Amino acid dipepetide frequency for Vittaforma corneae (strain ATCC 50505) (Microsporidian parasite) (Nosema corneum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.386AlaAla: 2.386 ± 0.076	0.939AlaCys: 0.939 ± 0.038	2.324AlaAsp: 2.324 ± 0.059	3.213AlaGlu: 3.213 ± 0.071	2.548AlaPhe: 2.548 ± 0.066	1.998AlaGly: 1.998 ± 0.063	0.823AlaHis: 0.823 ± 0.033	3.819AlaIle: 3.819 ± 0.076	3.566AlaLys: 3.566 ± 0.088	4.871AlaLeu: 4.871 ± 0.092	1.113AlaMet: 1.113 ± 0.039	2.415AlaAsn: 2.415 ± 0.055	1.326AlaPro: 1.326 ± 0.059	1.459AlaGln: 1.459 ± 0.052	1.996AlaArg: 1.996 ± 0.054	3.716AlaSer: 3.716 ± 0.086	2.073AlaThr: 2.073 ± 0.056	3.048AlaVal: 3.048 ± 0.072	0.225AlaTrp: 0.225 ± 0.019	1.614AlaTyr: 1.614 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.876CysAla: 0.876 ± 0.036	0.571CysCys: 0.571 ± 0.03	1.04CysAsp: 1.04 ± 0.044	1.354CysGlu: 1.354 ± 0.05	1.239CysPhe: 1.239 ± 0.04	1.13CysGly: 1.13 ± 0.039	0.33CysHis: 0.33 ± 0.02	1.824CysIle: 1.824 ± 0.047	1.546CysLys: 1.546 ± 0.047	2.243CysLeu: 2.243 ± 0.064	0.426CysMet: 0.426 ± 0.028	0.955CysAsn: 0.955 ± 0.041	0.602CysPro: 0.602 ± 0.032	0.469CysGln: 0.469 ± 0.026	0.911CysArg: 0.911 ± 0.039	1.754CysSer: 1.754 ± 0.059	1.044CysThr: 1.044 ± 0.035	1.142CysVal: 1.142 ± 0.039	0.144CysTrp: 0.144 ± 0.015	0.762CysTyr: 0.762 ± 0.032	0.0CysXaa: 0.0 ± 0.0
Asp	2.505AspAla: 2.505 ± 0.06	1.134AspCys: 1.134 ± 0.044	2.884AspAsp: 2.884 ± 0.065	4.251AspGlu: 4.251 ± 0.078	3.424AspPhe: 3.424 ± 0.069	2.664AspGly: 2.664 ± 0.078	0.921AspHis: 0.921 ± 0.035	4.671AspIle: 4.671 ± 0.079	3.993AspLys: 3.993 ± 0.075	5.504AspLeu: 5.504 ± 0.091	1.219AspMet: 1.219 ± 0.05	2.848AspAsn: 2.848 ± 0.067	1.793AspPro: 1.793 ± 0.048	1.76AspGln: 1.76 ± 0.053	2.397AspArg: 2.397 ± 0.064	4.602AspSer: 4.602 ± 0.089	2.428AspThr: 2.428 ± 0.059	3.639AspVal: 3.639 ± 0.068	0.337AspTrp: 0.337 ± 0.025	2.099AspTyr: 2.099 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	3.168GluAla: 3.168 ± 0.068	1.585GluCys: 1.585 ± 0.051	4.323GluAsp: 4.323 ± 0.089	5.602GluGlu: 5.602 ± 0.095	3.625GluPhe: 3.625 ± 0.061	2.496GluGly: 2.496 ± 0.061	1.31GluHis: 1.31 ± 0.049	6.439GluIle: 6.439 ± 0.105	6.362GluLys: 6.362 ± 0.099	6.444GluLeu: 6.444 ± 0.118	1.991GluMet: 1.991 ± 0.049	5.54GluAsn: 5.54 ± 0.108	1.718GluPro: 1.718 ± 0.051	2.125GluGln: 2.125 ± 0.058	3.216GluArg: 3.216 ± 0.075	5.294GluSer: 5.294 ± 0.11	3.205GluThr: 3.205 ± 0.078	3.604GluVal: 3.604 ± 0.073	0.428GluTrp: 0.428 ± 0.027	3.311GluTyr: 3.311 ± 0.08	0.0GluXaa: 0.0 ± 0.0
