Amino acid dipepetide frequency for Mycobacterium phage Krili

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.222AlaAla: 14.222 ± 0.905
1.488AlaCys: 1.488 ± 0.264
5.382AlaAsp: 5.382 ± 0.57
8.664AlaGlu: 8.664 ± 0.793
3.282AlaPhe: 3.282 ± 0.526
8.533AlaGly: 8.533 ± 0.641
1.794AlaHis: 1.794 ± 0.327
5.12AlaIle: 5.12 ± 0.515
3.851AlaLys: 3.851 ± 0.45
8.839AlaLeu: 8.839 ± 0.588
3.019AlaMet: 3.019 ± 0.342
2.669AlaAsn: 2.669 ± 0.368
3.895AlaPro: 3.895 ± 0.503
3.763AlaGln: 3.763 ± 0.434
7.002AlaArg: 7.002 ± 0.583
5.076AlaSer: 5.076 ± 0.561
6.608AlaThr: 6.608 ± 0.594
7.964AlaVal: 7.964 ± 0.628
1.794AlaTrp: 1.794 ± 0.329
2.844AlaTyr: 2.844 ± 0.347
0.0AlaXaa: 0.0 ± 0.0
Cys
1.313CysAla: 1.313 ± 0.308
0.35CysCys: 0.35 ± 0.136
1.006CysAsp: 1.006 ± 0.208
0.744CysGlu: 0.744 ± 0.227
0.219CysPhe: 0.219 ± 0.107
1.444CysGly: 1.444 ± 0.246
0.263CysHis: 0.263 ± 0.116
0.569CysIle: 0.569 ± 0.177
0.263CysLys: 0.263 ± 0.107
0.656CysLeu: 0.656 ± 0.201
0.088CysMet: 0.088 ± 0.065
0.306CysAsn: 0.306 ± 0.111
1.313CysPro: 1.313 ± 0.311
0.35CysGln: 0.35 ± 0.129
0.875CysArg: 0.875 ± 0.237
0.613CysSer: 0.613 ± 0.186
0.481CysThr: 0.481 ± 0.147
0.963CysVal: 0.963 ± 0.283
0.175CysTrp: 0.175 ± 0.072
0.394CysTyr: 0.394 ± 0.155
0.0CysXaa: 0.0 ± 0.0
Asp
6.433AspAla: 6.433 ± 0.501
0.963AspCys: 0.963 ± 0.241
4.42AspAsp: 4.42 ± 0.486
4.42AspGlu: 4.42 ± 0.436
1.444AspPhe: 1.444 ± 0.28
6.52AspGly: 6.52 ± 0.676
0.744AspHis: 0.744 ± 0.224
3.019AspIle: 3.019 ± 0.373
1.882AspLys: 1.882 ± 0.294
5.689AspLeu: 5.689 ± 0.414
1.4AspMet: 1.4 ± 0.229
1.619AspAsn: 1.619 ± 0.311
3.851AspPro: 3.851 ± 0.383
1.75AspGln: 1.75 ± 0.334
4.201AspArg: 4.201 ± 0.478
2.888AspSer: 2.888 ± 0.422
3.457AspThr: 3.457 ± 0.367
4.113AspVal: 4.113 ± 0.374
1.619AspTrp: 1.619 ± 0.265
1.882AspTyr: 1.882 ± 0.264
0.0AspXaa: 0.0 ± 0.0
Glu
6.651GluAla: 6.651 ± 0.638
0.7GluCys: 0.7 ± 0.186
4.026GluAsp: 4.026 ± 0.38
4.245GluGlu: 4.245 ± 0.452
2.013GluPhe: 2.013 ± 0.308
4.464GluGly: 4.464 ± 0.516
1.532GluHis: 1.532 ± 0.271
2.801GluIle: 2.801 ± 0.371
2.363GluLys: 2.363 ± 0.296
6.301GluLeu: 6.301 ± 0.598
1.969GluMet: 1.969 ± 0.26
1.925GluAsn: 1.925 ± 0.293
3.851GluPro: 3.851 ± 0.501
3.063GluGln: 3.063 ± 0.411
4.726GluArg: 4.726 ± 0.484
4.026GluSer: 4.026 ± 0.374
3.632GluThr: 3.632 ± 0.43
5.951GluVal: 5.951 ± 0.559
1.094GluTrp: 1.094 ± 0.255
1.707GluTyr: 1.707 ± 0.265
0.0GluXaa: 0.0 ± 0.0
Phe
3.063PheAla: 3.063 ± 0.358
0.306PheCys: 0.306 ± 0.129
2.669PheAsp: 2.669 ± 0.299
2.013PheGlu: 2.013 ± 0.281
0.831PhePhe: 0.831 ± 0.201
3.238PheGly: 3.238 ± 0.452
0.569PheHis: 0.569 ± 0.165
0.831PheIle: 0.831 ± 0.219
0.875PheLys: 0.875 ± 0.156
1.488PheLeu: 1.488 ± 0.255
0.788PheMet: 0.788 ± 0.193
0.788PheAsn: 0.788 ± 0.169
1.182PhePro: 1.182 ± 0.191
0.744PheGln: 0.744 ± 0.197
2.057PheArg: 2.057 ± 0.28
1.532PheSer: 1.532 ± 0.26
1.925PheThr: 1.925 ± 0.338
2.451PheVal: 2.451 ± 0.323
0.656PheTrp: 0.656 ± 0.18
0.919PheTyr: 0.919 ± 0.247
0.0PheXaa: 0.0 ± 0.0
Gly
7.57GlyAla: 7.57 ± 1.048
1.006GlyCys: 1.006 ± 0.307
4.945GlyAsp: 4.945 ± 0.515
5.601GlyGlu: 5.601 ± 0.494
3.063GlyPhe: 3.063 ± 0.326
7.57GlyGly: 7.57 ± 0.779
1.575GlyHis: 1.575 ± 0.291
3.895GlyIle: 3.895 ± 0.556
3.457GlyLys: 3.457 ± 0.425
6.433GlyLeu: 6.433 ± 0.516
1.882GlyMet: 1.882 ± 0.276
3.37GlyAsn: 3.37 ± 0.522
5.032GlyPro: 5.032 ± 0.436
2.538GlyGln: 2.538 ± 0.331
5.207GlyArg: 5.207 ± 0.448
5.339GlySer: 5.339 ± 0.548
4.945GlyThr: 4.945 ± 0.531
6.433GlyVal: 6.433 ± 0.532
1.925GlyTrp: 1.925 ± 0.345
2.319GlyTyr: 2.319 ± 0.344
0.0GlyXaa: 0.0 ± 0.0
His
1.269HisAla: 1.269 ± 0.259
0.35HisCys: 0.35 ± 0.131
1.094HisAsp: 1.094 ± 0.228
1.138HisGlu: 1.138 ± 0.175
0.306HisPhe: 0.306 ± 0.143
1.313HisGly: 1.313 ± 0.26
0.569HisHis: 0.569 ± 0.152
1.006HisIle: 1.006 ± 0.188
0.263HisLys: 0.263 ± 0.109
1.882HisLeu: 1.882 ± 0.324
0.394HisMet: 0.394 ± 0.155
0.35HisAsn: 0.35 ± 0.117
1.4HisPro: 1.4 ± 0.271
0.7HisGln: 0.7 ± 0.201
1.969HisArg: 1.969 ± 0.275
0.875HisSer: 0.875 ± 0.204
1.182HisThr: 1.182 ± 0.198
1.269HisVal: 1.269 ± 0.303
0.613HisTrp: 0.613 ± 0.149
0.394HisTyr: 0.394 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
5.47IleAla: 5.47 ± 0.492
0.306IleCys: 0.306 ± 0.119
3.282IleAsp: 3.282 ± 0.463
3.413IleGlu: 3.413 ± 0.389
1.006IlePhe: 1.006 ± 0.186
4.245IleGly: 4.245 ± 0.387
0.569IleHis: 0.569 ± 0.133
2.1IleIle: 2.1 ± 0.294
1.357IleLys: 1.357 ± 0.202
2.932IleLeu: 2.932 ± 0.445
0.656IleMet: 0.656 ± 0.176
1.05IleAsn: 1.05 ± 0.237
3.063IlePro: 3.063 ± 0.314
1.313IleGln: 1.313 ± 0.275
3.107IleArg: 3.107 ± 0.381
2.757IleSer: 2.757 ± 0.397
2.976IleThr: 2.976 ± 0.314
3.413IleVal: 3.413 ± 0.383
1.094IleTrp: 1.094 ± 0.204
0.788IleTyr: 0.788 ± 0.167
