Amino acid dipepetide frequency for Streptomyces zhaozhouensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.975AlaAla: 21.975 ± 0.2	0.97AlaCys: 0.97 ± 0.025	8.46AlaAsp: 8.46 ± 0.077	10.896AlaGlu: 10.896 ± 0.106	3.584AlaPhe: 3.584 ± 0.055	14.427AlaGly: 14.427 ± 0.116	2.955AlaHis: 2.955 ± 0.045	2.969AlaIle: 2.969 ± 0.051	1.772AlaLys: 1.772 ± 0.042	16.291AlaLeu: 16.291 ± 0.123	2.343AlaMet: 2.343 ± 0.038	1.704AlaAsn: 1.704 ± 0.033	8.084AlaPro: 8.084 ± 0.101	3.216AlaGln: 3.216 ± 0.043	11.836AlaArg: 11.836 ± 0.104	5.716AlaSer: 5.716 ± 0.06	7.167AlaThr: 7.167 ± 0.066	12.028AlaVal: 12.028 ± 0.103	1.882AlaTrp: 1.882 ± 0.033	2.283AlaTyr: 2.283 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.071CysAla: 1.071 ± 0.028	0.091CysCys: 0.091 ± 0.007	0.459CysAsp: 0.459 ± 0.014	0.372CysGlu: 0.372 ± 0.014	0.195CysPhe: 0.195 ± 0.009	0.899CysGly: 0.899 ± 0.024	0.2CysHis: 0.2 ± 0.011	0.089CysIle: 0.089 ± 0.008	0.073CysLys: 0.073 ± 0.006	0.692CysLeu: 0.692 ± 0.019	0.092CysMet: 0.092 ± 0.007	0.097CysAsn: 0.097 ± 0.007	0.449CysPro: 0.449 ± 0.018	0.169CysGln: 0.169 ± 0.009	0.595CysArg: 0.595 ± 0.018	0.356CysSer: 0.356 ± 0.014	0.364CysThr: 0.364 ± 0.013	0.652CysVal: 0.652 ± 0.019	0.137CysTrp: 0.137 ± 0.008	0.15CysTyr: 0.15 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.286AspAla: 8.286 ± 0.076	0.406AspCys: 0.406 ± 0.015	3.746AspAsp: 3.746 ± 0.06	4.51AspGlu: 4.51 ± 0.057	1.593AspPhe: 1.593 ± 0.028	6.752AspGly: 6.752 ± 0.079	1.497AspHis: 1.497 ± 0.026	1.641AspIle: 1.641 ± 0.034	0.611AspLys: 0.611 ± 0.023	5.835AspLeu: 5.835 ± 0.065	0.742AspMet: 0.742 ± 0.02	0.884AspAsn: 0.884 ± 0.026	4.859AspPro: 4.859 ± 0.066	1.601AspGln: 1.601 ± 0.036	5.066AspArg: 5.066 ± 0.052	2.447AspSer: 2.447 ± 0.041	2.855AspThr: 2.855 ± 0.046	4.412AspVal: 4.412 ± 0.054	1.066AspTrp: 1.066 ± 0.028	1.143AspTyr: 1.143 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	8.645GluAla: 8.645 ± 0.092	0.374GluCys: 0.374 ± 0.015	3.234GluAsp: 3.234 ± 0.048	4.9GluGlu: 4.9 ± 0.065	1.608GluPhe: 1.608 ± 0.031	5.508GluGly: 5.508 ± 0.063	1.537GluHis: 1.537 ± 0.032	2.186GluIle: 2.186 ± 0.04	0.965GluLys: 0.965 ± 0.029	7.823GluLeu: 7.823 ± 0.07	0.933GluMet: 0.933 ± 0.021	1.154GluAsn: 1.154 ± 0.028	4.269GluPro: 4.269 ± 0.059	2.094GluGln: 2.094 ± 0.042	7.302GluArg: 7.302 ± 0.075	2.877GluSer: 2.877 ± 0.045	3.386GluThr: 3.386 ± 0.047	5.145GluVal: 5.145 ± 0.062	0.957GluTrp: 0.957 ± 0.019	