Phe	2.113PheAla: 2.113 ± 0.057	1.284PheCys: 1.284 ± 0.049	3.693PheAsp: 3.693 ± 0.079	4.309PheGlu: 4.309 ± 0.07	3.009PhePhe: 3.009 ± 0.083	2.551PheGly: 2.551 ± 0.071	0.921PheHis: 0.921 ± 0.037	4.599PheIle: 4.599 ± 0.093	4.546PheLys: 4.546 ± 0.084	5.758PheLeu: 5.758 ± 0.114	1.135PheMet: 1.135 ± 0.041	3.298PheAsn: 3.298 ± 0.076	1.635PhePro: 1.635 ± 0.051	1.471PheGln: 1.471 ± 0.05	2.177PheArg: 2.177 ± 0.057	4.799PheSer: 4.799 ± 0.093	2.699PheThr: 2.699 ± 0.062	3.539PheVal: 3.539 ± 0.074	0.356PheTrp: 0.356 ± 0.021	2.57PheTyr: 2.57 ± 0.062	0.003PheXaa: 0.003 ± 0.002
Gly	1.967GlyAla: 1.967 ± 0.069	0.914GlyCys: 0.914 ± 0.037	2.307GlyAsp: 2.307 ± 0.059	2.614GlyGlu: 2.614 ± 0.068	2.554GlyPhe: 2.554 ± 0.071	1.904GlyGly: 1.904 ± 0.068	0.993GlyHis: 0.993 ± 0.039	3.794GlyIle: 3.794 ± 0.078	3.488GlyLys: 3.488 ± 0.073	4.069GlyLeu: 4.069 ± 0.075	1.211GlyMet: 1.211 ± 0.045	2.629GlyAsn: 2.629 ± 0.062	0.972GlyPro: 0.972 ± 0.034	1.18GlyGln: 1.18 ± 0.048	2.037GlyArg: 2.037 ± 0.059	3.576GlySer: 3.576 ± 0.076	2.373GlyThr: 2.373 ± 0.063	2.619GlyVal: 2.619 ± 0.07	0.295GlyTrp: 0.295 ± 0.021	1.91GlyTyr: 1.91 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.802HisAla: 0.802 ± 0.037	0.426HisCys: 0.426 ± 0.023	0.812HisAsp: 0.812 ± 0.036	1.17HisGlu: 1.17 ± 0.042	1.173HisPhe: 1.173 ± 0.041	0.952HisGly: 0.952 ± 0.036	0.456HisHis: 0.456 ± 0.028	1.561HisIle: 1.561 ± 0.053	1.313HisLys: 1.313 ± 0.044	1.992HisLeu: 1.992 ± 0.063	0.382HisMet: 0.382 ± 0.024	0.948HisAsn: 0.948 ± 0.031	0.86HisPro: 0.86 ± 0.035	0.543HisGln: 0.543 ± 0.029	0.924HisArg: 0.924 ± 0.043	1.897HisSer: 1.897 ± 0.059	0.967HisThr: 0.967 ± 0.035	1.081HisVal: 1.081 ± 0.04	0.123HisTrp: 0.123 ± 0.013	0.741HisTyr: 0.741 ± 0.028	0.001HisXaa: 0.001 ± 0.002
Ile	3.891IleAla: 3.891 ± 0.076	1.838IleCys: 1.838 ± 0.057	4.96IleAsp: 4.96 ± 0.078	6.229IleGlu: 6.229 ± 0.102	5.0IlePhe: 5.0 ± 0.109	3.58IleGly: 3.58 ± 0.085	1.693IleHis: 1.693 ± 0.052	5.394IleIle: 5.394 ± 0.108	6.898IleLys: 6.898 ± 0.098	8.841IleLeu: 8.841 ± 0.137	1.408IleMet: 1.408 ± 0.046	4.37IleAsn: 4.37 ± 0.088	2.75IlePro: 2.75 ± 0.062	2.702IleGln: 2.702 ± 0.069	3.291IleArg: 3.291 ± 0.071	6.985IleSer: 6.985 ± 0.109	3.497IleThr: 3.497 ± 0.086	4.841IleVal: 4.841 ± 0.085	0.434IleTrp: 0.434 ± 0.024	3.142IleTyr: 3.142 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.013LysAla: 