0.0IleXaa: 0.0 ± 0.0
Lys
4.157LysAla: 4.157 ± 0.523
0.438LysCys: 0.438 ± 0.163
1.663LysAsp: 1.663 ± 0.234
2.494LysGlu: 2.494 ± 0.376
0.875LysPhe: 0.875 ± 0.205
2.582LysGly: 2.582 ± 0.296
0.481LysHis: 0.481 ± 0.168
1.575LysIle: 1.575 ± 0.302
1.619LysLys: 1.619 ± 0.337
3.763LysLeu: 3.763 ± 0.427
0.963LysMet: 0.963 ± 0.209
0.525LysAsn: 0.525 ± 0.224
2.494LysPro: 2.494 ± 0.466
1.269LysGln: 1.269 ± 0.249
2.232LysArg: 2.232 ± 0.317
1.707LysSer: 1.707 ± 0.285
2.144LysThr: 2.144 ± 0.228
3.501LysVal: 3.501 ± 0.424
0.525LysTrp: 0.525 ± 0.139
1.05LysTyr: 1.05 ± 0.224
0.0LysXaa: 0.0 ± 0.0
Leu
9.365LeuAla: 9.365 ± 0.699
0.919LeuCys: 0.919 ± 0.235
5.82LeuAsp: 5.82 ± 0.541
4.857LeuGlu: 4.857 ± 0.427
2.276LeuPhe: 2.276 ± 0.393
6.52LeuGly: 6.52 ± 0.737
1.313LeuHis: 1.313 ± 0.273
2.888LeuIle: 2.888 ± 0.321
2.888LeuLys: 2.888 ± 0.38
5.426LeuLeu: 5.426 ± 0.532
1.969LeuMet: 1.969 ± 0.289
2.888LeuAsn: 2.888 ± 0.356
5.12LeuPro: 5.12 ± 0.43
2.144LeuGln: 2.144 ± 0.353
5.908LeuArg: 5.908 ± 0.475
4.989LeuSer: 4.989 ± 0.5
5.382LeuThr: 5.382 ± 0.489
5.514LeuVal: 5.514 ± 0.494
1.225LeuTrp: 1.225 ± 0.29
1.969LeuTyr: 1.969 ± 0.315
0.0LeuXaa: 0.0 ± 0.0
Met
3.063MetAla: 3.063 ± 0.363
0.131MetCys: 0.131 ± 0.079
0.788MetAsp: 0.788 ± 0.175
1.357MetGlu: 1.357 ± 0.258
0.919MetPhe: 0.919 ± 0.179
1.138MetGly: 1.138 ± 0.247
0.525MetHis: 0.525 ± 0.159
1.094MetIle: 1.094 ± 0.233
1.138MetLys: 1.138 ± 0.215
1.75MetLeu: 1.75 ± 0.23
1.138MetMet: 1.138 ± 0.291
0.7MetAsn: 0.7 ± 0.175
1.488MetPro: 1.488 ± 0.248
0.919MetGln: 0.919 ± 0.158
2.013MetArg: 2.013 ± 0.322
2.451MetSer: 2.451 ± 0.345
2.276MetThr: 2.276 ± 0.318
1.969MetVal: 1.969 ± 0.28
0.613MetTrp: 0.613 ± 0.137
0.306MetTyr: 0.306 ± 0.142
0.0MetXaa: 0.0 ± 0.0
Asn
3.151AsnAla: 3.151 ± 0.432
0.306AsnCys: 0.306 ± 0.114
1.794AsnAsp: 1.794 ± 0.294
1.75AsnGlu: 1.75 ± 0.276
1.05AsnPhe: 1.05 ± 0.23
2.976AsnGly: 2.976 ± 0.445
0.438AsnHis: 0.438 ± 0.124
1.182AsnIle: 1.182 ± 0.195
0.875AsnLys: 0.875 ± 0.249
2.626AsnLeu: 2.626 ± 0.384
0.788AsnMet: 0.788 ± 0.188
1.532AsnAsn: 1.532 ± 0.243
2.057AsnPro: 2.057 ± 0.29
0.788AsnGln: 0.788 ± 0.208
2.582AsnArg: 2.582 ± 0.441
1.357AsnSer: 1.357 ± 0.268
2.319AsnThr: 2.319 ± 0.429
1.794AsnVal: 1.794 ± 0.239
0.831AsnTrp: 0.831 ± 0.163
0.831AsnTyr: 0.831 ± 0.243
0.0AsnXaa: 0.0 ± 0.0
Pro
4.77ProAla: 4.77 ± 0.513
0.788ProCys: 0.788 ± 0.236
4.245ProAsp: 4.245 ± 0.48
5.601ProGlu: 5.601 ± 0.675
1.532ProPhe: 1.532 ± 0.273
5.733ProGly: 5.733 ± 0.663
1.313ProHis: 1.313 ± 0.249
2.407ProIle: 2.407 ± 0.286
1.707ProLys: 1.707 ± 0.238
3.72ProLeu: 3.72 ± 0.387
1.882ProMet: 1.882 ± 0.28
2.538ProAsn: 2.538 ± 0.368
3.851ProPro: 3.851 ± 0.569
2.276ProGln: 2.276 ± 0.312
3.107ProArg: 3.107 ± 0.351
3.37ProSer: 3.37 ± 0.399
4.245ProThr: 4.245 ± 0.44
3.851ProVal: 3.851 ± 0.546
1.575ProTrp: 1.575 ± 0.263
1.313ProTyr: 1.313 ± 0.257
0.0ProXaa: 0.0 ± 0.0
Gln
4.07GlnAla: 4.07 ± 0.463
0.35GlnCys: 0.35 ± 0.126
1.75GlnAsp: 1.75 ± 0.285
1.75GlnGlu: 1.75 ± 0.224
0.919GlnPhe: 0.919 ± 0.195
2.451GlnGly: 2.451 ± 0.369
0.963GlnHis: 0.963 ± 0.186
1.838GlnIle: 1.838 ± 0.24
1.444GlnLys: 1.444 ± 0.264
3.107GlnLeu: 3.107 ± 0.566
0.744GlnMet: 0.744 ± 0.183
0.656GlnAsn: 0.656 ± 0.186
1.75GlnPro: 1.75 ± 0.282
1.619GlnGln: 1.619 ± 0.402
2.932GlnArg: 2.932 ± 0.378
1.575GlnSer: 1.575 ± 0.306
1.444GlnThr: 1.444 ± 0.217
3.194GlnVal: 3.194 ± 0.312
0.788GlnTrp: 0.788 ± 0.163
0.875GlnTyr: 0.875 ± 0.222
0.0GlnXaa: 0.0 ± 0.0
Arg
6.87ArgAla: 6.87 ± 0.615
1.094ArgCys: 1.094 ± 0.254
4.376ArgAsp: 4.376 ± 0.444
4.551ArgGlu: 4.551 ± 0.48
2.232ArgPhe: 2.232 ± 0.323
4.989ArgGly: 4.989 ± 0.559
1.182ArgHis: 1.182 ± 0.225
3.326ArgIle: 3.326 ± 0.387
3.326ArgLys: 3.326 ± 0.348
5.426ArgLeu: 5.426 ± 0.507
1.925ArgMet: 1.925 ± 0.275
2.757ArgAsn: 2.757 ± 0.309
3.588ArgPro: 3.588 ± 0.493
2.757ArgGln: 2.757 ± 0.322
6.214ArgArg: 6.214 ± 0.726
3.413ArgSer: 3.413 ± 0.357
4.026ArgThr: 4.026 ± 0.454
5.032ArgVal: 5.032 ± 0.477
2.057ArgTrp: 2.057 ± 0.398
1.532ArgTyr: 1.532 ± 0.267
0.0ArgXaa: 0.0 ± 0.0
Ser
5.032SerAla: 5.032 ± 0.465
0.569SerCys: 0.569 ± 0.155
3.763SerAsp: 3.763 ± 0.404
3.632SerGlu: 3.632 ± 0.336
1.619SerPhe: 1.619 ± 0.335
5.514SerGly: 5.514 ± 0.55
1.269SerHis: 1.269 ± 0.256
2.801SerIle: 2.801 ± 0.38
2.451SerLys: 2.451 ± 0.312
3.676SerLeu: 3.676 ± 0.374
1.969SerMet: 1.969 ± 0.287
1.75SerAsn: 1.75 ± 0.264
3.763SerPro: 3.763 ± 0.346
1.925SerGln: 1.925 ± 0.332
2.757SerArg: 2.757 ± 0.319
2.801SerSer: 2.801 ± 0.379
3.107SerThr: 3.107 ± 0.364
3.457SerVal: 3.457 ± 0.412
1.488SerTrp: 1.488 ± 0.246
1.532SerTyr: 1.532 ± 0.264
0.0SerXaa: 0.0 ± 0.0
Thr
7.089ThrAla: 7.089 ± 0.766
0.831ThrCys: 0.831 ± 0.206