1.101GluTyr: 1.101 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.664PheAla: 3.664 ± 0.048	0.241PheCys: 0.241 ± 0.011	2.09PheAsp: 2.09 ± 0.042	1.45PheGlu: 1.45 ± 0.03	0.839PhePhe: 0.839 ± 0.026	2.93PheGly: 2.93 ± 0.045	0.643PheHis: 0.643 ± 0.019	0.504PheIle: 0.504 ± 0.016	0.299PheLys: 0.299 ± 0.015	2.571PheLeu: 2.571 ± 0.046	0.324PheMet: 0.324 ± 0.014	0.475PheAsn: 0.475 ± 0.018	1.387PhePro: 1.387 ± 0.025	0.685PheGln: 0.685 ± 0.021	1.918PheArg: 1.918 ± 0.033	1.36PheSer: 1.36 ± 0.027	1.796PheThr: 1.796 ± 0.033	2.137PheVal: 2.137 ± 0.034	0.404PheTrp: 0.404 ± 0.016	0.512PheTyr: 0.512 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	12.373GlyAla: 12.373 ± 0.1	0.8GlyCys: 0.8 ± 0.022	5.617GlyAsp: 5.617 ± 0.072	6.676GlyGlu: 6.676 ± 0.075	2.753GlyPhe: 2.753 ± 0.037	9.935GlyGly: 9.935 ± 0.113	2.292GlyHis: 2.292 ± 0.036	2.806GlyIle: 2.806 ± 0.044	1.499GlyLys: 1.499 ± 0.029	9.677GlyLeu: 9.677 ± 0.088	1.991GlyMet: 1.991 ± 0.032	1.614GlyAsn: 1.614 ± 0.032	5.614GlyPro: 5.614 ± 0.061	2.742GlyGln: 2.742 ± 0.048	8.639GlyArg: 8.639 ± 0.081	4.932GlySer: 4.932 ± 0.052	5.807GlyThr: 5.807 ± 0.057	8.064GlyVal: 8.064 ± 0.072	1.783GlyTrp: 1.783 ± 0.032	2.259GlyTyr: 2.259 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.84HisAla: 2.84 ± 0.039	0.209HisCys: 0.209 ± 0.011	1.288HisAsp: 1.288 ± 0.029	1.237HisGlu: 1.237 ± 0.025	0.586HisPhe: 0.586 ± 0.019	2.415HisGly: 2.415 ± 0.036	0.749HisHis: 0.749 ± 0.021	0.519HisIle: 0.519 ± 0.016	0.195HisLys: 0.195 ± 0.012	2.384HisLeu: 2.384 ± 0.038	0.263HisMet: 0.263 ± 0.012	0.35HisAsn: 0.35 ± 0.014	1.868HisPro: 1.868 ± 0.029	0.662HisGln: 0.662 ± 0.019	2.335HisArg: 2.335 ± 0.041	0.961HisSer: 0.961 ± 0.02	1.249HisThr: 1.249 ± 0.033	1.623HisVal: 1.623 ± 0.031	0.381HisTrp: 0.381 ± 0.013	0.475HisTyr: 0.475 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.977IleAla: 3.977 ± 0.049	0.231IleCys: 0.231 ± 0.011	1.905IleAsp: 1.905 ± 0.034	1.771IleGlu: 1.771 ± 0.033	0.613IlePhe: 0.613 ± 0.018	2.876IleGly: 2.876 ± 0.044	0.515IleHis: 0.515 ± 0.015	0.7IleIle: 0.7 ± 0.025	0.459IleLys: 0.459 ± 0.018	1.84IleLeu: 1.84 ± 0.039	0.345IleMet: 0.345 ± 0.015	0.622IleAsn: 0.622 ± 0.018	1.477IlePro: 1.477 ± 0.03	0.588IleGln: 0.588 ± 0.019	1.891IleArg: 1.891 ± 0.035	1.466IleSer: 1.466 ± 0.029	1.818IleThr: 1.818 ± 0.029	2.187IleVal: 2.187 ± 0.039	0.333IleTrp: 0.333 ± 0.014	0.452IleTyr: 0.452 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	1.642LysAla: 1.642 ± 0.032	0.06LysCys: 0.06 ± 0.006	0.697LysAsp: 0.697 ± 0.024	0.809LysGlu: 0.809 ± 0.025	0.263LysPhe: 0.263 ± 0.011	1.062LysGly: 1.062 ± 0.033	0.278LysHis: 0.278 ± 0.013	0.522LysIle: 0.522 ± 0.017	0.382LysLys: 0.382 ± 0.023	1.302LysLeu: 1.302 ± 0.029	0.238LysMet: 0.238 ± 0.011	0.279LysAsn: 0.279 ± 0.014	0.86LysPro: 0.86 ± 0.027	0.366LysGln: 0.366 ± 0.017	1.044LysArg: 1.044 ± 0.027	0.758LysSer: 0.758 ± 0.021	0.778LysThr: 0.778 ± 0.023	1.085LysVal: 1.085 ± 0.027	0.146LysTrp: 0.146 ± 0.008	0.242LysTyr: 0.242 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	17.111LeuAla: 17.111 ± 0.128	0.792LeuCys: 0.792 ± 0.024	6.818LeuAsp: 6.818 ± 0.069	4.914LeuGlu: 4.914 ± 0.052	2.565LeuPhe: 2.565 ± 0.044	9.751LeuGly: 9.751 ± 0.075	2.183LeuHis: 2.183 ± 0.036	2.76LeuIle: 2.76 ± 0.045	1.191LeuLys: 1.191 ± 0.031	12.424LeuLeu: 12.424 ± 0.107	1.469LeuMet: 1.469 ± 0.033	1.607LeuAsn: 1.607 ± 0.034	7.089LeuPro: 7.089 ± 0.068	1.792LeuGln: 1.792 ± 0.035	9.71LeuArg: 9.71 ± 0.079	5.319LeuSer: 5.319 ± 0.054	7.427LeuThr: 7.427 ± 0.063	9.606LeuVal: 9.606 ± 0.097	1.413LeuTrp: 1.413 ± 0.028	1.702LeuTyr: 1.702 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.181MetAla: 2.181 ± 0.036	0.104MetCys: 0.104 ± 0.007	0.823MetAsp: 0.823 ± 0.024	0.741MetGlu: 0.741 ± 0.023	0.379MetPhe: 0.379 ± 0.015	1.22MetGly: 1.22 ± 0.028	0.278MetHis: 0.278 ± 0.011	0.556MetIle: 0.556 ± 0.018	0.237MetLys: 0.237 ± 0.011	1.529MetLeu: 1.529 ± 0.037	0.264MetMet: 0.264 ± 0.013	0.366MetAsn: 0.366 ± 0.013	0.959MetPro: 0.959 ± 0.026	0.294MetGln: 0.294 ± 0.013	1.44MetArg: 1.44 ± 0.028	1.195MetSer: 1.195 ± 0.026	1.406MetThr: 1.406 ± 0.027	1.314MetVal: 1.314 ± 0.029	0.169MetTrp: 0.169 ± 0.009	0.272MetTyr: 0.272 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.14AsnAla: 2.14 ± 0.035	0.137AsnCys: 0.137 ± 0.009	0.94AsnAsp: 0.94 ± 0.024	0.976AsnGlu: 0.976 ± 0.024	0.403AsnPhe: 0.403 ± 0.014	1.785AsnGly: 1.785 ± 0.031	0.366AsnHis: 0.366 ± 0.015	0.506AsnIle: 0.506 ± 0.02	0.227AsnLys: 0.227 ± 0.011	1.463AsnLeu: 1.463 ± 0.025	0.272AsnMet: 0.272 ± 0.013	0.365AsnAsn: 0.365 ± 0.014	1.194AsnPro: 1.194 ± 0.026	0.469AsnGln: 0.469 ± 0.016	1.189AsnArg: 1.189 ± 0.024	0.735AsnSer: 0.735 ± 0.021	0.905AsnThr: 0.905 ± 0.024	1.254AsnVal: 1.254 ± 0.029	0.273AsnTrp: 0.273 ± 0.013	0.356AsnTyr: 0.356 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.406ProAla: 9.406 ± 