Amino acid dipepetide frequency for Mycoplasma todarodis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.216AlaAla: 5.216 ± 0.458
0.268AlaCys: 0.268 ± 0.031
3.386AlaAsp: 3.386 ± 0.268
3.616AlaGlu: 3.616 ± 0.158
3.131AlaPhe: 3.131 ± 0.127
3.478AlaGly: 3.478 ± 0.131
1.101AlaHis: 1.101 ± 0.06
6.63AlaIle: 6.63 ± 0.189
7.304AlaLys: 7.304 ± 0.388
5.426AlaLeu: 5.426 ± 0.151
1.827AlaMet: 1.827 ± 0.082
3.592AlaAsn: 3.592 ± 0.117
1.559AlaPro: 1.559 ± 0.081
2.071AlaGln: 2.071 ± 0.12
2.205AlaArg: 2.205 ± 0.089
3.891AlaSer: 3.891 ± 0.156
4.259AlaThr: 4.259 ± 0.16
3.53AlaVal: 3.53 ± 0.132
0.578AlaTrp: 0.578 ± 0.047
1.82AlaTyr: 1.82 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.213CysAla: 0.213 ± 0.025
0.028CysCys: 0.028 ± 0.012
0.224CysAsp: 0.224 ± 0.029
0.306CysGlu: 0.306 ± 0.035
0.213CysPhe: 0.213 ± 0.027
0.485CysGly: 0.485 ± 0.042
0.103CysHis: 0.103 ± 0.021
0.382CysIle: 0.382 ± 0.038
0.334CysLys: 0.334 ± 0.037
0.303CysLeu: 0.303 ± 0.039
0.083CysMet: 0.083 ± 0.016
0.203CysAsn: 0.203 ± 0.026
0.155CysPro: 0.155 ± 0.024
0.1CysGln: 0.1 ± 0.022
0.1CysArg: 0.1 ± 0.019
0.299CysSer: 0.299 ± 0.03
0.182CysThr: 0.182 ± 0.023
0.282CysVal: 0.282 ± 0.027
0.065CysTrp: 0.065 ± 0.017
0.145CysTyr: 0.145 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.709AspAla: 3.709 ± 0.234
0.155AspCys: 0.155 ± 0.023
2.412AspAsp: 2.412 ± 0.105
3.871AspGlu: 3.871 ± 0.147
2.828AspPhe: 2.828 ± 0.116
3.282AspGly: 3.282 ± 0.126
0.843AspHis: 0.843 ± 0.056
4.923AspIle: 4.923 ± 0.134
5.735AspLys: 5.735 ± 0.192
4.538AspLeu: 4.538 ± 0.145
1.077AspMet: 1.077 ± 0.06
2.463AspAsn: 2.463 ± 0.098
1.586AspPro: 1.586 ± 0.087
1.383AspGln: 1.383 ± 0.081
1.531AspArg: 1.531 ± 0.071
3.021AspSer: 3.021 ± 0.096
2.374AspThr: 2.374 ± 0.095
3.503AspVal: 3.503 ± 0.127
0.502AspTrp: 0.502 ± 0.047
1.937AspTyr: 1.937 ± 0.092
0.0AspXaa: 0.0 ± 0.0
Glu
4.345GluAla: 4.345 ± 0.156
0.248GluCys: 0.248 ± 0.028
3.179GluAsp: 3.179 ± 0.118
6.031GluGlu: 6.031 ± 0.208
3.647GluPhe: 3.647 ± 0.119
3.699GluGly: 3.699 ± 0.139
1.101GluHis: 1.101 ± 0.067
6.73GluIle: 6.73 ± 0.178
7.476GluLys: 7.476 ± 0.208
6.867GluLeu: 6.867 ± 0.197
2.071GluMet: 2.071 ± 0.087
4.053GluAsn: 4.053 ± 0.138
1.39GluPro: 1.39 ± 0.077
2.35GluGln: 2.35 ± 0.105
2.498GluArg: 2.498 ± 0.101
3.131GluSer: 3.131 ± 0.091
3.922GluThr: 3.922 ± 0.132
5.202GluVal: 5.202 ± 0.146
0.822GluTrp: 0.822 ± 0.052
2.766GluTyr: 2.766 ± 0.099
0.0GluXaa: 0.0 ± 0.0
Phe
2.997PheAla: 2.997 ± 0.122
0.189PheCys: 0.189 ± 0.024
2.928PheAsp: 2.928 ± 0.097
3.361PheGlu: 3.361 ± 0.099
2.181PhePhe: 2.181 ± 0.125
3.086PheGly: 3.086 ± 0.114
0.723PheHis: 0.723 ± 0.057
4.686PheIle: 4.686 ± 0.177
4.886PheLys: 4.886 ± 0.157
3.709PheLeu: 3.709 ± 0.14
1.235PheMet: 1.235 ± 0.063
2.931PheAsn: 2.931 ± 0.11
1.332PhePro: 1.332 ± 0.073
1.266PheGln: 1.266 ± 0.068
1.29PheArg: 1.29 ± 0.068
3.441PheSer: 3.441 ± 0.138
2.663PheThr: 2.663 ± 0.112
3.231PheVal: 3.231 ± 0.118
0.585PheTrp: 0.585 ± 0.049
1.455PheTyr: 1.455 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
3.915GlyAla: 3.915 ± 0.137
0.244GlyCys: 0.244 ± 0.036
2.98GlyAsp: 2.98 ± 0.109
3.551GlyGlu: 3.551 ± 0.132
3.158GlyPhe: 3.158 ± 0.127
3.702GlyGly: 3.702 ± 0.175
1.153GlyHis: 1.153 ± 0.076
5.605GlyIle: 5.605 ± 0.156
5.966GlyLys: 5.966 ± 0.147
4.82GlyLeu: 4.82 ± 0.148
1.889GlyMet: 1.889 ± 0.092
2.694GlyAsn: 2.694 ± 0.121
1.173GlyPro: 1.173 ± 0.067
1.679GlyGln: 1.679 ± 0.077
1.837GlyArg: 1.837 ± 0.098
3.633GlySer: 3.633 ± 0.118
3.63GlyThr: 3.63 ± 0.15
4.493GlyVal: 4.493 ± 0.125
0.709GlyTrp: 0.709 ± 0.046
2.161GlyTyr: 2.161 ± 0.093
0.0GlyXaa: 0.0 ± 0.0
His
1.053HisAla: 1.053 ± 0.061
0.079HisCys: 0.079 ± 0.015
0.771HisAsp: 0.771 ± 0.057
1.07HisGlu: 1.07 ± 0.061
0.881HisPhe: 0.881 ± 0.059
1.266HisGly: 1.266 ± 0.066
0.327HisHis: 0.327 ± 0.038
1.493HisIle: 1.493 ± 0.073
1.535HisLys: 1.535 ± 0.076
1.335HisLeu: 1.335 ± 0.078
0.403HisMet: 0.403 ± 0.043
1.008HisAsn: 1.008 ± 0.057
0.633HisPro: 0.633 ± 0.05
0.434HisGln: 0.434 ± 0.035
0.55HisArg: 0.55 ± 0.039
1.077HisSer: 1.077 ± 0.056
0.991HisThr: 0.991 ± 0.062
0.895HisVal: 0.895 ± 0.064
0.175HisTrp: 0.175 ± 0.023
0.592HisTyr: 0.592 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.541IleAla: 6.541 ± 0.179
0.482IleCys: 0.482 ± 0.047
5.02IleAsp: 5.02 ± 0.146
6.572IleGlu: 6.572 ± 0.164
4.438IlePhe: 4.438 ± 0.152
5.288IleGly: 5.288 ± 0.157
1.369IleHis: 1.369 ± 0.065
8.168IleIle: 8.168 ± 0.216
9.555IleLys: 9.555 ± 0.204
7.218IleLeu: 7.218 ± 0.206
2.106IleMet: 2.106 ± 0.084
5.973IleAsn: 5.973 ± 0.154
2.876IlePro: 2.876 ± 0.106
2.433IleGln: 2.433 ± 0.077
2.625IleArg: 2.625 ± 0.1
6.695IleSer: 6.695 ± 0.17
5.532IleThr: 5.532 ± 0.154
5.598IleVal: 5.598 ± 0.167
0.908IleTrp: 0.908 ± 0.059
2.756IleTyr: 2.756 ± 0.117
0.0IleXaa: 0.0 ± 0.0
Lys
6.768LysAla: 6.768 ± 0.479
0.323LysCys: 0.323 ± 0.039
6.234LysAsp: 6.234 ± 0.204
10.033LysGlu: 10.033 ± 0.238
3.936LysPhe: 3.936 ± 0.117
5.319LysGly: 5.319 ± 0.145
1.923LysHis: 1.923 ± 0.078
8.653LysIle: 8.653 ± 0.198
11.161LysLys: 11.161 ± 0.302
8.178LysLeu: 8.178 ± 0.225
3.327LysMet: 3.327 ± 0.116
6.854LysAsn: 6.854 ± 0.178
2.976LysPro: 2.976 ± 0.113
3.585LysGln: 3.585 ± 0.123
3.709LysArg: 3.709 ± 0.116
5.319LysSer: 5.319 ± 0.147
6.726LysThr: 6.726 ± 0.189
6.224LysVal: 6.224 ± 0.168
1.197LysTrp: 1.197 ± 0.072
3.781LysTyr: 3.781 ± 0.124
0.0LysXaa: 0.0 ± 0.0
Leu
5.577LeuAla: 5.577 ± 0.169
0.413LeuCys: 0.413 ± 0.043
4.421LeuAsp: 4.421 ± 0.133
5.725LeuGlu: 5.725 ± 0.177
4.239LeuPhe: 4.239 ± 0.16
4.782LeuGly: 4.782 ± 0.141
1.208LeuHis: 1.208 ± 0.068
7.786LeuIle: 7.786 ± 0.19
8.87LeuLys: 8.87 ± 0.239
7.019LeuLeu: 7.019 ± 0.216
2.23LeuMet: 2.23 ± 0.093
5.075LeuAsn: 5.075 ± 0.148
2.519LeuPro: 2.519 ± 0.092
2.13LeuGln: 2.13 ± 0.084
2.811LeuArg: 2.811 ± 0.112
5.863LeuSer: 5.863 ± 0.144
4.741LeuThr: 4.741 ± 0.105
4.789LeuVal: 4.789 ± 0.157
0.781LeuTrp: 0.781 ± 0.054
2.264LeuTyr: 2.264 ± 0.095
0.0LeuXaa: 0.0 ± 0.0
Met
1.645MetAla: 1.645 ± 0.09
0.141MetCys: 0.141 ± 0.025
1.211MetAsp: 1.211 ± 0.064
1.813MetGlu: 1.813 ± 0.086
1.369MetPhe: 1.369 ± 0.071
1.583MetGly: 1.583 ± 0.076
0.423MetHis: 0.423 ± 0.039
2.271MetIle: 2.271 ± 0.095
3.048MetLys: 3.048 ± 0.098
2.068MetLeu: 2.068 ± 0.095
0.733MetMet: 0.733 ± 0.052
1.734MetAsn: 1.734 ± 0.082
0.874MetPro: 0.874 ± 0.058
0.774MetGln: 0.774 ± 0.043
0.891MetArg: 0.891 ± 0.052
1.638MetSer: 1.638 ± 0.072
1.466MetThr: 1.466 ± 0.073
1.607MetVal: 1.607 ± 0.078
0.258MetTrp: 0.258 ± 0.032
0.702MetTyr: 0.702 ± 0.053
0.0MetXaa: 0.0 ± 0.0
Asn
3.527AsnAla: 3.527 ± 0.104
0.169AsnCys: 0.169 ± 0.023
3.165AsnAsp: 3.165 ± 0.118
4.208AsnGlu: 4.208 ± 0.134
2.498AsnPhe: 2.498 ± 0.101
3.953AsnGly: 3.953 ± 0.163
0.977AsnHis: 0.977 ± 0.065
5.154AsnIle: 5.154 ± 0.152
7.71AsnLys: 7.71 ± 0.2
4.445AsnLeu: 4.445 ± 0.135
1.139AsnMet: 1.139 ± 0.058
4.142AsnAsn: 4.142 ± 0.142
2.257AsnPro: 2.257 ± 0.09
1.627AsnGln: 1.627 ± 0.088
1.638AsnArg: 1.638 ± 0.076
3.785AsnSer: 3.785 ± 0.138
3.066AsnThr: 3.066 ± 0.092
3.334AsnVal: 3.334 ± 0.1
0.685AsnTrp: 0.685 ± 0.051
2.044AsnTyr: 2.044 ± 0.096
0.0AsnXaa: 0.0 ± 0.0
Pro
1.634ProAla: 1.634 ± 0.076
0.11ProCys: 0.11 ± 0.02
1.173ProAsp: 1.173 ± 0.071
2.212ProGlu: 2.212 ± 0.094
1.466ProPhe: 1.466 ± 0.074
1.775ProGly: 1.775 ± 0.087
0.547ProHis: 0.547 ± 0.044
2.642ProIle: 2.642 ± 0.106
3.004ProLys: 3.004 ± 0.106
2.364ProLeu: 2.364 ± 0.097
0.736ProMet: 0.736 ± 0.052
1.741ProAsn: 1.741 ± 0.079
0.478ProPro: 0.478 ± 0.04
0.819ProGln: 0.819 ± 0.059
0.74ProArg: 0.74 ± 0.057
1.837ProSer: 1.837 ± 0.076
1.896ProThr: 1.896 ± 0.084
1.861ProVal: 1.861 ± 0.075
0.378ProTrp: 0.378 ± 0.03
0.857ProTyr: 0.857 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
1.799GlnAla: 1.799 ± 0.115
0.069GlnCys: 0.069 ± 0.014
1.424GlnAsp: 1.424 ± 0.072
2.309GlnGlu: 2.309 ± 0.092
1.132GlnPhe: 1.132 ± 0.057
1.731GlnGly: 1.731 ± 0.081
0.468GlnHis: 0.468 ± 0.036
2.488GlnIle: 2.488 ± 0.092
3.251GlnLys: 3.251 ± 0.113
2.426GlnLeu: 2.426 ± 0.103
0.764GlnMet: 0.764 ± 0.04
1.762GlnAsn: 1.762 ± 0.082
0.888GlnPro: 0.888 ± 0.067
0.96GlnGln: 0.96 ± 0.063
1.215GlnArg: 1.215 ± 0.073
1.438GlnSer: 1.438 ± 0.074
1.676GlnThr: 1.676 ± 0.079
1.6GlnVal: 1.6 ± 0.08
0.396GlnTrp: 0.396 ± 0.044
1.039GlnTyr: 1.039 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
1.748ArgAla: 1.748 ± 0.093
0.138ArgCys: 0.138 ± 0.021
1.607ArgAsp: 1.607 ± 0.082
2.257ArgGlu: 2.257 ± 0.095
1.593ArgPhe: 1.593 ± 0.069
1.782ArgGly: 1.782 ± 0.086
0.533ArgHis: 0.533 ± 0.051
2.955ArgIle: 2.955 ± 0.1
3.465ArgLys: 3.465 ± 0.119
2.491ArgLeu: 2.491 ± 0.091
0.994ArgMet: 0.994 ± 0.059
1.968ArgAsn: 1.968 ± 0.088
0.822ArgPro: 0.822 ± 0.058
1.032ArgGln: 1.032 ± 0.064
1.455ArgArg: 1.455 ± 0.072
1.614ArgSer: 1.614 ± 0.079
2.002ArgThr: 2.002 ± 0.087
2.099ArgVal: 2.099 ± 0.089
0.42ArgTrp: 0.42 ± 0.037
1.321ArgTyr: 1.321 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
3.334SerAla: 3.334 ± 0.125
0.406SerCys: 0.406 ± 0.043
2.928SerAsp: 2.928 ± 0.082
4.05SerGlu: 4.05 ± 0.122
3.128SerPhe: 3.128 ± 0.129
3.685SerGly: 3.685 ± 0.107
1.098SerHis: 1.098 ± 0.058
6.007SerIle: 6.007 ± 0.167
6.52SerLys: 6.52 ± 0.155
6.052SerLeu: 6.052 ± 0.155
1.531SerMet: 1.531 ± 0.075
3.606SerAsn: 3.606 ± 0.132
1.479SerPro: 1.479 ± 0.073
1.738SerGln: 1.738 ± 0.075
2.157SerArg: 2.157 ± 0.093
4.187SerSer: 4.187 ± 0.137
3.719SerThr: 3.719 ± 0.106
3.62SerVal: 3.62 ± 0.14
0.767SerTrp: 0.767 ± 0.046
1.879SerTyr: 1.879 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
3.454ThrAla: 3.454 ± 0.172
0.227ThrCys: 0.227 ± 0.031
2.687ThrAsp: 2.687 ± 0.112
3.069ThrGlu: 3.069 ± 0.102
2.883ThrPhe: 2.883 ± 0.089
3.585ThrGly: 3.585 ± 0.132
1.221ThrHis: 1.221 ± 0.069
5.959ThrIle: 5.959 ± 0.149
5.963ThrLys: 5.963 ± 0.194
5.622ThrLeu: 5.622 ± 0.152
1.311ThrMet: 1.311 ± 0.066
3.637ThrAsn: 3.637 ± 0.117
2.247ThrPro: 2.247 ± 0.091
1.696ThrGln: 1.696 ± 0.093
1.751ThrArg: 1.751 ± 0.072
3.774ThrSer: 3.774 ± 0.102
3.946ThrThr: 3.946 ± 0.143
3.179ThrVal: 3.179 ± 0.129
0.616ThrTrp: 0.616 ± 0.047
1.961ThrTyr: 1.961 ± 0.079
0.0ThrXaa: 0.0 ± 0.0
Val
4.634ValAla: 4.634 ± 0.138
0.382ValCys: 0.382 ± 0.037
3.489ValAsp: 3.489 ± 0.135
4.518ValGlu: 4.518 ± 0.146
3.062ValPhe: 3.062 ± 0.11
3.816ValGly: 3.816 ± 0.145
0.846ValHis: 0.846 ± 0.058
5.625ValIle: 5.625 ± 0.153
5.832ValLys: 5.832 ± 0.163
4.893ValLeu: 4.893 ± 0.108
1.645ValMet: 1.645 ± 0.082
3.403ValAsn: 3.403 ± 0.107
1.83ValPro: 1.83 ± 0.071
1.621ValGln: 1.621 ± 0.07
1.793ValArg: 1.793 ± 0.08
4.249ValSer: 4.249 ± 0.116
3.568ValThr: 3.568 ± 0.126
4.841ValVal: 4.841 ± 0.16
0.726ValTrp: 0.726 ± 0.054
1.782ValTyr: 1.782 ± 0.089
0.0ValXaa: 0.0 ± 0.0
Trp
0.698TrpAla: 0.698 ± 0.055
0.055TrpCys: 0.055 ± 0.016
0.592TrpAsp: 0.592 ± 0.049
0.657TrpGlu: 0.657 ± 0.047
0.585TrpPhe: 0.585 ± 0.055
0.661TrpGly: 0.661 ± 0.043
0.175TrpHis: 0.175 ± 0.026
1.111TrpIle: 1.111 ± 0.075
1.018TrpLys: 1.018 ± 0.063
0.888TrpLeu: 0.888 ± 0.063
0.354TrpMet: 0.354 ± 0.038
0.692TrpAsn: 0.692 ± 0.052
0.289TrpPro: 0.289 ± 0.029
0.213TrpGln: 0.213 ± 0.024
0.43TrpArg: 0.43 ± 0.038
0.64TrpSer: 0.64 ± 0.047
0.826TrpThr: 0.826 ± 0.059
0.753TrpVal: 0.753 ± 0.049
0.186TrpTrp: 0.186 ± 0.024
0.365TrpTyr: 0.365 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.082TyrAla: 2.082 ± 0.085
0.079TyrCys: 0.079 ± 0.017
1.844TyrAsp: 1.844 ± 0.079
2.305TyrGlu: 2.305 ± 0.1
1.806TyrPhe: 1.806 ± 0.1
2.033TyrGly: 2.033 ± 0.094
0.427TyrHis: 0.427 ± 0.043
2.883TyrIle: 2.883 ± 0.11
3.595TyrLys: 3.595 ± 0.114
2.58TyrLeu: 2.58 ± 0.11
0.791TyrMet: 0.791 ± 0.048
1.992TyrAsn: 1.992 ± 0.079
0.908TyrPro: 0.908 ± 0.057
0.922TyrGln: 0.922 ± 0.054
1.07TyrArg: 1.07 ± 0.054
2.357TyrSer: 2.357 ± 0.095
1.603TyrThr: 1.603 ± 0.071
1.913TyrVal: 1.913 ± 0.1
0.434TyrTrp: 0.434 ± 0.039
1.125TyrTyr: 1.125 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 894 proteins (290648 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski