Amino acid dipepetide frequency for Cetobacterium somerae ATCC BAA-474

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.443AlaAla: 3.443 ± 0.09	0.566AlaCys: 0.566 ± 0.027	2.181AlaAsp: 2.181 ± 0.053	3.077AlaGlu: 3.077 ± 0.064	2.657AlaPhe: 2.657 ± 0.058	4.016AlaGly: 4.016 ± 0.085	0.791AlaHis: 0.791 ± 0.032	5.478AlaIle: 5.478 ± 0.088	4.516AlaLys: 4.516 ± 0.076	5.766AlaLeu: 5.766 ± 0.1	1.563AlaMet: 1.563 ± 0.048	2.411AlaAsn: 2.411 ± 0.06	1.53AlaPro: 1.53 ± 0.048	1.414AlaGln: 1.414 ± 0.036	1.667AlaArg: 1.667 ± 0.045	2.835AlaSer: 2.835 ± 0.055	2.919AlaThr: 2.919 ± 0.059	3.506AlaVal: 3.506 ± 0.08	0.348AlaTrp: 0.348 ± 0.022	1.946AlaTyr: 1.946 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.422CysAla: 0.422 ± 0.021	0.118CysCys: 0.118 ± 0.011	0.477CysAsp: 0.477 ± 0.024	0.598CysGlu: 0.598 ± 0.031	0.387CysPhe: 0.387 ± 0.023	0.916CysGly: 0.916 ± 0.039	0.182CysHis: 0.182 ± 0.014	0.757CysIle: 0.757 ± 0.029	0.723CysLys: 0.723 ± 0.029	0.707CysLeu: 0.707 ± 0.028	0.212CysMet: 0.212 ± 0.015	0.512CysAsn: 0.512 ± 0.026	0.38CysPro: 0.38 ± 0.024	0.195CysGln: 0.195 ± 0.013	0.26CysArg: 0.26 ± 0.018	0.596CysSer: 0.596 ± 0.026	0.433CysThr: 0.433 ± 0.024	0.49CysVal: 0.49 ± 0.023	0.052CysTrp: 0.052 ± 0.007	0.289CysTyr: 0.289 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.23AspAla: 2.23 ± 0.055	0.43AspCys: 0.43 ± 0.023	2.138AspAsp: 2.138 ± 0.056	4.226AspGlu: 4.226 ± 0.067	2.988AspPhe: 2.988 ± 0.062	3.214AspGly: 3.214 ± 0.06	0.518AspHis: 0.518 ± 0.025	5.782AspIle: 5.782 ± 0.085	4.781AspLys: 4.781 ± 0.081	5.003AspLeu: 5.003 ± 0.086	1.301AspMet: 1.301 ± 0.037	2.763AspAsn: 2.763 ± 0.057	1.232AspPro: 1.232 ± 0.04	0.861AspGln: 0.861 ± 0.034	1.889AspArg: 1.889 ± 0.05	3.103AspSer: 3.103 ± 0.058	2.238AspThr: 2.238 ± 0.053	3.119AspVal: 3.119 ± 0.058	0.418AspTrp: 0.418 ± 0.021	2.584AspTyr: 2.584 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	3.921GluAla: 3.921 ± 0.072	0.49GluCys: 0.49 ± 0.026	3.825GluAsp: 3.825 ± 0.076	6.42GluGlu: 6.42 ± 0.114	3.616GluPhe: 3.616 ± 0.066	3.706GluGly: 3.706 ± 0.07	0.836GluHis: 0.836 ± 0.03	8.311GluIle: 8.311 ± 0.116	9.484GluLys: 9.484 ± 0.123	7.202GluLeu: 7.202 ± 0.101	1.831GluMet: 1.831 ± 0.047	6.354GluAsn: 6.354 ± 0.1	1.281GluPro: 1.281 ± 0.039	1.419GluGln: 1.419 ± 0.038	2.825GluArg: 2.825 ± 0.06	3.605GluSer: 3.605 ± 0.062	3.428GluThr: 3.428 ± 0.056	4.84GluVal: 4.84 ± 0.082	0.479GluTrp: 0.479 ± 0.025	3.148GluTyr: 3.148 ± 0.074	0.0GluXaa: 0.0 ± 0.0
Phe	2.297PheAla: 2.297 ± 0.057	0.43PheCys: 0.43 ± 0.022	2.437PheAsp: 2.437 ± 0.051	3.061PheGlu: 3.061 ± 0.062	2.886PhePhe: 2.886 ± 0.072	3.513PheGly: 3.513 ± 0.073	0.65PheHis: 0.65 ± 0.026	5.029PheIle: 5.029 ± 0.094	4.42PheLys: 4.42 ± 0.069	5.422PheLeu: 5.422 ± 0.1	1.269PheMet: 1.269 ± 0.039	3.112PheAsn: 3.112 ± 0.058	1.397PhePro: 1.397 ± 0.036	1.294PheGln: 1.294 ± 0.042	1.402PheArg: 1.402 ± 0.038	3.866PheSer: 3.866 ± 0.07	2.479PheThr: 2.479 ± 0.058	2.763PheVal: 2.763 ± 0.058	0.365PheTrp: 0.365 ± 0.02	2.183PheTyr: 2.183 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.4GlyAla: 4.4 ± 0.096	0.767GlyCys: 0.767 ± 0.035	3.481GlyAsp: 3.481 ± 0.074	4.811GlyGlu: 4.811 ± 0.087	3.345GlyPhe: 3.345 ± 0.07	4.941GlyGly: 4.941 ± 0.099	0.985GlyHis: 0.985 ± 0.031	7.102GlyIle: 7.102 ± 0.109	5.912GlyLys: 5.912 ± 0.087	5.768GlyLeu: 5.768 ± 0.093	1.962GlyMet: 1.962 ± 0.055	3.246GlyAsn: 3.246 ± 0.08	1.252GlyPro: 1.252 ± 0.037	1.363GlyGln: 1.363 ± 0.039	2.114GlyArg: 2.114 ± 0.05	3.608GlySer: 3.608 ± 0.067	3.782GlyThr: 3.782 ± 0.074	5.774GlyVal: 5.774 ± 0.087	0.524GlyTrp: 0.524 ± 0.026	2.972GlyTyr: 2.972 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.622HisAla: 0.622 ± 0.026	0.156HisCys: 0.156 ± 0.011	0.548HisAsp: 0.548 ± 0.025	0.782HisGlu: 0.782 ± 0.028	0.663HisPhe: 0.663 ± 0.029	0.999HisGly: 0.999 ± 0.036	0.288HisHis: 0.288 ± 0.017	1.167HisIle: 1.167 ± 0.04	0.926HisLys: 0.926 ± 0.028	1.309HisLeu: 1.309 ± 0.034	0.353HisMet: 0.353 ± 0.019	0.705HisAsn: 0.705 ± 0.028	0.588HisPro: 0.588 ± 0.027	0.285HisGln: 0.285 ± 0.017	0.44HisArg: 0.44 ± 0.022	0.821HisSer: 0.821 ± 0.03	0.69HisThr: 0.69 ± 0.028	0.644HisVal: 0.644 ± 0.028	0.105HisTrp: 0.105 ± 0.01	0.509HisTyr: 0.509 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.449IleAla: 5.449 ± 0.091	0.874IleCys: 0.874 ± 0.031	5.484IleAsp: 5.484 ± 0.1	7.562IleGlu: 7.562 ± 0.12	5.402IlePhe: 5.402 ± 0.092	6.702IleGly: 6.702 ± 0.104	1.143IleHis: 1.143 ± 0.035	8.599IleIle: 8.599 ± 0.101	8.78IleLys: 8.78 ± 0.106	10.151IleLeu: 10.151 ± 0.144	2.046IleMet: 2.046 ± 0.047	5.458IleAsn: 5.458 ± 0.098	3.631IlePro: 3.631 ± 0.074	2.081IleGln: 2.081 ± 0.043	2.638IleArg: 2.638 ± 0.057	6.574IleSer: 6.574 ± 0.09	4.785IleThr: 4.785 ± 0.082	6.204IleVal: 6.204 ± 0.091	0.594IleTrp: 0.594 ± 0.026	3.749IleTyr: 3.749 ± 0.074	0.0IleXaa: 0.0 ± 0.0
Lys	4.201LysAla: 4.201 ± 0.071	0.568LysCys: 0.568 ± 0.03	5.901LysAsp: 5.901 ± 0.089	9.437LysGlu: 9.437 ± 0.13	3.735LysPhe: 3.735 ± 0.065	5.292LysGly: 5.292 ± 0.069	0.949LysHis: 0.949 ± 0.035	9.636LysIle: 9.636 ± 0.134	9.506LysLys: 9.506 ± 0.119	7.607LysLeu: 7.607 ± 0.101	2.476LysMet: 2.476 ± 0.048	7.897LysAsn: 7.897 ± 0.117	1.901LysPro: 1.901 ± 0.048	1.671LysGln: 1.671 ± 0.045	3.124LysArg: 3.124 ± 0.063	4.893LysSer: 4.893 ± 0.073	4.372LysThr: 4.372 ± 0.072	6.079LysVal: 6.079 ± 0.083	0.566LysTrp: 0.566 ± 0.02	4.172LysTyr: 4.172 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	5.517LeuAla: 5.517 ± 0.093	0.832LeuCys: 0.832 ± 0.03	5.454LeuAsp: 5.454 ± 0.087	8.422LeuGlu: 8.422 ± 0.122	4.354LeuPhe: 4.354 ± 0.085	7.183LeuGly: 7.183 ± 0.098	1.043LeuHis: 1.043 ± 0.036	8.074LeuIle: 8.074 ± 0.104	10.667LeuLys: 10.667 ± 0.134	8.643LeuLeu: 8.643 ± 0.119	2.233LeuMet: 2.233 ± 0.05	6.54LeuAsn: 6.54 ± 0.1	2.955LeuPro: 2.955 ± 0.062	2.074LeuGln: 2.074 ± 0.049	2.809LeuArg: 2.809 ± 0.065	6.449LeuSer: 6.449 ± 0.096	4.975LeuThr: 4.975 ± 0.075	5.606LeuVal: 5.606 ± 0.092	0.566LeuTrp: 0.566 ± 0.025	3.143LeuTyr: 3.143 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.58MetAla: 1.58 ± 0.05	0.189MetCys: 0.189 ± 0.014	1.268MetAsp: 1.268 ± 0.037	1.793MetGlu: 1.793 ± 0.047	1.108MetPhe: 1.108 ± 0.04	2.026MetGly: 2.026 ± 0.053	0.253MetHis: 0.253 ± 0.016	2.092MetIle: 2.092 ± 0.047	2.649MetLys: 2.649 ± 0.062	2.26MetLeu: 2.26 ± 0.049	0.585MetMet: 0.585 ± 0.026	1.441MetAsn: 1.441 ± 0.042	0.748MetPro: 0.748 ± 0.029	0.504MetGln: 0.504 ± 0.027	0.86MetArg: 0.86 ± 0.034	1.482MetSer: 1.482 ± 0.046	1.202MetThr: 1.202 ± 0.04	1.523MetVal: 1.523 ± 0.043	0.176MetTrp: 0.176 ± 0.016	0.825MetTyr: 0.825 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.316AsnAla: 2.316 ± 0.052	0.525AsnCys: 0.525 ± 0.021	2.551AsnAsp: 2.551 ± 0.063	4.169AsnGlu: 4.169 ± 0.075	3.482AsnPhe: 3.482 ± 0.057	4.011AsnGly: 4.011 ± 0.102	0.812AsnHis: 0.812 ± 0.029	7.009AsnIle: 7.009 ± 0.104	5.391AsnLys: 5.391 ± 0.078	6.682AsnLeu: 6.682 ± 0.105	1.499AsnMet: 1.499 ± 0.038	3.791AsnAsn: 3.791 ± 0.083	2.46AsnPro: 2.46 ± 0.061	1.492AsnGln: 1.492 ± 0.045	2.142AsnArg: 2.142 ± 0.048	4.186AsnSer: 4.186 ± 0.086	2.752AsnThr: 2.752 ± 0.066	2.979AsnVal: 2.979 ± 0.064	0.522AsnTrp: 0.522 ± 0.022	2.943AsnTyr: 2.943 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	1.548ProAla: 1.548 ± 0.05	0.245ProCys: 0.245 ± 0.019	1.177ProAsp: 1.177 ± 0.038	2.476ProGlu: 2.476 ± 0.056	1.511ProPhe: 1.511 ± 0.047	1.903ProGly: 1.903 ± 0.056	0.482ProHis: 0.482 ± 0.023	2.869ProIle: 2.869 ± 0.064	2.389ProLys: 2.389 ± 0.053	2.805ProLeu: 2.805 ± 0.049	0.773ProMet: 0.773 ± 0.028	1.657ProAsn: 1.657 ± 0.044	0.623ProPro: 0.623 ± 0.028	0.832ProGln: 0.832 ± 0.027	0.798ProArg: 0.798 ± 0.032	1.6ProSer: 1.6 ± 0.042	1.658ProThr: 1.658 ± 0.041	1.958ProVal: 1.958 ± 0.057	0.254ProTrp: 0.254 ± 0.019	1.187ProTyr: 1.187 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.11GlnAla: 1.11 ± 0.032	0.2GlnCys: 0.2 ± 0.014	1.094GlnAsp: 1.094 ± 0.037	1.962GlnGlu: 1.962 ± 0.046	0.876GlnPhe: 0.876 ± 0.031	1.564GlnGly: 1.564 ± 0.046	0.283GlnHis: 0.283 ± 0.017	2.023GlnIle: 2.023 ± 0.051	2.111GlnLys: 2.111 ± 0.051	2.006GlnLeu: 2.006 ± 0.045	0.607GlnMet: 0.607 ± 0.027	1.541GlnAsn: 1.541 ± 0.041	0.547GlnPro: 0.547 ± 0.025	0.518GlnGln: 0.518 ± 0.028	0.818GlnArg: 0.818 ± 0.028	1.198GlnSer: 1.198 ± 0.041	1.021GlnThr: 1.021 ± 0.032	1.329GlnVal: 1.329 ± 0.039	0.226GlnTrp: 0.226 ± 0.015	0.886GlnTyr: 0.886 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.716ArgAla: 1.716 ± 0.048	0.312ArgCys: 0.312 ± 0.02	1.919ArgAsp: 1.919 ± 0.05	3.07ArgGlu: 3.07 ± 0.071	1.562ArgPhe: 1.562 ± 0.039	2.076ArgGly: 2.076 ± 0.052	0.375ArgHis: 0.375 ± 0.019	2.747ArgIle: 2.747 ± 0.063	3.027ArgLys: 3.027 ± 0.057	2.725ArgLeu: 2.725 ± 0.058	0.803ArgMet: 0.803 ± 0.029	1.798ArgAsn: 1.798 ± 0.047	0.722ArgPro: 0.722 ± 0.03	0.622ArgGln: 0.622 ± 0.027	1.203ArgArg: 1.203 ± 0.036	1.427ArgSer: 1.427 ± 0.044	1.408ArgThr: 1.408 ± 0.037	2.548ArgVal: 2.548 ± 0.058	0.236ArgTrp: 0.236 ± 0.014	1.486ArgTyr: 1.486 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	2.914SerAla: 2.914 ± 0.056	0.603SerCys: 0.603 ± 0.028	2.736SerAsp: 2.736 ± 0.058	3.863SerGlu: 3.863 ± 0.069	3.474SerPhe: 3.474 ± 0.071	4.438SerGly: 4.438 ± 0.09	0.874SerHis: 0.874 ± 0.034	5.973SerIle: 5.973 ± 0.094	5.533SerLys: 5.533 ± 0.086	6.593SerLeu: 6.593 ± 0.091	1.386SerMet: 1.386 ± 0.039	3.51SerAsn: 3.51 ± 0.068	1.792SerPro: 1.792 ± 0.041	1.68SerGln: 1.68 ± 0.039	1.867SerArg: 1.867 ± 0.042	4.035SerSer: 4.035 ± 0.071	3.077SerThr: 3.077 ± 0.062	3.408SerVal: 3.408 ± 0.065	0.481SerTrp: 0.481 ± 0.022	2.676SerTyr: 2.676 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	2.777ThrAla: 2.777 ± 0.07	0.367ThrCys: 0.367 ± 0.019	2.268ThrAsp: 2.268 ± 0.054	3.091ThrGlu: 3.091 ± 0.051	2.555ThrPhe: 2.555 ± 0.054	3.806ThrGly: 3.806 ± 0.078	0.744ThrHis: 0.744 ± 0.027	4.805ThrIle: 4.805 ± 0.075	3.77ThrLys: 3.77 ± 0.062	5.683ThrLeu: 5.683 ± 0.088	1.085ThrMet: 1.085 ± 0.036	2.656ThrAsn: 2.656 ± 0.068	2.19ThrPro: 2.19 ± 0.047	1.067ThrGln: 1.067 ± 0.036	1.467ThrArg: 1.467 ± 0.039	3.143ThrSer: 3.143 ± 0.076	2.868ThrThr: 2.868 ± 0.053	3.103ThrVal: 3.103 ± 0.057	0.313ThrTrp: 0.313 ± 0.02	2.025ThrTyr: 2.025 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.016ValAla: 4.016 ± 0.086	0.596ValCys: 0.596 ± 0.028	3.403ValAsp: 3.403 ± 0.068	4.873ValGlu: 4.873 ± 0.081	2.962ValPhe: 2.962 ± 0.068	4.58ValGly: 4.58 ± 0.089	0.745ValHis: 0.745 ± 0.028	5.972ValIle: 5.972 ± 0.08	5.14ValLys: 5.14 ± 0.076	6.185ValLeu: 6.185 ± 0.076	1.487ValMet: 1.487 ± 0.043	3.199ValAsn: 3.199 ± 0.061	1.978ValPro: 1.978 ± 0.049	1.358ValGln: 1.358 ± 0.037	1.846ValArg: 1.846 ± 0.046	3.963ValSer: 3.963 ± 0.064	3.394ValThr: 3.394 ± 0.069	4.653ValVal: 4.653 ± 0.08	0.405ValTrp: 0.405 ± 0.024	2.204ValTyr: 2.204 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.376TrpAla: 0.376 ± 0.019	0.073TrpCys: 0.073 ± 0.009	0.409TrpAsp: 0.409 ± 0.023	0.544TrpGlu: 0.544 ± 0.024	0.355TrpPhe: 0.355 ± 0.022	0.551TrpGly: 0.551 ± 0.027	0.1TrpHis: 0.1 ± 0.01	0.72TrpIle: 0.72 ± 0.029	0.582TrpLys: 0.582 ± 0.025	0.618TrpLeu: 0.618 ± 0.028	0.197TrpMet: 0.197 ± 0.017	0.426TrpAsn: 0.426 ± 0.022	0.145TrpPro: 0.145 ± 0.011	0.211TrpGln: 0.211 ± 0.014	0.242TrpArg: 0.242 ± 0.017	0.405TrpSer: 0.405 ± 0.023	0.309TrpThr: 0.309 ± 0.018	0.389TrpVal: 0.389 ± 0.021	0.093TrpTrp: 0.093 ± 0.01	0.26TrpTyr: 0.26 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.773TyrAla: 1.773 ± 0.044	0.365TyrCys: 0.365 ± 0.018	2.067TyrAsp: 2.067 ± 0.051	2.784TyrGlu: 2.784 ± 0.069	2.36TyrPhe: 2.36 ± 0.054	2.67TyrGly: 2.67 ± 0.059	0.545TyrHis: 0.545 ± 0.025	3.761TyrIle: 3.761 ± 0.067	3.676TyrLys: 3.676 ± 0.072	4.405TyrLeu: 4.405 ± 0.078	0.896TyrMet: 0.896 ± 0.034	2.695TyrAsn: 2.695 ± 0.065	1.393TyrPro: 1.393 ± 0.044	0.981TyrGln: 0.981 ± 0.031	1.371TyrArg: 1.371 ± 0.042	3.126TyrSer: 3.126 ± 0.063	1.994TyrThr: 1.994 ± 0.041	2.043TyrVal: 2.043 ± 0.053	0.283TyrTrp: 0.283 ± 0.02	1.844TyrTyr: 1.844 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2974 proteins (943243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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