0.106	0.321ProCys: 0.321 ± 0.013	4.726ProAsp: 4.726 ± 0.06	5.721ProGlu: 5.721 ± 0.072	1.591ProPhe: 1.591 ± 0.026	7.239ProGly: 7.239 ± 0.078	1.455ProHis: 1.455 ± 0.026	1.159ProIle: 1.159 ± 0.023	0.765ProLys: 0.765 ± 0.021	5.921ProLeu: 5.921 ± 0.064	0.954ProMet: 0.954 ± 0.023	0.82ProAsn: 0.82 ± 0.023	4.666ProPro: 4.666 ± 0.098	1.422ProGln: 1.422 ± 0.034	4.621ProArg: 4.621 ± 0.051	3.044ProSer: 3.044 ± 0.046	3.433ProThr: 3.433 ± 0.056	5.396ProVal: 5.396 ± 0.053	0.945ProTrp: 0.945 ± 0.023	1.078ProTyr: 1.078 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.114GlnAla: 3.114 ± 0.047	0.134GlnCys: 0.134 ± 0.008	1.192GlnAsp: 1.192 ± 0.026	1.416GlnGlu: 1.416 ± 0.029	0.586GlnPhe: 0.586 ± 0.018	2.068GlnGly: 2.068 ± 0.036	0.579GlnHis: 0.579 ± 0.017	0.813GlnIle: 0.813 ± 0.022	0.3GlnLys: 0.3 ± 0.013	3.061GlnLeu: 3.061 ± 0.049	0.371GlnMet: 0.371 ± 0.016	0.408GlnAsn: 0.408 ± 0.015	1.708GlnPro: 1.708 ± 0.045	1.015GlnGln: 1.015 ± 0.03	2.548GlnArg: 2.548 ± 0.039	1.08GlnSer: 1.08 ± 0.028	1.129GlnThr: 1.129 ± 0.026	2.078GlnVal: 2.078 ± 0.035	0.376GlnTrp: 0.376 ± 0.014	0.473GlnTyr: 0.473 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	11.762ArgAla: 11.762 ± 0.098	0.637ArgCys: 0.637 ± 0.019	4.613ArgAsp: 4.613 ± 0.048	5.931ArgGlu: 5.931 ± 0.063	2.376ArgPhe: 2.376 ± 0.038	6.777ArgGly: 6.777 ± 0.076	2.267ArgHis: 2.267 ± 0.034	2.6ArgIle: 2.6 ± 0.039	1.13ArgLys: 1.13 ± 0.03	10.31ArgLeu: 10.31 ± 0.099	1.718ArgMet: 1.718 ± 0.033	1.326ArgAsn: 1.326 ± 0.026	5.664ArgPro: 5.664 ± 0.067	2.367ArgGln: 2.367 ± 0.037	9.103ArgArg: 9.103 ± 0.106	3.912ArgSer: 3.912 ± 0.047	4.742ArgThr: 4.742 ± 0.056	7.227ArgVal: 7.227 ± 0.068	1.601ArgTrp: 1.601 ± 0.028	1.879ArgTyr: 1.879 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.363SerAla: 6.363 ± 0.069	0.361SerCys: 0.361 ± 0.013	2.604SerAsp: 2.604 ± 0.045	2.626SerGlu: 2.626 ± 0.044	1.435SerPhe: 1.435 ± 0.026	5.791SerGly: 5.791 ± 0.063	1.0SerHis: 1.0 ± 0.024	1.124SerIle: 1.124 ± 0.027	0.592SerLys: 0.592 ± 0.02	4.79SerLeu: 4.79 ± 0.055	0.889SerMet: 0.889 ± 0.021	0.742SerAsn: 0.742 ± 0.022	3.16SerPro: 3.16 ± 0.048	1.098SerGln: 1.098 ± 0.029	3.63SerArg: 3.63 ± 0.047	2.499SerSer: 2.499 ± 0.04	2.667SerThr: 2.667 ± 0.034	4.126SerVal: 4.126 ± 0.05	0.898SerTrp: 0.898 ± 0.024	1.104SerTyr: 1.104 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.117ThrAla: 8.117 ± 0.071	0.336ThrCys: 0.336 ± 0.014	3.386ThrAsp: 3.386 ± 0.053	3.651ThrGlu: 3.651 ± 0.049	1.507ThrPhe: 1.507 ± 0.029	6.364ThrGly: 6.364 ± 0.072	1.225ThrHis: 1.225 ± 0.029	1.357ThrIle: 1.357 ± 0.034	0.651ThrLys: 0.651 ± 0.018	6.075ThrLeu: 6.075 ± 0.061	0.829ThrMet: 0.829 ± 0.023	0.835ThrAsn: 0.835 ± 0.023	4.113ThrPro: 4.113 ± 0.051	1.129ThrGln: 1.129 ± 0.024	4.134ThrArg: 4.134 ± 0.055	2.794ThrSer: 2.794 ± 0.042	3.537ThrThr: 3.537 ± 0.049	5.94ThrVal: 5.94 ± 0.059	0.791ThrTrp: 0.791 ± 0.023	1.127ThrTyr: 1.127 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.66ValAla: 11.66 ± 0.1	0.672ValCys: 0.672 ± 0.019	5.189ValAsp: 5.189 ± 0.053	5.395ValGlu: 5.395 ± 0.065	2.308ValPhe: 2.308 ± 0.042	7.055ValGly: 7.055 ± 0.072	1.778ValHis: 1.778 ± 0.031	2.517ValIle: 2.517 ± 0.039	1.076ValLys: 1.076 ± 0.024	9.716ValLeu: 9.716 ± 0.079	1.223ValMet: 1.223 ± 0.029	1.61ValAsn: 1.61 ± 0.031	5.283ValPro: 5.283 ± 0.061	1.57ValGln: 1.57 ± 0.03	7.395ValArg: 7.395 ± 0.063	4.281ValSer: 4.281 ± 0.05	5.474ValThr: 5.474 ± 0.064	7.989ValVal: 7.989 ± 0.088	1.132ValTrp: 1.132 ± 0.025	1.433ValTyr: 1.433 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.703TrpAla: 1.703 ± 0.03	0.158TrpCys: 0.158 ± 0.009	0.884TrpAsp: 0.884 ± 0.025	0.924TrpGlu: 0.924 ± 0.023	0.493TrpPhe: 0.493 ± 0.017	1.111TrpGly: 1.111 ± 0.026	0.375TrpHis: 0.375 ± 0.014	0.418TrpIle: 0.418 ± 0.015	0.203TrpLys: 0.203 ± 0.011	1.882TrpLeu: 1.882 ± 0.038	0.256TrpMet: 0.256 ± 0.012	0.374TrpAsn: 0.374 ± 0.014	0.883TrpPro: 0.883 ± 0.022	0.542TrpGln: 0.542 ± 0.017	1.606TrpArg: 1.606 ± 0.035	0.96TrpSer: 0.96 ± 0.023	0.893TrpThr: 0.893 ± 0.023	1.059TrpVal: 1.059 ± 0.025	0.364TrpTrp: 0.364 ± 0.014	0.312TrpTyr: 0.312 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.528TyrAla: 2.528 ± 0.043	0.166TyrCys: 0.166 ± 0.011	1.28TyrAsp: 1.28 ± 0.034	1.083TyrGlu: 1.083 ± 0.024	0.551TyrPhe: 0.551 ± 0.016	1.905TyrGly: 1.905 ± 0.035	0.417TyrHis: 0.417 ± 0.015	0.32TyrIle: 0.32 ± 0.013	0.189TyrLys: 0.189 ± 0.009	2.056TyrLeu: 2.056 ± 0.035	0.213TyrMet: 0.213 ± 0.01	0.321TyrAsn: 0.321 ± 0.012	1.095TyrPro: 1.095 ± 0.026	0.631TyrGln: 0.631 ± 0.021	1.942TyrArg: 1.942 ± 0.03	0.807TyrSer: 0.807 ± 0.02	1.065TyrThr: 1.065 ± 0.025	1.435TyrVal: 1.435 ± 0.029	0.348TyrTrp: 0.348 ± 0.015	0.416TyrTyr: 0.416 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5537 proteins (1918315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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