4.013 ± 0.083	1.491LysCys: 1.491 ± 0.049	4.836LysAsp: 4.836 ± 0.08	6.328LysGlu: 6.328 ± 0.106	3.636LysPhe: 3.636 ± 0.073	2.989LysGly: 2.989 ± 0.061	1.77LysHis: 1.77 ± 0.053	7.815LysIle: 7.815 ± 0.11	7.293LysLys: 7.293 ± 0.116	7.319LysLeu: 7.319 ± 0.122	2.366LysMet: 2.366 ± 0.061	5.781LysAsn: 5.781 ± 0.103	2.191LysPro: 2.191 ± 0.055	2.353LysGln: 2.353 ± 0.055	4.013LysArg: 4.013 ± 0.076	6.311LysSer: 6.311 ± 0.101	4.746LysThr: 4.746 ± 0.074	4.329LysVal: 4.329 ± 0.089	0.433LysTrp: 0.433 ± 0.026	3.559LysTyr: 3.559 ± 0.074	0.0LysXaa: 0.0 ± 0.0
Leu	4.367LeuAla: 4.367 ± 0.077	2.094LeuCys: 2.094 ± 0.057	5.446LeuAsp: 5.446 ± 0.099	7.254LeuGlu: 7.254 ± 0.12	5.544LeuPhe: 5.544 ± 0.117	4.231LeuGly: 4.231 ± 0.086	1.838LeuHis: 1.838 ± 0.057	7.028LeuIle: 7.028 ± 0.13	9.838LeuLys: 9.838 ± 0.153	9.902LeuLeu: 9.902 ± 0.187	2.117LeuMet: 2.117 ± 0.056	5.995LeuAsn: 5.995 ± 0.106	3.416LeuPro: 3.416 ± 0.09	3.153LeuGln: 3.153 ± 0.075	4.783LeuArg: 4.783 ± 0.104	8.584LeuSer: 8.584 ± 0.126	4.206LeuThr: 4.206 ± 0.096	5.543LeuVal: 5.543 ± 0.09	0.543LeuTrp: 0.543 ± 0.032	3.838LeuTyr: 3.838 ± 0.077	0.0LeuXaa: 0.0 ± 0.0
Met	1.397MetAla: 1.397 ± 0.043	0.472MetCys: 0.472 ± 0.026	1.344MetAsp: 1.344 ± 0.049	1.41MetGlu: 1.41 ± 0.047	1.247MetPhe: 1.247 ± 0.043	1.015MetGly: 1.015 ± 0.042	0.581MetHis: 0.581 ± 0.029	1.687MetIle: 1.687 ± 0.048	2.241MetLys: 2.241 ± 0.055	2.23MetLeu: 2.23 ± 0.061	0.5MetMet: 0.5 ± 0.025	1.383MetAsn: 1.383 ± 0.04	0.963MetPro: 0.963 ± 0.033	0.727MetGln: 0.727 ± 0.034	0.987MetArg: 0.987 ± 0.044	1.791MetSer: 1.791 ± 0.049	0.892MetThr: 0.892 ± 0.033	1.385MetVal: 1.385 ± 0.046	0.155MetTrp: 0.155 ± 0.015	0.753MetTyr: 0.753 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.839AsnAla: 2.839 ± 0.074	1.03AsnCys: 1.03 ± 0.041	3.198AsnAsp: 3.198 ± 0.081	4.424AsnGlu: 4.424 ± 0.075	2.982AsnPhe: 2.982 ± 0.058	2.822AsnGly: 2.822 ± 0.065	1.009AsnHis: 1.009 ± 0.036	5.504AsnIle: 5.504 ± 0.095	4.482AsnLys: 4.482 ± 0.081	5.798AsnLeu: 5.798 ± 0.116	1.48AsnMet: 1.48 ± 0.043	3.336AsnAsn: 3.336 ± 0.082	2.191AsnPro: 2.191 ± 0.056	1.813AsnGln: 1.813 ± 0.053	2.475AsnArg: 2.475 ± 0.06	4.886AsnSer: 4.886 ± 0.108	3.336AsnThr: 3.336 ± 0.076	3.3AsnVal: 3.3 ± 0.068	0.3AsnTrp: 0.3 ± 0.021	1.928AsnTyr: 1.928 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	1.561ProAla: 1.561 ± 0.046	0.566ProCys: 0.566 ± 0.031	1.632ProAsp: 1.632 ± 0.048	2.544ProGlu: 2.544 ± 0.055	1.912ProPhe: 1.912 ± 0.058	1.344ProGly: 1.344 ± 0.054	0.584ProHis: 0.584 ± 0.032	2.373ProIle: 2.373 ± 0.066	2.39ProLys: 2.39 ± 0.063	2.736ProLeu: 2.736 ± 0.066	0.615ProMet: 0.615 ± 0.028	1.644ProAsn: 1.644 ± 0.052	1.061ProPro: 1.061 ± 0.045	1.0ProGln: 1.0 ± 0.046	1.295ProArg: 1.295 ± 0.045	2.94ProSer: 2.94 ± 0.08	1.635ProThr: 1.635 ± 0.048	2.104ProVal: 2.104 ± 0.057	0.164ProTrp: 0.164 ± 0.015	1.317ProTyr: 1.317 ± 0.063	0.0ProXaa: 0.0 ± 0.0
Gln	1.483GlnAla: 1.483 ± 0.047	0.545GlnCys: 0.545 ± 0.033	1.516GlnAsp: 1.516 ± 0.048	2.064GlnGlu: 2.064 ± 0.061	1.397GlnPhe: 1.397 ± 0.039	1.224GlnGly: 1.224 ± 0.044	0.592GlnHis: 0.592 ± 0.029	2.61GlnIle: 2.61 ± 0.055	2.849GlnLys: 2.849 ± 0.064	2.573GlnLeu: 2.573 ± 0.06	0.889GlnMet: 0.889 ± 0.034	2.139GlnAsn: 2.139 ± 0.051	1.037GlnPro: 1.037 ± 0.05	1.112GlnGln: 1.112 ± 0.05	1.484GlnArg: 1.484 ± 0.048	2.622GlnSer: 2.622 ± 0.064	1.463GlnThr: 1.463 ± 0.044	1.425GlnVal: 1.425 ± 0.044	0.16GlnTrp: 0.16 ± 0.014	1.148GlnTyr: 1.148 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	1.949ArgAla: 1.949 ± 0.056	0.851ArgCys: 0.851 ± 0.036	2.202ArgAsp: 2.202 ± 0.066	3.025ArgGlu: 3.025 ± 0.075	2.367ArgPhe: 2.367 ± 0.053	1.716ArgGly: 1.716 ± 0.062	0.861ArgHis: 0.861 ± 0.037	4.084ArgIle: 4.084 ± 0.074	3.887ArgLys: 3.887 ± 0.074	4.148ArgLeu: 4.148 ± 0.08	1.261ArgMet: 1.261 ± 0.044	2.971ArgAsn: 2.971 ± 0.061	1.289ArgPro: 1.289 ± 0.043	1.298ArgGln: 1.298 ± 0.043	2.332ArgArg: 2.332 ± 0.06	3.307ArgSer: 3.307 ± 0.065	2.139ArgThr: 2.139 ± 0.057	2.457ArgVal: 2.457 ± 0.062	0.27ArgTrp: 0.27 ± 0.02	1.658ArgTyr: 1.658 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	3.441SerAla: 3.441 ± 0.093	1.408SerCys: 1.408 ± 0.05	4.19SerAsp: 4.19 ± 0.089	5.732SerGlu: 5.732 ± 0.086	4.938SerPhe: 4.938 ± 0.101	3.621SerGly: 3.621 ± 0.088	1.533SerHis: 1.533 ± 0.047	7.395SerIle: 7.395 ± 0.113	7.207SerLys: 7.207 ± 0.107	8.649SerLeu: 8.649 ± 0.131	1.919SerMet: 1.919 ± 0.049	4.773SerAsn: 4.773 ± 0.088	2.418SerPro: 2.418 ± 0.07	2.65SerGln: 2.65 ± 0.06	3.576SerArg: 3.576 ± 0.074	7.517SerSer: 7.517 ± 0.137	4.48SerThr: 4.48 ± 0.091	4.588SerVal: 4.588 ± 0.084	0.459SerTrp: 0.459 ± 0.026	3.018SerTyr: 3.018 ± 0.077	0.0SerXaa: 0.0 ± 0.0
