Amino acid dipepetide frequency for Microbulbifer thermotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.143AlaAla: 12.143 ± 0.14	1.158AlaCys: 1.158 ± 0.046	6.097AlaAsp: 6.097 ± 0.087	7.599AlaGlu: 7.599 ± 0.113	3.41AlaPhe: 3.41 ± 0.057	8.569AlaGly: 8.569 ± 0.106	1.89AlaHis: 1.89 ± 0.043	5.123AlaIle: 5.123 ± 0.07	3.441AlaLys: 3.441 ± 0.072	11.846AlaLeu: 11.846 ± 0.131	2.408AlaMet: 2.408 ± 0.053	2.901AlaAsn: 2.901 ± 0.053	4.201AlaPro: 4.201 ± 0.077	4.235AlaGln: 4.235 ± 0.08	6.651AlaArg: 6.651 ± 0.084	5.442AlaSer: 5.442 ± 0.073	4.464AlaThr: 4.464 ± 0.081	7.317AlaVal: 7.317 ± 0.095	1.164AlaTrp: 1.164 ± 0.037	2.589AlaTyr: 2.589 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.143CysAla: 1.143 ± 0.035	0.16CysCys: 0.16 ± 0.012	0.645CysAsp: 0.645 ± 0.043	0.647CysGlu: 0.647 ± 0.024	0.339CysPhe: 0.339 ± 0.017	1.1CysGly: 1.1 ± 0.035	0.308CysHis: 0.308 ± 0.019	0.447CysIle: 0.447 ± 0.02	0.306CysLys: 0.306 ± 0.016	0.978CysLeu: 0.978 ± 0.034	0.19CysMet: 0.19 ± 0.013	0.348CysAsn: 0.348 ± 0.019	0.594CysPro: 0.594 ± 0.036	0.327CysGln: 0.327 ± 0.017	0.719CysArg: 0.719 ± 0.031	0.622CysSer: 0.622 ± 0.025	0.491CysThr: 0.491 ± 0.021	0.643CysVal: 0.643 ± 0.028	0.145CysTrp: 0.145 ± 0.012	0.319CysTyr: 0.319 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.221AspAla: 5.221 ± 0.08	0.627AspCys: 0.627 ± 0.022	2.913AspAsp: 2.913 ± 0.1	3.503AspGlu: 3.503 ± 0.07	2.576AspPhe: 2.576 ± 0.056	4.786AspGly: 4.786 ± 0.147	1.165AspHis: 1.165 ± 0.035	3.426AspIle: 3.426 ± 0.059	2.403AspLys: 2.403 ± 0.047	5.641AspLeu: 5.641 ± 0.068	1.301AspMet: 1.301 ± 0.035	2.157AspAsn: 2.157 ± 0.077	2.891AspPro: 2.891 ± 0.057	1.983AspGln: 1.983 ± 0.049	3.377AspArg: 3.377 ± 0.053	3.525AspSer: 3.525 ± 0.072	3.048AspThr: 3.048 ± 0.068	3.317AspVal: 3.317 ± 0.063	1.087AspTrp: 1.087 ± 0.037	2.128AspTyr: 2.128 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	6.647GluAla: 6.647 ± 0.091	0.475GluCys: 0.475 ± 0.021	3.3GluAsp: 3.3 ± 0.065	4.75GluGlu: 4.75 ± 0.076	2.245GluPhe: 2.245 ± 0.046	4.411GluGly: 4.411 ± 0.075	1.446GluHis: 1.446 ± 0.041	3.832GluIle: 3.832 ± 0.064	3.409GluLys: 3.409 ± 0.065	7.214GluLeu: 7.214 ± 0.095	1.522GluMet: 1.522 ± 0.041	2.396GluAsn: 2.396 ± 0.062	2.55GluPro: 2.55 ± 0.05	3.532GluGln: 3.532 ± 0.067	4.973GluArg: 4.973 ± 0.079	3.567GluSer: 3.567 ± 0.062	3.181GluThr: 3.181 ± 0.059	4.586GluVal: 4.586 ± 0.074	0.822GluTrp: 0.822 ± 0.029	1.758GluTyr: 