Amino acid dipepetide frequency for Tolumonas auensis (strain DSM 9187 / TA4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.914AlaAla: 9.914 ± 0.15	1.118AlaCys: 1.118 ± 0.032	5.315AlaAsp: 5.315 ± 0.076	6.466AlaGlu: 6.466 ± 0.077	3.355AlaPhe: 3.355 ± 0.064	7.37AlaGly: 7.37 ± 0.1	1.926AlaHis: 1.926 ± 0.045	5.936AlaIle: 5.936 ± 0.087	4.429AlaLys: 4.429 ± 0.083	10.824AlaLeu: 10.824 ± 0.128	2.77AlaMet: 2.77 ± 0.046	3.173AlaAsn: 3.173 ± 0.06	3.292AlaPro: 3.292 ± 0.055	4.064AlaGln: 4.064 ± 0.072	4.717AlaArg: 4.717 ± 0.086	4.874AlaSer: 4.874 ± 0.082	4.709AlaThr: 4.709 ± 0.078	6.658AlaVal: 6.658 ± 0.08	1.166AlaTrp: 1.166 ± 0.033	2.436AlaTyr: 2.436 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.918CysAla: 0.918 ± 0.026	0.208CysCys: 0.208 ± 0.016	0.634CysAsp: 0.634 ± 0.028	0.62CysGlu: 0.62 ± 0.025	0.514CysPhe: 0.514 ± 0.022	1.063CysGly: 1.063 ± 0.034	0.367CysHis: 0.367 ± 0.022	0.613CysIle: 0.613 ± 0.028	0.408CysLys: 0.408 ± 0.022	1.086CysLeu: 1.086 ± 0.035	0.238CysMet: 0.238 ± 0.014	0.376CysAsn: 0.376 ± 0.018	0.55CysPro: 0.55 ± 0.025	0.564CysGln: 0.564 ± 0.023	0.674CysArg: 0.674 ± 0.027	0.712CysSer: 0.712 ± 0.026	0.51CysThr: 0.51 ± 0.022	0.694CysVal: 0.694 ± 0.028	0.162CysTrp: 0.162 ± 0.013	0.37CysTyr: 0.37 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.877AspAla: 4.877 ± 0.074	0.593AspCys: 0.593 ± 0.024	2.922AspAsp: 2.922 ± 0.077	3.781AspGlu: 3.781 ± 0.064	2.152AspPhe: 2.152 ± 0.042	3.767AspGly: 3.767 ± 0.069	1.138AspHis: 1.138 ± 0.043	3.529AspIle: 3.529 ± 0.063	2.596AspLys: 2.596 ± 0.051	5.423AspLeu: 5.423 ± 0.074	1.36AspMet: 1.36 ± 0.033	2.03AspAsn: 2.03 ± 0.048	2.386AspPro: 2.386 ± 0.056	1.925AspGln: 1.925 ± 0.045	2.571AspArg: 2.571 ± 0.046	2.86AspSer: 2.86 ± 0.048	2.627AspThr: 2.627 ± 0.057	3.916AspVal: 3.916 ± 0.069	0.976AspTrp: 0.976 ± 0.033	1.867AspTyr: 1.867 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.102GluAla: 5.102 ± 0.078	0.572GluCys: 0.572 ± 0.026	2.431GluAsp: 2.431 ± 0.053	3.359GluGlu: 3.359 ± 0.075	2.114GluPhe: 2.114 ± 0.043	3.293GluGly: 3.293 ± 0.058	1.552GluHis: 1.552 ± 0.043	3.685GluIle: 3.685 ± 0.068	3.281GluLys: 3.281 ± 0.065	7.334GluLeu: 7.334 ± 0.085	1.688GluMet: 1.688 ± 0.044	2.33GluAsn: 2.33 ± 0.047	2.231GluPro: 2.231 ± 0.052	4.125GluGln: 4.125 ± 0.068	3.571GluArg: 3.571 ± 0.058	2.985GluSer: 2.985 ± 0.062	2.91GluThr: 2.91 ± 0.058	3.612GluVal: 3.612 ± 0.068	0.83GluTrp: 0.83 ± 0.029	1.699GluTyr: 1.699 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.567PheAla: 3.567 ± 0.066	0.539PheCys: 0.539 ± 0.023	2.387PheAsp: 2.387 ± 0.052	1.938PheGlu: 1.938 ± 0.042	1.655PhePhe: 1.655 ± 0.048	3.173PheGly: 3.173 ± 0.072	0.887PheHis: 0.887 ± 0.03	2.635PheIle: 2.635 ± 0.064	1.497PheLys: 1.497 ± 0.04	3.592PheLeu: 3.592 ± 0.066	1.027PheMet: 1.027 ± 0.035	1.717PheAsn: 1.717 ± 0.042	1.545PhePro: 1.545 ± 0.041	1.243PheGln: 1.243 ± 0.036	1.914PheArg: 1.914 ± 0.039	3.01PheSer: 3.01 ± 0.056	2.182PheThr: 2.182 ± 0.044	2.536PheVal: 2.536 ± 0.053	0.551PheTrp: 0.551 ± 0.022	1.241PheTyr: 1.241 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.631GlyAla: 5.631 ± 0.086	1.026GlyCys: 1.026 ± 0.032	3.563GlyAsp: 3.563 ± 0.067	4.168GlyGlu: 4.168 ± 0.067	3.183GlyPhe: 3.183 ± 0.057	5.043GlyGly: 5.043 ± 0.085	1.75GlyHis: 1.75 ± 0.042	5.155GlyIle: 5.155 ± 0.076	4.014GlyLys: 4.014 ± 0.059	7.454GlyLeu: 7.454 ± 0.087	2.217GlyMet: 2.217 ± 0.044	2.48GlyAsn: 2.48 ± 0.061	1.879GlyPro: 1.879 ± 0.042	2.936GlyGln: 2.936 ± 0.056	3.496GlyArg: 3.496 ± 0.061	4.208GlySer: 4.208 ± 0.066	3.536GlyThr: 3.536 ± 0.059	5.16GlyVal: 5.16 ± 0.079	1.12GlyTrp: 1.12 ± 0.035	2.56GlyTyr: 2.56 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.993HisAla: 1.993 ± 0.042	0.328HisCys: 0.328 ± 0.021	1.277HisAsp: 1.277 ± 0.038	1.16HisGlu: 1.16 ± 0.036	1.099HisPhe: 1.099 ± 0.039	1.833HisGly: 1.833 ± 0.043	0.846HisHis: 0.846 ± 0.036	1.44HisIle: 1.44 ± 0.04	0.958HisLys: 0.958 ± 0.031	2.557HisLeu: 2.557 ± 0.055	0.542HisMet: 0.542 ± 0.023	0.843HisAsn: 0.843 ± 0.027	1.432HisPro: 1.432 ± 0.036	1.254HisGln: 1.254 ± 0.035	1.279HisArg: 1.279 ± 0.04	1.338HisSer: 1.338 ± 0.04	1.087HisThr: 1.087 ± 0.033	1.338HisVal: 1.338 ± 0.038	0.423HisTrp: 0.423 ± 0.026	0.882HisTyr: 0.882 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.52IleAla: 6.52 ± 0.08	0.82IleCys: 0.82 ± 0.033	3.694IleAsp: 3.694 ± 0.061	3.647IleGlu: 3.647 ± 0.07	2.045IlePhe: 2.045 ± 0.053	4.757IleGly: 4.757 ± 0.075	1.344IleHis: 1.344 ± 0.038	3.465IleIle: 3.465 ± 0.063	2.781IleLys: 2.781 ± 0.053	5.36IleLeu: 5.36 ± 0.083	1.398IleMet: 1.398 ± 0.038	2.563IleAsn: 2.563 ± 0.048	3.036IlePro: 3.036 ± 0.049	2.31IleGln: 2.31 ± 0.055	3.401IleArg: 3.401 ± 0.063	4.114IleSer: 4.114 ± 0.071	3.601IleThr: 3.601 ± 0.061	3.92IleVal: 3.92 ± 0.071	0.675IleTrp: 0.675 ± 0.029	1.747IleTyr: 1.747 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.579LysAla: 