Amino acid dipepetide frequency for Olsenella scatoligenes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.652AlaAla: 13.652 ± 0.215	1.918AlaCys: 1.918 ± 0.058	6.977AlaAsp: 6.977 ± 0.119	7.005AlaGlu: 7.005 ± 0.105	3.67AlaPhe: 3.67 ± 0.083	9.272AlaGly: 9.272 ± 0.132	2.177AlaHis: 2.177 ± 0.059	5.637AlaIle: 5.637 ± 0.091	4.042AlaLys: 4.042 ± 0.09	10.57AlaLeu: 10.57 ± 0.143	3.042AlaMet: 3.042 ± 0.065	3.111AlaAsn: 3.111 ± 0.072	4.17AlaPro: 4.17 ± 0.124	3.688AlaGln: 3.688 ± 0.083	7.0AlaArg: 7.0 ± 0.124	6.876AlaSer: 6.876 ± 0.121	6.302AlaThr: 6.302 ± 0.116	8.109AlaVal: 8.109 ± 0.124	1.232AlaTrp: 1.232 ± 0.044	2.908AlaTyr: 2.908 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	1.661CysAla: 1.661 ± 0.052	0.311CysCys: 0.311 ± 0.02	1.029CysAsp: 1.029 ± 0.041	1.024CysGlu: 1.024 ± 0.043	0.43CysPhe: 0.43 ± 0.026	1.682CysGly: 1.682 ± 0.053	0.354CysHis: 0.354 ± 0.022	0.701CysIle: 0.701 ± 0.033	0.419CysLys: 0.419 ± 0.023	1.217CysLeu: 1.217 ± 0.045	0.371CysMet: 0.371 ± 0.023	0.403CysAsn: 0.403 ± 0.026	0.827CysPro: 0.827 ± 0.037	0.386CysGln: 0.386 ± 0.025	0.818CysArg: 0.818 ± 0.033	0.849CysSer: 0.849 ± 0.042	0.834CysThr: 0.834 ± 0.037	1.42CysVal: 1.42 ± 0.044	0.155CysTrp: 0.155 ± 0.017	0.438CysTyr: 0.438 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	7.96AspAla: 7.96 ± 0.133	0.812AspCys: 0.812 ± 0.037	4.052AspAsp: 4.052 ± 0.082	5.387AspGlu: 5.387 ± 0.088	2.36AspPhe: 2.36 ± 0.065	5.744AspGly: 5.744 ± 0.112	1.195AspHis: 1.195 ± 0.046	3.038AspIle: 3.038 ± 0.066	2.056AspLys: 2.056 ± 0.07	5.709AspLeu: 5.709 ± 0.102	1.54AspMet: 1.54 ± 0.05	1.629AspAsn: 1.629 ± 0.045	3.15AspPro: 3.15 ± 0.074	1.761AspGln: 1.761 ± 0.055	3.228AspArg: 3.228 ± 0.072	3.28AspSer: 3.28 ± 0.077	3.166AspThr: 3.166 ± 0.075	5.563AspVal: 5.563 ± 0.1	0.83AspTrp: 0.83 ± 0.035	2.051AspTyr: 2.051 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	6.841GluAla: 6.841 ± 0.118	0.779GluCys: 0.779 ± 0.038	3.878GluAsp: 3.878 ± 0.069	4.467GluGlu: 4.467 ± 0.098	2.05GluPhe: 2.05 ± 0.058	5.254GluGly: 5.254 ± 0.087	1.467GluHis: 1.467 ± 0.046	2.496GluIle: 2.496 ± 0.062	3.555GluLys: 3.555 ± 0.077	6.45GluLeu: 6.45 ± 0.095	1.638GluMet: 1.638 ± 0.049	2.154GluAsn: 2.154 ± 0.059	2.465GluPro: 2.465 ± 0.064	2.358GluGln: 2.358 ± 0.063	5.145GluArg: 5.145 ± 0.099	3.022GluSer: 3.022 ± 0.065	3.016GluThr: 3.016 ± 0.069	5.066GluVal: 5.066 ± 0.107	0.69GluTrp: 0.69 ± 0.031	1.597GluTyr: 1.597 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.53PheAla: 3.53 ± 0.069	0.652PheCys: 0.652 ± 0.029	2.816PheAsp: 2.816 ± 0.058	2.081PheGlu: 2.081 ± 0.067	1.292PhePhe: 1.292 ± 0.045	3.223PheGly: 3.223 ± 0.063	0.644PheHis: 0.644 ± 0.032	1.439PheIle: 1.439 ± 0.049	1.046PheLys: 1.046 ± 0.036	2.903PheLeu: 2.903 ± 0.07	0.894PheMet: 0.894 ± 0.037	0.944PheAsn: 0.944 ± 0.04	1.302PhePro: 1.302 ± 0.041	0.75PheGln: 0.75 ± 0.033	1.571PheArg: 1.571 ± 0.055	2.762PheSer: 2.762 ± 0.063	1.845PheThr: 1.845 ± 0.057	3.063PheVal: 3.063 ± 0.064	0.424PheTrp: 0.424 ± 0.029	0.998PheTyr: 0.998 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	8.228GlyAla: 8.228 ± 0.128	1.413GlyCys: 1.413 ± 0.052	4.794GlyAsp: 4.794 ± 0.09	5.574GlyGlu: 5.574 ± 0.104	3.172GlyPhe: 3.172 ± 0.065	6.414GlyGly: 6.414 ± 0.128	1.809GlyHis: 1.809 ± 0.065	4.898GlyIle: 4.898 ± 0.086	3.555GlyLys: 3.555 ± 0.08	7.281GlyLeu: 7.281 ± 0.114	2.582GlyMet: 2.582 ± 0.063	2.477GlyAsn: 2.477 ± 0.073	2.452GlyPro: 2.452 ± 0.065	2.275GlyGln: 2.275 ± 0.057	5.099GlyArg: 5.099 ± 0.087	5.52GlySer: 5.52 ± 0.114	5.542GlyThr: 5.542 ± 0.096	6.935GlyVal: 6.935 ± 0.1	1.048GlyTrp: 1.048 ± 0.045	2.808GlyTyr: 2.808 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.152HisAla: 2.152 ± 0.055	0.286HisCys: 0.286 ± 0.025	1.492HisAsp: 1.492 ± 0.049	1.395HisGlu: 1.395 ± 0.048	0.706HisPhe: 0.706 ± 0.029	1.897HisGly: 1.897 ± 0.06	0.478HisHis: 0.478 ± 0.028	0.904HisIle: 0.904 ± 0.032	0.571HisLys: 0.571 ± 0.029	1.635HisLeu: 1.635 ± 0.05	0.522HisMet: 0.522 ± 0.025	0.544HisAsn: 0.544 ± 0.027	1.122HisPro: 1.122 ± 0.038	0.489HisGln: 0.489 ± 0.03	1.154HisArg: 1.154 ± 0.035	0.865HisSer: 0.865 ± 0.035	0.997HisThr: 0.997 ± 0.037	1.891HisVal: 1.891 ± 0.052	0.186HisTrp: 0.186 ± 0.015	0.609HisTyr: 0.609 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.504IleAla: 5.504 ± 0.084	0.923IleCys: 0.923 ± 0.032	3.568IleAsp: 3.568 ± 0.069	3.02IleGlu: 3.02 ± 0.074	1.466IlePhe: 1.466 ± 0.054	3.584IleGly: 3.584 ± 0.076	0.859IleHis: 0.859 ± 0.036	2.215IleIle: 2.215 ± 0.073	1.562IleLys: 1.562 ± 0.054	3.909IleLeu: 3.909 ± 0.087	1.106IleMet: 1.106 ± 0.043	1.407IleAsn: 1.407 ± 0.043	2.379IlePro: 2.379 ± 0.059	1.232IleGln: 1.232 ± 0.042	2.563IleArg: 2.563 ± 0.063	2.972IleSer: 2.972 ± 0.075	2.754IleThr: 2.754 ± 0.071	4.483IleVal: 4.483 ± 0.083	0.46IleTrp: 0.46 ± 0.028	1.27IleTyr: 1.27 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	3.855LysAla: 3.855 ± 0.084	0.395LysCys: 0.395 ± 0.026	2.312LysAsp: 2.312 ± 0.063	1.981LysGlu: 1.981 ± 0.058	0.945LysPhe: 0.945 ± 0.042	2.912LysGly: 2.912 ± 0.061	0.741LysHis: 0.741 ± 0.029	1.788LysIle: 1.788 ± 0.061	1.677LysLys: 1.677 ± 0.062	3.178LysLeu: 3.178 ± 0.07	0.872LysMet: 0.872 ± 0.034	1.268LysAsn: 1.268 ± 0.047	1.784LysPro: 1.784 ± 0.061	1.083LysGln: 1.083 ± 0.041	2.558LysArg: 2.558 ± 0.069	2.018LysSer: 2.018 ± 0.065	2.135LysThr: 2.135 ± 0.069	2.949LysVal: 2.949 ± 0.073	0.298LysTrp: 0.298 ± 0.021	0.929LysTyr: 0.929 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	11.518LeuAla: 11.518 ± 0.153	1.286LeuCys: 1.286 ± 0.046	6.42LeuAsp: 6.42 ± 0.093	5.456LeuGlu: 5.456 ± 0.102	2.992LeuPhe: 2.992 ± 0.062	7.994LeuGly: 7.994 ± 0.135	1.506LeuHis: 1.506 ± 0.048	3.583LeuIle: 3.583 ± 0.08	2.814LeuLys: 2.814 ± 0.078	8.228LeuLeu: 8.228 ± 0.142	2.336LeuMet: 2.336 ± 0.059	2.234LeuAsn: 2.234 ± 0.062	4.264LeuPro: 4.264 ± 0.088	2.032LeuGln: 2.032 ± 0.056	5.43LeuArg: 5.43 ± 0.089	6.623LeuSer: 6.623 ± 0.108	4.921LeuThr: 4.921 ± 0.101	8.402LeuVal: 8.402 ± 0.147	0.839LeuTrp: 0.839 ± 0.037	2.173LeuTyr: 2.173 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	3.216MetAla: 3.216 ± 0.072	0.402MetCys: 0.402 ± 0.025	1.695MetAsp: 1.695 ± 0.049	1.458MetGlu: 1.458 ± 0.041	0.633MetPhe: 0.633 ± 0.034	2.484MetGly: 2.484 ± 0.06	0.479MetHis: 0.479 ± 0.03	0.928MetIle: 0.928 ± 0.039	0.834MetLys: 0.834 ± 0.042	2.385MetLeu: 2.385 ± 0.066	0.589MetMet: 0.589 ± 0.031	0.786MetAsn: 0.786 ± 0.033	1.432MetPro: 1.432 ± 0.049	0.735MetGln: 0.735 ± 0.034	1.902MetArg: 1.902 ± 0.056	1.784MetSer: 1.784 ± 0.053	1.438MetThr: 1.438 ± 0.044	1.951MetVal: 1.951 ± 0.053	0.243MetTrp: 0.243 ± 0.019	0.546MetTyr: 0.546 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.121AsnAla: 3.121 ± 0.085	0.406AsnCys: 0.406 ± 0.027	1.807AsnAsp: 1.807 ± 0.058	1.61AsnGlu: 1.61 ± 0.048	0.961AsnPhe: 0.961 ± 0.042	2.633AsnGly: 2.633 ± 0.076	0.587AsnHis: 0.587 ± 0.036	1.438AsnIle: 1.438 ± 0.051	0.96AsnLys: 0.96 ± 0.043	2.544AsnLeu: 2.544 ± 0.061	0.78AsnMet: 0.78 ± 0.035	0.872AsnAsn: 0.872 ± 0.038	1.824AsnPro: 1.824 ± 0.051	0.777AsnGln: 0.777 ± 0.034	1.471AsnArg: 1.471 ± 0.048	1.581AsnSer: 1.581 ± 0.057	1.521AsnThr: 1.521 ± 0.058	2.668AsnVal: 2.668 ± 0.059	0.349AsnTrp: 0.349 ± 0.023	0.907AsnTyr: 0.907 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	5.034ProAla: 5.034 ± 0.118	0.552ProCys: 0.552 ± 0.027	2.836ProAsp: 2.836 ± 0.065	3.624ProGlu: 3.624 ± 0.082	1.572ProPhe: 1.572 ± 0.045	3.508ProGly: 3.508 ± 0.074	0.921ProHis: 0.921 ± 0.035	1.929ProIle: 1.929 ± 0.053	1.729ProLys: 1.729 ± 0.055	3.523ProLeu: 3.523 ± 0.077	0.983ProMet: 0.983 ± 0.035	1.39ProAsn: 1.39 ± 0.054	1.074ProPro: 1.074 ± 0.04	1.536ProGln: 1.536 ± 0.055	2.206ProArg: 2.206 ± 0.063	2.737ProSer: 2.737 ± 0.074	2.691ProThr: 2.691 ± 0.07	3.665ProVal: 3.665 ± 0.086	0.536ProTrp: 0.536 ± 0.028	1.39ProTyr: 1.39 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	3.25GlnAla: 3.25 ± 0.076	0.319GlnCys: 0.319 ± 0.024	1.721GlnAsp: 1.721 ± 0.058	1.805GlnGlu: 1.805 ± 0.054	0.823GlnPhe: 0.823 ± 0.034	2.259GlnGly: 2.259 ± 0.06	0.481GlnHis: 0.481 ± 0.027	1.539GlnIle: 1.539 ± 0.045	0.982GlnLys: 0.982 ± 0.042	3.026GlnLeu: 3.026 ± 0.065	0.883GlnMet: 0.883 ± 0.041	0.866GlnAsn: 0.866 ± 0.036	1.194GlnPro: 1.194 ± 0.046	1.109GlnGln: 1.109 ± 0.048	2.028GlnArg: 2.028 ± 0.062	1.699GlnSer: 1.699 ± 0.052	1.704GlnThr: 1.704 ± 0.051	2.525GlnVal: 2.525 ± 0.06	0.311GlnTrp: 0.311 ± 0.023	0.789GlnTyr: 0.789 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	6.318ArgAla: 6.318 ± 0.12	0.929ArgCys: 0.929 ± 0.04	3.811ArgAsp: 3.811 ± 0.089	4.709ArgGlu: 4.709 ± 0.088	2.054ArgPhe: 2.054 ± 0.054	4.5ArgGly: 4.5 ± 0.087	1.352ArgHis: 1.352 ± 0.045	3.096ArgIle: 3.096 ± 0.076	2.122ArgLys: 2.122 ± 0.06	5.717ArgLeu: 5.717 ± 0.097	1.93ArgMet: 1.93 ± 0.055	1.622ArgAsn: 1.622 ± 0.054	2.494ArgPro: 2.494 ± 0.07	1.936ArgGln: 1.936 ± 0.053	4.896ArgArg: 4.896 ± 0.102	3.362ArgSer: 3.362 ± 0.07	3.285ArgThr: 3.285 ± 0.076	5.002ArgVal: 5.002 ± 0.104	0.674ArgTrp: 0.674 ± 0.034	1.838ArgTyr: 1.838 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.518SerAla: 6.518 ± 0.127	0.926SerCys: 0.926 ± 0.037	3.628SerAsp: 3.628 ± 0.08	3.374SerGlu: 3.374 ± 0.074	2.534SerPhe: 2.534 ± 0.063	5.555SerGly: 5.555 ± 0.109	1.28SerHis: 1.28 ± 0.043	2.881SerIle: 2.881 ± 0.067	2.157SerLys: 2.157 ± 0.064	5.773SerLeu: 5.773 ± 0.109	1.563SerMet: 1.563 ± 0.052	1.803SerAsn: 1.803 ± 0.063	2.607SerPro: 2.607 ± 0.063	1.992SerGln: 1.992 ± 0.064	3.654SerArg: 3.654 ± 0.078	4.471SerSer: 4.471 ± 0.137	3.662SerThr: 3.662 ± 0.087	5.057SerVal: 5.057 ± 0.094	0.88SerTrp: 0.88 ± 0.036	2.035SerTyr: 2.035 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	5.511ThrAla: 5.511 ± 0.108	0.935ThrCys: 0.935 ± 0.031	3.307ThrAsp: 3.307 ± 0.077	2.817ThrGlu: 2.817 ± 0.069	2.122ThrPhe: 2.122 ± 0.062	5.041ThrGly: 5.041 ± 0.107	1.186ThrHis: 1.186 ± 0.045	3.0ThrIle: 3.0 ± 0.068	1.791ThrLys: 1.791 ± 0.056	5.412ThrLeu: 5.412 ± 0.097	1.319ThrMet: 1.319 ± 0.043	1.724ThrAsn: 1.724 ± 0.047	3.175ThrPro: 3.175 ± 0.064	1.664ThrGln: 1.664 ± 0.051	3.052ThrArg: 3.052 ± 0.074	3.948ThrSer: 3.948 ± 0.097	3.456ThrThr: 3.456 ± 0.085	4.711ThrVal: 4.711 ± 0.105	0.704ThrTrp: 0.704 ± 0.034	2.002ThrTyr: 2.002 ± 0.067	0.0ThrXaa: 0.0 ± 0.0
Val	9.518ValAla: 9.518 ± 0.14	1.54ValCys: 1.54 ± 0.044	5.519ValAsp: 5.519 ± 0.095	5.184ValGlu: 5.184 ± 0.104	2.887ValPhe: 2.887 ± 0.072	6.435ValGly: 6.435 ± 0.115	1.448ValHis: 1.448 ± 0.049	4.226ValIle: 4.226 ± 0.085	2.566ValLys: 2.566 ± 0.071	7.659ValLeu: 7.659 ± 0.132	2.038ValMet: 2.038 ± 0.054	2.279ValAsn: 2.279 ± 0.06	4.052ValPro: 4.052 ± 0.082	1.964ValGln: 1.964 ± 0.049	5.329ValArg: 5.329 ± 0.099	5.712ValSer: 5.712 ± 0.108	5.419ValThr: 5.419 ± 0.098	7.513ValVal: 7.513 ± 0.129	0.881ValTrp: 0.881 ± 0.037	2.037ValTyr: 2.037 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.094TrpAla: 1.094 ± 0.038	0.188TrpCys: 0.188 ± 0.018	0.747TrpAsp: 0.747 ± 0.034	0.646TrpGlu: 0.646 ± 0.032	0.402TrpPhe: 0.402 ± 0.026	0.95TrpGly: 0.95 ± 0.042	0.3TrpHis: 0.3 ± 0.022	0.473TrpIle: 0.473 ± 0.027	0.359TrpLys: 0.359 ± 0.025	1.118TrpLeu: 1.118 ± 0.046	0.316TrpMet: 0.316 ± 0.02	0.37TrpAsn: 0.37 ± 0.025	0.478TrpPro: 0.478 ± 0.029	0.46TrpGln: 0.46 ± 0.027	0.745TrpArg: 0.745 ± 0.039	0.694TrpSer: 0.694 ± 0.04	0.536TrpThr: 0.536 ± 0.032	0.801TrpVal: 0.801 ± 0.037	0.183TrpTrp: 0.183 ± 0.016	0.38TrpTyr: 0.38 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.877TyrAla: 2.877 ± 0.078	0.357TyrCys: 0.357 ± 0.025	2.104TyrAsp: 2.104 ± 0.051	1.769TyrGlu: 1.769 ± 0.052	1.108TyrPhe: 1.108 ± 0.041	2.534TyrGly: 2.534 ± 0.057	0.631TyrHis: 0.631 ± 0.031	1.027TyrIle: 1.027 ± 0.038	0.881TyrLys: 0.881 ± 0.043	2.816TyrLeu: 2.816 ± 0.064	0.612TyrMet: 0.612 ± 0.032	0.937TyrAsn: 0.937 ± 0.044	1.191TyrPro: 1.191 ± 0.045	1.084TyrGln: 1.084 ± 0.042	1.796TyrArg: 1.796 ± 0.054	1.575TyrSer: 1.575 ± 0.05	1.654TyrThr: 1.654 ± 0.058	2.436TyrVal: 2.436 ± 0.061	0.319TyrTrp: 0.319 ± 0.026	0.989TyrTyr: 0.989 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2032 proteins (684394 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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