1.758 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.831PheAla: 3.831 ± 0.069	0.465PheCys: 0.465 ± 0.023	2.535PheAsp: 2.535 ± 0.052	2.268PheGlu: 2.268 ± 0.044	1.524PhePhe: 1.524 ± 0.047	3.136PheGly: 3.136 ± 0.057	0.808PheHis: 0.808 ± 0.03	1.853PheIle: 1.853 ± 0.051	1.234PheLys: 1.234 ± 0.035	3.237PheLeu: 3.237 ± 0.071	0.773PheMet: 0.773 ± 0.03	1.479PheAsn: 1.479 ± 0.046	1.59PhePro: 1.59 ± 0.04	1.128PheGln: 1.128 ± 0.034	2.082PheArg: 2.082 ± 0.057	2.898PheSer: 2.898 ± 0.073	2.113PheThr: 2.113 ± 0.053	2.465PheVal: 2.465 ± 0.048	0.489PheTrp: 0.489 ± 0.021	1.243PheTyr: 1.243 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	7.438GlyAla: 7.438 ± 0.102	0.972GlyCys: 0.972 ± 0.038	4.799GlyAsp: 4.799 ± 0.106	5.643GlyGlu: 5.643 ± 0.081	3.195GlyPhe: 3.195 ± 0.057	6.778GlyGly: 6.778 ± 0.123	1.669GlyHis: 1.669 ± 0.038	4.447GlyIle: 4.447 ± 0.094	3.365GlyLys: 3.365 ± 0.072	7.826GlyLeu: 7.826 ± 0.094	1.926GlyMet: 1.926 ± 0.044	2.78GlyAsn: 2.78 ± 0.053	2.496GlyPro: 2.496 ± 0.05	2.879GlyGln: 2.879 ± 0.051	5.076GlyArg: 5.076 ± 0.07	4.685GlySer: 4.685 ± 0.104	3.869GlyThr: 3.869 ± 0.069	5.667GlyVal: 5.667 ± 0.085	1.242GlyTrp: 1.242 ± 0.037	2.653GlyTyr: 2.653 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.598HisAla: 1.598 ± 0.042	0.366HisCys: 0.366 ± 0.018	0.876HisAsp: 0.876 ± 0.031	0.916HisGlu: 0.916 ± 0.03	1.028HisPhe: 1.028 ± 0.034	1.568HisGly: 1.568 ± 0.042	0.554HisHis: 0.554 ± 0.026	1.106HisIle: 1.106 ± 0.032	0.835HisLys: 0.835 ± 0.03	2.388HisLeu: 2.388 ± 0.052	0.477HisMet: 0.477 ± 0.022	0.742HisAsn: 0.742 ± 0.026	1.274HisPro: 1.274 ± 0.034	0.912HisGln: 0.912 ± 0.03	1.616HisArg: 1.616 ± 0.046	1.354HisSer: 1.354 ± 0.039	1.08HisThr: 1.08 ± 0.03	0.954HisVal: 0.954 ± 0.027	0.498HisTrp: 0.498 ± 0.023	0.843HisTyr: 0.843 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.885IleAla: 5.885 ± 0.078	0.61IleCys: 0.61 ± 0.026	3.542IleAsp: 3.542 ± 0.056	3.745IleGlu: 3.745 ± 0.068	1.797IlePhe: 1.797 ± 0.044	4.11IleGly: 4.11 ± 0.071	1.121IleHis: 1.121 ± 0.035	2.047IleIle: 2.047 ± 0.046	1.86IleLys: 1.86 ± 0.044	4.255IleLeu: 4.255 ± 0.069	0.84IleMet: 0.84 ± 0.032	2.032IleAsn: 2.032 ± 0.045	2.5IlePro: 2.5 ± 0.045	1.696IleGln: 1.696 ± 0.041	3.119IleArg: 3.119 ± 0.048	3.413IleSer: 3.413 ± 0.061	2.93IleThr: 2.93 ± 0.08	3.333IleVal: 3.333 ± 0.066	0.609IleTrp: 0.609 ± 0.023	1.606IleTyr: 1.606 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	3.753LysAla: 3.753 ± 0.068	0.245LysCys: 0.245 ± 0.017	1.792LysAsp: 1.792 ± 0.051	2.192LysGlu: 2.192 ± 0.057	1.158LysPhe: 1.158 ± 0.031	2.614LysGly: 2.614 ± 0.053	0.739LysHis: 0.739 ± 0.026	2.052LysIle: 2.052 ± 0.048	2.026LysLys: 2.026 ± 0.063	4.159LysLeu: 4.159 ± 0.073	0.837LysMet: 0.837 ± 0.028	1.407LysAsn: 1.407 ± 0.041	1.927LysPro: 1.927 ± 0.044	1.544LysGln: 1.544 ± 0.045	2.572LysArg: 2.572 ± 0.056	2.13LysSer: 2.13 ± 0.049	1.996LysThr: 1.996 ± 0.047	2.913LysVal: 2.913 ± 0.062	0.413LysTrp: 0.413 ± 0.021	1.034LysTyr: 1.034 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	12.073LeuAla: 12.073 ± 0.132	1.134LeuCys: 1.134 ± 0.036	6.08LeuAsp: 6.08 ± 0.084	6.868LeuGlu: 6.868 ± 0.099	3.736LeuPhe: 3.736 ± 0.065	7.778LeuGly: 7.778 ± 0.085	2.251LeuHis: 2.251 ± 0.052	5.005LeuIle: 5.005 ± 0.082	3.982LeuLys: 3.982 ± 0.071	12.15LeuLeu: 12.15 ± 0.194	2.299LeuMet: 2.299 ± 0.052	3.444LeuAsn: 3.444 ± 0.053	5.565LeuPro: 5.565 ± 0.074	4.692LeuGln: 4.692 ± 0.083	7.102LeuArg: 7.102 ± 0.09	6.819LeuSer: 6.819 ± 0.084	5.252LeuThr: 5.252 ± 0.096	7.244LeuVal: 7.244 ± 0.112	1.368LeuTrp: 1.368 ± 0.041	2.604LeuTyr: 2.604 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.545MetAla: 2.545 ± 0.057	0.163MetCys: 0.163 ± 0.011	1.182MetAsp: 1.182 ± 0.035	1.403MetGlu: 1.403 ± 0.035	0.584MetPhe: 0.584 ± 0.024	1.612MetGly: 1.612 ± 0.043	0.451MetHis: 0.451 ± 0.022	0.96MetIle: 0.96 ± 0.033	0.921MetLys: 0.921 ± 0.027	2.215MetLeu: 2.215 ± 0.053	0.451MetMet: 0.451 ± 0.021	0.737MetAsn: 0.737 ± 0.031	1.197MetPro: 1.197 ± 0.036	0.948MetGln: 0.948 ± 0.029	1.536MetArg: 1.536 ± 0.037	1.373MetSer: 1.373 ± 0.036	1.223MetThr: 1.223 ± 0.033	1.524MetVal: 1.524 ± 0.043	0.181MetTrp: 0.181 ± 0.012	0.431MetTyr: 0.431 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.069AsnAla: 3.069 ± 0.068	0.429AsnCys: 0.429 ± 0.038	1.58AsnAsp: 1.58 ± 0.047	1.604AsnGlu: 1.604 ± 0.044	1.429AsnPhe: 1.429 ± 0.04	2.923AsnGly: 2.923 ± 0.06	0.678AsnHis: 0.678 ± 0.023	2.016AsnIle: 2.016 ± 0.043	1.157AsnLys: 1.157 ± 0.032	3.596AsnLeu: 3.596 ± 0.062	0.662AsnMet: 0.662 ± 0.023	1.301AsnAsn: 1.301 ± 0.047	2.274AsnPro: 2.274 ± 0.047	1.207AsnGln: 1.207 ± 0.037	2.304AsnArg: 2.304 ± 0.044	2.033AsnSer: 2.033 ± 0.059	1.897AsnThr: 1.897 ± 0.046	1.873AsnVal: 1.873 ± 0.049	0.627AsnTrp: 0.627 ± 0.03	1.241AsnTyr: 1.241 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.677ProAla: 4.677 ± 0.068	0.328ProCys: 0.328 ± 0.018	3.018ProAsp: 3.018 ± 0.053	3.956ProGlu: 3.956 ± 0.067	1.67ProPhe: 1.67 ± 0.042	3.895ProGly: 3.895 ± 0.072	0.946ProHis: 0.946 ± 0.03	1.968ProIle: 1.968 ± 0.044	1.473ProLys: 1.473 ± 0.044	5.211ProLeu: 5.211 ± 0.079	0.966ProMet: 0.966 ± 0.029	1.425ProAsn: 1.425 ± 0.042	2.028ProPro: 2.028 ± 0.053	2.179ProGln: 2.179 ± 0.048	2.552ProArg: 2.552 ± 0.056	2.403ProSer: 2.403 ± 0.047	1.907ProThr: 1.907 ± 0.039	3.893ProVal: 3.893 ± 0.056	0.663ProTrp: 0.663 ± 0.024	1.314ProTyr: 1.314 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.932GlnAla: 3.932 ± 0.063	0.362GlnCys: 0.362 ± 0.019	1.604GlnAsp: 1.604 ± 0.039	2.215GlnGlu: 2.215 ± 0.056	1.477GlnPhe: 1.477 ± 0.042	2.66GlnGly: 2.66 ± 0.05	0.799GlnHis: 0.799 ± 0.032	1.998GlnIle: 1.998 ± 0.046	1.585GlnLys: 1.585 ± 0.038	5.814GlnLeu: 5.814 ± 0.112	0.973GlnMet: 0.973 ± 0.031	1.177GlnAsn: 1.177 ± 0.031	2.05GlnPro: 2.05 ± 0.046	2.359GlnGln: 2.359 ± 0.065	3.108GlnArg: 3.108 ± 0.065	2.207GlnSer: 2.207 ± 0.05	1.775GlnThr: 1.775 ± 0.042	3.169GlnVal: 3.169 ± 0.056	0.728GlnTrp: 0.728 ± 0.026	1.078GlnTyr: 1.078 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.527ArgAla: 6.527 ± 0.083	0.665ArgCys: 0.665 ± 0.026	3.86ArgAsp: 3.86 ± 0.072	5.37ArgGlu: 5.37 ± 0.083	2.619ArgPhe: 2.619 ± 0.052	4.599ArgGly: 4.599 ± 0.071	1.6ArgHis: 1.6 ± 0.046	3.622ArgIle: 3.622 ± 0.064	2.449ArgLys: 2.449 ± 0.05	7.073ArgLeu: 7.073 ± 0.097	1.389ArgMet: 1.389 ± 0.038	2.233ArgAsn: 2.233 ± 0.04	2.696ArgPro: 2.696 ± 0.046	3.02ArgGln: 3.02 ± 0.06	4.83ArgArg: 4.83 ± 0.093	3.256ArgSer: 3.256 ± 0.059	2.576ArgThr: 2.576 ± 0.043	4.316ArgVal: 4.316 ± 0.07	1.178ArgTrp: 1.178 ± 0.033	2.184ArgTyr: 2.184 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.369SerAla: 6.369 ± 0.094	0.603SerCys: 0.603 ± 0.028	3.591SerAsp: 3.591 ± 0.074	3.774SerGlu: 3.774 ± 0.072	2.169SerPhe: 2.169 ± 0.046	6.257SerGly: 6.257 ± 0.11	1.212SerHis: 1.212 ± 0.034	2.733SerIle: 2.733 ± 0.052	1.803SerLys: 1.803 ± 0.044	6.194SerLeu: 6.194 ± 0.091	1.2SerMet: 1.2 ± 0.027	1.851SerAsn: 1.851 ± 0.049	2.689SerPro: 2.689 ± 0.051	1.982SerGln: 1.982 ± 0.045	3.678SerArg: 3.678 ± 0.064	3.736SerSer: 3.736 ± 0.136	2.576SerThr: 2.576 ± 0.053	4.046SerVal: 4.046 ± 0.076	0.935SerTrp: 0.935 ± 0.032	1.889SerTyr: 1.889 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.125ThrAla: 5.125 ± 0.094	0.441ThrCys: 0.441 ± 0.021	2.88ThrAsp: 2.88 ± 0.064	3.007ThrGlu: 3.007 ± 0.05	1.865ThrPhe: 1.865 ± 0.058	4.422ThrGly: 4.422 ± 0.095	0.943ThrHis: 0.943 ± 0.031	2.506ThrIle: 2.506 ± 0.051	1.291ThrLys: 1.291 ± 0.036	5.874ThrLeu: 5.874 ± 0.088	0.894ThrMet: 0.894 ± 0.033	1.499ThrAsn: 1.499 ± 0.043	2.781ThrPro: 2.781 ± 0.063	1.661ThrGln: 1.661 ± 0.041	2.701ThrArg: 2.701 ± 0.056	2.768ThrSer: 2.768 ± 0.058	2.371ThrThr: 2.371 ± 0.056	3.772ThrVal: 3.772 ± 0.073	0.644ThrTrp: 0.644 ± 0.024	1.373ThrTyr: 1.373 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	7.132ValAla: 7.132 ± 0.081	0.733ValCys: 0.733 ± 0.034	4.352ValAsp: 4.352 ± 0.083	4.879ValGlu: 4.879 ± 0.08	2.489ValPhe: 2.489 ± 0.049	4.751ValGly: 4.751 ± 0.077	1.327ValHis: 1.327 ± 0.039	3.869ValIle: 3.869 ± 0.073	2.517ValLys: 2.517 ± 0.062	6.489ValLeu: 6.489 ± 0.093	1.638ValMet: 1.638 ± 0.042	2.46ValAsn: 2.46 ± 0.063	3.276ValPro: 3.276 ± 0.059	2.495ValGln: 2.495 ± 0.048	4.237ValArg: 4.237 ± 0.069	4.375ValSer: 4.375 ± 0.069	3.852ValThr: 3.852 ± 0.066	5.043ValVal: 5.043 ± 0.1	0.788ValTrp: 0.788 ± 0.027	1.86ValTyr: 1.86 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.085TrpAla: 1.085 ± 0.034	0.177TrpCys: 0.177 ± 0.013	0.68TrpAsp: 0.68 ± 0.028	0.707TrpGlu: 0.707 ± 0.024	0.553TrpPhe: 0.553 ± 0.023	0.995TrpGly: 0.995 ± 0.034	0.418TrpHis: 0.418 ± 0.019	0.676TrpIle: 0.676 ± 0.026	0.486TrpLys: 0.486 ± 0.02	2.021TrpLeu: 2.021 ± 0.063	0.389TrpMet: 0.389 ± 0.021	0.518TrpAsn: 0.518 ± 0.027	0.576TrpPro: 0.576 ± 0.025	0.901TrpGln: 0.901 ± 0.035	1.211TrpArg: 1.211 ± 0.034	0.854TrpSer: 0.854 ± 0.031	0.59TrpThr: 0.59 ± 0.025	0.856TrpVal: 0.856 ± 0.03	0.248TrpTrp: 0.248 ± 0.015	0.397TrpTyr: 0.397 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.455TyrAla: 2.455 ± 0.046	0.358TyrCys: 0.358 ± 0.018	1.747TyrAsp: 1.747 ± 0.053	1.568TyrGlu: 1.568 ± 0.043	1.289TyrPhe: 1.289 ± 0.036	2.444TyrGly: 2.444 ± 0.062	0.662TyrHis: 0.662 ± 0.028	1.364TyrIle: 1.364 ± 0.037	0.96TyrLys: 0.96 ± 0.037	3.265TyrLeu: 3.265 ± 0.06	0.498TyrMet: 0.498 ± 0.023	1.013TyrAsn: 1.013 ± 0.034	1.318TyrPro: 1.318 ± 0.039	1.386TyrGln: 1.386 ± 0.04	2.617TyrArg: 2.617 ± 0.061	1.827TyrSer: 1.827 ± 0.045	1.628TyrThr: 1.628 ± 0.042	1.635TyrVal: 1.635 ± 0.043	0.512TyrTrp: 0.512 ± 0.022	0.967TyrTyr: 0.967 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3126 proteins (1082839 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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