Amino acid dipepetide frequency for Arthrobacter phage vB_ArtM-ArV1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.838AlaAla: 17.838 ± 1.781
0.791AlaCys: 0.791 ± 0.172
7.206AlaAsp: 7.206 ± 0.643
7.425AlaGlu: 7.425 ± 0.745
2.812AlaPhe: 2.812 ± 0.4
7.909AlaGly: 7.909 ± 0.798
2.636AlaHis: 2.636 ± 0.453
4.921AlaIle: 4.921 ± 0.491
6.898AlaLys: 6.898 ± 0.648
9.974AlaLeu: 9.974 ± 0.791
3.295AlaMet: 3.295 ± 0.449
5.36AlaAsn: 5.36 ± 0.617
6.722AlaPro: 6.722 ± 0.591
3.779AlaGln: 3.779 ± 0.403
6.415AlaArg: 6.415 ± 0.683
5.141AlaSer: 5.141 ± 0.6
7.909AlaThr: 7.909 ± 0.84
7.777AlaVal: 7.777 ± 0.852
1.801AlaTrp: 1.801 ± 0.319
2.548AlaTyr: 2.548 ± 0.337
0.0AlaXaa: 0.0 ± 0.0
Cys
0.879CysAla: 0.879 ± 0.215
0.264CysCys: 0.264 ± 0.124
0.308CysAsp: 0.308 ± 0.114
0.483CysGlu: 0.483 ± 0.163
0.176CysPhe: 0.176 ± 0.09
0.615CysGly: 0.615 ± 0.175
0.395CysHis: 0.395 ± 0.171
0.527CysIle: 0.527 ± 0.157
0.351CysLys: 0.351 ± 0.124
0.308CysLeu: 0.308 ± 0.119
0.176CysMet: 0.176 ± 0.088
0.264CysAsn: 0.264 ± 0.103
0.879CysPro: 0.879 ± 0.235
0.483CysGln: 0.483 ± 0.142
0.747CysArg: 0.747 ± 0.202
0.308CysSer: 0.308 ± 0.144
0.439CysThr: 0.439 ± 0.149
0.527CysVal: 0.527 ± 0.151
0.308CysTrp: 0.308 ± 0.134
0.176CysTyr: 0.176 ± 0.085
0.0CysXaa: 0.0 ± 0.0
Asp
8.216AspAla: 8.216 ± 0.673
0.351AspCys: 0.351 ± 0.134
2.285AspAsp: 2.285 ± 0.311
3.032AspGlu: 3.032 ± 0.362
1.714AspPhe: 1.714 ± 0.366
6.503AspGly: 6.503 ± 0.511
1.318AspHis: 1.318 ± 0.25
2.329AspIle: 2.329 ± 0.296
2.373AspLys: 2.373 ± 0.304
5.185AspLeu: 5.185 ± 0.498
1.538AspMet: 1.538 ± 0.262
1.889AspAsn: 1.889 ± 0.291
4.965AspPro: 4.965 ± 0.607
1.406AspGln: 1.406 ± 0.247
2.153AspArg: 2.153 ± 0.288
2.373AspSer: 2.373 ± 0.343
3.383AspThr: 3.383 ± 0.338
4.218AspVal: 4.218 ± 0.519
1.274AspTrp: 1.274 ± 0.314
2.329AspTyr: 2.329 ± 0.298
0.0AspXaa: 0.0 ± 0.0
Glu
7.821GluAla: 7.821 ± 0.728
0.659GluCys: 0.659 ± 0.156
3.295GluAsp: 3.295 ± 0.447
3.251GluGlu: 3.251 ± 0.36
1.494GluPhe: 1.494 ± 0.296
4.13GluGly: 4.13 ± 0.445
1.318GluHis: 1.318 ± 0.295
3.076GluIle: 3.076 ± 0.357
2.065GluLys: 2.065 ± 0.313
4.657GluLeu: 4.657 ± 0.575
1.318GluMet: 1.318 ± 0.245
1.889GluAsn: 1.889 ± 0.337
4.042GluPro: 4.042 ± 0.547
2.636GluGln: 2.636 ± 0.422
3.691GluArg: 3.691 ± 0.381
3.076GluSer: 3.076 ± 0.363
3.779GluThr: 3.779 ± 0.372
5.053GluVal: 5.053 ± 0.423
1.362GluTrp: 1.362 ± 0.305
1.977GluTyr: 1.977 ± 0.369
0.0GluXaa: 0.0 ± 0.0
Phe
2.241PheAla: 2.241 ± 0.254
0.395PheCys: 0.395 ± 0.142
1.801PheAsp: 1.801 ± 0.306
2.329PheGlu: 2.329 ± 0.402
0.747PhePhe: 0.747 ± 0.207
1.889PheGly: 1.889 ± 0.349
0.571PheHis: 0.571 ± 0.185
1.362PheIle: 1.362 ± 0.27
1.45PheLys: 1.45 ± 0.27
2.109PheLeu: 2.109 ± 0.341
1.142PheMet: 1.142 ± 0.215
1.054PheAsn: 1.054 ± 0.228
1.757PhePro: 1.757 ± 0.241
1.274PheGln: 1.274 ± 0.261
1.626PheArg: 1.626 ± 0.306
1.494PheSer: 1.494 ± 0.327
2.021PheThr: 2.021 ± 0.289
1.889PheVal: 1.889 ± 0.28
0.571PheTrp: 0.571 ± 0.211
0.615PheTyr: 0.615 ± 0.13
0.0PheXaa: 0.0 ± 0.0
Gly
7.821GlyAla: 7.821 ± 0.623
0.571GlyCys: 0.571 ± 0.203
5.053GlyAsp: 5.053 ± 0.498
4.086GlyGlu: 4.086 ± 0.399
3.251GlyPhe: 3.251 ± 0.508
8.348GlyGly: 8.348 ± 1.093
2.68GlyHis: 2.68 ± 0.432
3.735GlyIle: 3.735 ± 0.747
4.438GlyLys: 4.438 ± 0.505
5.36GlyLeu: 5.36 ± 0.524
2.109GlyMet: 2.109 ± 0.274
3.471GlyAsn: 3.471 ± 0.418
3.647GlyPro: 3.647 ± 0.357
3.076GlyGln: 3.076 ± 0.321
4.525GlyArg: 4.525 ± 0.433
5.009GlySer: 5.009 ± 0.502
5.668GlyThr: 5.668 ± 0.592
6.415GlyVal: 6.415 ± 0.632
1.977GlyTrp: 1.977 ± 0.333
2.285GlyTyr: 2.285 ± 0.312
0.0GlyXaa: 0.0 ± 0.0
His
2.329HisAla: 2.329 ± 0.383
0.351HisCys: 0.351 ± 0.162
1.406HisAsp: 1.406 ± 0.3
1.801HisGlu: 1.801 ± 0.346
0.483HisPhe: 0.483 ± 0.144
1.538HisGly: 1.538 ± 0.295
0.439HisHis: 0.439 ± 0.132
1.054HisIle: 1.054 ± 0.218
0.879HisLys: 0.879 ± 0.226
2.021HisLeu: 2.021 ± 0.278
0.835HisMet: 0.835 ± 0.19
0.835HisAsn: 0.835 ± 0.218
1.626HisPro: 1.626 ± 0.33
0.527HisGln: 0.527 ± 0.141
1.45HisArg: 1.45 ± 0.369
1.054HisSer: 1.054 ± 0.281
1.318HisThr: 1.318 ± 0.268
1.845HisVal: 1.845 ± 0.291
0.395HisTrp: 0.395 ± 0.123
0.703HisTyr: 0.703 ± 0.166
0.0HisXaa: 0.0 ± 0.0
Ile
4.438IleAla: 4.438 ± 0.521
0.176IleCys: 0.176 ± 0.083
2.636IleAsp: 2.636 ± 0.373
2.9IleGlu: 2.9 ± 0.347
0.967IlePhe: 0.967 ± 0.255
2.988IleGly: 2.988 ± 0.549
0.923IleHis: 0.923 ± 0.184
1.494IleIle: 1.494 ± 0.258
1.933IleLys: 1.933 ± 0.259
3.032IleLeu: 3.032 ± 0.383
0.967IleMet: 0.967 ± 0.177
1.406IleAsn: 1.406 ± 0.223
2.46IlePro: 2.46 ± 0.284
1.45IleGln: 1.45 ± 0.261
2.417IleArg: 2.417 ± 0.367
1.538IleSer: 1.538 ± 0.265
3.515IleThr: 3.515 ± 0.421
3.339IleVal: 3.339 ± 0.435
0.659IleTrp: 0.659 ± 0.158
0.923IleTyr: 0.923 ± 0.201
0.0IleXaa: 0.0 ± 0.0
Lys
6.942LysAla: 6.942 ± 0.583
0.132LysCys: 0.132 ± 0.071
2.812LysAsp: 2.812 ± 0.415
2.153LysGlu: 2.153 ± 0.291
0.967LysPhe: 0.967 ± 0.212
3.471LysGly: 3.471 ± 0.442
0.879LysHis: 0.879 ± 0.198
1.362LysIle: 1.362 ± 0.248
1.406LysLys: 1.406 ± 0.332
3.91LysLeu: 3.91 ± 0.442
0.923LysMet: 0.923 ± 0.175
1.757LysAsn: 1.757 ± 0.289
3.515LysPro: 3.515 ± 0.47
1.054LysGln: 1.054 ± 0.21
3.163LysArg: 3.163 ± 0.502
1.757LysSer: 1.757 ± 0.245
2.636LysThr: 2.636 ± 0.37
3.647LysVal: 3.647 ± 0.471
0.439LysTrp: 0.439 ± 0.152
1.098LysTyr: 1.098 ± 0.211
0.0LysXaa: 0.0 ± 0.0
Leu
8.392LeuAla: 8.392 ± 0.553
0.351LeuCys: 0.351 ± 0.118
4.833LeuAsp: 4.833 ± 0.486
4.965LeuGlu: 4.965 ± 0.546
1.977LeuPhe: 1.977 ± 0.347
5.448LeuGly: 5.448 ± 0.537
1.67LeuHis: 1.67 ± 0.268
2.636LeuIle: 2.636 ± 0.401
3.471LeuLys: 3.471 ± 0.415
5.448LeuLeu: 5.448 ± 0.521
1.933LeuMet: 1.933 ± 0.24
3.559LeuAsn: 3.559 ± 0.536
5.36LeuPro: 5.36 ± 0.567
2.636LeuGln: 2.636 ± 0.328
4.13LeuArg: 4.13 ± 0.491
4.394LeuSer: 4.394 ± 0.535
6.239LeuThr: 6.239 ± 0.548
4.789LeuVal: 4.789 ± 0.522
1.186LeuTrp: 1.186 ± 0.231
1.23LeuTyr: 1.23 ± 0.237
0.0LeuXaa: 0.0 ± 0.0
Met
3.076MetAla: 3.076 ± 0.349
0.176MetCys: 0.176 ± 0.087
1.757MetAsp: 1.757 ± 0.314
1.406MetGlu: 1.406 ± 0.249
0.571MetPhe: 0.571 ± 0.141
2.065MetGly: 2.065 ± 0.432
0.395MetHis: 0.395 ± 0.131
0.615MetIle: 0.615 ± 0.178
0.967MetLys: 0.967 ± 0.178
2.109MetLeu: 2.109 ± 0.273
0.176MetMet: 0.176 ± 0.092
0.835MetAsn: 0.835 ± 0.222
1.845MetPro: 1.845 ± 0.302
0.527MetGln: 0.527 ± 0.164
2.065MetArg: 2.065 ± 0.288
1.67MetSer: 1.67 ± 0.296
2.285MetThr: 2.285 ± 0.353
1.582MetVal: 1.582 ± 0.28
0.439MetTrp: 0.439 ± 0.164
0.22MetTyr: 0.22 ± 0.101
0.0MetXaa: 0.0 ± 0.0
Asn
3.822AsnAla: 3.822 ± 0.394
0.527AsnCys: 0.527 ± 0.181
1.67AsnAsp: 1.67 ± 0.29
2.021AsnGlu: 2.021 ± 0.301
0.791AsnPhe: 0.791 ± 0.21
4.306AsnGly: 4.306 ± 0.429
0.615AsnHis: 0.615 ± 0.145
1.318AsnIle: 1.318 ± 0.274
1.186AsnLys: 1.186 ± 0.298
2.856AsnLeu: 2.856 ± 0.395
0.659AsnMet: 0.659 ± 0.168
1.582AsnAsn: 1.582 ± 0.312
3.779AsnPro: 3.779 ± 0.481
1.845AsnGln: 1.845 ± 0.308
2.373AsnArg: 2.373 ± 0.363
1.933AsnSer: 1.933 ± 0.268
2.68AsnThr: 2.68 ± 0.412
2.46AsnVal: 2.46 ± 0.323
0.967AsnTrp: 0.967 ± 0.214
1.098AsnTyr: 1.098 ± 0.277
0.0AsnXaa: 0.0 ± 0.0
Pro
8.04ProAla: 8.04 ± 0.623
0.747ProCys: 0.747 ± 0.266
4.35ProAsp: 4.35 ± 0.485
4.657ProGlu: 4.657 ± 0.497
1.801ProPhe: 1.801 ± 0.266
6.415ProGly: 6.415 ± 0.557
1.582ProHis: 1.582 ± 0.275
2.724ProIle: 2.724 ± 0.282
2.9ProLys: 2.9 ± 0.443
4.657ProLeu: 4.657 ± 0.466
1.757ProMet: 1.757 ± 0.264
2.504ProAsn: 2.504 ± 0.313
3.471ProPro: 3.471 ± 0.52
1.977ProGln: 1.977 ± 0.334
3.91ProArg: 3.91 ± 0.529
2.636ProSer: 2.636 ± 0.37
4.921ProThr: 4.921 ± 0.644
4.877ProVal: 4.877 ± 0.351
0.791ProTrp: 0.791 ± 0.177
1.098ProTyr: 1.098 ± 0.246
0.0ProXaa: 0.0 ± 0.0
Gln
3.822GlnAla: 3.822 ± 0.508
0.483GlnCys: 0.483 ± 0.164
2.021GlnAsp: 2.021 ± 0.243
1.45GlnGlu: 1.45 ± 0.307
1.186GlnPhe: 1.186 ± 0.25
2.724GlnGly: 2.724 ± 0.369
0.615GlnHis: 0.615 ± 0.157
1.494GlnIle: 1.494 ± 0.252
0.703GlnLys: 0.703 ± 0.201
2.636GlnLeu: 2.636 ± 0.332
1.098GlnMet: 1.098 ± 0.227
0.923GlnAsn: 0.923 ± 0.213
2.329GlnPro: 2.329 ± 0.402
1.186GlnGln: 1.186 ± 0.274
1.977GlnArg: 1.977 ± 0.32
1.889GlnSer: 1.889 ± 0.301
2.329GlnThr: 2.329 ± 0.308
3.12GlnVal: 3.12 ± 0.388
0.879GlnTrp: 0.879 ± 0.211
1.362GlnTyr: 1.362 ± 0.235
0.0GlnXaa: 0.0 ± 0.0
Arg
6.591ArgAla: 6.591 ± 0.587
0.615ArgCys: 0.615 ± 0.183
3.603ArgAsp: 3.603 ± 0.445
3.822ArgGlu: 3.822 ± 0.482
2.197ArgPhe: 2.197 ± 0.364
4.262ArgGly: 4.262 ± 0.443
1.67ArgHis: 1.67 ± 0.311
2.285ArgIle: 2.285 ± 0.372
3.339ArgLys: 3.339 ± 0.404
4.306ArgLeu: 4.306 ± 0.497
1.362ArgMet: 1.362 ± 0.253
2.241ArgAsn: 2.241 ± 0.319
3.515ArgPro: 3.515 ± 0.469
1.933ArgGln: 1.933 ± 0.33
3.866ArgArg: 3.866 ± 0.715
2.724ArgSer: 2.724 ± 0.356
3.735ArgThr: 3.735 ± 0.448
3.954ArgVal: 3.954 ± 0.414
1.098ArgTrp: 1.098 ± 0.225
1.845ArgTyr: 1.845 ± 0.279
0.0ArgXaa: 0.0 ± 0.0
Ser
5.975SerAla: 5.975 ± 0.704
0.439SerCys: 0.439 ± 0.139
2.065SerAsp: 2.065 ± 0.302
2.988SerGlu: 2.988 ± 0.425
1.45SerPhe: 1.45 ± 0.245
4.921SerGly: 4.921 ± 0.666
1.054SerHis: 1.054 ± 0.259
2.109SerIle: 2.109 ± 0.286
2.021SerLys: 2.021 ± 0.229
3.032SerLeu: 3.032 ± 0.366
1.714SerMet: 1.714 ± 0.242
1.714SerAsn: 1.714 ± 0.288
3.076SerPro: 3.076 ± 0.353
1.45SerGln: 1.45 ± 0.303
2.9SerArg: 2.9 ± 0.344
2.021SerSer: 2.021 ± 0.281
3.779SerThr: 3.779 ± 0.527
3.822SerVal: 3.822 ± 0.399
1.011SerTrp: 1.011 ± 0.196
1.362SerTyr: 1.362 ± 0.29
0.0SerXaa: 0.0 ± 0.0
Thr
8.743ThrAla: 8.743 ± 0.708
0.571ThrCys: 0.571 ± 0.158
3.603ThrAsp: 3.603 ± 0.336
4.174ThrGlu: 4.174 ± 0.444
2.197ThrPhe: 2.197 ± 0.331
5.756ThrGly: 5.756 ± 0.672
1.406ThrHis: 1.406 ± 0.28
2.68ThrIle: 2.68 ± 0.336
2.812ThrLys: 2.812 ± 0.395
4.877ThrLeu: 4.877 ± 0.423
1.23ThrMet: 1.23 ± 0.246
2.504ThrAsn: 2.504 ± 0.383
4.877ThrPro: 4.877 ± 0.535
2.504ThrGln: 2.504 ± 0.469
4.35ThrArg: 4.35 ± 0.482
3.295ThrSer: 3.295 ± 0.533
5.316ThrThr: 5.316 ± 0.663
6.503ThrVal: 6.503 ± 0.734
1.274ThrTrp: 1.274 ± 0.224
1.757ThrTyr: 1.757 ± 0.339
0.0ThrXaa: 0.0 ± 0.0
Val
8.392ValAla: 8.392 ± 0.796
0.527ValCys: 0.527 ± 0.163
5.624ValAsp: 5.624 ± 0.505
4.789ValGlu: 4.789 ± 0.43
2.329ValPhe: 2.329 ± 0.249
5.975ValGly: 5.975 ± 0.796
1.714ValHis: 1.714 ± 0.299
2.944ValIle: 2.944 ± 0.411
3.295ValLys: 3.295 ± 0.369
4.833ValLeu: 4.833 ± 0.591
1.67ValMet: 1.67 ± 0.297
2.417ValAsn: 2.417 ± 0.337
4.657ValPro: 4.657 ± 0.448
2.417ValGln: 2.417 ± 0.364
4.613ValArg: 4.613 ± 0.535
4.833ValSer: 4.833 ± 0.414
5.668ValThr: 5.668 ± 0.57
5.931ValVal: 5.931 ± 0.639
0.879ValTrp: 0.879 ± 0.187
1.186ValTyr: 1.186 ± 0.204
0.0ValXaa: 0.0 ± 0.0
Trp
1.362TrpAla: 1.362 ± 0.272
0.264TrpCys: 0.264 ± 0.124
0.967TrpAsp: 0.967 ± 0.217
1.23TrpGlu: 1.23 ± 0.287
0.835TrpPhe: 0.835 ± 0.387
1.538TrpGly: 1.538 ± 0.257
0.527TrpHis: 0.527 ± 0.155
0.879TrpIle: 0.879 ± 0.296
0.835TrpLys: 0.835 ± 0.168
1.714TrpLeu: 1.714 ± 0.345
0.264TrpMet: 0.264 ± 0.103
1.098TrpAsn: 1.098 ± 0.323
1.318TrpPro: 1.318 ± 0.248
0.791TrpGln: 0.791 ± 0.186
0.923TrpArg: 0.923 ± 0.215
0.791TrpSer: 0.791 ± 0.156
1.011TrpThr: 1.011 ± 0.208
1.186TrpVal: 1.186 ± 0.26
0.615TrpTrp: 0.615 ± 0.231
0.22TrpTyr: 0.22 ± 0.095
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.417TyrAla: 2.417 ± 0.323
0.22TyrCys: 0.22 ± 0.122
1.538TyrAsp: 1.538 ± 0.262
1.626TyrGlu: 1.626 ± 0.302
0.395TyrPhe: 0.395 ± 0.114
2.724TyrGly: 2.724 ± 0.449
0.483TyrHis: 0.483 ± 0.184
0.615TyrIle: 0.615 ± 0.166
0.703TyrLys: 0.703 ± 0.176
1.626TyrLeu: 1.626 ± 0.343
0.571TyrMet: 0.571 ± 0.18
1.186TyrAsn: 1.186 ± 0.208
1.977TyrPro: 1.977 ± 0.313
1.274TyrGln: 1.274 ± 0.266
1.67TyrArg: 1.67 ± 0.323
0.967TyrSer: 0.967 ± 0.195
1.801TyrThr: 1.801 ± 0.268
1.801TyrVal: 1.801 ± 0.346
0.439TyrTrp: 0.439 ± 0.15
0.527TyrTyr: 0.527 ± 0.172
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 101 proteins (22761 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski