Amino acid dipepetide frequency for Escherichia phage 1720a-02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.873AlaAla: 10.873 ± 1.288
1.13AlaCys: 1.13 ± 0.342
6.99AlaAsp: 6.99 ± 0.689
7.484AlaGlu: 7.484 ± 0.704
3.389AlaPhe: 3.389 ± 0.521
9.178AlaGly: 9.178 ± 1.0
1.765AlaHis: 1.765 ± 0.267
4.377AlaIle: 4.377 ± 0.534
3.389AlaLys: 3.389 ± 0.479
7.343AlaLeu: 7.343 ± 0.748
3.459AlaMet: 3.459 ± 0.511
3.036AlaAsn: 3.036 ± 0.509
3.036AlaPro: 3.036 ± 0.41
3.671AlaGln: 3.671 ± 0.611
6.566AlaArg: 6.566 ± 0.798
5.578AlaSer: 5.578 ± 0.549
5.436AlaThr: 5.436 ± 0.77
6.99AlaVal: 6.99 ± 0.706
1.341AlaTrp: 1.341 ± 0.325
2.542AlaTyr: 2.542 ± 0.366
0.0AlaXaa: 0.0 ± 0.0
Cys
1.059CysAla: 1.059 ± 0.272
0.494CysCys: 0.494 ± 0.182
0.847CysAsp: 0.847 ± 0.237
0.918CysGlu: 0.918 ± 0.318
0.424CysPhe: 0.424 ± 0.17
0.918CysGly: 0.918 ± 0.265
0.424CysHis: 0.424 ± 0.193
0.565CysIle: 0.565 ± 0.206
0.424CysLys: 0.424 ± 0.196
1.271CysLeu: 1.271 ± 0.294
0.565CysMet: 0.565 ± 0.217
0.212CysAsn: 0.212 ± 0.098
0.565CysPro: 0.565 ± 0.219
0.635CysGln: 0.635 ± 0.219
0.918CysArg: 0.918 ± 0.307
0.988CysSer: 0.988 ± 0.261
0.777CysThr: 0.777 ± 0.271
0.847CysVal: 0.847 ± 0.24
0.424CysTrp: 0.424 ± 0.191
0.565CysTyr: 0.565 ± 0.242
0.0CysXaa: 0.0 ± 0.0
Asp
6.001AspAla: 6.001 ± 0.592
0.777AspCys: 0.777 ± 0.243
3.177AspAsp: 3.177 ± 0.579
3.601AspGlu: 3.601 ± 0.546
1.765AspPhe: 1.765 ± 0.393
5.931AspGly: 5.931 ± 0.587
0.424AspHis: 0.424 ± 0.131
3.671AspIle: 3.671 ± 0.452
2.4AspLys: 2.4 ± 0.447
4.589AspLeu: 4.589 ± 0.632
1.836AspMet: 1.836 ± 0.338
3.036AspAsn: 3.036 ± 0.458
2.33AspPro: 2.33 ± 0.369
1.765AspGln: 1.765 ± 0.445
3.248AspArg: 3.248 ± 0.582
2.471AspSer: 2.471 ± 0.405
2.895AspThr: 2.895 ± 0.483
4.024AspVal: 4.024 ± 0.549
1.341AspTrp: 1.341 ± 0.361
1.836AspTyr: 1.836 ± 0.321
0.0AspXaa: 0.0 ± 0.0
Glu
6.072GluAla: 6.072 ± 0.74
0.777GluCys: 0.777 ± 0.261
2.471GluAsp: 2.471 ± 0.376
3.459GluGlu: 3.459 ± 0.515
2.047GluPhe: 2.047 ± 0.329
4.307GluGly: 4.307 ± 0.601
1.13GluHis: 1.13 ± 0.253
3.036GluIle: 3.036 ± 0.433
5.507GluLys: 5.507 ± 0.602
6.637GluLeu: 6.637 ± 0.812
2.047GluMet: 2.047 ± 0.396
3.389GluAsn: 3.389 ± 0.458
3.036GluPro: 3.036 ± 0.503
3.177GluGln: 3.177 ± 0.438
4.518GluArg: 4.518 ± 0.612
3.883GluSer: 3.883 ± 0.583
4.448GluThr: 4.448 ± 0.466
3.177GluVal: 3.177 ± 0.445
1.341GluTrp: 1.341 ± 0.282
1.906GluTyr: 1.906 ± 0.298
0.0GluXaa: 0.0 ± 0.0
Phe
2.259PheAla: 2.259 ± 0.348
0.847PheCys: 0.847 ± 0.274
2.4PheAsp: 2.4 ± 0.465
2.4PheGlu: 2.4 ± 0.374
1.2PhePhe: 1.2 ± 0.306
2.4PheGly: 2.4 ± 0.43
0.565PheHis: 0.565 ± 0.204
1.906PheIle: 1.906 ± 0.424
1.977PheLys: 1.977 ± 0.35
2.33PheLeu: 2.33 ± 0.382
1.341PheMet: 1.341 ± 0.276
1.059PheAsn: 1.059 ± 0.301
1.341PhePro: 1.341 ± 0.326
0.706PheGln: 0.706 ± 0.216
3.177PheArg: 3.177 ± 0.532
3.177PheSer: 3.177 ± 0.46
2.047PheThr: 2.047 ± 0.345
2.612PheVal: 2.612 ± 0.33
0.988PheTrp: 0.988 ± 0.217
0.988PheTyr: 0.988 ± 0.283
0.0PheXaa: 0.0 ± 0.0
Gly
7.201GlyAla: 7.201 ± 0.946
0.988GlyCys: 0.988 ± 0.294
5.013GlyAsp: 5.013 ± 0.74
6.354GlyGlu: 6.354 ± 0.996
3.248GlyPhe: 3.248 ± 0.486
5.86GlyGly: 5.86 ± 0.939
0.777GlyHis: 0.777 ± 0.301
4.236GlyIle: 4.236 ± 0.555
5.154GlyLys: 5.154 ± 0.528
4.589GlyLeu: 4.589 ± 0.5
2.33GlyMet: 2.33 ± 0.327
3.389GlyAsn: 3.389 ± 0.426
3.177GlyPro: 3.177 ± 0.849
3.248GlyGln: 3.248 ± 0.58
5.295GlyArg: 5.295 ± 0.509
4.307GlySer: 4.307 ± 0.443
3.742GlyThr: 3.742 ± 0.529
5.578GlyVal: 5.578 ± 0.548
1.624GlyTrp: 1.624 ± 0.304
1.694GlyTyr: 1.694 ± 0.29
0.0GlyXaa: 0.0 ± 0.0
His
1.553HisAla: 1.553 ± 0.346
0.424HisCys: 0.424 ± 0.186
1.412HisAsp: 1.412 ± 0.356
1.2HisGlu: 1.2 ± 0.297
1.059HisPhe: 1.059 ± 0.281
0.777HisGly: 0.777 ± 0.197
0.424HisHis: 0.424 ± 0.165
1.624HisIle: 1.624 ± 0.315
0.847HisLys: 0.847 ± 0.257
1.13HisLeu: 1.13 ± 0.301
0.282HisMet: 0.282 ± 0.158
0.635HisAsn: 0.635 ± 0.243
0.777HisPro: 0.777 ± 0.249
0.635HisGln: 0.635 ± 0.252
1.13HisArg: 1.13 ± 0.268
1.483HisSer: 1.483 ± 0.33
0.777HisThr: 0.777 ± 0.264
0.988HisVal: 0.988 ± 0.228
0.494HisTrp: 0.494 ± 0.175
0.424HisTyr: 0.424 ± 0.177
0.0HisXaa: 0.0 ± 0.0
Ile
4.518IleAla: 4.518 ± 0.694
0.777IleCys: 0.777 ± 0.244
3.106IleAsp: 3.106 ± 0.421
3.106IleGlu: 3.106 ± 0.538
1.271IlePhe: 1.271 ± 0.335
3.954IleGly: 3.954 ± 0.479
1.412IleHis: 1.412 ± 0.284
2.683IleIle: 2.683 ± 0.62
2.118IleLys: 2.118 ± 0.401
3.318IleLeu: 3.318 ± 0.385
0.635IleMet: 0.635 ± 0.184
3.318IleAsn: 3.318 ± 0.467
2.33IlePro: 2.33 ± 0.354
1.553IleGln: 1.553 ± 0.368
4.024IleArg: 4.024 ± 0.548
3.742IleSer: 3.742 ± 0.539
4.73IleThr: 4.73 ± 0.72
2.4IleVal: 2.4 ± 0.316
0.847IleTrp: 0.847 ± 0.234
1.271IleTyr: 1.271 ± 0.357
0.0IleXaa: 0.0 ± 0.0
Lys
5.719LysAla: 5.719 ± 1.068
0.777LysCys: 0.777 ± 0.264
2.612LysAsp: 2.612 ± 0.349
3.177LysGlu: 3.177 ± 0.494
1.271LysPhe: 1.271 ± 0.336
4.73LysGly: 4.73 ± 0.927
1.13LysHis: 1.13 ± 0.311
2.895LysIle: 2.895 ± 0.571
2.965LysLys: 2.965 ± 0.543
3.742LysLeu: 3.742 ± 0.604
1.412LysMet: 1.412 ± 0.386
2.612LysAsn: 2.612 ± 0.406
2.965LysPro: 2.965 ± 0.449
2.189LysGln: 2.189 ± 0.434
3.459LysArg: 3.459 ± 0.427
2.895LysSer: 2.895 ± 0.461
2.965LysThr: 2.965 ± 0.512
3.248LysVal: 3.248 ± 0.431
0.918LysTrp: 0.918 ± 0.23
1.694LysTyr: 1.694 ± 0.453
0.0LysXaa: 0.0 ± 0.0
Leu
7.978LeuAla: 7.978 ± 0.807
0.847LeuCys: 0.847 ± 0.283
3.954LeuAsp: 3.954 ± 0.505
4.801LeuGlu: 4.801 ± 0.686
3.036LeuPhe: 3.036 ± 0.485
3.459LeuGly: 3.459 ± 0.492
1.624LeuHis: 1.624 ± 0.308
4.448LeuIle: 4.448 ± 0.551
5.436LeuLys: 5.436 ± 0.615
5.436LeuLeu: 5.436 ± 0.678
2.118LeuMet: 2.118 ± 0.431
3.671LeuAsn: 3.671 ± 0.424
3.954LeuPro: 3.954 ± 0.505
3.389LeuGln: 3.389 ± 0.49
4.872LeuArg: 4.872 ± 0.648
6.001LeuSer: 6.001 ± 0.662
5.154LeuThr: 5.154 ± 0.821
5.013LeuVal: 5.013 ± 0.414
1.271LeuTrp: 1.271 ± 0.252
2.118LeuTyr: 2.118 ± 0.345
0.0LeuXaa: 0.0 ± 0.0
Met
3.036MetAla: 3.036 ± 0.498
0.353MetCys: 0.353 ± 0.169
1.059MetAsp: 1.059 ± 0.369
1.412MetGlu: 1.412 ± 0.35
0.918MetPhe: 0.918 ± 0.191
1.553MetGly: 1.553 ± 0.358
0.353MetHis: 0.353 ± 0.183
1.13MetIle: 1.13 ± 0.24
1.624MetLys: 1.624 ± 0.268
2.824MetLeu: 2.824 ± 0.494
1.13MetMet: 1.13 ± 0.316
1.059MetAsn: 1.059 ± 0.247
1.341MetPro: 1.341 ± 0.354
1.483MetGln: 1.483 ± 0.311
1.836MetArg: 1.836 ± 0.305
1.977MetSer: 1.977 ± 0.321
1.765MetThr: 1.765 ± 0.356
1.483MetVal: 1.483 ± 0.365
0.494MetTrp: 0.494 ± 0.199
0.353MetTyr: 0.353 ± 0.173
0.0MetXaa: 0.0 ± 0.0
Asn
3.883AsnAla: 3.883 ± 0.592
0.494AsnCys: 0.494 ± 0.168
2.118AsnAsp: 2.118 ± 0.34
2.542AsnGlu: 2.542 ± 0.428
1.271AsnPhe: 1.271 ± 0.31
3.954AsnGly: 3.954 ± 0.792
1.059AsnHis: 1.059 ± 0.253
2.612AsnIle: 2.612 ± 0.446
2.118AsnLys: 2.118 ± 0.431
2.824AsnLeu: 2.824 ± 0.5
1.341AsnMet: 1.341 ± 0.296
1.906AsnAsn: 1.906 ± 0.417
2.118AsnPro: 2.118 ± 0.315
1.977AsnGln: 1.977 ± 0.338
2.33AsnArg: 2.33 ± 0.541
2.471AsnSer: 2.471 ± 0.616
2.542AsnThr: 2.542 ± 0.393
1.624AsnVal: 1.624 ± 0.404
0.212AsnTrp: 0.212 ± 0.107
0.988AsnTyr: 0.988 ± 0.289
0.0AsnXaa: 0.0 ± 0.0
Pro
5.295ProAla: 5.295 ± 0.556
0.565ProCys: 0.565 ± 0.2
3.106ProAsp: 3.106 ± 0.475
4.872ProGlu: 4.872 ± 0.685
1.271ProPhe: 1.271 ± 0.37
4.518ProGly: 4.518 ± 0.707
0.777ProHis: 0.777 ± 0.241
0.847ProIle: 0.847 ± 0.23
2.189ProLys: 2.189 ± 0.639
2.683ProLeu: 2.683 ± 0.415
0.918ProMet: 0.918 ± 0.261
1.059ProAsn: 1.059 ± 0.249
1.483ProPro: 1.483 ± 0.341
1.13ProGln: 1.13 ± 0.246
2.4ProArg: 2.4 ± 0.391
2.4ProSer: 2.4 ± 0.36
1.836ProThr: 1.836 ± 0.36
4.448ProVal: 4.448 ± 0.644
0.777ProTrp: 0.777 ± 0.239
1.341ProTyr: 1.341 ± 0.28
0.0ProXaa: 0.0 ± 0.0
Gln
3.742GlnAla: 3.742 ± 0.817
0.706GlnCys: 0.706 ± 0.204
1.341GlnAsp: 1.341 ± 0.296
2.471GlnGlu: 2.471 ± 0.312
1.13GlnPhe: 1.13 ± 0.255
2.965GlnGly: 2.965 ± 0.414
0.635GlnHis: 0.635 ± 0.196
2.259GlnIle: 2.259 ± 0.505
2.471GlnLys: 2.471 ± 0.465
3.177GlnLeu: 3.177 ± 0.461
1.483GlnMet: 1.483 ± 0.258
1.836GlnAsn: 1.836 ± 0.446
1.341GlnPro: 1.341 ± 0.252
2.047GlnGln: 2.047 ± 0.537
2.4GlnArg: 2.4 ± 0.361
2.542GlnSer: 2.542 ± 0.476
2.33GlnThr: 2.33 ± 0.465
2.259GlnVal: 2.259 ± 0.371
0.777GlnTrp: 0.777 ± 0.249
1.341GlnTyr: 1.341 ± 0.312
0.0GlnXaa: 0.0 ± 0.0
Arg
5.719ArgAla: 5.719 ± 0.62
1.2ArgCys: 1.2 ± 0.298
3.883ArgAsp: 3.883 ± 0.676
4.307ArgGlu: 4.307 ± 0.628
2.753ArgPhe: 2.753 ± 0.431
4.73ArgGly: 4.73 ± 0.672
1.694ArgHis: 1.694 ± 0.375
3.106ArgIle: 3.106 ± 0.571
3.601ArgLys: 3.601 ± 0.523
6.566ArgLeu: 6.566 ± 0.567
1.694ArgMet: 1.694 ± 0.424
2.4ArgAsn: 2.4 ± 0.402
2.542ArgPro: 2.542 ± 0.429
2.33ArgGln: 2.33 ± 0.512
5.931ArgArg: 5.931 ± 1.002
2.683ArgSer: 2.683 ± 0.461
3.036ArgThr: 3.036 ± 0.497
3.883ArgVal: 3.883 ± 0.577
1.341ArgTrp: 1.341 ± 0.4
2.683ArgTyr: 2.683 ± 0.404
0.0ArgXaa: 0.0 ± 0.0
Ser
8.472SerAla: 8.472 ± 0.813
0.706SerCys: 0.706 ± 0.209
3.671SerAsp: 3.671 ± 0.423
3.812SerGlu: 3.812 ± 0.649
1.977SerPhe: 1.977 ± 0.331
5.578SerGly: 5.578 ± 0.873
0.918SerHis: 0.918 ± 0.207
2.33SerIle: 2.33 ± 0.44
2.612SerLys: 2.612 ± 0.466
5.225SerLeu: 5.225 ± 0.53
1.2SerMet: 1.2 ± 0.311
1.906SerAsn: 1.906 ± 0.417
2.824SerPro: 2.824 ± 0.515
3.601SerGln: 3.601 ± 0.494
3.318SerArg: 3.318 ± 0.551
3.53SerSer: 3.53 ± 0.499
2.824SerThr: 2.824 ± 0.406
5.225SerVal: 5.225 ± 0.667
0.494SerTrp: 0.494 ± 0.143
1.977SerTyr: 1.977 ± 0.463
0.0SerXaa: 0.0 ± 0.0
Thr
4.73ThrAla: 4.73 ± 0.721
0.424ThrCys: 0.424 ± 0.162
3.954ThrAsp: 3.954 ± 0.526
4.377ThrGlu: 4.377 ± 0.531
2.471ThrPhe: 2.471 ± 0.399
5.86ThrGly: 5.86 ± 0.997
1.2ThrHis: 1.2 ± 0.268
2.4ThrIle: 2.4 ± 0.572
2.189ThrLys: 2.189 ± 0.405
4.872ThrLeu: 4.872 ± 0.87
0.706ThrMet: 0.706 ± 0.259
1.341ThrAsn: 1.341 ± 0.294
3.742ThrPro: 3.742 ± 0.495
1.694ThrGln: 1.694 ± 0.3
2.895ThrArg: 2.895 ± 0.507
3.812ThrSer: 3.812 ± 0.627
3.601ThrThr: 3.601 ± 0.599
4.66ThrVal: 4.66 ± 0.676
1.271ThrTrp: 1.271 ± 0.326
2.047ThrTyr: 2.047 ± 0.384
0.0ThrXaa: 0.0 ± 0.0
Val
6.213ValAla: 6.213 ± 0.654
0.706ValCys: 0.706 ± 0.24
3.53ValAsp: 3.53 ± 0.568
3.53ValGlu: 3.53 ± 0.62
2.612ValPhe: 2.612 ± 0.525
3.742ValGly: 3.742 ± 0.504
0.777ValHis: 0.777 ± 0.274
4.377ValIle: 4.377 ± 0.58
4.236ValLys: 4.236 ± 0.651
5.225ValLeu: 5.225 ± 0.639
1.624ValMet: 1.624 ± 0.361
2.612ValAsn: 2.612 ± 0.424
3.177ValPro: 3.177 ± 0.446
2.118ValGln: 2.118 ± 0.516
3.812ValArg: 3.812 ± 0.413
5.578ValSer: 5.578 ± 0.57
4.448ValThr: 4.448 ± 0.596
4.165ValVal: 4.165 ± 0.649
1.13ValTrp: 1.13 ± 0.325
2.047ValTyr: 2.047 ± 0.274
0.0ValXaa: 0.0 ± 0.0
Trp
1.341TrpAla: 1.341 ± 0.266
0.282TrpCys: 0.282 ± 0.132
0.918TrpAsp: 0.918 ± 0.284
1.2TrpGlu: 1.2 ± 0.271
0.918TrpPhe: 0.918 ± 0.238
1.2TrpGly: 1.2 ± 0.196
0.424TrpHis: 0.424 ± 0.184
0.847TrpIle: 0.847 ± 0.294
0.918TrpLys: 0.918 ± 0.29
1.977TrpLeu: 1.977 ± 0.396
0.494TrpMet: 0.494 ± 0.164
0.353TrpAsn: 0.353 ± 0.158
0.918TrpPro: 0.918 ± 0.275
0.706TrpGln: 0.706 ± 0.205
1.553TrpArg: 1.553 ± 0.392
0.777TrpSer: 0.777 ± 0.214
0.777TrpThr: 0.777 ± 0.195
1.13TrpVal: 1.13 ± 0.337
0.565TrpTrp: 0.565 ± 0.197
0.847TrpTyr: 0.847 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.906TyrAla: 1.906 ± 0.353
0.565TyrCys: 0.565 ± 0.185
1.553TyrAsp: 1.553 ± 0.291
1.341TyrGlu: 1.341 ± 0.298
1.694TyrPhe: 1.694 ± 0.332
2.189TyrGly: 2.189 ± 0.466
0.565TyrHis: 0.565 ± 0.185
1.765TyrIle: 1.765 ± 0.413
1.271TyrLys: 1.271 ± 0.286
2.824TyrLeu: 2.824 ± 0.48
0.494TyrMet: 0.494 ± 0.182
1.553TyrAsn: 1.553 ± 0.294
0.918TyrPro: 0.918 ± 0.208
1.2TyrGln: 1.2 ± 0.254
2.4TyrArg: 2.4 ± 0.349
1.906TyrSer: 1.906 ± 0.421
2.118TyrThr: 2.118 ± 0.37
1.906TyrVal: 1.906 ± 0.369
0.494TyrTrp: 0.494 ± 0.182
0.706TyrTyr: 0.706 ± 0.221
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (14165 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski