Amino acid dipepetide frequency for Rose leaf rosette-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.016AlaAla: 7.016 ± 1.141
1.052AlaCys: 1.052 ± 0.323
3.333AlaAsp: 3.333 ± 0.705
4.385AlaGlu: 4.385 ± 0.536
3.333AlaPhe: 3.333 ± 0.788
3.157AlaGly: 3.157 ± 0.548
1.052AlaHis: 1.052 ± 0.35
2.807AlaIle: 2.807 ± 1.042
4.034AlaLys: 4.034 ± 0.923
9.472AlaLeu: 9.472 ± 1.413
2.631AlaMet: 2.631 ± 1.355
1.929AlaAsn: 1.929 ± 0.346
4.911AlaPro: 4.911 ± 0.823
1.579AlaGln: 1.579 ± 0.388
2.631AlaArg: 2.631 ± 0.934
4.736AlaSer: 4.736 ± 1.228
5.262AlaThr: 5.262 ± 0.851
5.262AlaVal: 5.262 ± 0.693
0.526AlaTrp: 0.526 ± 0.248
2.631AlaTyr: 2.631 ± 0.772
0.0AlaXaa: 0.0 ± 0.0
Cys
2.982CysAla: 2.982 ± 0.846
0.526CysCys: 0.526 ± 0.242
1.403CysAsp: 1.403 ± 0.567
2.105CysGlu: 2.105 ± 0.582
1.403CysPhe: 1.403 ± 0.546
1.754CysGly: 1.754 ± 0.633
0.175CysHis: 0.175 ± 0.105
0.702CysIle: 0.702 ± 0.25
1.403CysLys: 1.403 ± 0.591
2.456CysLeu: 2.456 ± 0.926
0.0CysMet: 0.0 ± 0.0
0.526CysAsn: 0.526 ± 0.366
1.228CysPro: 1.228 ± 0.449
0.0CysGln: 0.0 ± 0.0
1.403CysArg: 1.403 ± 0.455
1.228CysSer: 1.228 ± 0.392
1.754CysThr: 1.754 ± 0.369
2.456CysVal: 2.456 ± 0.973
0.0CysTrp: 0.0 ± 0.0
0.526CysTyr: 0.526 ± 0.292
0.0CysXaa: 0.0 ± 0.0
Asp
4.21AspAla: 4.21 ± 1.034
1.403AspCys: 1.403 ± 0.469
3.684AspAsp: 3.684 ± 0.491
3.684AspGlu: 3.684 ± 0.905
3.859AspPhe: 3.859 ± 1.187
3.157AspGly: 3.157 ± 0.622
1.403AspHis: 1.403 ± 0.475
3.684AspIle: 3.684 ± 0.54
1.929AspLys: 1.929 ± 1.105
6.49AspLeu: 6.49 ± 0.635
1.228AspMet: 1.228 ± 0.723
1.403AspAsn: 1.403 ± 0.487
2.456AspPro: 2.456 ± 0.609
0.526AspGln: 0.526 ± 0.248
2.105AspArg: 2.105 ± 0.568
4.911AspSer: 4.911 ± 0.976
2.456AspThr: 2.456 ± 0.548
5.438AspVal: 5.438 ± 0.934
0.0AspTrp: 0.0 ± 0.0
2.105AspTyr: 2.105 ± 0.53
0.0AspXaa: 0.0 ± 0.0
Glu
3.333GluAla: 3.333 ± 0.656
2.28GluCys: 2.28 ± 0.668
2.631GluAsp: 2.631 ± 0.651
4.034GluGlu: 4.034 ± 0.938
2.807GluPhe: 2.807 ± 0.674
3.508GluGly: 3.508 ± 1.249
1.403GluHis: 1.403 ± 0.657
3.859GluIle: 3.859 ± 0.978
2.105GluLys: 2.105 ± 0.618
4.736GluLeu: 4.736 ± 1.284
1.579GluMet: 1.579 ± 0.577
1.403GluAsn: 1.403 ± 0.382
1.754GluPro: 1.754 ± 0.434
0.526GluGln: 0.526 ± 0.484
5.262GluArg: 5.262 ± 0.893
3.508GluSer: 3.508 ± 1.281
2.631GluThr: 2.631 ± 0.683
4.736GluVal: 4.736 ± 0.671
1.228GluTrp: 1.228 ± 0.413
2.982GluTyr: 2.982 ± 0.645
0.0GluXaa: 0.0 ± 0.0
Phe
2.631PheAla: 2.631 ± 0.792
1.228PheCys: 1.228 ± 0.572
2.982PheAsp: 2.982 ± 0.91
3.684PheGlu: 3.684 ± 0.632
4.21PhePhe: 4.21 ± 1.007
2.807PheGly: 2.807 ± 1.033
0.526PheHis: 0.526 ± 0.229
2.982PheIle: 2.982 ± 0.433
2.105PheLys: 2.105 ± 0.453
5.613PheLeu: 5.613 ± 1.18
1.579PheMet: 1.579 ± 0.523
1.929PheAsn: 1.929 ± 0.488
1.579PhePro: 1.579 ± 0.477
0.702PheGln: 0.702 ± 0.238
3.157PheArg: 3.157 ± 0.82
4.911PheSer: 4.911 ± 0.961
5.262PheThr: 5.262 ± 0.806
4.561PheVal: 4.561 ± 0.831
0.175PheTrp: 0.175 ± 0.105
2.28PheTyr: 2.28 ± 0.881
0.0PheXaa: 0.0 ± 0.0
Gly
4.21GlyAla: 4.21 ± 1.087
2.105GlyCys: 2.105 ± 0.615
4.034GlyAsp: 4.034 ± 0.639
5.613GlyGlu: 5.613 ± 0.892
3.508GlyPhe: 3.508 ± 0.867
5.087GlyGly: 5.087 ± 0.989
1.052GlyHis: 1.052 ± 0.397
1.754GlyIle: 1.754 ± 0.679
3.684GlyLys: 3.684 ± 0.692
5.438GlyLeu: 5.438 ± 0.865
0.351GlyMet: 0.351 ± 0.209
1.403GlyAsn: 1.403 ± 0.431
1.403GlyPro: 1.403 ± 0.485
1.403GlyGln: 1.403 ± 0.362
2.807GlyArg: 2.807 ± 0.878
5.438GlySer: 5.438 ± 0.76
2.456GlyThr: 2.456 ± 0.809
6.49GlyVal: 6.49 ± 0.868
1.052GlyTrp: 1.052 ± 0.226
1.228GlyTyr: 1.228 ± 0.602
0.0GlyXaa: 0.0 ± 0.0
His
1.754HisAla: 1.754 ± 0.555
1.052HisCys: 1.052 ± 0.45
1.052HisAsp: 1.052 ± 0.383
1.579HisGlu: 1.579 ± 0.62
1.052HisPhe: 1.052 ± 0.431
0.526HisGly: 0.526 ± 0.368
0.877HisHis: 0.877 ± 0.38
1.052HisIle: 1.052 ± 0.497
0.877HisLys: 0.877 ± 0.404
1.929HisLeu: 1.929 ± 0.34
0.351HisMet: 0.351 ± 0.209
0.175HisAsn: 0.175 ± 0.105
0.351HisPro: 0.351 ± 0.24
0.175HisGln: 0.175 ± 0.212
1.579HisArg: 1.579 ± 0.33
1.579HisSer: 1.579 ± 0.46
0.702HisThr: 0.702 ± 0.285
1.929HisVal: 1.929 ± 0.812
0.351HisTrp: 0.351 ± 0.24
0.702HisTyr: 0.702 ± 0.365
0.0HisXaa: 0.0 ± 0.0
Ile
3.508IleAla: 3.508 ± 0.657
1.579IleCys: 1.579 ± 0.715
1.579IleAsp: 1.579 ± 0.306
1.929IleGlu: 1.929 ± 0.489
1.754IlePhe: 1.754 ± 0.521
2.456IleGly: 2.456 ± 0.713
1.052IleHis: 1.052 ± 0.589
1.754IleIle: 1.754 ± 0.808
2.28IleLys: 2.28 ± 0.407
3.508IleLeu: 3.508 ± 1.18
1.403IleMet: 1.403 ± 0.572
2.982IleAsn: 2.982 ± 0.61
2.982IlePro: 2.982 ± 0.748
0.175IleGln: 0.175 ± 0.239
1.754IleArg: 1.754 ± 0.604
4.911IleSer: 4.911 ± 1.183
2.807IleThr: 2.807 ± 0.793
4.561IleVal: 4.561 ± 0.913
0.351IleTrp: 0.351 ± 0.378
1.403IleTyr: 1.403 ± 0.36
0.0IleXaa: 0.0 ± 0.0
Lys
3.157LysAla: 3.157 ± 0.595
1.929LysCys: 1.929 ± 0.613
2.631LysAsp: 2.631 ± 0.839
3.157LysGlu: 3.157 ± 0.83
2.982LysPhe: 2.982 ± 0.686
2.631LysGly: 2.631 ± 0.452
0.526LysHis: 0.526 ± 0.392
3.859LysIle: 3.859 ± 0.577
3.508LysLys: 3.508 ± 0.812
5.262LysLeu: 5.262 ± 1.228
0.526LysMet: 0.526 ± 0.314
1.929LysAsn: 1.929 ± 0.449
0.877LysPro: 0.877 ± 0.296
0.351LysGln: 0.351 ± 0.352
3.859LysArg: 3.859 ± 0.642
5.788LysSer: 5.788 ± 1.014
4.736LysThr: 4.736 ± 1.071
3.684LysVal: 3.684 ± 0.825
0.351LysTrp: 0.351 ± 0.209
2.807LysTyr: 2.807 ± 0.506
0.0LysXaa: 0.0 ± 0.0
Leu
5.613LeuAla: 5.613 ± 1.217
2.456LeuCys: 2.456 ± 0.806
3.333LeuAsp: 3.333 ± 0.782
3.157LeuGlu: 3.157 ± 0.459
5.262LeuPhe: 5.262 ± 0.658
6.49LeuGly: 6.49 ± 1.018
1.579LeuHis: 1.579 ± 0.528
2.105LeuIle: 2.105 ± 0.338
5.788LeuLys: 5.788 ± 1.95
8.069LeuLeu: 8.069 ± 1.123
2.28LeuMet: 2.28 ± 0.488
5.788LeuAsn: 5.788 ± 0.752
3.684LeuPro: 3.684 ± 0.802
1.929LeuGln: 1.929 ± 0.634
5.613LeuArg: 5.613 ± 1.754
10.524LeuSer: 10.524 ± 1.406
6.49LeuThr: 6.49 ± 0.912
8.946LeuVal: 8.946 ± 1.351
0.702LeuTrp: 0.702 ± 0.421
4.034LeuTyr: 4.034 ± 0.893
0.0LeuXaa: 0.0 ± 0.0
Met
2.456MetAla: 2.456 ± 1.066
0.175MetCys: 0.175 ± 0.105
1.754MetAsp: 1.754 ± 0.718
0.175MetGlu: 0.175 ± 0.289
0.702MetPhe: 0.702 ± 0.312
1.228MetGly: 1.228 ± 0.32
0.351MetHis: 0.351 ± 0.209
0.702MetIle: 0.702 ± 0.273
1.579MetLys: 1.579 ± 0.43
1.403MetLeu: 1.403 ± 0.52
0.175MetMet: 0.175 ± 0.249
0.351MetAsn: 0.351 ± 0.195
0.526MetPro: 0.526 ± 0.314
0.526MetGln: 0.526 ± 0.248
1.579MetArg: 1.579 ± 0.438
1.754MetSer: 1.754 ± 0.504
1.754MetThr: 1.754 ± 0.407
1.579MetVal: 1.579 ± 0.595
0.175MetTrp: 0.175 ± 0.213
0.702MetTyr: 0.702 ± 0.648
0.0MetXaa: 0.0 ± 0.0
Asn
3.684AsnAla: 3.684 ± 0.557
0.526AsnCys: 0.526 ± 0.292
1.579AsnAsp: 1.579 ± 0.594
1.929AsnGlu: 1.929 ± 0.457
2.807AsnPhe: 2.807 ± 1.175
2.28AsnGly: 2.28 ± 0.678
0.877AsnHis: 0.877 ± 0.272
1.403AsnIle: 1.403 ± 0.314
1.228AsnLys: 1.228 ± 0.433
4.21AsnLeu: 4.21 ± 0.662
1.052AsnMet: 1.052 ± 0.458
1.228AsnAsn: 1.228 ± 0.493
1.579AsnPro: 1.579 ± 0.52
0.702AsnGln: 0.702 ± 0.507
1.754AsnArg: 1.754 ± 0.353
2.982AsnSer: 2.982 ± 0.851
1.579AsnThr: 1.579 ± 0.445
1.754AsnVal: 1.754 ± 0.673
0.0AsnTrp: 0.0 ± 0.0
1.579AsnTyr: 1.579 ± 0.615
0.0AsnXaa: 0.0 ± 0.0
Pro
2.456ProAla: 2.456 ± 0.556
0.175ProCys: 0.175 ± 0.213
2.631ProAsp: 2.631 ± 0.473
2.456ProGlu: 2.456 ± 0.756
3.157ProPhe: 3.157 ± 0.538
2.631ProGly: 2.631 ± 0.687
1.052ProHis: 1.052 ± 0.372
1.929ProIle: 1.929 ± 0.801
2.456ProLys: 2.456 ± 0.726
4.385ProLeu: 4.385 ± 0.798
0.877ProMet: 0.877 ± 0.585
1.228ProAsn: 1.228 ± 0.322
2.456ProPro: 2.456 ± 0.73
1.052ProGln: 1.052 ± 0.475
2.28ProArg: 2.28 ± 0.783
4.385ProSer: 4.385 ± 0.665
1.754ProThr: 1.754 ± 0.47
2.982ProVal: 2.982 ± 0.879
0.175ProTrp: 0.175 ± 0.105
1.754ProTyr: 1.754 ± 0.683
0.0ProXaa: 0.0 ± 0.0
Gln
1.403GlnAla: 1.403 ± 0.452
0.0GlnCys: 0.0 ± 0.0
2.105GlnAsp: 2.105 ± 0.497
0.702GlnGlu: 0.702 ± 0.245
0.877GlnPhe: 0.877 ± 0.478
1.228GlnGly: 1.228 ± 0.304
0.175GlnHis: 0.175 ± 0.212
1.052GlnIle: 1.052 ± 0.473
0.877GlnLys: 0.877 ± 0.227
2.105GlnLeu: 2.105 ± 0.434
0.175GlnMet: 0.175 ± 0.209
0.702GlnAsn: 0.702 ± 0.285
0.877GlnPro: 0.877 ± 0.35
0.351GlnGln: 0.351 ± 0.352
1.579GlnArg: 1.579 ± 0.387
2.28GlnSer: 2.28 ± 0.513
0.526GlnThr: 0.526 ± 0.248
1.929GlnVal: 1.929 ± 0.538
0.351GlnTrp: 0.351 ± 0.332
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
4.561ArgAla: 4.561 ± 1.225
1.403ArgCys: 1.403 ± 0.464
4.21ArgAsp: 4.21 ± 1.567
2.456ArgGlu: 2.456 ± 0.429
3.157ArgPhe: 3.157 ± 0.998
4.034ArgGly: 4.034 ± 0.592
1.929ArgHis: 1.929 ± 0.772
1.579ArgIle: 1.579 ± 0.495
3.157ArgLys: 3.157 ± 0.495
6.139ArgLeu: 6.139 ± 0.606
0.877ArgMet: 0.877 ± 0.761
1.403ArgAsn: 1.403 ± 0.496
1.579ArgPro: 1.579 ± 0.467
1.754ArgGln: 1.754 ± 0.685
5.087ArgArg: 5.087 ± 1.072
4.561ArgSer: 4.561 ± 0.679
2.105ArgThr: 2.105 ± 0.523
6.665ArgVal: 6.665 ± 1.404
0.702ArgTrp: 0.702 ± 0.25
1.754ArgTyr: 1.754 ± 0.859
0.0ArgXaa: 0.0 ± 0.0
Ser
6.49SerAla: 6.49 ± 1.386
1.754SerCys: 1.754 ± 0.681
5.788SerAsp: 5.788 ± 0.59
5.613SerGlu: 5.613 ± 0.891
2.631SerPhe: 2.631 ± 0.749
4.911SerGly: 4.911 ± 0.577
1.403SerHis: 1.403 ± 0.597
3.684SerIle: 3.684 ± 1.449
4.385SerLys: 4.385 ± 0.636
8.069SerLeu: 8.069 ± 1.643
1.228SerMet: 1.228 ± 0.575
3.508SerAsn: 3.508 ± 0.958
2.982SerPro: 2.982 ± 0.631
1.929SerGln: 1.929 ± 0.476
5.964SerArg: 5.964 ± 1.079
7.718SerSer: 7.718 ± 1.3
5.964SerThr: 5.964 ± 1.831
9.647SerVal: 9.647 ± 2.594
0.877SerTrp: 0.877 ± 0.442
4.385SerTyr: 4.385 ± 0.818
0.0SerXaa: 0.0 ± 0.0
Thr
3.684ThrAla: 3.684 ± 1.176
1.228ThrCys: 1.228 ± 0.592
3.333ThrAsp: 3.333 ± 1.313
2.631ThrGlu: 2.631 ± 0.914
3.333ThrPhe: 3.333 ± 0.64
3.508ThrGly: 3.508 ± 0.508
1.403ThrHis: 1.403 ± 0.494
3.333ThrIle: 3.333 ± 0.644
4.385ThrLys: 4.385 ± 0.66
4.736ThrLeu: 4.736 ± 1.53
0.702ThrMet: 0.702 ± 0.318
1.403ThrAsn: 1.403 ± 0.377
3.157ThrPro: 3.157 ± 0.976
2.28ThrGln: 2.28 ± 0.558
2.28ThrArg: 2.28 ± 0.359
5.262ThrSer: 5.262 ± 1.183
4.034ThrThr: 4.034 ± 2.014
4.561ThrVal: 4.561 ± 0.72
0.526ThrTrp: 0.526 ± 0.208
3.333ThrTyr: 3.333 ± 0.525
0.0ThrXaa: 0.0 ± 0.0
Val
5.788ValAla: 5.788 ± 1.096
2.105ValCys: 2.105 ± 0.548
6.139ValAsp: 6.139 ± 1.208
4.911ValGlu: 4.911 ± 0.87
5.087ValPhe: 5.087 ± 0.528
5.262ValGly: 5.262 ± 0.636
1.754ValHis: 1.754 ± 0.557
3.157ValIle: 3.157 ± 0.746
6.139ValLys: 6.139 ± 0.98
6.665ValLeu: 6.665 ± 0.943
1.403ValMet: 1.403 ± 0.493
3.157ValAsn: 3.157 ± 1.117
5.087ValPro: 5.087 ± 1.18
2.631ValGln: 2.631 ± 0.588
5.613ValArg: 5.613 ± 1.277
8.42ValSer: 8.42 ± 1.577
4.736ValThr: 4.736 ± 1.689
10.174ValVal: 10.174 ± 1.118
0.877ValTrp: 0.877 ± 0.305
3.157ValTyr: 3.157 ± 0.438
0.0ValXaa: 0.0 ± 0.0
Trp
0.877TrpAla: 0.877 ± 0.308
0.175TrpCys: 0.175 ± 0.181
0.175TrpAsp: 0.175 ± 0.105
0.351TrpGlu: 0.351 ± 0.209
0.702TrpPhe: 0.702 ± 0.205
0.877TrpGly: 0.877 ± 0.349
0.0TrpHis: 0.0 ± 0.0
0.526TrpIle: 0.526 ± 0.24
0.351TrpLys: 0.351 ± 0.209
0.175TrpLeu: 0.175 ± 0.105
0.351TrpMet: 0.351 ± 0.333
0.175TrpAsn: 0.175 ± 0.289
0.175TrpPro: 0.175 ± 0.105
0.175TrpGln: 0.175 ± 0.239
0.526TrpArg: 0.526 ± 0.248
1.052TrpSer: 1.052 ± 0.478
0.0TrpThr: 0.0 ± 0.0
1.052TrpVal: 1.052 ± 0.301
0.175TrpTrp: 0.175 ± 0.105
0.702TrpTyr: 0.702 ± 0.419
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.105TyrAla: 2.105 ± 0.547
0.877TyrCys: 0.877 ± 0.491
1.754TyrAsp: 1.754 ± 0.54
1.754TyrGlu: 1.754 ± 0.525
2.28TyrPhe: 2.28 ± 0.631
2.807TyrGly: 2.807 ± 0.598
1.052TyrHis: 1.052 ± 0.349
2.807TyrIle: 2.807 ± 0.702
2.28TyrLys: 2.28 ± 1.088
2.982TyrLeu: 2.982 ± 0.59
0.877TyrMet: 0.877 ± 0.419
2.105TyrAsn: 2.105 ± 0.592
2.631TyrPro: 2.631 ± 0.772
0.526TyrGln: 0.526 ± 0.285
2.28TyrArg: 2.28 ± 0.527
2.982TyrSer: 2.982 ± 0.773
2.105TyrThr: 2.105 ± 0.816
3.859TyrVal: 3.859 ± 1.186
0.0TyrTrp: 0.0 ± 0.0
1.579TyrTyr: 1.579 ± 0.613
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (5702 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski