Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA261O19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.23AlaAla: 5.23 ± 0.196
0.866AlaCys: 0.866 ± 0.071
3.468AlaAsp: 3.468 ± 0.151
5.724AlaGlu: 5.724 ± 0.194
2.571AlaPhe: 2.571 ± 0.113
5.876AlaGly: 5.876 ± 0.181
1.18AlaHis: 1.18 ± 0.076
5.204AlaIle: 5.204 ± 0.177
4.459AlaLys: 4.459 ± 0.166
7.072AlaLeu: 7.072 ± 0.219
1.406AlaMet: 1.406 ± 0.082
1.868AlaAsn: 1.868 ± 0.125
2.597AlaPro: 2.597 ± 0.113
1.7AlaGln: 1.7 ± 0.091
4.59AlaArg: 4.59 ± 0.148
4.223AlaSer: 4.223 ± 0.158
3.373AlaThr: 3.373 ± 0.155
4.8AlaVal: 4.8 ± 0.191
0.692AlaTrp: 0.692 ± 0.055
1.857AlaTyr: 1.857 ± 0.109
0.0AlaXaa: 0.0 ± 0.0
Cys
0.619CysAla: 0.619 ± 0.065
0.121CysCys: 0.121 ± 0.025
0.514CysAsp: 0.514 ± 0.05
0.797CysGlu: 0.797 ± 0.067
0.346CysPhe: 0.346 ± 0.041
1.212CysGly: 1.212 ± 0.079
0.215CysHis: 0.215 ± 0.034
0.519CysIle: 0.519 ± 0.052
0.588CysLys: 0.588 ± 0.057
0.729CysLeu: 0.729 ± 0.06
0.231CysMet: 0.231 ± 0.035
0.278CysAsn: 0.278 ± 0.036
0.698CysPro: 0.698 ± 0.066
0.257CysGln: 0.257 ± 0.039
0.362CysArg: 0.362 ± 0.049
0.603CysSer: 0.603 ± 0.054
0.483CysThr: 0.483 ± 0.055
0.614CysVal: 0.614 ± 0.063
0.136CysTrp: 0.136 ± 0.024
0.331CysTyr: 0.331 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
3.546AspAla: 3.546 ± 0.158
0.488AspCys: 0.488 ± 0.054
2.613AspAsp: 2.613 ± 0.115
5.23AspGlu: 5.23 ± 0.172
2.487AspPhe: 2.487 ± 0.117
3.803AspGly: 3.803 ± 0.165
1.06AspHis: 1.06 ± 0.079
3.72AspIle: 3.72 ± 0.174
3.195AspLys: 3.195 ± 0.142
6.395AspLeu: 6.395 ± 0.177
1.348AspMet: 1.348 ± 0.076
1.815AspAsn: 1.815 ± 0.17
2.665AspPro: 2.665 ± 0.112
1.322AspGln: 1.322 ± 0.086
2.854AspArg: 2.854 ± 0.133
3.001AspSer: 3.001 ± 0.131
2.261AspThr: 2.261 ± 0.127
4.255AspVal: 4.255 ± 0.149
0.818AspTrp: 0.818 ± 0.068
1.973AspTyr: 1.973 ± 0.122
0.0AspXaa: 0.0 ± 0.0
Glu
6.096GluAla: 6.096 ± 0.197
0.713GluCys: 0.713 ± 0.072
5.718GluAsp: 5.718 ± 0.179
11.342GluGlu: 11.342 ± 0.329
3.3GluPhe: 3.3 ± 0.132
5.928GluGly: 5.928 ± 0.21
1.464GluHis: 1.464 ± 0.097
7.497GluIle: 7.497 ± 0.193
8.441GluLys: 8.441 ± 0.223
9.422GluLeu: 9.422 ± 0.235
2.161GluMet: 2.161 ± 0.113
4.412GluAsn: 4.412 ± 0.218
2.707GluPro: 2.707 ± 0.125
1.71GluGln: 1.71 ± 0.098
5.278GluArg: 5.278 ± 0.178
4.59GluSer: 4.59 ± 0.169
3.982GluThr: 3.982 ± 0.131
6.815GluVal: 6.815 ± 0.198
0.834GluTrp: 0.834 ± 0.073
2.303GluTyr: 2.303 ± 0.112
0.0GluXaa: 0.0 ± 0.0
Phe
2.371PheAla: 2.371 ± 0.123
0.414PheCys: 0.414 ± 0.046
2.13PheAsp: 2.13 ± 0.112
3.436PheGlu: 3.436 ± 0.135
1.689PhePhe: 1.689 ± 0.087
2.927PheGly: 2.927 ± 0.154
0.708PheHis: 0.708 ± 0.052
2.219PheIle: 2.219 ± 0.127
2.109PheLys: 2.109 ± 0.106
4.029PheLeu: 4.029 ± 0.161
0.845PheMet: 0.845 ± 0.064
1.312PheAsn: 1.312 ± 0.095
1.401PhePro: 1.401 ± 0.088
0.96PheGln: 0.96 ± 0.068
1.857PheArg: 1.857 ± 0.096
2.639PheSer: 2.639 ± 0.113
2.125PheThr: 2.125 ± 0.089
2.335PheVal: 2.335 ± 0.104
0.399PheTrp: 0.399 ± 0.048
1.18PheTyr: 1.18 ± 0.082
0.0PheXaa: 0.0 ± 0.0
Gly
5.43GlyAla: 5.43 ± 0.213
0.976GlyCys: 0.976 ± 0.087
3.657GlyAsp: 3.657 ± 0.126
7.465GlyGlu: 7.465 ± 0.191
3.079GlyPhe: 3.079 ± 0.141
5.891GlyGly: 5.891 ± 0.24
1.312GlyHis: 1.312 ± 0.079
5.886GlyIle: 5.886 ± 0.186
5.781GlyLys: 5.781 ± 0.178
7.056GlyLeu: 7.056 ± 0.217
2.03GlyMet: 2.03 ± 0.102
1.91GlyAsn: 1.91 ± 0.108
2.45GlyPro: 2.45 ± 0.121
1.453GlyGln: 1.453 ± 0.092
4.265GlyArg: 4.265 ± 0.151
4.165GlySer: 4.165 ± 0.156
3.84GlyThr: 3.84 ± 0.139
6.495GlyVal: 6.495 ± 0.202
0.944GlyTrp: 0.944 ± 0.073
2.502GlyTyr: 2.502 ± 0.122
0.0GlyXaa: 0.0 ± 0.0
His
1.275HisAla: 1.275 ± 0.087
0.283HisCys: 0.283 ± 0.042
1.07HisAsp: 1.07 ± 0.08
1.521HisGlu: 1.521 ± 0.108
0.682HisPhe: 0.682 ± 0.058
1.6HisGly: 1.6 ± 0.098
0.362HisHis: 0.362 ± 0.044
1.049HisIle: 1.049 ± 0.083
0.839HisLys: 0.839 ± 0.067
1.952HisLeu: 1.952 ± 0.115
0.289HisMet: 0.289 ± 0.039
0.498HisAsn: 0.498 ± 0.045
1.217HisPro: 1.217 ± 0.083
0.635HisGln: 0.635 ± 0.055
0.992HisArg: 0.992 ± 0.073
1.117HisSer: 1.117 ± 0.082
0.908HisThr: 0.908 ± 0.071
1.249HisVal: 1.249 ± 0.074
0.252HisTrp: 0.252 ± 0.041
0.504HisTyr: 0.504 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
5.288IleAla: 5.288 ± 0.163
0.651IleCys: 0.651 ± 0.059
4.144IleAsp: 4.144 ± 0.148
5.944IleGlu: 5.944 ± 0.2
2.639IlePhe: 2.639 ± 0.137
6.232IleGly: 6.232 ± 0.212
1.359IleHis: 1.359 ± 0.08
5.021IleIle: 5.021 ± 0.193
4.396IleLys: 4.396 ± 0.163
7.208IleLeu: 7.208 ± 0.234
1.411IleMet: 1.411 ± 0.088
2.251IleAsn: 2.251 ± 0.113
3.567IlePro: 3.567 ± 0.133
2.046IleGln: 2.046 ± 0.093
4.071IleArg: 4.071 ± 0.15
4.868IleSer: 4.868 ± 0.165
3.641IleThr: 3.641 ± 0.15
4.847IleVal: 4.847 ± 0.18
0.609IleTrp: 0.609 ± 0.054
1.899IleTyr: 1.899 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
4.832LysAla: 4.832 ± 0.167
0.719LysCys: 0.719 ± 0.063
3.578LysAsp: 3.578 ± 0.144
6.631LysGlu: 6.631 ± 0.217
2.476LysPhe: 2.476 ± 0.135
4.543LysGly: 4.543 ± 0.171
1.222LysHis: 1.222 ± 0.083
6.227LysIle: 6.227 ± 0.201
5.765LysLys: 5.765 ± 0.234
7.276LysLeu: 7.276 ± 0.214
1.668LysMet: 1.668 ± 0.094
2.56LysAsn: 2.56 ± 0.128
2.707LysPro: 2.707 ± 0.114
1.689LysGln: 1.689 ± 0.113
4.055LysArg: 4.055 ± 0.147
4.15LysSer: 4.15 ± 0.153
3.788LysThr: 3.788 ± 0.142
5.073LysVal: 5.073 ± 0.197
0.845LysTrp: 0.845 ± 0.069
1.983LysTyr: 1.983 ± 0.116
0.0LysXaa: 0.0 ± 0.0
Leu
7.885LeuAla: 7.885 ± 0.237
0.803LeuCys: 0.803 ± 0.062
6.106LeuAsp: 6.106 ± 0.206
9.616LeuGlu: 9.616 ± 0.23
3.268LeuPhe: 3.268 ± 0.144
7.57LeuGly: 7.57 ± 0.203
1.605LeuHis: 1.605 ± 0.095
6.531LeuIle: 6.531 ± 0.222
7.334LeuLys: 7.334 ± 0.199
8.231LeuLeu: 8.231 ± 0.275
2.03LeuMet: 2.03 ± 0.102
3.342LeuAsn: 3.342 ± 0.152
4.05LeuPro: 4.05 ± 0.136
2.392LeuGln: 2.392 ± 0.104
5.844LeuArg: 5.844 ± 0.2
6.395LeuSer: 6.395 ± 0.184
4.968LeuThr: 4.968 ± 0.162
6.311LeuVal: 6.311 ± 0.219
0.95LeuTrp: 0.95 ± 0.076
2.293LeuTyr: 2.293 ± 0.112
0.0LeuXaa: 0.0 ± 0.0
Met
1.548MetAla: 1.548 ± 0.09
0.126MetCys: 0.126 ± 0.027
1.207MetAsp: 1.207 ± 0.073
1.768MetGlu: 1.768 ± 0.099
0.525MetPhe: 0.525 ± 0.053
1.915MetGly: 1.915 ± 0.11
0.346MetHis: 0.346 ± 0.039
1.71MetIle: 1.71 ± 0.101
1.941MetLys: 1.941 ± 0.094
1.925MetLeu: 1.925 ± 0.095
0.551MetMet: 0.551 ± 0.054
0.845MetAsn: 0.845 ± 0.068
1.123MetPro: 1.123 ± 0.081
0.409MetGln: 0.409 ± 0.045
1.374MetArg: 1.374 ± 0.085
1.422MetSer: 1.422 ± 0.089
1.364MetThr: 1.364 ± 0.081
1.479MetVal: 1.479 ± 0.086
0.152MetTrp: 0.152 ± 0.03
0.43MetTyr: 0.43 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
2.214AsnAla: 2.214 ± 0.109
0.42AsnCys: 0.42 ± 0.044
1.474AsnAsp: 1.474 ± 0.099
2.565AsnGlu: 2.565 ± 0.112
1.406AsnPhe: 1.406 ± 0.091
2.015AsnGly: 2.015 ± 0.101
0.656AsnHis: 0.656 ± 0.066
2.324AsnIle: 2.324 ± 0.12
1.726AsnLys: 1.726 ± 0.101
3.882AsnLeu: 3.882 ± 0.142
0.708AsnMet: 0.708 ± 0.058
0.934AsnAsn: 0.934 ± 0.075
2.518AsnPro: 2.518 ± 0.115
1.112AsnGln: 1.112 ± 0.075
1.736AsnArg: 1.736 ± 0.098
1.957AsnSer: 1.957 ± 0.121
1.59AsnThr: 1.59 ± 0.119
2.518AsnVal: 2.518 ± 0.117
0.556AsnTrp: 0.556 ± 0.059
1.154AsnTyr: 1.154 ± 0.08
0.0AsnXaa: 0.0 ± 0.0
Pro
2.476ProAla: 2.476 ± 0.132
0.388ProCys: 0.388 ± 0.048
2.738ProAsp: 2.738 ± 0.125
4.464ProGlu: 4.464 ± 0.158
1.5ProPhe: 1.5 ± 0.08
2.838ProGly: 2.838 ± 0.127
0.955ProHis: 0.955 ± 0.072
2.964ProIle: 2.964 ± 0.12
2.833ProLys: 2.833 ± 0.115
3.798ProLeu: 3.798 ± 0.14
0.771ProMet: 0.771 ± 0.069
1.506ProAsn: 1.506 ± 0.095
1.91ProPro: 1.91 ± 0.114
1.254ProGln: 1.254 ± 0.086
2.151ProArg: 2.151 ± 0.111
2.817ProSer: 2.817 ± 0.123
2.371ProThr: 2.371 ± 0.108
2.948ProVal: 2.948 ± 0.121
0.467ProTrp: 0.467 ± 0.051
1.49ProTyr: 1.49 ± 0.088
0.0ProXaa: 0.0 ± 0.0
Gln
1.973GlnAla: 1.973 ± 0.119
0.142GlnCys: 0.142 ± 0.027
1.38GlnAsp: 1.38 ± 0.089
2.539GlnGlu: 2.539 ± 0.106
0.682GlnPhe: 0.682 ± 0.065
1.668GlnGly: 1.668 ± 0.1
0.462GlnHis: 0.462 ± 0.056
2.02GlnIle: 2.02 ± 0.111
1.757GlnLys: 1.757 ± 0.103
2.272GlnLeu: 2.272 ± 0.114
0.703GlnMet: 0.703 ± 0.059
0.829GlnAsn: 0.829 ± 0.072
0.881GlnPro: 0.881 ± 0.067
0.651GlnGln: 0.651 ± 0.057
1.364GlnArg: 1.364 ± 0.086
1.233GlnSer: 1.233 ± 0.083
1.228GlnThr: 1.228 ± 0.083
1.946GlnVal: 1.946 ± 0.083
0.231GlnTrp: 0.231 ± 0.032
0.635GlnTyr: 0.635 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
3.777ArgAla: 3.777 ± 0.151
0.451ArgCys: 0.451 ± 0.049
3.048ArgAsp: 3.048 ± 0.141
6.552ArgGlu: 6.552 ± 0.19
2.062ArgPhe: 2.062 ± 0.096
4.438ArgGly: 4.438 ± 0.151
0.86ArgHis: 0.86 ± 0.062
3.982ArgIle: 3.982 ± 0.143
5.251ArgLys: 5.251 ± 0.195
5.026ArgLeu: 5.026 ± 0.154
1.353ArgMet: 1.353 ± 0.084
1.705ArgAsn: 1.705 ± 0.105
1.973ArgPro: 1.973 ± 0.108
1.27ArgGln: 1.27 ± 0.093
3.767ArgArg: 3.767 ± 0.179
2.765ArgSer: 2.765 ± 0.114
2.403ArgThr: 2.403 ± 0.129
4.102ArgVal: 4.102 ± 0.134
0.708ArgTrp: 0.708 ± 0.054
1.668ArgTyr: 1.668 ± 0.091
0.0ArgXaa: 0.0 ± 0.0
Ser
3.798SerAla: 3.798 ± 0.164
0.556SerCys: 0.556 ± 0.051
3.31SerAsp: 3.31 ± 0.136
5.697SerGlu: 5.697 ± 0.179
2.492SerPhe: 2.492 ± 0.12
5.115SerGly: 5.115 ± 0.165
1.238SerHis: 1.238 ± 0.069
4.433SerIle: 4.433 ± 0.137
4.459SerLys: 4.459 ± 0.168
5.561SerLeu: 5.561 ± 0.189
1.27SerMet: 1.27 ± 0.101
1.784SerAsn: 1.784 ± 0.087
2.717SerPro: 2.717 ± 0.121
1.784SerGln: 1.784 ± 0.101
3.31SerArg: 3.31 ± 0.144
3.903SerSer: 3.903 ± 0.162
2.959SerThr: 2.959 ± 0.13
3.678SerVal: 3.678 ± 0.16
0.677SerTrp: 0.677 ± 0.066
1.511SerTyr: 1.511 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
3.352ThrAla: 3.352 ± 0.149
0.456ThrCys: 0.456 ± 0.045
2.424ThrAsp: 2.424 ± 0.12
3.452ThrGlu: 3.452 ± 0.146
1.768ThrPhe: 1.768 ± 0.099
4.15ThrGly: 4.15 ± 0.151
1.075ThrHis: 1.075 ± 0.072
3.772ThrIle: 3.772 ± 0.147
2.649ThrLys: 2.649 ± 0.128
5.314ThrLeu: 5.314 ± 0.154
1.028ThrMet: 1.028 ± 0.069
1.715ThrAsn: 1.715 ± 0.094
2.885ThrPro: 2.885 ± 0.129
1.312ThrGln: 1.312 ± 0.1
2.859ThrArg: 2.859 ± 0.123
3.242ThrSer: 3.242 ± 0.129
2.723ThrThr: 2.723 ± 0.132
3.232ThrVal: 3.232 ± 0.124
0.451ThrTrp: 0.451 ± 0.052
1.479ThrTyr: 1.479 ± 0.107
0.0ThrXaa: 0.0 ± 0.0
Val
4.48ValAla: 4.48 ± 0.169
0.64ValCys: 0.64 ± 0.056
4.071ValAsp: 4.071 ± 0.152
6.783ValGlu: 6.783 ± 0.193
2.513ValPhe: 2.513 ± 0.119
5.718ValGly: 5.718 ± 0.191
1.28ValHis: 1.28 ± 0.084
4.895ValIle: 4.895 ± 0.187
5.834ValLys: 5.834 ± 0.187
6.385ValLeu: 6.385 ± 0.173
1.511ValMet: 1.511 ± 0.09
2.555ValAsn: 2.555 ± 0.138
2.754ValPro: 2.754 ± 0.102
1.359ValGln: 1.359 ± 0.095
4.05ValArg: 4.05 ± 0.158
4.559ValSer: 4.559 ± 0.15
3.531ValThr: 3.531 ± 0.139
4.48ValVal: 4.48 ± 0.154
0.719ValTrp: 0.719 ± 0.067
1.621ValTyr: 1.621 ± 0.099
0.0ValXaa: 0.0 ± 0.0
Trp
0.734TrpAla: 0.734 ± 0.065
0.084TrpCys: 0.084 ± 0.027
0.593TrpAsp: 0.593 ± 0.061
0.787TrpGlu: 0.787 ± 0.061
0.462TrpPhe: 0.462 ± 0.049
0.745TrpGly: 0.745 ± 0.065
0.236TrpHis: 0.236 ± 0.035
0.813TrpIle: 0.813 ± 0.072
0.855TrpLys: 0.855 ± 0.069
1.102TrpLeu: 1.102 ± 0.082
0.325TrpMet: 0.325 ± 0.042
0.393TrpAsn: 0.393 ± 0.046
0.409TrpPro: 0.409 ± 0.043
0.357TrpGln: 0.357 ± 0.049
0.75TrpArg: 0.75 ± 0.074
0.771TrpSer: 0.771 ± 0.069
0.467TrpThr: 0.467 ± 0.045
0.766TrpVal: 0.766 ± 0.062
0.215TrpTrp: 0.215 ± 0.034
0.278TrpTyr: 0.278 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.831TyrAla: 1.831 ± 0.094
0.357TyrCys: 0.357 ± 0.041
1.605TyrAsp: 1.605 ± 0.087
2.397TyrGlu: 2.397 ± 0.128
1.138TyrPhe: 1.138 ± 0.078
2.403TyrGly: 2.403 ± 0.112
0.698TyrHis: 0.698 ± 0.052
1.306TyrIle: 1.306 ± 0.092
1.579TyrLys: 1.579 ± 0.099
2.891TyrLeu: 2.891 ± 0.123
0.514TyrMet: 0.514 ± 0.05
0.955TyrAsn: 0.955 ± 0.072
1.411TyrPro: 1.411 ± 0.098
0.923TyrGln: 0.923 ± 0.07
1.632TyrArg: 1.632 ± 0.099
1.831TyrSer: 1.831 ± 0.098
1.338TyrThr: 1.338 ± 0.082
1.794TyrVal: 1.794 ± 0.093
0.488TyrTrp: 0.488 ± 0.054
1.075TyrTyr: 1.075 ± 0.085
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 779 proteins (190618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski