.476SerMet: 1.476 ± 0.029	1.858SerAsn: 1.858 ± 0.046	2.656SerPro: 2.656 ± 0.042	2.408SerGln: 2.408 ± 0.039	3.967SerArg: 3.967 ± 0.049	3.686SerSer: 3.686 ± 0.051	2.926SerThr: 2.926 ± 0.051	4.208SerVal: 4.208 ± 0.069	0.896SerTrp: 0.896 ± 0.026	1.623SerTyr: 1.623 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.948ThrAla: 4.948 ± 0.076	0.453ThrCys: 0.453 ± 0.018	2.798ThrAsp: 2.798 ± 0.058	2.831ThrGlu: 2.831 ± 0.047	1.686ThrPhe: 1.686 ± 0.043	4.307ThrGly: 4.307 ± 0.073	0.996ThrHis: 0.996 ± 0.027	2.199ThrIle: 2.199 ± 0.067	1.079ThrLys: 1.079 ± 0.032	6.959ThrLeu: 6.959 ± 0.09	0.88ThrMet: 0.88 ± 0.026	1.177ThrAsn: 1.177 ± 0.031	2.959ThrPro: 2.959 ± 0.054	2.051ThrGln: 2.051 ± 0.038	2.946ThrArg: 2.946 ± 0.053	2.661ThrSer: 2.661 ± 0.051	2.4ThrThr: 2.4 ± 0.056	3.284ThrVal: 3.284 ± 0.059	0.534ThrTrp: 0.534 ± 0.021	1.133ThrTyr: 1.133 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.387ValAla: 7.387 ± 0.087	0.802ValCys: 0.802 ± 0.022	3.896ValAsp: 3.896 ± 0.056	4.159ValGlu: 4.159 ± 0.061	2.557ValPhe: 2.557 ± 0.043	4.958ValGly: 4.958 ± 0.066	1.354ValHis: 1.354 ± 0.033	3.988ValIle: 3.988 ± 0.052	2.182ValLys: 2.182 ± 0.045	8.124ValLeu: 8.124 ± 0.084	1.845ValMet: 1.845 ± 0.04	2.136ValAsn: 2.136 ± 0.039	3.216ValPro: 3.216 ± 0.045	2.751ValGln: 2.751 ± 0.047	4.182ValArg: 4.182 ± 0.058	4.448ValSer: 4.448 ± 0.059	3.877ValThr: 3.877 ± 0.067	5.176ValVal: 5.176 ± 0.077	0.754ValTrp: 0.754 ± 0.024	1.609ValTyr: 1.609 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	0.991TrpAla: 0.991 ± 0.027	0.154TrpCys: 0.154 ± 0.01	0.661TrpAsp: 0.661 ± 0.023	0.551TrpGlu: 0.551 ± 0.019	0.578TrpPhe: 0.578 ± 0.021	0.854TrpGly: 0.854 ± 0.025	0.375TrpHis: 0.375 ± 0.017	0.679TrpIle: 0.679 ± 0.025	0.426TrpLys: 0.426 ± 0.018	2.034TrpLeu: 2.034 ± 0.046	0.343TrpMet: 0.343 ± 0.015	0.454TrpAsn: 0.454 ± 0.018	0.634TrpPro: 0.634 ± 0.023	0.827TrpGln: 0.827 ± 0.025	0.92TrpArg: 0.92 ± 0.027	0.814TrpSer: 0.814 ± 0.023	0.559TrpThr: 0.559 ± 0.022	0.909TrpVal: 0.909 ± 0.027	0.212TrpTrp: 0.212 ± 0.013	0.333TrpTyr: 0.333 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.4TyrAla: 2.4 ± 0.038	0.337TyrCys: 0.337 ± 0.015	1.469TyrAsp: 1.469 ± 0.034	1.302TyrGlu: 1.302 ± 0.029	1.089TyrPhe: 1.089 ± 0.029	2.16TyrGly: 2.16 ± 0.035	0.578TyrHis: 0.578 ± 0.019	1.237TyrIle: 1.237 ± 0.033	0.752TyrLys: 0.752 ± 0.024	3.13TyrLeu: 3.13 ± 0.052	0.556TyrMet: 0.556 ± 0.022	0.765TyrAsn: 0.765 ± 0.026	1.335TyrPro: 1.335 ± 0.031	1.323TyrGln: 1.323 ± 0.033	2.158TyrArg: 2.158 ± 0.037	1.744TyrSer: 1.744 ± 0.035	1.093TyrThr: 1.093 ± 0.027	1.517TyrVal: 1.517 ± 0.035	0.421TyrTrp: 0.421 ± 0.019	0.817TyrTyr: 0.817 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4388 proteins (1459467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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