Thr	2.366ThrAla: 2.366 ± 0.056	0.808ThrCys: 0.808 ± 0.038	2.461ThrAsp: 2.461 ± 0.053	3.006ThrGlu: 3.006 ± 0.065	2.761ThrPhe: 2.761 ± 0.056	2.416ThrGly: 2.416 ± 0.068	0.942ThrHis: 0.942 ± 0.042	3.73ThrIle: 3.73 ± 0.071	3.657ThrLys: 3.657 ± 0.072	5.023ThrLeu: 5.023 ± 0.099	0.976ThrMet: 0.976 ± 0.033	2.534ThrAsn: 2.534 ± 0.071	1.809ThrPro: 1.809 ± 0.049	1.463ThrGln: 1.463 ± 0.048	1.973ThrArg: 1.973 ± 0.055	4.143ThrSer: 4.143 ± 0.081	2.535ThrThr: 2.535 ± 0.062	3.598ThrVal: 3.598 ± 0.088	0.239ThrTrp: 0.239 ± 0.017	1.585ThrTyr: 1.585 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	2.601ValAla: 2.601 ± 0.066	1.338ValCys: 1.338 ± 0.043	3.593ValAsp: 3.593 ± 0.075	4.42ValGlu: 4.42 ± 0.098	3.992ValPhe: 3.992 ± 0.081	2.822ValGly: 2.822 ± 0.065	1.148ValHis: 1.148 ± 0.035	3.906ValIle: 3.906 ± 0.073	4.475ValLys: 4.475 ± 0.08	6.267ValLeu: 6.267 ± 0.09	1.159ValMet: 1.159 ± 0.047	3.013ValAsn: 3.013 ± 0.071	2.003ValPro: 2.003 ± 0.054	1.82ValGln: 1.82 ± 0.046	2.289ValArg: 2.289 ± 0.059	4.802ValSer: 4.802 ± 0.095	2.124ValThr: 2.124 ± 0.061	4.007ValVal: 4.007 ± 0.083	0.356ValTrp: 0.356 ± 0.022	2.407ValTyr: 2.407 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.242TrpAla: 0.242 ± 0.02	0.101TrpCys: 0.101 ± 0.012	0.332TrpAsp: 0.332 ± 0.021	0.344TrpGlu: 0.344 ± 0.023	0.297TrpPhe: 0.297 ± 0.02	0.239TrpGly: 0.239 ± 0.018	0.088TrpHis: 0.088 ± 0.011	0.543TrpIle: 0.543 ± 0.03	0.484TrpLys: 0.484 ± 0.025	0.486TrpLeu: 0.486 ± 0.029	0.207TrpMet: 0.207 ± 0.018	0.452TrpAsn: 0.452 ± 0.03	0.167TrpPro: 0.167 ± 0.015	0.137TrpGln: 0.137 ± 0.014	0.288TrpArg: 0.288 ± 0.018	0.47TrpSer: 0.47 ± 0.023	0.28TrpThr: 0.28 ± 0.017	0.277TrpVal: 0.277 ± 0.02	0.073TrpTrp: 0.073 ± 0.011	0.231TrpTyr: 0.231 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.506TyrAla: 1.506 ± 0.048	0.967TyrCys: 0.967 ± 0.039	1.977TyrAsp: 1.977 ± 0.054	2.493TyrGlu: 2.493 ± 0.074	2.822TyrPhe: 2.822 ± 0.064	1.69TyrGly: 1.69 ± 0.045	0.729TyrHis: 0.729 ± 0.037	2.967TyrIle: 2.967 ± 0.071	3.058TyrLys: 3.058 ± 0.076	4.865TyrLeu: 4.865 ± 0.094	0.784TyrMet: 0.784 ± 0.032	2.111TyrAsn: 2.111 ± 0.057	1.215TyrPro: 1.215 ± 0.047	1.096TyrGln: 1.096 ± 0.034	1.63TyrArg: 1.63 ± 0.046	3.518TyrSer: 3.518 ± 0.084	1.9TyrThr: 1.9 ± 0.044	2.015TyrVal: 2.015 ± 0.051	0.245TyrTrp: 0.245 ± 0.017	1.739TyrTyr: 1.739 ± 0.079	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.002	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2236 proteins (714266 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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