4.579 ± 0.074	0.306LysCys: 0.306 ± 0.017	2.291LysAsp: 2.291 ± 0.053	2.927LysGlu: 2.927 ± 0.059	1.364LysPhe: 1.364 ± 0.038	2.864LysGly: 2.864 ± 0.059	0.984LysHis: 0.984 ± 0.03	2.773LysIle: 2.773 ± 0.052	2.52LysLys: 2.52 ± 0.062	4.872LysLeu: 4.872 ± 0.078	1.278LysMet: 1.278 ± 0.032	1.876LysAsn: 1.876 ± 0.049	2.251LysPro: 2.251 ± 0.05	2.496LysGln: 2.496 ± 0.052	2.401LysArg: 2.401 ± 0.046	2.559LysSer: 2.559 ± 0.056	2.727LysThr: 2.727 ± 0.057	3.24LysVal: 3.24 ± 0.059	0.482LysTrp: 0.482 ± 0.024	1.234LysTyr: 1.234 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	11.125LeuAla: 11.125 ± 0.11	1.234LeuCys: 1.234 ± 0.036	5.858LeuAsp: 5.858 ± 0.077	5.754LeuGlu: 5.754 ± 0.084	4.474LeuPhe: 4.474 ± 0.086	7.106LeuGly: 7.106 ± 0.087	2.538LeuHis: 2.538 ± 0.058	6.394LeuIle: 6.394 ± 0.08	5.053LeuLys: 5.053 ± 0.069	12.855LeuLeu: 12.855 ± 0.175	2.863LeuMet: 2.863 ± 0.051	4.224LeuAsn: 4.224 ± 0.063	5.708LeuPro: 5.708 ± 0.088	5.314LeuGln: 5.314 ± 0.103	5.727LeuArg: 5.727 ± 0.08	7.565LeuSer: 7.565 ± 0.106	6.224LeuThr: 6.224 ± 0.089	6.936LeuVal: 6.936 ± 0.085	1.32LeuTrp: 1.32 ± 0.039	2.621LeuTyr: 2.621 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.71MetAla: 2.71 ± 0.059	0.216MetCys: 0.216 ± 0.015	1.238MetAsp: 1.238 ± 0.033	1.286MetGlu: 1.286 ± 0.043	0.831MetPhe: 0.831 ± 0.033	1.775MetGly: 1.775 ± 0.042	0.526MetHis: 0.526 ± 0.023	1.396MetIle: 1.396 ± 0.038	1.367MetLys: 1.367 ± 0.035	3.083MetLeu: 3.083 ± 0.063	0.772MetMet: 0.772 ± 0.029	1.101MetAsn: 1.101 ± 0.029	1.269MetPro: 1.269 ± 0.032	1.365MetGln: 1.365 ± 0.034	1.267MetArg: 1.267 ± 0.04	1.911MetSer: 1.911 ± 0.047	1.735MetThr: 1.735 ± 0.041	1.852MetVal: 1.852 ± 0.04	0.234MetTrp: 0.234 ± 0.016	0.5MetTyr: 0.5 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.316AsnAla: 3.316 ± 0.053	0.382AsnCys: 0.382 ± 0.021	2.043AsnAsp: 2.043 ± 0.052	2.092AsnGlu: 2.092 ± 0.05	1.248AsnPhe: 1.248 ± 0.038	2.874AsnGly: 2.874 ± 0.059	0.81AsnHis: 0.81 ± 0.027	2.43AsnIle: 2.43 ± 0.051	1.846AsnLys: 1.846 ± 0.048	3.499AsnLeu: 3.499 ± 0.051	0.927AsnMet: 0.927 ± 0.033	1.595AsnAsn: 1.595 ± 0.044	2.109AsnPro: 2.109 ± 0.049	1.797AsnGln: 1.797 ± 0.04	1.897AsnArg: 1.897 ± 0.049	2.028AsnSer: 2.028 ± 0.047	1.885AsnThr: 1.885 ± 0.05	2.286AsnVal: 2.286 ± 0.042	0.616AsnTrp: 0.616 ± 0.026	1.167AsnTyr: 1.167 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.647ProAla: 4.647 ± 0.075	0.406ProCys: 0.406 ± 0.021	2.891ProAsp: 2.891 ± 0.064	3.534ProGlu: 3.534 ± 0.06	1.824ProPhe: 1.824 ± 0.044	2.96ProGly: 2.96 ± 0.069	1.061ProHis: 1.061 ± 0.031	2.108ProIle: 2.108 ± 0.051	1.71ProLys: 1.71 ± 0.042	4.823ProLeu: 4.823 ± 0.094	1.086ProMet: 1.086 ± 0.035	1.39ProAsn: 1.39 ± 0.035	1.379ProPro: 1.379 ± 0.042	1.95ProGln: 1.95 ± 0.045	1.822ProArg: 1.822 ± 0.042	2.192ProSer: 2.192 ± 0.052	2.051ProThr: 2.051 ± 0.047	3.997ProVal: 3.997 ± 0.068	0.573ProTrp: 0.573 ± 0.024	1.302ProTyr: 1.302 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.789GlnAla: 4.789 ± 0.08	0.407GlnCys: 0.407 ± 0.023	2.022GlnAsp: 2.022 ± 0.049	2.463GlnGlu: 2.463 ± 0.052	1.803GlnPhe: 1.803 ± 0.041	2.959GlnGly: 2.959 ± 0.055	1.478GlnHis: 1.478 ± 0.042	2.883GlnIle: 2.883 ± 0.055	2.08GlnLys: 2.08 ± 0.052	5.978GlnLeu: 5.978 ± 0.114	1.137GlnMet: 1.137 ± 0.033	1.568GlnAsn: 1.568 ± 0.042	2.212GlnPro: 2.212 ± 0.049	3.973GlnGln: 3.973 ± 0.105	2.967GlnArg: 2.967 ± 0.055	2.571GlnSer: 2.571 ± 0.052	2.321GlnThr: 2.321 ± 0.047	3.048GlnVal: 3.048 ± 0.065	0.718GlnTrp: 0.718 ± 0.029	1.309GlnTyr: 1.309 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	4.022ArgAla: 4.022 ± 0.072	0.593ArgCys: 0.593 ± 0.025	2.731ArgAsp: 2.731 ± 0.05	3.337ArgGlu: 3.337 ± 0.062	2.409ArgPhe: 2.409 ± 0.048	2.9ArgGly: 2.9 ± 0.052	1.508ArgHis: 1.508 ± 0.043	3.423ArgIle: 3.423 ± 0.057	2.408ArgLys: 2.408 ± 0.053	6.161ArgLeu: 6.161 ± 0.083	1.464ArgMet: 1.464 ± 0.044	1.914ArgAsn: 1.914 ± 0.046	2.036ArgPro: 2.036 ± 0.046	3.117ArgGln: 3.117 ± 0.067	3.032ArgArg: 3.032 ± 0.064	2.749ArgSer: 2.749 ± 0.048	2.425ArgThr: 2.425 ± 0.059	3.325ArgVal: 3.325 ± 0.068	0.855ArgTrp: 0.855 ± 0.033	2.06ArgTyr: 2.06 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.737SerAla: 5.737 ± 0.079	0.679SerCys: 0.679 ± 0.028	3.278SerAsp: 3.278 ± 0.057	3.345SerGlu: 3.345 ± 0.059	2.458SerPhe: 2.458 ± 0.052	5.074SerGly: 5.074 ± 0.072	1.477SerHis: 1.477 ± 0.036	3.318SerIle: 3.318 ± 0.059	2.408SerLys: 2.408 ± 0.051	6.677SerLeu: 6.677 ± 0.093	1.55SerMet: 1.55 ± 0.039	1.995SerAsn: 1.995 ± 0.045	2.465SerPro: 2.465 ± 0.055	2.55SerGln: 2.55 ± 0.055	3.115SerArg: 3.115 ± 0.058	3.765SerSer: 3.765 ± 0.072	2.698SerThr: 2.698 ± 0.057	4.39SerVal: 4.39 ± 0.071	0.848SerTrp: 0.848 ± 0.03	1.69SerTyr: 1.69 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.996ThrAla: 4.996 ± 0.075	0.474ThrCys: 0.474 ± 0.02	2.867ThrAsp: 2.867 ± 0.067	3.097ThrGlu: 3.097 ± 0.061	1.863ThrPhe: 1.863 ± 0.041	4.34ThrGly: 4.34 ± 0.067	1.195ThrHis: 1.195 ± 0.033	3.052ThrIle: 3.052 ± 0.058	1.872ThrLys: 1.872 ± 0.052	6.241ThrLeu: 6.241 ± 0.079	1.077ThrMet: 1.077 ± 0.03	1.706ThrAsn: 1.706 ± 0.042	3.007ThrPro: 3.007 ± 0.056	2.13ThrGln: 2.13 ± 0.045	2.629ThrArg: 2.629 ± 0.062	2.993ThrSer: 2.993 ± 0.055	2.811ThrThr: 2.811 ± 0.063	3.74ThrVal: 3.74 ± 0.08	0.581ThrTrp: 0.581 ± 0.026	1.307ThrTyr: 1.307 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.763ValAla: 6.763 ± 0.089	0.802ValCys: 0.802 ± 0.028	3.672ValAsp: 3.672 ± 0.075	3.776ValGlu: 3.776 ± 0.071	2.615ValPhe: 2.615 ± 0.057	4.518ValGly: 4.518 ± 0.078	1.318ValHis: 1.318 ± 0.036	4.705ValIle: 4.705 ± 0.071	3.216ValLys: 3.216 ± 0.063	7.289ValLeu: 7.289 ± 0.099	2.021ValMet: 2.021 ± 0.044	2.533ValAsn: 2.533 ± 0.06	2.913ValPro: 2.913 ± 0.051	2.497ValGln: 2.497 ± 0.051	3.357ValArg: 3.357 ± 0.062	4.583ValSer: 4.583 ± 0.065	4.033ValThr: 4.033 ± 0.067	5.141ValVal: 5.141 ± 0.088	0.799ValTrp: 0.799 ± 0.028	1.824ValTyr: 1.824 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.86TrpAla: 0.86 ± 0.027	0.18TrpCys: 0.18 ± 0.013	0.61TrpAsp: 0.61 ± 0.025	0.538TrpGlu: 0.538 ± 0.024	0.625TrpPhe: 0.625 ± 0.024	0.796TrpGly: 0.796 ± 0.028	0.413TrpHis: 0.413 ± 0.023	0.752TrpIle: 0.752 ± 0.027	0.483TrpLys: 0.483 ± 0.023	2.332TrpLeu: 2.332 ± 0.06	0.379TrpMet: 0.379 ± 0.019	0.452TrpAsn: 0.452 ± 0.019	0.557TrpPro: 0.557 ± 0.025	1.188TrpGln: 1.188 ± 0.043	0.788TrpArg: 0.788 ± 0.028	0.757TrpSer: 0.757 ± 0.029	0.535TrpThr: 0.535 ± 0.021	0.803TrpVal: 0.803 ± 0.029	0.211TrpTrp: 0.211 ± 0.015	0.366TrpTyr: 0.366 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.449TyrAla: 2.449 ± 0.056	0.399TyrCys: 0.399 ± 0.02	1.57TyrAsp: 1.57 ± 0.042	1.416TyrGlu: 1.416 ± 0.043	1.207TyrPhe: 1.207 ± 0.034	2.114TyrGly: 2.114 ± 0.051	0.79TyrHis: 0.79 ± 0.032	1.511TyrIle: 1.511 ± 0.036	1.097TyrLys: 1.097 ± 0.033	3.456TyrLeu: 3.456 ± 0.066	0.636TyrMet: 0.636 ± 0.023	0.981TyrAsn: 0.981 ± 0.033	1.447TyrPro: 1.447 ± 0.039	1.884TyrGln: 1.884 ± 0.048	1.845TyrArg: 1.845 ± 0.041	1.739TyrSer: 1.739 ± 0.045	1.371TyrThr: 1.371 ± 0.04	1.785TyrVal: 1.785 ± 0.043	0.484TyrTrp: 0.484 ± 0.02	0.944TyrTyr: 0.944 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3126 proteins (1023253 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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