3.545ThrAsp: 3.545 ± 0.388
4.245ThrGlu: 4.245 ± 0.5
1.75ThrPhe: 1.75 ± 0.305
5.12ThrGly: 5.12 ± 0.455
0.656ThrHis: 0.656 ± 0.179
2.626ThrIle: 2.626 ± 0.316
2.1ThrLys: 2.1 ± 0.318
6.126ThrLeu: 6.126 ± 0.547
1.269ThrMet: 1.269 ± 0.195
2.057ThrAsn: 2.057 ± 0.285
5.076ThrPro: 5.076 ± 0.416
1.794ThrGln: 1.794 ± 0.301
4.201ThrArg: 4.201 ± 0.378
3.063ThrSer: 3.063 ± 0.344
3.107ThrThr: 3.107 ± 0.36
4.595ThrVal: 4.595 ± 0.465
1.006ThrTrp: 1.006 ± 0.24
1.663ThrTyr: 1.663 ± 0.309
0.0ThrXaa: 0.0 ± 0.0
Val
7.658ValAla: 7.658 ± 0.521
0.875ValCys: 0.875 ± 0.235
4.726ValAsp: 4.726 ± 0.423
4.682ValGlu: 4.682 ± 0.629
2.232ValPhe: 2.232 ± 0.243
5.995ValGly: 5.995 ± 0.653
1.357ValHis: 1.357 ± 0.266
3.413ValIle: 3.413 ± 0.491
3.063ValLys: 3.063 ± 0.331
6.083ValLeu: 6.083 ± 0.572
1.75ValMet: 1.75 ± 0.276
2.319ValAsn: 2.319 ± 0.441
4.245ValPro: 4.245 ± 0.405
2.407ValGln: 2.407 ± 0.318
5.47ValArg: 5.47 ± 0.608
4.07ValSer: 4.07 ± 0.371
5.733ValThr: 5.733 ± 0.578
6.476ValVal: 6.476 ± 0.734
1.575ValTrp: 1.575 ± 0.25
1.444ValTyr: 1.444 ± 0.229
0.0ValXaa: 0.0 ± 0.0
Trp
2.232TrpAla: 2.232 ± 0.346
0.394TrpCys: 0.394 ± 0.137
1.4TrpAsp: 1.4 ± 0.25
0.831TrpGlu: 0.831 ± 0.18
0.569TrpPhe: 0.569 ± 0.187
1.269TrpGly: 1.269 ± 0.252
0.656TrpHis: 0.656 ± 0.17
1.313TrpIle: 1.313 ± 0.254
0.656TrpLys: 0.656 ± 0.151
1.838TrpLeu: 1.838 ± 0.318
0.744TrpMet: 0.744 ± 0.171
0.35TrpAsn: 0.35 ± 0.113
1.488TrpPro: 1.488 ± 0.254
1.094TrpGln: 1.094 ± 0.194
1.969TrpArg: 1.969 ± 0.326
1.313TrpSer: 1.313 ± 0.242
1.269TrpThr: 1.269 ± 0.236
1.488TrpVal: 1.488 ± 0.233
0.7TrpTrp: 0.7 ± 0.193
0.525TrpTyr: 0.525 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.363TyrAla: 2.363 ± 0.381
0.219TyrCys: 0.219 ± 0.107
1.619TyrAsp: 1.619 ± 0.288
1.05TyrGlu: 1.05 ± 0.2
0.788TyrPhe: 0.788 ± 0.215
2.494TyrGly: 2.494 ± 0.466
0.569TyrHis: 0.569 ± 0.164
1.094TyrIle: 1.094 ± 0.272
0.481TyrLys: 0.481 ± 0.128
1.619TyrLeu: 1.619 ± 0.293
0.394TyrMet: 0.394 ± 0.126
0.875TyrAsn: 0.875 ± 0.217
1.313TyrPro: 1.313 ± 0.275
1.006TyrGln: 1.006 ± 0.225
2.144TyrArg: 2.144 ± 0.42
1.663TyrSer: 1.663 ± 0.255
1.663TyrThr: 1.663 ± 0.276
2.144TyrVal: 2.144 ± 0.319
0.744TyrTrp: 0.744 ± 0.157
0.525TyrTyr: 0.525 ± 0.143
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 129 proteins (22853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski